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Risk indictors in cats with preclinical hypertrophic cardiomyopathy: a prospective cohort study (2020)
Journal Article
Ironside, V. A., Tricklebank, P. R., & Boswood, A. (2020). Risk indictors in cats with preclinical hypertrophic cardiomyopathy: a prospective cohort study. Journal of Feline Medicine and Surgery, 1098612X2093865

Objectives
This study aimed to identify indicators of the risk of progression of preclinical hypertrophic cardiomyopathy (HCM).

Methods
This was a prospective cohort study following a population of cats with preclinical HCM. Cats serially underw... Read More about Risk indictors in cats with preclinical hypertrophic cardiomyopathy: a prospective cohort study.

Temporal changes in clinical and radiographic variables in dogs with preclinical myxomatous mitral valve disease: The EPIC study (2020)
Journal Article
Boswood, A., Gordon, S. G., Häggström, J., Vanselow, M., Wess, G., Stepien, R. L., Oyama, M. A., Keene, B. W., Bonagura, J., MacDonald, K. A., Patteson, M., Smith, S., Fox, P. R., Sanderson, K., Woolley, R., Szatmári, V., Menaut, P., Church, W. M., O'Sullivan, M. L., Jaudon, J.-P., …Watson, P. (2020). Temporal changes in clinical and radiographic variables in dogs with preclinical myxomatous mitral valve disease: The EPIC study. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.15753

The Evaluation of pimobendan in dogs with cardiomegaly caused by preclinical myxomatous mitral valve disease (EPIC) study monitored dogs with myxomatous mitral valve disease (MMVD) as they developed congestive heart failure (CHF).

Factors associated with disease progression in dogs with presumed preclinical degenerative mitral valve disease attending primary care veterinary practices in the United Kingdom (2019)
Journal Article
Mattin, M. J., Brodbelt, D. C., Church, D. B., & Boswood, A. (2019). Factors associated with disease progression in dogs with presumed preclinical degenerative mitral valve disease attending primary care veterinary practices in the United Kingdom. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.15390

Longitudinal Analysis of Quality of Life, Clinical, Radiographic, Echocardiographic, and Laboratory Variables in Dogs with Preclinical Myxomatous Mitral Valve Disease Receiving Pimobendan or Placebo: The EPIC Study (2018)
Journal Article
Boswood, A., Gordon, S. G., Häggström, J., Wess, G., Stepien, R. L., Oyama, M. A., Keene, B. W., Bonagura, J. D., MacDonald, K. A., Patteson, M., Smith, S., Fox, P. R., Sanderson, K., Woolley, R., Szatmári, V., Menaut, P., Church, W. M., O'Sullivan, M. L., Jaudon, J. P., Kresken, J.-G., …Watson, P. (2018). Longitudinal Analysis of Quality of Life, Clinical, Radiographic, Echocardiographic, and Laboratory Variables in Dogs with Preclinical Myxomatous Mitral Valve Disease Receiving Pimobendan or Placebo: The EPIC Study. Journal of Veterinary Internal Medicine, 32(1), 72-85. https://doi.org/10.1111/jvim.14885

Background: Changes in clinical variables associated with the administration of pimobendan to dogs with preclinical myxomatous mitral valve disease (MMVD) and cardiomegaly have not been described.

Objectives: To investigate the effect of pimobenda... Read More about Longitudinal Analysis of Quality of Life, Clinical, Radiographic, Echocardiographic, and Laboratory Variables in Dogs with Preclinical Myxomatous Mitral Valve Disease Receiving Pimobendan or Placebo: The EPIC Study.

Treatment of dogs with compensated myxomatous mitral valve disease with spironolactone-a pilot study (2017)
Journal Article
Hezzell, M. J., Boswood, A., Lopez-Alvarez, J., Lotter, N. S., & Elliott, J. (2017). Treatment of dogs with compensated myxomatous mitral valve disease with spironolactone-a pilot study. Journal of Veterinary Cardiology, 19(4), 325-328. https://doi.org/10.1016/j.jvc.2017.06.001

Spironolactone improves outcome in dogs with advanced myxomatous mitral valve disease (MMVD). Its efficacy in preclinical MMVD is unknown. The hypothesis was the administration of spironolactone to dogs with compensated MMVD demonstrating risk factor... Read More about Treatment of dogs with compensated myxomatous mitral valve disease with spironolactone-a pilot study.

Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study - A Randomized Clinical Trial (2016)
Journal Article
Boswood, A., Haggstrom, J., Gordon, S. G., Wess, G., Stepien, R. L., Oyama, M. A., Keene, B. W., Bonagura, J. D., MacDonald, K. A., Patteson, M., Smith, S., Fox, P. R., Sanderson, K., Woolley, R., Szatmari, V., Menaut, P., Church, W. M., O'Sullivan, M. L., Jaudon, J. P., Kresken, J. G., …Watson, P. (2016). Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study - A Randomized Clinical Trial. Journal of Veterinary Internal Medicine, 30(6), 1765-1779. https://doi.org/10.1111/jvim.14586

Differentiation of Cardiac from Noncardiac Pleural Effusions in Cats using Second-Generation Quantitative and Point-of-Care NT-proBNP Measurements (2016)
Journal Article
Hezzell, M. J., Rush, J. E., Humm, K. R., Rozanski, E. A., Sargent, J., Connolly, D. J., Boswood, A., & Oyama, M. A. (2016). Differentiation of Cardiac from Noncardiac Pleural Effusions in Cats using Second-Generation Quantitative and Point-of-Care NT-proBNP Measurements. Journal of Veterinary Internal Medicine, 30(2), 536-542. https://doi.org/10.1111/jvim.13831

Prevalence of and risk factors for degenerative mitral valve disease in dogs attending primary-care veterinary practices in england (2015)
Journal Article
Mattin, M. J., Boswood, A., Church, D. B., Lopez-Alvarez, J., McGreevy, P. D., O'Neill, D. G., Thomson, P. C., & Brodbelt, D. C. (2015). Prevalence of and risk factors for degenerative mitral valve disease in dogs attending primary-care veterinary practices in england. Journal of Veterinary Internal Medicine, 29(3), 847-854. https://doi.org/10.1111/jvim.12591

Longitudinal Analysis of Quality of Life, Clinical, Radiographic, Echocardiographic, and Laboratory Variables in Dogs with Myxomatous Mitral Valve Disease Receiving Pimobendan or Benazepril: The QUEST Study. (2013)
Journal Article
Haggstrom, J. H., Boswood, A., O'Grady, M., Joens, O., Smith, S., Swift, S., Borgarelli, M., Gavaghan, B., Kresken, J. G., Patteson, M., Ablad, B., Bussadori, C., Glaus, T., Kovacevic, A., Rapp, M., Santilli, R. A., Tidholm, A., Eriksson, A., Belanger, M. C., Deinert, M., …DiFruscia, R. (2013). Longitudinal Analysis of Quality of Life, Clinical, Radiographic, Echocardiographic, and Laboratory Variables in Dogs with Myxomatous Mitral Valve Disease Receiving Pimobendan or Benazepril: The QUEST Study. Journal of Veterinary Internal Medicine, 27(6), 1441-1451. https://doi.org/10.1111/jvim.12181

Effect of pimobendan or benazepril hydrochloride on survival times in dogs with congestive heart failure caused by naturally occurring myxomatous mitral valve disease: The QUEST study (2008)
Journal Article
Haggstrom, J., Boswood, A., O'Grady, M., Jons, O., Smith, S., Swift, S., Borgarelli, M., Gavaghan, B., Kresken, J. G., Patteson, M., Ablad, B., Bussadori, C., Glaus, T., Kovacevic, A., Rapp, M., Santilli, R. A., Tidholm, A., Eriksson, A., Belanger, M. C., Deinert, M., …DiFruscia, R. (2008). Effect of pimobendan or benazepril hydrochloride on survival times in dogs with congestive heart failure caused by naturally occurring myxomatous mitral valve disease: The QUEST study. Journal of Veterinary Internal Medicine, 22(5), 1124-1135. https://doi.org/10.1111/j.1939-1676.2008.0150.x

Background: Myxomatous mitral valve disease (MMVD) continues to be an important cause of morbidity and mortality in geriatric dogs despite conventional therapy.