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A new method for segmentation and analysis of bone callus in rodent fracture models using micro-CT (2022)
Journal Article
Hopkinson, M., Jones, G., Evans, L., Gohin, S., Magnusdottir, R., Salmon, P., …Pitsillides, A. (2022). A new method for segmentation and analysis of bone callus in rodent fracture models using micro-CT. Journal of Orthopaedic Research, https://doi.org/10.1002/jor.25507

Fracture burden has created a need to better understand bone repair processes under different pathophysiological states. Evaluation of structural and material properties of the mineralized callus, which is integral to restoring biomechanical stabilit... Read More about A new method for segmentation and analysis of bone callus in rodent fracture models using micro-CT.

Feline Femoral Fracture Fixation: What are the options? (2022)
Journal Article
Roberts, V. J., & Meeson, R. L. (in press). Feline Femoral Fracture Fixation: What are the options?. Journal of Feline Medicine and Surgery, 1098612X2210903. https://doi.org/10.1177/1098612x221090391

Practical relevance: The femur is the most commonly fractured bone in cats. Femoral fractures usually result from high-velocity trauma such as a road traffic accident or fall from a height and, as such, are associated with a wide variety of concurren... Read More about Feline Femoral Fracture Fixation: What are the options?.

Moving beyond the limits of detection: the past, the present, and the future of diagnostic imaging in canine osteoarthritis (2022)
Journal Article
Jones, G., Pitsillidies, A., & Meeson, R. (2022). Moving beyond the limits of detection: the past, the present, and the future of diagnostic imaging in canine osteoarthritis. Frontiers in Veterinary Science, https://doi.org/10.3389/fvets.2022.789898

Osteoarthritis (OA) is the most common orthopaedic condition in dogs, characterised as chronic, painful end-point of a synovial joint with limited therapeutic options other than palliative pain control or surgical salvage. Since the 1970s, radiograph... Read More about Moving beyond the limits of detection: the past, the present, and the future of diagnostic imaging in canine osteoarthritis.

Position Statement: Minimal criteria for reporting veterinary and animal medicine research for mesenchymal stromal/stem cells in orthopaedic applications. (2022)
Journal Article
Guest, D. J., Dudhia, J., Smith, R. K., Roberts, S., Conzemius, M., Innes, J. F., …Meeson, R. L. (2022). Position Statement: Minimal criteria for reporting veterinary and animal medicine research for mesenchymal stromal/stem cells in orthopaedic applications. Frontiers in Veterinary Science, https://doi.org/10.3389/fvets.2022.817041

Mesenchymal stromal/stem cells (MSCs) are being used in an increasingly broad range of clinical applications in horses, dogs and cats. In this position statement, we aim to provide guidelines to improve reporting research involving the use of MSCs in... Read More about Position Statement: Minimal criteria for reporting veterinary and animal medicine research for mesenchymal stromal/stem cells in orthopaedic applications..

An examination of two different approaches for the study of femoral neck fracture: towards a more relevant rodent model (2021)
Journal Article
Monzem, S., Gohin, S., Yagüe Ballester, R., Lopes de Souza, R., Meeson, R., & Anthony Pitsillides, A. (2021). An examination of two different approaches for the study of femoral neck fracture: towards a more relevant rodent model. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, https://doi.org/10.1177/09544119211053057

Femoral neck fractures are a massive personal and health programme burden. Methods to study femoral neck strength, across its combined trabecular and cortical components are therefore essential. Rodent ovariectomy-induced osteoporosis models are comm... Read More about An examination of two different approaches for the study of femoral neck fracture: towards a more relevant rodent model.

CD146 Delineates an Interfascicular Cell Sub-Population in Tendon That Is Recruited during Injury through Its Ligand Laminin-α4 (2021)
Journal Article
Marr, N., Meeson, R., Kelly, E., Fang, Y., Peffers, M., Pitsillides, A., …Thorpe, C. (2021). CD146 Delineates an Interfascicular Cell Sub-Population in Tendon That Is Recruited during Injury through Its Ligand Laminin-α4. International Journal of Molecular Sciences, https://doi.org/10.3390/ijms22189729

The interfascicular matrix (IFM) binds tendon fascicles and contains a population of morphologically distinct cells; however the role of IFM-localised cell populations in tendon repair remains to be determined. The basement membrane protein laminin-α... Read More about CD146 Delineates an Interfascicular Cell Sub-Population in Tendon That Is Recruited during Injury through Its Ligand Laminin-α4.

