Outputs (8)

In vivo testing of novel vaccine prototypes against Actinobacillus pleuropneumoniae (2018)
Journal Article
Antenucci, F., Fougeroux, C., Deeney, A., Orskov, C., Rycroft, A. N., Holst, P. J., & Bojesen, A. M. (2018). In vivo testing of novel vaccine prototypes against Actinobacillus pleuropneumoniae. Veterinary Research, 49, 4. https://doi.org/10.1186/s13567-017-0502-x

Actinobacillus pleuropneumoniae (A. pleuropneumoniae) is a Gram-negative bacterium that represents the main cause of porcine pleuropneumonia in pigs, causing significant economic losses to the livestock industry worldwide. A. pleuropneumoniae, as the... Read More about In vivo testing of novel vaccine prototypes against Actinobacillus pleuropneumoniae.

Use of proteins identified through a functional genomic screen to develop a protein subunit vaccine that provides significant protection against virulent Streptococcus suis in pigs (2018)
Journal Article
Brockmeier, S. L., Loving, C. L., Nicholson, T. L., Wang, J., Peters, S. E., Weinert, L., Chaudhuri, R., Seilly, D. J., Langford, P. R., Rycroft, A. N., Wren, B. W., Maskell, D. J., & Tucker, A. W. (2018). Use of proteins identified through a functional genomic screen to develop a protein subunit vaccine that provides significant protection against virulent Streptococcus suis in pigs. Infection and Immunity, 86(3), e00559. https://doi.org/10.1128/IAI.00559-17

Streptococcus suis is a bacterium that is commonly carried in the respiratory tract and that is also one of the most important invasive pathogens of swine, commonly causing meningitis, arthritis, and septicemia. Due to the existence of many serotypes... Read More about Use of proteins identified through a functional genomic screen to develop a protein subunit vaccine that provides significant protection against virulent Streptococcus suis in pigs.

Whole Genome Sequencing for Surveillance of Antimicrobial Resistance in Actinobacillus pleuropneumoniae (2017)
Journal Article
Bossé, J. T., Li, Y., Rogers, J., Fernandez Crespo, R., Li, Y., Chaudhuri, R. R., Holden, M. T. G., Maskell, D. J., Tucker, A. W., Wren, B. W., Rycroft, A. N., & Langford, P. R. (2017). Whole Genome Sequencing for Surveillance of Antimicrobial Resistance in Actinobacillus pleuropneumoniae. Frontiers in Microbiology, 8(311), https://doi.org/10.3389/fmicb.2017.00311

The aim of this study was to evaluate the correlation between antimicrobial resistance (AMR) profiles of 96 clinical isolates of Actinobacillus pleuropneumoniae, an important porcine respiratory pathogen, and the identification of AMR genes in whole... Read More about Whole Genome Sequencing for Surveillance of Antimicrobial Resistance in Actinobacillus pleuropneumoniae.

A Unique Capsule Locus in the Newly Designated Actinobacillus pleuropneumoniae Serovar 16 and Development of a Diagnostic PCR Assay (2017)
Journal Article
Bossé, J. T., Li, Y., Sárközi, R., Gottschalk, M., Angen, Ø., Nedbalcova, K., Rycroft, A. N., Fodor, L., & Langford, P. R. (2017). A Unique Capsule Locus in the Newly Designated Actinobacillus pleuropneumoniae Serovar 16 and Development of a Diagnostic PCR Assay. Journal of Clinical Microbiology, 55(3), 902-907. https://doi.org/10.1128/JCM.02166-16

Actinobacillus pleuropneumoniae causes pleuropneumonia, an economically significant lung disease of pigs. Recently, isolates of A. pleuropneumoniae that were serologically distinct from the previously characterized 15 serovars were described, and a p... Read More about A Unique Capsule Locus in the Newly Designated Actinobacillus pleuropneumoniae Serovar 16 and Development of a Diagnostic PCR Assay.

