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Feline Comorbidities: Balancing Hyperthyroidism and Concurrent Chronic Kidney Disease (2022)
Journal Article
Geddes, R., & Aguiar, J. (2022). Feline Comorbidities: Balancing Hyperthyroidism and Concurrent Chronic Kidney Disease. Journal of Feline Medicine and Surgery, https://doi.org/10.1177/1098612X221090390

Practical relevance - Both hyperthyroidism and chronic kidney disease are common long-lasting conditions in older cats, which might be diagnosed concurrently or develop at different times. Hyperthyroidism may mask the presence of chronic kidney disea... Read More about Feline Comorbidities: Balancing Hyperthyroidism and Concurrent Chronic Kidney Disease.

Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor (2022)
Journal Article
Miller, D., Reuillon, T., Molyneux, L., Blackburn, T., Cook, S., Edwards, N., Endicott, J., Golding, B., Griffin, R., Hardcastle, I., Harnor, S., Heptinstall, A., Lochhead, P., Martin, M., Martin, N., Newell, D., Noble, R., Phillips, N., Rigoreau, L., Thomas, H., …Cano, C. (2022). Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor. Journal of Medicinal Chemistry, 65(9), 6513-6540. https://doi.org/10.1021/acs.jmedchem.1c01756

The nonclassical extracellular signal-related kinase 5 (ERK5) mitogen-activated protein kinase pathway has beenimplicated in increased cellular proliferation, migration, survival, and angiogenesis; hence, ERK5 inhibition may be an attractiveapproach... Read More about Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor.

Phylogenetic analysis of migration, differentiation, and class switching in B cells (2022)
Journal Article
Hoehn, K., Pybus, O., & Kleinstein, S. (2022). Phylogenetic analysis of migration, differentiation, and class switching in B cells. PLoS Computational Biology, 18(4), https://doi.org/10.1371/journal.pcbi.1009885

B cells undergo rapid mutation and selection for antibody binding affinity when producing antibodies capable of neutralizing pathogens. This evolutionary process can be intermixed with migration between tissues, differentiation between cellular subse... Read More about Phylogenetic analysis of migration, differentiation, and class switching in B cells.

Spatial links between subchondral bone architectural features and cartilage degeneration in osteoarthritic joints (2022)
Journal Article
Ajami, S., Javaheri, B., Chang, Y., Maruthainar, N., Khan, T., Donaldson, J., Pitsillides, A., & Liu, C. (2022). Spatial links between subchondral bone architectural features and cartilage degeneration in osteoarthritic joints. Scientific Reports, 12(1), https://doi.org/10.1038/s41598-022-10600-6

Early diagnosis of osteoarthritis (OA), before the onset of irreversible changes is crucial for understanding the disease process and identifying potential disease-modifying treatments from the earliest stage. OA is a whole joint disease and affects... Read More about Spatial links between subchondral bone architectural features and cartilage degeneration in osteoarthritic joints.

Revisiting the original Akin technique: A comparative analysis of radiographic outcome (2022)
Journal Article
Dellonder-Frigole, J., Matas-Pareja, M., Calle-Garcia, J., Bowen, J., Fatjo-Rios, J., & Alberti-Fito, G. (2022). Revisiting the original Akin technique: A comparative analysis of radiographic outcome. Foot and Ankle Surgery, 28(3), 394-401. https://doi.org/10.1016/j.fas.2021.05.004

Background: The Akin osteotomy is widely used to correct the hallux valgus and different fixation techniques have been proposed. Currently most of these procedures coexist, with disagreement on which offers the best results. The aim of this study is... Read More about Revisiting the original Akin technique: A comparative analysis of radiographic outcome.

Insights Into Pneumococcal Pneumonia Using Lung Aspirates and Nasopharyngeal Swabs Collected From Pneumonia Patients in The Gambia (2022)
Journal Article
Dunne, E., Hua, Y., Salaudeen, R., Hossain, I., Ndiaye, M., Ortika, B., Mulholland, E., Hinds, J., Manna, S., Mackenzie, G., & Satzke, C. (2022). Insights Into Pneumococcal Pneumonia Using Lung Aspirates and Nasopharyngeal Swabs Collected From Pneumonia Patients in The Gambia. Journal of Infectious Diseases, 225(8), 1447-1451. https://doi.org/10.1093/infdis/jiaa186

Background We investigated the pathogenesis of pneumococcal pneumonia using clinical specimens collected for pneumonia surveillance in The Gambia. Methods Lung aspirates and nasopharyngeal swabs from 31 patients were examined by culture, quantitative... Read More about Insights Into Pneumococcal Pneumonia Using Lung Aspirates and Nasopharyngeal Swabs Collected From Pneumonia Patients in The Gambia.

Pharmacology, safety, efficacy and clinical uses of the COX‐2 inhibitor robenacoxib (2022)
Journal Article
Lees, P., Toutain, P., Elliott, J., Giraudel, J. M., Pelligand, L., & King, J. N. (2022). Pharmacology, safety, efficacy and clinical uses of the COX‐2 inhibitor robenacoxib. Journal of Veterinary Pharmacology and Therapeutics, 45(4), 325-351. https://doi.org/10.1111/jvp.13052

Robenacoxib is a veterinary-approved non-steroidal anti-inflammatory drug (NSAID) of the coxib group. It possesses anti-hyperalgesic, anti-inflammatory and anti-pyretic properties. Robenacoxib inhibits the cyclooxygenase (COX)-2 isoform of COX select... Read More about Pharmacology, safety, efficacy and clinical uses of the COX‐2 inhibitor robenacoxib.

