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Multivariable analysis to determine risk factors associated with abortion in mares (2022)
Journal Article
Roach, J., Arango-Sabogal, Smith, K., Foote, Verheyen, & de Mestre, M. (2022). Multivariable analysis to determine risk factors associated with abortion in mares. Reproduction and Fertility, https://doi.org/10.1530/RAF-22-0087

Risk factors associated with equine reproductive efficiency have been identified along with those associated specifically with early pregnancy loss (EPL). In contrast, no studies have reported risk factors associated with abortion (loss between day 7... Read More about Multivariable analysis to determine risk factors associated with abortion in mares.

Descriptive study of medication usage and occurrence of disease and injury during gestation in Thoroughbred broodmares (2022)
Journal Article
Mouncey, R., Arango Sabogal, J., De Mestre, A., & Verheyen, K. (2022). Descriptive study of medication usage and occurrence of disease and injury during gestation in Thoroughbred broodmares. Journal of Equine Veterinary Science, https://doi.org/10.1016/j.jevs.2022.104104

The study aimed to (i) describe the use of reproductive therapeutics; (ii) estimate the incidence of disease and injury; and (iii) describe non-reproductive medications administered during pregnancy in Thoroughbred broodmares. A prospective birth co... Read More about Descriptive study of medication usage and occurrence of disease and injury during gestation in Thoroughbred broodmares.

Mixed-Effects Modelling of the Risk Factors Associated with Multiple Pregnancies in Thoroughbred Mares (2022)
Journal Article
Salem, S. E., Sinnott, A., Roach, J. M., Verheyen, K. L. P., & de Mestre, A. M. (in press). Mixed-Effects Modelling of the Risk Factors Associated with Multiple Pregnancies in Thoroughbred Mares. Animals, 12(14), 1841. https://doi.org/10.3390/ani12141841

Multiple pregnancies (MPs) are commonly diagnosed during breeding management of mares. Whilst some studies have reported on factors associated with the risk of MPs, few have utilised multivariable data analysis to control for confounding variables. A... Read More about Mixed-Effects Modelling of the Risk Factors Associated with Multiple Pregnancies in Thoroughbred Mares.

First reported case of fragile foal syndrome type 1 in the Thoroughbred caused by PLOD1 c.2032G>A (2021)
Journal Article
Grillos, A., Roach, J., de Mestre, A., Foote, A., Kinglsey, N., Mienaltowski, M., & Bellone, R. (in press). First reported case of fragile foal syndrome type 1 in the Thoroughbred caused by PLOD1 c.2032G>A. Equine Veterinary Journal, https://doi.org/10.1111/evj.13547

Background Warmblood Fragile Foal Syndrome Type 1 (WFFS) is an autosomal recessive disorder reported previously only in warmbloods and thought to be caused by a variant in the gene procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (PLOD1, c.2032G>A,... Read More about First reported case of fragile foal syndrome type 1 in the Thoroughbred caused by PLOD1 c.2032G>A.

Retrospective Analysis Of Post-mortem Findings In Thoroughbreds Aged From Birth To 18 Months Presented To A Pathology Laboratory In Newmarket. (2021)
Journal Article
Mouncey, R., Verheyen, K., de Mestre, A., Arango-Sabogal, J. C., & Foote, A. Retrospective Analysis Of Post-mortem Findings In Thoroughbreds Aged From Birth To 18 Months Presented To A Pathology Laboratory In Newmarket. Manuscript submitted for publication

Enhanced understanding is needed of causes and timings of death in Thoroughbreds prior to entering race training, which would also provide insight into this population’s health status. The aims of this study were to describe causes of death in Thor... Read More about Retrospective Analysis Of Post-mortem Findings In Thoroughbreds Aged From Birth To 18 Months Presented To A Pathology Laboratory In Newmarket..

Retrospective analysis of the population dynamics and racing outcomes of the 2014 and 2015 UK and Ireland Thoroughbred foal crops (2021)
Journal Article
Arango‐Sabogal, J. C., Mouncey, R., Verheyen, K., & de Mestre, A. M. (in press). Retrospective analysis of the population dynamics and racing outcomes of the 2014 and 2015 UK and Ireland Thoroughbred foal crops. Veterinary Record, https://doi.org/10.1002/vetr.298

Abstract Background: Up-to-date figures on early losses of Thoroughbreds from the racing industry can inform strategies to improve retention and incentivise traceability of Thoroughbreds during this early life period. Methods: Data on Thoroughbred m... Read More about Retrospective analysis of the population dynamics and racing outcomes of the 2014 and 2015 UK and Ireland Thoroughbred foal crops.

Preliminary testing of psychometric properties of the ‘student perceptions of veterinary interprofessional education and work scale’ (SP-VIEWS) (2021)
Journal Article
Kinnison, T., Lumbis, R., de Mestre, A., & Cardwell, J. M. (in press). Preliminary testing of psychometric properties of the ‘student perceptions of veterinary interprofessional education and work scale’ (SP-VIEWS). Journal of Interprofessional Care,

Responsibility for the provision of veterinary care and services is increasingly shared between veterinary surgeons/veterinarians and registered veterinary nurses/veterinary technicians. Interprofessional education of these clinical professionals is... Read More about Preliminary testing of psychometric properties of the ‘student perceptions of veterinary interprofessional education and work scale’ (SP-VIEWS).

