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A cluster-randomised, non-inferiority trial of the impact of a two-dose compared to three-dose schedule of pneumococcal conjugate vaccination in rural Gambia: the PVS trial (2022)
Journal Article
Mackenzie, G., Osei, I., Salaudeen, R., Hossain, I., Young, B., Secka, O., …Greenwood, B. (2022). A cluster-randomised, non-inferiority trial of the impact of a two-dose compared to three-dose schedule of pneumococcal conjugate vaccination in rural Gambia: the PVS trial. Trials, 23(1), https://doi.org/10.1186/s13063-021-05964-5

Background: Pneumococcal conjugate vaccines (PCV) effectively prevent pneumococcal disease but the global impact of pneumococcal vaccination is hampered by the cost of PCV. The relevance and feasibility of trials of reduced dose schedules is greatest... Read More about A cluster-randomised, non-inferiority trial of the impact of a two-dose compared to three-dose schedule of pneumococcal conjugate vaccination in rural Gambia: the PVS trial.

Regional variations in discrete collagen fibre mechanics within intact intervertebral disc resolved using synchrotron computed tomography and digital volume correlation (2022)
Journal Article
Disney, C., Mo, J., Eckersley, A., Bodey, A., Hoyland, J., Sherratt, M., …Bay, B. (2022). Regional variations in discrete collagen fibre mechanics within intact intervertebral disc resolved using synchrotron computed tomography and digital volume correlation. Acta Biomaterialia, 138, 361-374. https://doi.org/10.1016/j.actbio.2021.10.012

Many soft tissues, such as the intervertebral disc (IVD), have a hierarchical fibrous composite structure which suffers from regional damage. We hypothesise that these tissue regions have distinct, inherent fibre structure and structural response upo... Read More about Regional variations in discrete collagen fibre mechanics within intact intervertebral disc resolved using synchrotron computed tomography and digital volume correlation.

Use of multivariate analysis to evaluate antigenic relationships between US BVDV vaccine strains and non-US genetically divergent isolates (2022)
Journal Article
Mosena, A., Falkenberg, S., Ma, H., Casas, E., Dassanayake, R., Booth, R., …Neill, J. (2022). Use of multivariate analysis to evaluate antigenic relationships between US BVDV vaccine strains and non-US genetically divergent isolates. Journal of Virological Methods, 299, https://doi.org/10.1016/j.jviromet.2021.114328

Bovine viral diarrhea virus (BVDV) comprises two species, BVDV-1 and BVDV-2. But given the genetic diversity among pestiviruses, at least 22 subgenotypes are described for BVDV-1 and 3-4 for BVDV-2. Genetic characterization is generally accomplished... Read More about Use of multivariate analysis to evaluate antigenic relationships between US BVDV vaccine strains and non-US genetically divergent isolates.

Who's Getting a Head Start? Mesocephalic Dogs in Still Images Are Attributed More Positively Valenced Emotions Than Dogs of Other Cephalic Index Groups (2022)
Journal Article
Brincat, B., McGreevy, P., Bowell, V., & Packer, R. (2022). Who's Getting a Head Start? Mesocephalic Dogs in Still Images Are Attributed More Positively Valenced Emotions Than Dogs of Other Cephalic Index Groups. Animals, 12(1), https://doi.org/10.3390/ani12010049

Simple Summary Elements of a dog's appearance in still images affect how positively human observers interpret that individual's personality. Given that this may influence caregiving and other aspects of dog ownership, it is important to examine this... Read More about Who's Getting a Head Start? Mesocephalic Dogs in Still Images Are Attributed More Positively Valenced Emotions Than Dogs of Other Cephalic Index Groups.

Ocular pathology in aquarium fish with a focus on the Syngnathidae and Apogonidae families (2022)
Journal Article
Kumaratunga, V., Adams, V., Donaldson, D., Pont, R., & Stidworthy, M. (2023). Ocular pathology in aquarium fish with a focus on the Syngnathidae and Apogonidae families. Journal of Comparative Pathology, 200, 1-11. https://doi.org/10.1016/j.jcpa.2022.11.002

This study catalogued ocular pathology in fish histopathology submissions to a specialist diagnostic service and investigated associations with species and systemic disease, with a focus on species of conservation interest. Cross-tabulations and Fish... Read More about Ocular pathology in aquarium fish with a focus on the Syngnathidae and Apogonidae families.

A new method for segmentation and analysis of bone callus in rodent fracture models using micro-CT (2022)
Journal Article
Hopkinson, M., Jones, G., Evans, L., Gohin, S., Magnusdottir, R., Salmon, P., …Pitsillides, A. (2022). A new method for segmentation and analysis of bone callus in rodent fracture models using micro-CT. Journal of Orthopaedic Research, https://doi.org/10.1002/jor.25507

Fracture burden has created a need to better understand bone repair processes under different pathophysiological states. Evaluation of structural and material properties of the mineralized callus, which is integral to restoring biomechanical stabilit... Read More about A new method for segmentation and analysis of bone callus in rodent fracture models using micro-CT.

Dinosaurs: Comparative Cytogenomics of Their Reptile Cousins and Avian Descendants (2022)
Journal Article
Griffin, D., Larkin, D., O'Connor, R., & Romanov, M. (2023). Dinosaurs: Comparative Cytogenomics of Their Reptile Cousins and Avian Descendants. Animals, 13(1), https://doi.org/10.3390/ani13010106

Simple Summary Dinosaurs have been in scientific and popular culture since early fossil discoveries, but increased interest, particularly in their genomes, is expanding. Birds are reptiles, specifically theropod dinosaurs, meaning that if we compare... Read More about Dinosaurs: Comparative Cytogenomics of Their Reptile Cousins and Avian Descendants.

Serum anti‐GM2 and anti‐GalNAc‐GD1a ganglioside IgG antibodies are biomarkers for immune‐mediated polyneuropathies in cats (2022)
Journal Article
Halstead, S. K., Jackson, M., Bianchi, E., Rupp, S., Granger, N., Menchetti, M., …Rupp, A. (2022). Serum anti‐GM2 and anti‐GalNAc‐GD1a ganglioside IgG antibodies are biomarkers for immune‐mediated polyneuropathies in cats. Journal of the Peripheral Nervous System, https://doi.org/10.1111/jns.12529

Background and Aims Recent work identified anti-GM2 and anti-GalNAc-GD1a IgG ganglioside antibodies as biomarkers in dogs clinically diagnosed with acute canine polyradiculoneuritis, in turn considered a canine equivalent of Guillain-Barré syndrome.... Read More about Serum anti‐GM2 and anti‐GalNAc‐GD1a ganglioside IgG antibodies are biomarkers for immune‐mediated polyneuropathies in cats.

Comparison of toxicokinetic properties of eleven analogues of Bisphenol A in pig after intravenous and oral administrations (2022)
Journal Article
Gely, C., Lacroix, M., Roques, B., Toutain, P., Gayrard, V., & Picard-Hagen, N. (2023). Comparison of toxicokinetic properties of eleven analogues of Bisphenol A in pig after intravenous and oral administrations. Environment International, 171, https://doi.org/10.1016/j.envint.2022.107722

Due to the restrictions of its use, Bisphenol A (BPA) has been replaced by many structurally related bisphenols (BPs) in consumer products. The endocrine disrupting potential similar to that of BPA has been described for several bisphenols, there is... Read More about Comparison of toxicokinetic properties of eleven analogues of Bisphenol A in pig after intravenous and oral administrations.

Tumour necrosis factor alpha, Interleukin 1 beta and Interferon gamma have detrimental effects on equine tenocytes that cannot be rescued by IL-1RA or mesenchymal stromal cell-derived factors (2022)
Journal Article
Guest, D., Smith, E., Beaumont, R., McClellan, A., Sze, C., Palomino Lago, E., …Smith, R. (in press). Tumour necrosis factor alpha, Interleukin 1 beta and Interferon gamma have detrimental effects on equine tenocytes that cannot be rescued by IL-1RA or mesenchymal stromal cell-derived factors. Cell and Tissue Research, https://doi.org/10.1007/s00441-022-03726-6

Tendon injuries occur commonly in both human and equine athletes, and poor tendon regeneration leads to functionally deficient scar tissue and an increased frequency of re-injury. Despite evidence suggesting inadequate resolution of inflammation le... Read More about Tumour necrosis factor alpha, Interleukin 1 beta and Interferon gamma have detrimental effects on equine tenocytes that cannot be rescued by IL-1RA or mesenchymal stromal cell-derived factors.

Proportion of concentrate in the diet of early lactation dairy cows has contrasting effects on circulating leukocyte global transcriptomic profiles, health and fertility according to parity (2022)
Journal Article
Cheng, Z., McLaughlin, D., Little, M., Ferris, C., Salavati, M., Ingvartsen, K., …Wathes, D. C. (2022). Proportion of concentrate in the diet of early lactation dairy cows has contrasting effects on circulating leukocyte global transcriptomic profiles, health and fertility according to parity. International Journal of Molecular Sciences, https://doi.org/10.3390/ijms24010039

The functionality of circulating leukocytes in dairy cows is suppressed after calving, with negative energy balance as a risk factor. Leukocyte transcriptomic profiles were compared separately in 44 multiparous (MP) and 18 primiparous (PP) Holstein–F... Read More about Proportion of concentrate in the diet of early lactation dairy cows has contrasting effects on circulating leukocyte global transcriptomic profiles, health and fertility according to parity.