Antimicrobial Resistance Patterns of Fecal Escherichia coli in Wildlife, Urban Wildlife, and Livestock in the Eastern Region of Sri Lanka, and Differences Between Carnivores, Omnivores, and Herbivores (2022)
Journal Article
Bamunusinghage, N., Neelawala, R., Magedara, H., Ekanayaka, N., Kalupahana, R., Silva-Fletcher, A., & Kottawatta, S. (2022). Antimicrobial Resistance Patterns of Fecal Escherichia coli in Wildlife, Urban Wildlife, and Livestock in the Eastern Region of Sri Lanka, and Differences Between Carnivores, Omnivores, and Herbivores. Bio One Complete, 58(2), 380-383. https://doi.org/10.7589/JWD-D-21-00048

Antimicrobial resistance (AMR) is a major public health concern. We identified AMR in fecal Escherichia coli of wildlife (WI.), urban wildlife (UVVL), and livestock in the eastern region in Sri Lanka and compared the prevalence of AMR bacteria from c... Read More about Antimicrobial Resistance Patterns of Fecal Escherichia coli in Wildlife, Urban Wildlife, and Livestock in the Eastern Region of Sri Lanka, and Differences Between Carnivores, Omnivores, and Herbivores.

Systematic review to evaluate a potential association between helminth infection and physical stunting in children (2022)
Journal Article
Raj, E., Calvo-Urbano, B., Heffernan, C., Halder, J., & Webster, J. (2022). Systematic review to evaluate a potential association between helminth infection and physical stunting in children. Parasites and Vectors, 15(1), https://doi.org/10.1186/s13071-022-05235-5

Background: Despite considerable public health efforts over the past 20 years, childhood stunting (physical and/or cognitive) levels globally remain unacceptably high-at 22% amongst children under 5 years old in 2020. The aetiology of stunting is com... Read More about Systematic review to evaluate a potential association between helminth infection and physical stunting in children.

Housing and Environmental Enrichment of the Domestic Ferret: A Multi-Sector Survey (2022)
Journal Article
Dancer, A. M., Díez-León, M., Bizley, J. K., & Burn, C. C. (2022). Housing and Environmental Enrichment of the Domestic Ferret: A Multi-Sector Survey. Animals, 12, Article 1065. https://doi.org/10.3390/ani12091065

Ferrets (Mustela putorius furo) are kept and used in multiple sectors of society, but little is known about how they are housed and what environmental enrichment (EE) they may benefit from. We aimed to help guide caretakers about what housing and EE... Read More about Housing and Environmental Enrichment of the Domestic Ferret: A Multi-Sector Survey.

A systematic review of the methods used to analyse the economic impact of endemic foot-and-mouth disease (2022)
Journal Article
Compston, P., Limon, G., & Hasler, B. (2022). A systematic review of the methods used to analyse the economic impact of endemic foot-and-mouth disease. Transboundary and Emerging Diseases, https://doi.org/10.1111/tbed.14564

Foot-and-mouth disease (FMD) has large economic consequences in livestock systems, which must be
robustly assessed to support disease control policy. This study described and assessed methods used
within economic analyses of FMD and its control in... Read More about A systematic review of the methods used to analyse the economic impact of endemic foot-and-mouth disease.

Environmentally Acquired Bacillus and Their Role in C. difficile Colonization Resistance (2022)
Journal Article
Ferreira, W., Hong, H., Adams, J., Hess, M., Kotowicz, N., Tan, S., Ferrari, E., Brisson, A., Zentek, J., Soloviev, M., & Cutting, S. (2022). Environmentally Acquired Bacillus and Their Role in C. difficile Colonization Resistance. Biomedicines, 10(5), https://doi.org/10.3390/biomedicines10050930

Clostridioides difficile is an environmentally acquired, anaerobic, spore-forming bacterium which ordinarily causes disease following antibiotic-mediated dysbiosis of the intestinal microbiota. Although much is understood regarding the life cycle of... Read More about Environmentally Acquired Bacillus and Their Role in C. difficile Colonization Resistance.

Development and Evaluation of Molecular Pen-Side Assays without Prior RNA Extraction for Peste des Petits Ruminants (PPR) and Foot and Mouth Disease (FMD) (2022)
Journal Article
Edge, D., Mahapatra, M., Strachan, S., Turton, J., Waters, R., Benfield, C., Nazareth, N., Njeumi, F., Nazareth, N., & Parida, S. (2022). Development and Evaluation of Molecular Pen-Side Assays without Prior RNA Extraction for Peste des Petits Ruminants (PPR) and Foot and Mouth Disease (FMD). Viruses, 14(4), https://doi.org/10.3390/v14040835

Animal diseases such as peste des petits ruminants (PPR) and foot and mouth disease (FMD) cause significant economic losses in endemic countries and fast, accurate in-field diagnostics would assist with surveillance and outbreak control. The detectio... Read More about Development and Evaluation of Molecular Pen-Side Assays without Prior RNA Extraction for Peste des Petits Ruminants (PPR) and Foot and Mouth Disease (FMD).

Systematic characterization of wing mechanosensors that monitor airflow and wing deformations (2022)
Journal Article
Fabian, J., Siwanowicz, I., Uhrhan, M., Maeda, M., Bomphrey, R., & Lin, H. (2022). Systematic characterization of wing mechanosensors that monitor airflow and wing deformations. iScience, 25(4), https://doi.org/10.1016/j.isci.2022.104150

Animal wings deform during flight in ways that can enhance lift, facilitate flight control, and mitigate damage. Monitoring the structural and aerodynamic state of the wing is challenging because deformations are passive, and the flow fields are unst... Read More about Systematic characterization of wing mechanosensors that monitor airflow and wing deformations.