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Outputs (122)

What is the true in vitro potency of oxytetracycline for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida? (2017)
Journal Article
Dorey, L., Hobson, S., & Lees, P. (2017). What is the true in vitro potency of oxytetracycline for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida?. Journal of Veterinary Pharmacology and Therapeutics, 40(5), 517-529. https://doi.org/10.1111/jvp.12386

The pharmacodynamics of oxytetracycline was determined for pig respiratory tract pathogens, Actinobacillus pleuropneumoniae and Pasteurella multocida. Indices of potency were determined for the following: (i) two matrices, broth and pig serum; (ii) f... Read More about What is the true in vitro potency of oxytetracycline for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida?.

An Age-Associated Decline in Thymic Output Differs in Dog Breeds According to Their Longevity (2016)
Journal Article
Holder, A., Mella, S., Palmer, D. B., Aspinall, R., & Catchpole, B. (2016). An Age-Associated Decline in Thymic Output Differs in Dog Breeds According to Their Longevity. PLoS ONE, 11, e0165968. https://doi.org/10.1371/journal.pone.0165968

The age associated decline in immune function is preceded in mammals by a reduction in thymic output. Furthermore, there is increasing evidence of a link between immune competence and lifespan. One approach to determining thymic output is to quantify... Read More about An Age-Associated Decline in Thymic Output Differs in Dog Breeds According to Their Longevity.

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease (2016)
Journal Article
Deas, E., Cremades, N., Angelova, P. R., Ludtmann, M. H. R., Yao, Z., Chen, S., Horrocks, M. H., Banushi, B., Little, D., Devine, M. J., Gissen, P., Klenerman, D., Dobson, C. M., Wood, N. W., Gandhi, S., & Abramov, A. Y. (2016). Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease. https://doi.org/10.1089/ars.2015.6343

Protein aggregation and oxidative stress are both key pathogenic processes in Parkinson's disease, although the mechanism by which misfolded proteins induce oxidative stress and neuronal death remains unknown. In this study, we describe how aggregati... Read More about Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease.

MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR (2015)
Journal Article
Singh, Y., Garden, O. A., Lang, F., & Cobb, B. S. (2015). MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR. Journal of Immunology, 195(12), 5667-5677. https://doi.org/10.4049/jimmunol.1401875

CD4(+) regulatory T cells (Tregs) are essential for controlling immune responses and preventing autoimmunity. Their development requires regulation of gene expression by microRNAs (miRNAs). To understand miRNA function in Treg development, we searche... Read More about MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR.

Influence of oxytetracycline on carprofen pharmacodynamics and pharmacokinetics in calves (2013)
Journal Article
Brentnall, C., Cheng, Z. R., McKellar, Q. A., & Lees, P. (2013). Influence of oxytetracycline on carprofen pharmacodynamics and pharmacokinetics in calves. Journal of Veterinary Pharmacology and Therapeutics, 36(4), 320-328. https://doi.org/10.1111/jvp.12000

A tissue cage model of inflammation in calves was used to determine the pharmacokinetic and pharmacodynamic properties of individual carprofen enantiomers, following the administration of the racemate. RS(±) carprofen was administered subcutaneously... Read More about Influence of oxytetracycline on carprofen pharmacodynamics and pharmacokinetics in calves.

A comprehensive pathological survey of duodenal biopsies from dogs with diet-responsive chronic enteropathy (2013)
Journal Article
Walker, D. J., Knuchel-Takano, A., McCutchan, A., Chang, Y. M., Downes, C., Miller, S., Stevens, K. B., Verheyen, K. L. P., Phillips, A. D., Miah, S., Turmaine, M., Hibbert, A., Steiner, J. M., Suchodolski, J. S., Mohan, K., Eastwood, J., Allenspach, K., Smith, K., & Garden, O. A. (2013). A comprehensive pathological survey of duodenal biopsies from dogs with diet-responsive chronic enteropathy. Journal of Veterinary Internal Medicine, 27(4), 862-874. https://doi.org/10.1111/jvim.12093

LRRK2 deficiency induced mitochondrial Ca2+ efflux inhibition can be rescued by Na+/Ca2+/Li+ exchanger upregulation
Journal Article
Ludtmann, M. H. R., Kostic, M., Horne, A., Gandhi, S., Sekler, I., & Abramov, A. Y. (in press). LRRK2 deficiency induced mitochondrial Ca2+ efflux inhibition can be rescued by Na+/Ca2+/Li+ exchanger upregulation. https://doi.org/10.1038/s41419-019-1469-5

Variants of leucine-rich repeat kinase 2 (lrrk2) are associated with an increased risk in developing Parkinson’s disease (PD). Mitochondrial dysfunction and specifically mitochondrial Ca2+ handling has been linked to the pathogenesis of PD. Here we d... Read More about LRRK2 deficiency induced mitochondrial Ca2+ efflux inhibition can be rescued by Na+/Ca2+/Li+ exchanger upregulation.

Anesthesia Case of the Month
Journal Article
Robinson, R. L., & Borer-Weir, K. E. Anesthesia Case of the Month. Journal of the American Veterinary Medical Association, 250(2), 169-172