Full‐field strain of regenerated bone tissue in a femoral fracture model (2020)
Journal Article
KARALI, A., KAO, A., MEESON, R., ROLDO, M., BLUNN, G., & TOZZI, G. (2020). Full‐field strain of regenerated bone tissue in a femoral fracture model. Journal of Microscopy, https://doi.org/10.1111/jmi.12937

The mechanical behavior of regenerated bone tissue during fracture healing is key in determining its ability to withstand physiological loads. However, the strain distribution in the newly formed tissue and how this influences the way a fracture heal... Read More about Full‐field strain of regenerated bone tissue in a femoral fracture model.

Risk Factors for Canine Osteoarthritis and Its Predisposing Arthropathies: A Systematic Review (2020)
Journal Article
Anderson, K. L., Zulch, H., O'Neill, D. G., Meeson, R. L., & Collins, L. M. (2020). Risk Factors for Canine Osteoarthritis and Its Predisposing Arthropathies: A Systematic Review. Frontiers in Veterinary Science, 7, https://doi.org/10.3389/fvets.2020.00220

Osteoarthritis is a common clinical and pathological end-point from a range of joint disorders, that ultimately lead to structural and functional decline of the joint with associated lameness and pain. Increasing understanding of the risk factors ass... Read More about Risk Factors for Canine Osteoarthritis and Its Predisposing Arthropathies: A Systematic Review.

Epidemiology and clinical management of elbow joint disease in dogs under primary veterinary care in the UK (2020)
Journal Article
O'Neill, D. G., Brodbelt, D. C., Hodge, R., Church, D. B., & Meeson, R. L. (2020). Epidemiology and clinical management of elbow joint disease in dogs under primary veterinary care in the UK. https://doi.org/10.1186/s40575-020-0080-5

Conditions affecting the elbow joint are a common cause of lameness in dogs. Primary-care veterinary clinical data are now recognised as a valuable research resource. Using data from the VetCompass Programme, this study aimed to report the frequency... Read More about Epidemiology and clinical management of elbow joint disease in dogs under primary veterinary care in the UK.

The influence of parathyroid hormone 1-34 on the osteogenic characteristics of adipose- and bone-marrow-derived mesenchymal stem cells from juvenile and ovarectomized rats (2019)
Journal Article
Osagie-Clouard, L., Sanghani-Kerai, A., Coathup, M., Meeson, R., Briggs, T., & Blunn, G. (2019). The influence of parathyroid hormone 1-34 on the osteogenic characteristics of adipose- and bone-marrow-derived mesenchymal stem cells from juvenile and ovarectomized rats. https://doi.org/10.1302/2046-3758.88.BJR-2019-0018.R1

Mesenchymal stem cells (MSCs) are of growing interest in terms of bone regeneration. Most preclinical trials utilize bone-marrow-derived mesenchymal stem cells (bMSCs), although this is not without isolation and expansion difficulties. The aim of thi... Read More about The influence of parathyroid hormone 1-34 on the osteogenic characteristics of adipose- and bone-marrow-derived mesenchymal stem cells from juvenile and ovarectomized rats.

The influence of gap size on the development of fracture union with a micro external fixator (2019)
Journal Article
Meeson, R. L., Moazen, M., Sanghani-Keri, A., Osagie-Clouard, L., Coathup, M., & Blunn, G. (2019). The influence of gap size on the development of fracture union with a micro external fixator. Journal of the Mechanical Behavior of Biomedical Materials, 99, 161-168. https://doi.org/10.1016/j.jmbbm.2019.07.015

Increasingly, the rat femoral fracture model is being used for preclinical investigations of fracture healing, however, the effect of gap size and its influence on mechanobiology is not well understood. We aimed to evaluate the influence of osteotomy... Read More about The influence of gap size on the development of fracture union with a micro external fixator.

VEGF with AMD3100 Endogenously Mobilizes Mesenchymal Stem Cells and Improves Fracture Healing (2019)
Journal Article
Meeson, R. L., Sanghani-Keri, A., Coathup, M., & Blunn, G. (2019). VEGF with AMD3100 Endogenously Mobilizes Mesenchymal Stem Cells and Improves Fracture Healing. Journal of Orthopaedic Research, 37(6), 1294-1302. https://doi.org/10.1002/jor.24164

A significant number of fractures develop non‐union. Mesenchymal stem cell (MSC) therapy may be beneficial, however, this requires cell acquisition, culture and delivery. Endogenous mobilization of stem cells offers a non‐invasive alternative. The hy... Read More about VEGF with AMD3100 Endogenously Mobilizes Mesenchymal Stem Cells and Improves Fracture Healing.