Detection of Clade 2.3.4.4b Avian Influenza A(H5N8) Virus in Cambodia, 2021 (2022)
Journal Article
Edwards, K., Siegers, J., Wei, X., Aziz, A., Deng, Y., Yann, S., …Karlsson, E. (2022). Detection of Clade 2.3.4.4b Avian Influenza A(H5N8) Virus in Cambodia, 2021. Emerging Infectious Disease, 29(1), 170-174. https://doi.org/10.3201/eid2901.220934

Institute in Cambodia have partnered with the Food and Agriculture Organization of the United Nations to enhance ongoing longitudinal AIV surveillance in live bird markets and poultry storage facilities throughout Cambodia. This active surveillance r... Read More about Detection of Clade 2.3.4.4b Avian Influenza A(H5N8) Virus in Cambodia, 2021.

Deletion of the P2Y(2) receptor aggravates internal elastic lamina calcification in chronic kidney disease mice through upregulation of alkaline phosphatase and lipocalin-2 (2022)
Journal Article
Opdebeeck, B., Huysmans, I., van den Branden, A., Orriss, I., D'Haese, P., & Verhulst, A. (2023). Deletion of the P2Y(2) receptor aggravates internal elastic lamina calcification in chronic kidney disease mice through upregulation of alkaline phosphatase and lipocalin-2. FASEB Journal, 37(1), https://doi.org/10.1096/fj.202201044R

Calcification of the medial layer, inducing arterial stiffness, contributes significantly to cardiovascular mortality in patients with chronic kidney disease (CKD). Extracellular nucleotides block the mineralization of arteries by binding to purinerg... Read More about Deletion of the P2Y(2) receptor aggravates internal elastic lamina calcification in chronic kidney disease mice through upregulation of alkaline phosphatase and lipocalin-2.

The Prrx1eGFP Mouse Labels the Periosteum During Development and a Subpopulation of Osteogenic Periosteal Cells in the Adult (2022)
Journal Article
Brown, S., Malik, S., Aljammal, M., O'Flynn, A., Hobbs, C., Shah, M., …Logan, M. P. (in press). The Prrx1eGFP Mouse Labels the Periosteum During Development and a Subpopulation of Osteogenic Periosteal Cells in the Adult. JBMR Plus, e10707, https://doi.org/10.1002/jbm4.10707

The identity of the cells that form the periosteum during development is controversial with current dogma suggesting these are derived from a Sox9-positive progenitor. Herein, we characterize a newly created Prrx1eGFP reporter transgenic mouse line d... Read More about The Prrx1eGFP Mouse Labels the Periosteum During Development and a Subpopulation of Osteogenic Periosteal Cells in the Adult.

Serum inflammatory cytokines as disease biomarkers in the DE50-MD dog model of Duchenne muscular dystrophy (2022)
Journal Article
Piercy, R., Riddell, D., Hildyard, J., Harron, R., & Wells, D. (2022). Serum inflammatory cytokines as disease biomarkers in the DE50-MD dog model of Duchenne muscular dystrophy. Neuromuscular Disorders, https://doi.org/10.1242/dmm.049394

Duchenne muscular dystrophy (DMD) is a fatal muscle-wasting disease, caused by mutations in the dystrophin gene, characterised by cycles of muscle degeneration, inflammation and regeneration. The DE50-MD dog is a canine model of DMD that closely mimi... Read More about Serum inflammatory cytokines as disease biomarkers in the DE50-MD dog model of Duchenne muscular dystrophy.

Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy of prematurity (2022)
Journal Article
Yates, A., Kislitsyna, E., Alfonso Martin, C., Zhang, J., Sewell, A., Goikolea-Vives, A., …Stolp, H. (in press). Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy of prematurity. Journal of Neuroinflammation, https://doi.org/10.1186/s12974-022-02625-5

Encephalopathy of prematurity (EoP) affects approximately 30% of infants born

JSAP-2022-0090.R2 Proof Fl (2022)
Journal Article
Berrezaie, M., Connoly, D., Cruzado, J., Mederska, E., Dukes-McEwan, J., & Humm, K. (2022). JSAP-2022-0090.R2 Proof Fl. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13561

Objectives: To determine the causative organisms, clinical features and outcome of 4 canine infective endocarditis (IE) in the UK. 5 6 Methods: Medical records of 3 veterinary referral hospitals were searched for dogs with 7 IE between December 2009... Read More about JSAP-2022-0090.R2 Proof Fl.

Populations of NK Cells and Regulatory T Cells in the Endometrium of Cycling Mares-A Preliminary Study (2022)
Journal Article
Jaworska, J., de Mestre, A., Wisniewska, J., Wagner, B., Nowicki, A., Kowalczyk-Zieba, I., & Woclawek-Potocka, I. (2022). Populations of NK Cells and Regulatory T Cells in the Endometrium of Cycling Mares-A Preliminary Study. Animals, 12(23), https://doi.org/10.3390/ani12233373

Simple Summary Endometrial immune cells, such as regulatory T cells and NK cells, are not well known in mares. Nevertheless, these cells play important roles both in physiological and pathological processes in equine reproduction. This work aimed to... Read More about Populations of NK Cells and Regulatory T Cells in the Endometrium of Cycling Mares-A Preliminary Study.