Effect of the synthetic Toll-like receptor ligands LPS, Pam3CSK4, HKLM and FSL-1 in the function of bovine polymorphonuclear neutrophils
Journal Article
Conejeros, I., Gibson, A. J., Werling, D., Munoz-Caro, T., Hermosilla, C., Taubert, A., & Burgos, R. A. (in press). Effect of the synthetic Toll-like receptor ligands LPS, Pam3CSK4, HKLM and FSL-1 in the function of bovine polymorphonuclear neutrophils. Developmental and Comparative Immunology, 52(2), 215-225. https://doi.org/10.1016/j.dci.2015.05.012

Toll-like receptors (TLR) are a family of pattern recognition receptors that sense microbial associated molecular patterns (MAMP) such as microbial membrane components and nucleic acids of bacterial origin. Polymorphonuclear neutrophils (PMN) are the... Read More about Effect of the synthetic Toll-like receptor ligands LPS, Pam3CSK4, HKLM and FSL-1 in the function of bovine polymorphonuclear neutrophils.

Bovine macrophages sense Escherichia coli Shiga toxin 1
Journal Article
Menge, C., Loos, D., Bridger, P. S., Barth, S., Werling, D., & Baljier, G. (in press). Bovine macrophages sense Escherichia coli Shiga toxin 1. Innate Immunity, 21(6), 655-664. https://doi.org/10.1177/1753425915581215

Effects of Ex-Vivo and In-Vivo Treatment with Probiotics on the Inflammasome in Dogs with Chronic Enteropathy
Journal Article
Schmitz, S., Werling, D., & Allenspach, K. (in press). Effects of Ex-Vivo and In-Vivo Treatment with Probiotics on the Inflammasome in Dogs with Chronic Enteropathy. PLoS ONE, 10(3), e0120779. https://doi.org/10.1371/journal.pone.0120779

Inflammasomes coordinate the maturation of IL-1β and IL-18 in response to danger signals. They are vital for maintenance of intestinal homeostasis and have been linked to chronic intestinal inflammation in humans. Probiotics have been advocated as tr... Read More about Effects of Ex-Vivo and In-Vivo Treatment with Probiotics on the Inflammasome in Dogs with Chronic Enteropathy.

Lack of Correlation between Mucosal Immunoglobulin A-positive Plasma Cell Numbers and TLR5 Genotypes in German Shepherd Dogs with Idiopathic Chronic Enteropathy
Journal Article
Lee, A., Kathrani, A., Priestnall, S. L., Smith, K. C., Werling, D., & Allenspach, K. (in press). Lack of Correlation between Mucosal Immunoglobulin A-positive Plasma Cell Numbers and TLR5 Genotypes in German Shepherd Dogs with Idiopathic Chronic Enteropathy. Journal of Comparative Pathology, 152(2-3), 201-5. https://doi.org/10.1016/j.jcpa.2015.01.002

Vaccination of calves with yeast- and bacterial-expressed paramyosin from the bovine lungworm Dictyocaulus viviparus
Journal Article
Joekel, D., Hinse, P., Raulf, M. K., Schicht, S., Baumer, W., Werling, D., Kremmer, E., & Strube, C. Vaccination of calves with yeast- and bacterial-expressed paramyosin from the bovine lungworm Dictyocaulus viviparus. Parasite Immunology, 37(12), 614-623. https://doi.org/10.1111/pim.12280

The Phylogeography of Rabies in Grenada, West Indies, and Implications for Control
Journal Article
Zieger, U., Marston, D. A., Sharma, R., Chikweto, A., Tiwari, K., Sayyid, M., Louison, B., Goharriz, H., Voller, K., Breed, A. C., Werling, D., Fooks, A. R., & Horton, D. L. (in press). The Phylogeography of Rabies in Grenada, West Indies, and Implications for Control. PLoS Neglected Tropical Diseases, 8(10), e3251. https://doi.org/10.1371/journal.pntd.0003251

In Grenada, West Indies, rabies is endemic, and is thought to be maintained in a wildlife host, the small Indian mongoose (Herpestes auropunctatus) with occasional spillover into other hosts. Therefore, the present study was undertaken to improve und... Read More about The Phylogeography of Rabies in Grenada, West Indies, and Implications for Control.

Lack of Genetic Diversity in Newly Sequenced Porcine Circovirus Type 1 Strains Isolated 20 Years Apart
Journal Article
Tombacz, K., Patterson, R., Grierson, S. S., & Werling, D. (in press). Lack of Genetic Diversity in Newly Sequenced Porcine Circovirus Type 1 Strains Isolated 20 Years Apart. Genome Announcements, 2(2), e00156-14. https://doi.org/10.1128/genomeA.00156-14

The complete genome sequences of a porcine circovirus type 1 (PCV1) strain isolated in 1990 and one isolated in 2011 were obtained and compared to the sequences of other available PCV1 isolates. Phylogenetic analyses revealed very low genetic diversi... Read More about Lack of Genetic Diversity in Newly Sequenced Porcine Circovirus Type 1 Strains Isolated 20 Years Apart.

