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Respiratory compromise in French bulldogs presented with intervertebral disc extrusion (2023)
Journal Article
Foster, E., West, N., Butterfield, S., Rusbridge, C., & Crawford, A. (in press). Respiratory compromise in French bulldogs presented with intervertebral disc extrusion. Veterinary Record, https://doi.org/10.1002/vetr.3603

Background French bulldogs hospitalised for the management of intervertebral disc extrusion (IVDE) are frequently affected by respiratory compromise, typically brachycephalic-associated upper respiratory obstruction and/or aspiration events. We eval... Read More about Respiratory compromise in French bulldogs presented with intervertebral disc extrusion.

Respiratory compromise in French bulldogs presented with intervertebral disc extrusion (2023)
Journal Article
Foster, E., West, N., Butterfield, S., Rusbridge, C., & Crawford, A. (2023). Respiratory compromise in French bulldogs presented with intervertebral disc extrusion. Veterinary Record, https://doi.org/10.1002/vetr.3603

BackgroundFrench bulldogs hospitalised for the management of intervertebral disc extrusion (IVDE) are frequently affected by respiratory compromise, typically brachycephalic-associated upper respiratory obstruction and/or aspiration events. We evalua... Read More about Respiratory compromise in French bulldogs presented with intervertebral disc extrusion.

Clinical presentation, diagnosis, treatment, and outcome in 8 dogs and 2 cats with global hypoxic-ischemic brain injury (2010-2022) (2023)
Journal Article
Crawford, A., Beltran, E., Danciu, C., & Yaffy, D. (2023). Clinical presentation, diagnosis, treatment, and outcome in 8 dogs and 2 cats with global hypoxic-ischemic brain injury (2010-2022). Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16790

BackgroundGlobal hypoxic-ischemic brain injury (GHIBI) results in variable degrees of neurological dysfunction. Limited data exists to guide prognostication on likelihood of functional recovery. HypothesisProlonged duration of hypoxic-ischemic insult... Read More about Clinical presentation, diagnosis, treatment, and outcome in 8 dogs and 2 cats with global hypoxic-ischemic brain injury (2010-2022).

Bacterial meningitis secondary to otogenic infection in 10 French bulldogs: A retrospective case series (2023)
Journal Article
Butterfield, S., Whittaker, D., Tabanez, J., Carrete, J., Pitchford, C., Mattias, C., …Rusbridge, C. (2023). Bacterial meningitis secondary to otogenic infection in 10 French bulldogs: A retrospective case series. Veterinary Record Open, 10(1), https://doi.org/10.1002/vro2.63

BackgroundThere is limited published information to guide the clinical management of bacterial meningitis/encephalitis in dogs. MethodsThis was a retrospective case series comprising 10 French bulldogs from two referral centres. The cases were diagno... Read More about Bacterial meningitis secondary to otogenic infection in 10 French bulldogs: A retrospective case series.

Brain magnetic resonance imaging in the DE50-MD dog model of Duchenne muscular dystrophy reveals regional reductions in cerebral gray matter (2023)
Journal Article
Crawford, A. H., Hornby, N. L., De La Fuente, A. G., & Piercy, R. J. (2023). Brain magnetic resonance imaging in the DE50-MD dog model of Duchenne muscular dystrophy reveals regional reductions in cerebral gray matter. BMC Neuroscience, https://doi.org/10.1186/s12868-023-00788-2

Background Duchenne muscular dystrophy is a X-linked disease characterized by severe and progressive muscle weakness, alongside cognitive impairment and a range of neurobehavioral disorders secondary to brain dystrophin deficiency. Duchenne muscular... Read More about Brain magnetic resonance imaging in the DE50-MD dog model of Duchenne muscular dystrophy reveals regional reductions in cerebral gray matter.