Incidence and causes of pregnancy loss after day 70 of gestation in Thoroughbreds (2020)
Journal Article
Roach, J., Foote, A., Smith, K., Verheyen, K., & de Mestre, A. (in press). Incidence and causes of pregnancy loss after day 70 of gestation in Thoroughbreds. Equine Veterinary Journal, https://doi.org/10.1111/evj.13386

Background Pregnancy loss after day 70 of gestation manifests as abortion, stillbirth or perinatal death. While previous studies have reported the diagnoses of laboratory submissions, none have quantified the incidence and causes of abortions, still... Read More about Incidence and causes of pregnancy loss after day 70 of gestation in Thoroughbreds.

Whole genome analysis reveals aneuploidies in early pregnancy loss in the horse (2020)
Journal Article
Shilton, C. A., Kahler, A., Davis, B. W., Crabtree, J. R., Crowhurst, J., McGladdery, A. J., …de Mestre, A. M. (2020). Whole genome analysis reveals aneuploidies in early pregnancy loss in the horse. Scientific Reports, 10(1), https://doi.org/10.1038/s41598-020-69967-z

The first 8 weeks of pregnancy is a critical time, with the majority of pregnancy losses occurring during this period. Abnormal chromosome number (aneuploidy) is a common finding in human miscarriage, yet is rarely reported in domestic animals. Equin... Read More about Whole genome analysis reveals aneuploidies in early pregnancy loss in the horse.

Efficacy of ovulation synchronization with timed artificial insemination in treatment of follicular cysts in dairy cows (2020)
Journal Article
Abdalla, H., de Mestre, A. M., & Salem, S. E. (2020). Efficacy of ovulation synchronization with timed artificial insemination in treatment of follicular cysts in dairy cows. Theriogenology, https://doi.org/10.1016/j.theriogenology.2020.05.029

The efficacy of five ovulation-synchronization protocols with FTAI in treatment of cows diagnosed with follicular cysts was investigated in a nonrandomized study in a single herd. Cows identified with follicular structures >25 mm on two subsequent ul... Read More about Efficacy of ovulation synchronization with timed artificial insemination in treatment of follicular cysts in dairy cows.

Fetal morphological features and abnormalities associated with equine early pregnancy loss (2019)
Dataset
Kahler, A., McGonnell, I. M., Smart, H., Kowalski, A. A., Smith, K. C., Wathes, D. C., & De Mestre, A. M. (2019). Fetal morphological features and abnormalities associated with equine early pregnancy loss. [Dataset]. https://doi.org/10.34840/S712-PX78

Pregnancy loss in early gestation (EPL) occurs in approximately 8% of equine pregnancies, although the aetiology is mostly unknown and fetal morphological abnormalities associated with early abortions are not defined. The data here were used (i) to c... Read More about Fetal morphological features and abnormalities associated with equine early pregnancy loss.

Multivariable analysis to determine risk factors associated with early pregnancy loss in thoroughbred broodmares (2019)
Journal Article
De Mestre, A. M., Rose, V. B., Chang, Y. M., Wathes, D. C., & Verheyen, K. L. P. (2019). Multivariable analysis to determine risk factors associated with early pregnancy loss in thoroughbred broodmares. Theriogenology, 124, 18-23. https://doi.org/10.1016/j.theriogenology.2018.10.008

Early pregnancy loss (EPL) between days 15–65 after breeding has been shown to occur in 7.9% of equine pregnancies with substantial economical, welfare and safety implications. Whilst maternal age has been recognised as an important risk factor in re... Read More about Multivariable analysis to determine risk factors associated with early pregnancy loss in thoroughbred broodmares.

Dynamic changes in gene expression and signalling during trophoblast development in the horse (2018)
Journal Article
Read, J. E., Cabrera-Sharp, V., Offord, V., Mirczuk, S. M., Allen, S. P., Fowkes, R. C., & De Mestre, A. M. (2018). Dynamic changes in gene expression and signalling during trophoblast development in the horse. Reproduction, 156(4), 313-330. https://doi.org/10.1530/REP-18-0270

Equine chorionic girdle trophoblast cells play important endocrine and immune functions critical in supporting pregnancy. Very little is known about the genes and pathways that regulate chorionic girdle trophoblast development. Our aim was to identif... Read More about Dynamic changes in gene expression and signalling during trophoblast development in the horse.

Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies (2018)
Journal Article
Timpson, A., De Mestre, A. M., Elliott, J., Harris, P. A., Cheng, Z. R., Mirczuk, S. M., …Menzies-Gow, N. J. (2018). Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies. Journal of Equine Veterinary Science, https://doi.org/10.1016/j.jevs.2018.06.009

The aims of the study were to determine whether adipose tissue global gene expression (i) differs between never laminitic (NL) and previously laminitic (PL) ponies; (ii) is influenced by season and/or a diet designed to simulate spring grass and (iii... Read More about Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies.