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Pegbovigrastim treatment in vivo does not affect granulocyte ability to migrate to endometrial cells and kill bacteria in vitro in healthy cows (2019)
Journal Article
Tombacz, K., Peters, L. M., Chang, Y. M., Steele, M., Werling, D., & Gibson, A. J. (2019). Pegbovigrastim treatment in vivo does not affect granulocyte ability to migrate to endometrial cells and kill bacteria in vitro in healthy cows. Journal of Dairy Science, 102(10), 9389-9395. https://doi.org/10.3168/jds.2019-16563

In periparturient dairy cows, immune suppression, resulting in decreased neutrophil numbers and function, leads to increased susceptibility to postpartum conditions such as mastitis, retained placenta, and metritis. Administration of polyethylene gly... Read More about Pegbovigrastim treatment in vivo does not affect granulocyte ability to migrate to endometrial cells and kill bacteria in vitro in healthy cows.

Searching for the source of Ebola: the elusive factors driving its spillover into humans during the West African outbreak of 2013–2016 (2019)
Book Chapter
Kock, R. A., Begovoeva, M., Ansumana, R., & Suluku, R. (2019). Searching for the source of Ebola: the elusive factors driving its spillover into humans during the West African outbreak of 2013–2016. . https://doi.org/10.20506/rst.issue.38.1.2937

The natural ecology of Ebola virus infection remains enigmatic. No clear reservoir species has been confirmed but there is evidence of infection in a wide spectrum of mammals, including humans, non-human primates, domestic and wild ungulates and a va... Read More about Searching for the source of Ebola: the elusive factors driving its spillover into humans during the West African outbreak of 2013–2016.

Identifying hotspots for antibiotic resistance emergence and selection, and elucidating pathways to human exposure: Application of a systems-thinking approach to aquaculture systems (2019)
Journal Article
Brunton, L. A., Desbois, A. P., Garza, M., Wieland, B., Mohan, C. V., Haesler, B., Tam, C. C., Le, P. N. T., Phuong, N. T., Van, P. T., Nguyen-Viet, H., El Tholth, M., Pham, D. K., Duc, P. P., Linh, N. T., Rich, K. M., Mateus, A. L. P., Hoque, M. A., Ahad, A., Khan, M. N. A., …Guitian, J. (2019). Identifying hotspots for antibiotic resistance emergence and selection, and elucidating pathways to human exposure: Application of a systems-thinking approach to aquaculture systems. Science of the Total Environment, 687, 1344-1356. https://doi.org/10.1016/j.scitotenv.2019.06.134

Aquaculture systems are highly complex, dynamic and interconnected systems influenced by environmental, biological, cultural, socio-economic and human behavioural factors. Intensification of aquaculture production is likely to drive indiscriminate us... Read More about Identifying hotspots for antibiotic resistance emergence and selection, and elucidating pathways to human exposure: Application of a systems-thinking approach to aquaculture systems.

Updated unified phylogenetic classification system and revised nomenclature for Newcastle disease virus (2019)
Journal Article
Dimitrov, K. M., Abolnik, C., Afonso, C. L., Albina, E., Bahl, J., Berg, M., Briand, F.-X., Brown, I. H., Choi, K.-S., Chvala, I., Diel, D. G., Durr, P. A., Ferreira, H. L., Fusaro, A., Gil, P., Goujgoulova, G. V., Grund, C., Hicks, J. T., Joannis, T. M., Torchetti, M. K., …Wong, F. Y. K. (2019). Updated unified phylogenetic classification system and revised nomenclature for Newcastle disease virus. https://doi.org/10.1016/j.meegid.2019.103917

Mass Die-Off of Saiga Antelopes, Kazakhstan, 2015 (2019)
Journal Article
Fereidouni, S., Freimanis, G. L., Orynbayev, M., Ribeca, P., Flannery, J., King, D. P., Zuther, S., Beer, M., Höper, D., Kydyrmanov, A., Karamendin, K., & Kock, R. A. (2019). Mass Die-Off of Saiga Antelopes, Kazakhstan, 2015. https://doi.org/10.3201/eid2506.180990

In 2015, a mass die-off of ≈200,000 saiga antelope in central Kazakhstan was caused by hemorrhagic septicemia attributable to the bacterium Pasteurella multocida serotype B. Previous analyses have indicated that environmental triggers associated with... Read More about Mass Die-Off of Saiga Antelopes, Kazakhstan, 2015.