Validation of DE50-MD dogs as a model for the cognitive and biochemical defects in the brain phenotype of Duchenne muscular dystrophy (2022)
Journal Article
Crawford, A., Hildyard, J., Rushing, S., Wells, D., Diez Leon, M., & Piercy, R. (in press). Validation of DE50-MD dogs as a model for the cognitive and biochemical defects in the brain phenotype of Duchenne muscular dystrophy. eLife, https://doi.org/10.1242/dmm.049291

Duchenne muscular dystrophy (DMD), a fatal musculoskeletal disorder, is associated with neurodevelopmental problems and cognitive impairment caused by dystrophin deficiency in the brain. Dog models of DMD represent key translational tools to study... Read More about Validation of DE50-MD dogs as a model for the cognitive and biochemical defects in the brain phenotype of Duchenne muscular dystrophy.

Imaging of focal seizures with Electrical Impedance Tomography and depth electrodes in real time (2021)
Journal Article
Witkowska-Wrobel, A., Aristovich, K., Crawford, A., Perkins, J., & Holder, D. (2021). Imaging of focal seizures with Electrical Impedance Tomography and depth electrodes in real time. NeuroImage, 234, https://doi.org/10.1016/j.neuroimage.2021.117972

A B S T R A C T Intracranial EEG is the current gold standard technique for localizing seizures for surgery, but it can be insen-sitive to tangential dipole or distant sources. Electrical Impedance Tomography (EIT) offers a novel method to improve co... Read More about Imaging of focal seizures with Electrical Impedance Tomography and depth electrodes in real time.

Human-relevant near-organ neuromodulation of the immune via the nerve (2021)
Journal Article
Donega, M., Fjordbakk, C., Kirk, J., Sokal, D., Gupta, I., Hunsberger, G., …Perkins, J. (2021). Human-relevant near-organ neuromodulation of the immune via the nerve. Proceedings of the National Academy of Sciences, 118(20), https://doi.org/10.1073/pnas.2025428118

Neuromodulation of immune function by stimulating the autonomic connections to the spleen has been demonstrated in rodent models. Consequently, neuroimmune modulation has been proposed as a new therapeutic strategy for the treatment of inflammatory c... Read More about Human-relevant near-organ neuromodulation of the immune via the nerve.

Model-based geometrical optimisation and in vivo validation of a spatially selective multielectrode cuff array for vagus nerve neuromodulation (2021)
Journal Article
Aristovich, K., Donega, M., Fjordbakk, C., Tarotin, I., Chapman, C., Viscasillas, J., …Holder, D. (2021). Model-based geometrical optimisation and in vivo validation of a spatially selective multielectrode cuff array for vagus nerve neuromodulation. Journal of Neuroscience Methods, 352, https://doi.org/10.1016/j.jneumeth.2021.109079

Background: Neuromodulation by electrical stimulation of the human cervical vagus nerve may be limited by adverse side effects due to stimulation of off-target organs. It may be possible to overcome this by spatially selective stimulation of peripher... Read More about Model-based geometrical optimisation and in vivo validation of a spatially selective multielectrode cuff array for vagus nerve neuromodulation.

Neurological Examination In Healthy Juvenile Bearded Dragons (Pogona Vitticeps) And Adult Leopard Geckos (Eublepharis Macularius) (2021)
Journal Article
Hedley, J., MacHale, J., Rendle, M., & Crawford, A. (2021). Neurological Examination In Healthy Juvenile Bearded Dragons (Pogona Vitticeps) And Adult Leopard Geckos (Eublepharis Macularius). Journal of Herpetological Medicine and Surgery, https://doi.org/10.5818/JHMS-D-20-00006

A variety of neurological disorders have been reported in reptiles, but evaluation of a reptile patient with suspected neurological disease can be challenging. The feasibility of performing and interpreting neurological examinations may be affected b... Read More about Neurological Examination In Healthy Juvenile Bearded Dragons (Pogona Vitticeps) And Adult Leopard Geckos (Eublepharis Macularius).

Is there a link between bacteriuria and a reversible encephalopathy in dogs and cats? (2020)
Journal Article
Crawford, A. (2020). Is there a link between bacteriuria and a reversible encephalopathy in dogs and cats?. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13178

Bacteriuria has been associated with abnormal neurological status in humans, particularly the geriatric population. In this report, we review 11 cases (7 dogs and 4 cats) that support an association between bacteriuria and abnormal neurological statu... Read More about Is there a link between bacteriuria and a reversible encephalopathy in dogs and cats?.