Correlation of cell surface marker expression with African swine fever virus infection
Journal Article
Lithgow, P., Takamatsu, H. H., Werling, D., Dixon, L., & Chapman, D. Correlation of cell surface marker expression with African swine fever virus infection. Veterinary Microbiology, 168(2-4), 413-419. https://doi.org/10.1016/j.vetmic.2013.12.001

Functional characterisation of bovine TLR5 indicates species-specific recognition of flagellin
Journal Article
Metcalfe, H. J., La Ragione, R. M., Smith, D. G. E., & Werling, D. Functional characterisation of bovine TLR5 indicates species-specific recognition of flagellin. Veterinary Immunology and Immunopathology, 157(3-4), 197-205. https://doi.org/10.1016/j.vetimm.2013.12.006

Replacement of two aminoacids in the bovine Toll-like receptor 5 TIR domain with their human counterparts partially restores functional response to flagellin
Journal Article
Osvaldova, A., Woodman, S., Patterson, N. J., Offord, V., Mwangi, D., Gibson, A. J., Matiasovic, J., & Werling, D. Replacement of two aminoacids in the bovine Toll-like receptor 5 TIR domain with their human counterparts partially restores functional response to flagellin. Developmental and Comparative Immunology, 47(1), 90-94. https://doi.org/10.1016/j.dci.2014.07.002

Stimulation of Duodenal Biopsies and Whole Blood from Dogs with Food-Responsive Chronic Enteropathy and Healthy Dogs with Toll-Like Receptor Ligands and Probiotic Enterococcus faecium
Journal Article
Schmitz, S., Henrich, M., Neiger, R., Werling, D., & Allenspach, K. Stimulation of Duodenal Biopsies and Whole Blood from Dogs with Food-Responsive Chronic Enteropathy and Healthy Dogs with Toll-Like Receptor Ligands and Probiotic Enterococcus faecium. Scandinavian Journal of Immunology, https://doi.org/10.1111/sji.12186

Why is vaccination against mastitis so difficult?
Presentation / Conference Contribution
Werling, D. Why is vaccination against mastitis so difficult?

Of creatures great and small: the advantages of farm animal models in immunology research
Journal Article
Gibson, A. J., Coffey, T., & Werling, D. Of creatures great and small: the advantages of farm animal models in immunology research. Frontiers in Immunology, 4, 124. https://doi.org/10.3389/fimmu.2013.00124

LRRfinder2.0: A webserver for the prediction of leucine-rich repeats.
Journal Article
Offord, V., & Werling, D. LRRfinder2.0: A webserver for the prediction of leucine-rich repeats. Innate Immunity, 19(4), 398-402. https://doi.org/10.1177/1753425912465661

To con protection: TIR-domain containing proteins (Tcp) and innate immune evasion.
Journal Article
Patterson, N. J., & Werling, D. To con protection: TIR-domain containing proteins (Tcp) and innate immune evasion. Veterinary Immunology and Immunopathology, 155(3), 149-154. https://doi.org/10.1016/j.vetimm.2013.06.017

Comparison of TNF alpha responses induced by Toll-like receptor ligands and probiotic Enterococcus faecium in whole blood and peripheral blood mononuclear cells of healthy dogs
Journal Article
Schmitz, S., Henrich, M., Neiger, R., Werling, D., & Allenspach, K. Comparison of TNF alpha responses induced by Toll-like receptor ligands and probiotic Enterococcus faecium in whole blood and peripheral blood mononuclear cells of healthy dogs. Veterinary Immunology and Immunopathology, 153(1-2), 170-174. https://doi.org/10.1016/j.vetimm.2013.02.014

Expression of trefoil factor genes in the duodenum and colon of dogs with inflammatory bowel disease and healthy dogs
Journal Article
Schmitz, S., Hill, S., Werling, D., & Allenspach, K. Expression of trefoil factor genes in the duodenum and colon of dogs with inflammatory bowel disease and healthy dogs. Veterinary Immunology and Immunopathology, 151(1-2), 168-172. https://doi.org/10.1016/j.vetimm.2012.10.009

Effectiveness of porcine circovirus type 2 vaccination in reducing the severity of post-weaning multisystemic wasting syndrome in pigs
Journal Article
Velasova, M., Alarcon, P., Werling, D., Nevel, M., & Wieland, B. Effectiveness of porcine circovirus type 2 vaccination in reducing the severity of post-weaning multisystemic wasting syndrome in pigs. https://doi.org/10.1016/j.tvjl.2013.05.043

Species-specific PAMP recognition by TLR2 and evidence for species-restricted interaction with Dectin-1
Journal Article
Willcocks, S., Offord, V., Seyfert, H. M., Coffey, T., & Werling, D. Species-specific PAMP recognition by TLR2 and evidence for species-restricted interaction with Dectin-1. Journal of Leukocyte Biology, 94(3), 449-58. https://doi.org/10.1189/jlb.0812390

Inhibition of cytosolic phospholipase A2 prevents prion peptide-induced neuronal damage and co-localisation with Beta III Tubulin
Journal Article
Last, V., Williams, A., & Werling, D. (in press). Inhibition of cytosolic phospholipase A2 prevents prion peptide-induced neuronal damage and co-localisation with Beta III Tubulin. BMC Neuroscience, 13(1), https://doi.org/10.1186/1471-2202-13-106