Differential Responses of Bovine Monocyte-Derived Macrophages to Infection by Neospora caninum Isolates of High and Low Virulence (2019)
Journal Article
García-Sánchez, M., Jiménez-Pelayo, L., Horcajo, P., Regidor-Cerrillo, J., Ólafsson, E. B., Bhandage, A. K., Barragan, A., Werling, D., Ortega-Mora, L. M., & Collantes-Fernández, E. (2019). Differential Responses of Bovine Monocyte-Derived Macrophages to Infection by Neospora caninum Isolates of High and Low Virulence. Frontiers in Immunology, 10(915), https://doi.org/10.3389/fimmu.2019.00915

Neospora caninum, a protozoan parasite closely related to Toxoplasma gondii, represents one of the main causes of abortion in cattle. Macrophages (MØs) are mediators of the innate immune response against infection and likely one of the first cells en... Read More about Differential Responses of Bovine Monocyte-Derived Macrophages to Infection by Neospora caninum Isolates of High and Low Virulence.

Evaluation of vaccine delivery systems for inducing long-lived antibody responses to Dermanyssus gallinae antigen in laying hens (2019)
Journal Article
Price, D. R. G., Küster, T., Øines, Ø., Margaret Oliver, E., Bartley, K., Nunn, F., Barbero, J. F. L., Pritchard, J., Karp-Tatham, E., Hauge, H., Blake, D. P., Tomley, F. M., & Nisbet, A. J. (2019). Evaluation of vaccine delivery systems for inducing long-lived antibody responses to Dermanyssus gallinae antigen in laying hens. Avian Pathology, 48, S60-S74. https://doi.org/10.1080/03079457.2019.1612514

Dermanyssus gallinae, the poultry red mite, is a global threat to the commercial egg-laying industry. Control of D. gallinae is difficult, with only a limited number of effective pesticides and non-chemical treatments available. Here we characterise... Read More about Evaluation of vaccine delivery systems for inducing long-lived antibody responses to Dermanyssus gallinae antigen in laying hens.

Evaluation of DNA extraction methods on individual helminth egg and larval stages for whole genome sequencing (2019)
Journal Article
Doyle, S. R., Sankaranarayan, G., Berger, D., Jimenez Castro, P. D., Collins, J. B., Crellen, T., Duque-Correa, M. A., Ellis, P., Jaleta, T. G., Laing, R., Maitland, K., McCarthy, C., Moundai, T., Softley, B., Thiele, E., Tchindebet Ouakou, P., Tushabe, J. V., Webster, J. P., Weiss, A. J., Lok, J., …Holroyd, N. (2019). Evaluation of DNA extraction methods on individual helminth egg and larval stages for whole genome sequencing. https://doi.org/10.1101/616672

Co-circulation of genetically distinct highly pathogenic avian influenza A clade 2.3.4.4 (H5N6) viruses in wild waterfowl and poultry in Europe and East Asia, 2017–18 (2019)
Journal Article
Poen, M. J., Venkatesh, D., Bestebroer, T. M., Vuong, O., Scheuer, R. D., Oude Munnink, B. B., De Meulder, D., Richard, M., Kuiken, T., Koopmans, M. P. G., Kelder, L., Kim, Y.-J., Lee, Y.-J., Steensels, M., Lambrecht, B., Dan, A., Pohlmann, A., Beer, M., Savic, V., Brown, I. H., …Lewis, N. S. (2019). Co-circulation of genetically distinct highly pathogenic avian influenza A clade 2.3.4.4 (H5N6) viruses in wild waterfowl and poultry in Europe and East Asia, 2017–18. Virus Evolution, 5(1), vez004. https://doi.org/10.1093/ve/vez004

Highly pathogenic avian influenza (HPAI) H5 clade 2.3.4.4 viruses were first introduced into Europe in late 2014 and re-introduced in late 2016, following detections in Asia and Russia. In contrast to the 2014–15 H5N8 wave, there was substantial loca... Read More about Co-circulation of genetically distinct highly pathogenic avian influenza A clade 2.3.4.4 (H5N6) viruses in wild waterfowl and poultry in Europe and East Asia, 2017–18.