Single-transcript multiplex in situ hybridisation reveals unique patterns of dystrophin isoform expression in the developing mammalian embryo (2020)
Journal Article
Hildyard, J. C. W., Crawford, A. H., Rawson, F., Riddell, D. O., Harron, R. C. M., & Piercy, R. J. (2020). Single-transcript multiplex in situ hybridisation reveals unique patterns of dystrophin isoform expression in the developing mammalian embryo. Wellcome Open Research, 5, 76. https://doi.org/10.12688/wellcomeopenres.15762.2

Background: The dystrophin gene has multiple isoforms: full-length dystrophin (dp427) is principally known for its expression in skeletal and cardiac muscle, but is also expressed in the brain, and several internal promoters give rise to shorter, N-t... Read More about Single-transcript multiplex in situ hybridisation reveals unique patterns of dystrophin isoform expression in the developing mammalian embryo.

Ventral Slot Surgery to Manage Cervical Intervertebral Disc Disease in Three Cats (2018)
Journal Article
Crawford, A. H., Cappello, R., Alexander, A., & De Decker, S. (2018). Ventral Slot Surgery to Manage Cervical Intervertebral Disc Disease in Three Cats. Veterinary and Comparative Orthopaedics and Traumatology, 31(1), 71-76. https://doi.org/10.3415/vcot-17-05-0074

This is a retrospective case series evaluating client-owned cats undergoing a ventral slot surgical procedure to manage cervical intervertebral disc disease (n = 3).

Clinicopathologic Features and Magnetic Resonance Imaging Findings in 24 Cats With Histopathologically Confirmed Neurologic Feline Infectious Peritonitis (2017)
Journal Article
Crawford, A. H., Stoll, A. L., Sanchez-Masian, D., Shea, A., Michaels, J., Fraser, A. R., & Beltran, E. (2017). Clinicopathologic Features and Magnetic Resonance Imaging Findings in 24 Cats With Histopathologically Confirmed Neurologic Feline Infectious Peritonitis. Journal of Veterinary Internal Medicine, 31(5), 1477-1486. https://doi.org/10.1111/jvim.14791

Background: Feline infectious peritonitis (FIP) is the most common infectious central nervous system (CNS) disease in the cat and is invariably fatal. Improved means of antemortem diagnosis is required to facilitate clinical decision making. Informat... Read More about Clinicopathologic Features and Magnetic Resonance Imaging Findings in 24 Cats With Histopathologically Confirmed Neurologic Feline Infectious Peritonitis.

MRI and clinical resolution of a suspected intracranial toxoplasma granuloma with medical treatment in a domestic short hair cat (2017)
Journal Article
Crawford, A. H., Drees, R., & Beltran, E. (2017). MRI and clinical resolution of a suspected intracranial toxoplasma granuloma with medical treatment in a domestic short hair cat. https://doi.org/10.1136/vetreccr-2017-000480

A two-year-old cat was presented with a left paradoxical vestibular syndrome. MRI of the brain revealed an extra-axial homogenously contrast enhancing mass in the region of the left caudal cerebellar peduncle. Toxoplasma serology was consistent with... Read More about MRI and clinical resolution of a suspected intracranial toxoplasma granuloma with medical treatment in a domestic short hair cat.

Clinical presentation and outcome of dogs treated medically or surgically for thoracolumbar intervertebral disc protrusion (2017)
Journal Article
Crawford, A. H., & De Decker, S. (2017). Clinical presentation and outcome of dogs treated medically or surgically for thoracolumbar intervertebral disc protrusion. Veterinary Record, 180(23), https://doi.org/10.1136/vr.103871

To date, few studies have investigated the clinical characteristics of thoracolumbar intervertebral disc protrusion (IVDP). The aim of this retrospective study was to evaluate the presentation and outcome of dogs receiving medical or surgical treatme... Read More about Clinical presentation and outcome of dogs treated medically or surgically for thoracolumbar intervertebral disc protrusion.