ICEApl1, an Integrative Conjugative Element Related to ICEHin1056, Identified in the Pig Pathogen Actinobacillus pleuropneumoniae (2016)
Journal Article
Bossé, J. T., Li, Y., Fernandez Crespo, R., Chaudhuri, R. R., Rogers, J., Holden, M. T., Maskell, D. J., Tucker, A. W., Wren, B. W., Rycroft, A. N., Langford, P. R., & BRaDP1T Consortium. (2016). ICEApl1, an Integrative Conjugative Element Related to ICEHin1056, Identified in the Pig Pathogen Actinobacillus pleuropneumoniae. Frontiers in Microbiology, 7, https://doi.org/10.3389/fmicb.2016.00810

Complete Genome Sequence of MIDG2331, a Genetically Tractable Serovar 8 Clinical Isolate of Actinobacillus pleuropneumoniae (2016)
Journal Article
Bossé, J. T., Chaudhuri, R. R., Li, Y., Leanse, L. G., Fernandez Crespo, R., Coupland, P., Holden, M. T., Bazzoli, D. M., Maskell, D. J., Tucker, A. W., Wren, B. W., Rycroft, A. N., & Langford, P. R. (2016). Complete Genome Sequence of MIDG2331, a Genetically Tractable Serovar 8 Clinical Isolate of Actinobacillus pleuropneumoniae. Genome Announcements, 4(i), e01667-15. https://doi.org/10.1128/genomeA.01667-15

We report here the complete annotated genome sequence of a clinical serovar 8 isolate Actinobacillus pleuropneumoniae MIDG2331. Unlike the serovar 8 reference strain 405, MIDG2331 is amenable to genetic manipulation via natural transformation as well... Read More about Complete Genome Sequence of MIDG2331, a Genetically Tractable Serovar 8 Clinical Isolate of Actinobacillus pleuropneumoniae.

Mycoplasma hyopneumoniae evades phagocytic uptake by porcine alveolar macrophages in vitro
Journal Article
Deeney, A. S., Maglennon, G. A., Chapat, L., Crussard, S., Jolivet, E., & Rycroft, A. N. (in press). Mycoplasma hyopneumoniae evades phagocytic uptake by porcine alveolar macrophages in vitro. Veterinary Research, 50(51), https://doi.org/10.1186/s13567-019-0667-6

Mycoplasma hyopneumoniae, the agent of porcine enzootic pneumonia (EP), is able to persist in the lung tissue and evade destruction by the host for several weeks. To understand the mechanism of pathogen survival, phagocytic uptake of M. hyopneumoniae... Read More about Mycoplasma hyopneumoniae evades phagocytic uptake by porcine alveolar macrophages in vitro.

Multiplex PCR assay for Unequivocal Differentiation of Actinobacillus pleuropneumoniae Serovars 1 to 3, 5 to 8, 10 and 12
Journal Article
Bossé, J. T., Li, Y., Angen, Ø., Weinert, L. A., Chaudhuri, R. R., Holden, M. T., Williamson, S. M., Maskell, D. J., Tucker, A. W., Wren, B. W., Rycroft, A. N., & Langford, P. R. (in press). Multiplex PCR assay for Unequivocal Differentiation of Actinobacillus pleuropneumoniae Serovars 1 to 3, 5 to 8, 10 and 12. Journal of Clinical Microbiology, 52, 2380-2385. https://doi.org/10.1128/JCM.00685-14

An improved multiplex PCR, using redesigned primers targeting the serovar 3 capsule locus, which differentiates serovars 3, 6, and 8 Actinobacillus pleuropneumoniae isolates, is described. The new primers eliminate an aberrant serovar 3-indicative am... Read More about Multiplex PCR assay for Unequivocal Differentiation of Actinobacillus pleuropneumoniae Serovars 1 to 3, 5 to 8, 10 and 12.