Integrating Agriculture and Health Research for Development: LCIRAH as an Interdisciplinary Programme to Address a Global Challenge (2019)
Journal Article
Waage, J., Cornelsen, L., Dangour, A. D., Green, R., Haesler, B., Hull, E., Johnston, D., Kadiyala, S., Lock, K., Shankar, B., Smith, R. D., & Walls, H. L. (2019). Integrating Agriculture and Health Research for Development: LCIRAH as an Interdisciplinary Programme to Address a Global Challenge. https://doi.org/10.1002/gch2.201700104

The multiple burdens of persistent undernutrition and micronutrient deficiencies, along with the rapidly growing rates of overweight, obesity, and associated chronic diseases, are major challenges globally. The role of agriculture and the food system... Read More about Integrating Agriculture and Health Research for Development: LCIRAH as an Interdisciplinary Programme to Address a Global Challenge.

Fate of CMY-2-encoding plasmids introduced into the human fecal microbiota by exogenous Escherichia coli (2019)
Journal Article
Anjum, M., Madsen, J. S., Nesme, J., Jana, B., Wiese, M., Jasinskyte, D., Nielsen, D. S., Sørensen, S. J., Dalsgaard, A., Moodley, A., Bortolaia, V., & Guardabassi, L. (2019). Fate of CMY-2-encoding plasmids introduced into the human fecal microbiota by exogenous Escherichia coli. Antimicrobial Agents and Chemotherapy, 63(5), https://doi.org/10.1128/AAC.02528-18

The gut is a hot spot for transfer of antibiotic resistance genes from ingested exogenous bacteria to the indigenous microbiota. The objective of this study was to determine the fate of two nearly identical blaCMY-2-harboring plasmids introduced into... Read More about Fate of CMY-2-encoding plasmids introduced into the human fecal microbiota by exogenous Escherichia coli.

The transmission dynamics of Campylobacter jejuni among broilers in semi-commercial farms in Jordan (2019)
Journal Article
Neves, M. I., Malkawi, I., Walker, M., Alaboudi, A., Abu-Basha, E., Blake, D. P., Guitian, J., & Crotta, M. (2019). The transmission dynamics of Campylobacter jejuni among broilers in semi-commercial farms in Jordan. Epidemiology and Infection, 147, E134. https://doi.org/10.1017/S0950268818003308

Campylobacter is the leading cause of foodborne bacterial gastroenteritis in humans worldwide, often associated with the consumption of undercooked poultry. In Jordan, the majority of broiler chicken production occurs in semi-commercial farms, where... Read More about The transmission dynamics of Campylobacter jejuni among broilers in semi-commercial farms in Jordan.

Optimising the detectability of H5N1 and H5N6 highly pathogenic avian influenza viruses in Vietnamese live-bird markets (2019)
Journal Article
Vergne, T., Meyer, A., Long, P. T., Elkholly, D. A., Inui, K., Padungtod, P., Newman, S. H., Fournié, G., & Pfeiffer, D. U. (2019). Optimising the detectability of H5N1 and H5N6 highly pathogenic avian influenza viruses in Vietnamese live-bird markets. https://doi.org/10.1038/s41598-018-37616-1

Live bird markets (LBMs) are major targets for avian influenza virus (AIV) surveillance programmes. While sampling the LBM environment has become a widely used alternative to the labour-intensive sampling of live poultry, the design of surveillance p... Read More about Optimising the detectability of H5N1 and H5N6 highly pathogenic avian influenza viruses in Vietnamese live-bird markets.

Rapidly assessing the risks of infectious diseases to wildlife species (2019)
Journal Article
Beauvais, W., Zuther, S., Villeneuve, C., Kock, R. A., & Guitian, J. (2019). Rapidly assessing the risks of infectious diseases to wildlife species. Royal Society Open Science, 6(1), https://doi.org/10.1098/rsos.181043

Predicting the likelihood of rare events is increasingly demanded by risk managers. A key challenge is dealing with different types of uncertainty, including epistemic uncertainties (lack of knowledge), stochasticity (inherent randomness) and natural... Read More about Rapidly assessing the risks of infectious diseases to wildlife species.

Genome reconstruction of a novel carbohydrate digesting bacterium from the chicken caecal microflora (2019)
Journal Article
Hinsu, A. T., Pandit, R. J., Patel, S. H., Psifidi, A., Tomley, F. M., Das, S. K., Blake, D. P., & Joshi, C. G. (2019). Genome reconstruction of a novel carbohydrate digesting bacterium from the chicken caecal microflora. https://doi.org/10.1016/j.mgene.2019.01.002

The advent of metagenomics using Next-Generation Sequencing (NGS) has led to the acquisition of unprecedented quantities of bacterial sequence data. One use for these data is the recovery of complete genomes of uncultivable, and thus uncharacterised,... Read More about Genome reconstruction of a novel carbohydrate digesting bacterium from the chicken caecal microflora.

GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice (2019)
Journal Article
Puig, B., Altmeppen, H. C., Linsenmeier, L., Chakroun, K., Wegwitz, F., Piontek, U. K., Tatzelt, J., Bate, C., Magnus, T., & Glatzel, M. (2019). GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice. PLoS Pathogens, 15(1), e1007520. https://doi.org/10.1371/journal.ppat.1007520

The cellular prion protein (PrPC) is a cell surface glycoprotein attached to the membrane by a glycosylphosphatidylinositol (GPI)-anchor and plays a critical role in transmissible, neurodegenerative and fatal prion diseases. Alterations in membrane a... Read More about GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice.

Plasticity of Amino Acid Residue 145 Near the Receptor Binding Site of H3 Swine Influenza A Viruses and Its Impact on Receptor Binding and Antibody Recognition (2019)
Journal Article
Santos, J. J. S., Abente, E. J., Obadan, A. O., Thompson, A. J., Ferreri, L., Geiger, G., Gonzalez-Reiche, A. S., Lewis, N. S., Burke, D. F., Rajão, D. S., Paulson, J. C., Vincent, A. L., & Perez, D. R. (2019). Plasticity of Amino Acid Residue 145 Near the Receptor Binding Site of H3 Swine Influenza A Viruses and Its Impact on Receptor Binding and Antibody Recognition. Journal of Virology, 93(2), e01413-18. https://doi.org/10.1128/JVI.01413-18

The hemagglutinin (HA), a glycoprotein on the surface of influenza A virus (IAV), initiates the virus life cycle by binding to terminal sialic acid (SA) residues on host cells. The HA gradually accumulates amino acid substitutions that allow IAV to e... Read More about Plasticity of Amino Acid Residue 145 Near the Receptor Binding Site of H3 Swine Influenza A Viruses and Its Impact on Receptor Binding and Antibody Recognition.

A study of tuberculosis in road traffic-killed badgers on the edge of the British bovine TB epidemic area (2018)
Journal Article
Sandoval Barron, E., Swift, B. M. C., Chantrey, J., Christley, R., Gardner, R., Jewell, C., McGrath, I., Mitchell, A., O'Cathail, C., Prosser, A., Ridout, S., Sanchez-Cabezudo, G., Smith, N., Timofte, D., Williams, N., & Bennett, M. (2018). A study of tuberculosis in road traffic-killed badgers on the edge of the British bovine TB epidemic area. https://doi.org/10.1038/s41598-018-35652-5

The role of badgers in the geographic expansion of the bovine tuberculosis (bTB) epidemic in England is unknown: indeed there have been few published studies of bTB in badgers outside of the Southwest of England where the infection is now endemic in... Read More about A study of tuberculosis in road traffic-killed badgers on the edge of the British bovine TB epidemic area.