Cholesterol ester hydrolase inhibitors reduce the production of synaptotoxic amyloid-beta oligomers (2018)
Journal Article
McHale-Owen, H., & Bate, C. (2018). Cholesterol ester hydrolase inhibitors reduce the production of synaptotoxic amyloid-beta oligomers. https://doi.org/10.1016/j.bbadis.2017.12.017

The production of amyloid-β (Aβ) is the key factor driving pathogenesis in Alzheimer's disease (AD). Increasing concentrations of Aβ within the brain cause synapse degeneration and the dementia that is characteristic of AD. Here the factors that affe... Read More about Cholesterol ester hydrolase inhibitors reduce the production of synaptotoxic amyloid-beta oligomers.

Prognostic significance of clinical presentation, induction and rescue treatment in 42 cases of canine centroblastic diffuse large B-cell multicentric lymphoma in the United Kingdom (2018)
Journal Article
Davies, O., Szladovits, B., Polton, G., Garden, O. A., Leo, C., & Lara-Garcia, A. (2018). Prognostic significance of clinical presentation, induction and rescue treatment in 42 cases of canine centroblastic diffuse large B-cell multicentric lymphoma in the United Kingdom. Veterinary and Comparative Oncology, 16(2), 276-287. https://doi.org/10.1111/vco.12378

Canine lymphoma is a heterogeneous group of diseases and many previous studies have evaluated the response of a mixed population of lymphoma cases to one specific treatment protocol. The aim of this retrospective study was to describe the outcome and... Read More about Prognostic significance of clinical presentation, induction and rescue treatment in 42 cases of canine centroblastic diffuse large B-cell multicentric lymphoma in the United Kingdom.

Phenotypic indications of FtsZ inhibition in hok/sok-induced bacterial growth changes and stress response (2018)
Journal Article
Chukwudi, C. U., & Good, L. (2018). Phenotypic indications of FtsZ inhibition in hok/sok-induced bacterial growth changes and stress response. Microbial Pathogenesis, 114, 393-401. https://doi.org/10.1016/j.micpath.2017.12.023

The hok/sok locus has been shown to enhance the growth of bacteria in adverse growth conditions such as high temperature, low starting-culture densities and antibiotic treatment. This is in addition to their well-established plasmid-stabilization eff... Read More about Phenotypic indications of FtsZ inhibition in hok/sok-induced bacterial growth changes and stress response.

Polymorphisms in the canine IL7R 3 ' UTR are associated with thymic output in Labrador retriever dogs and influence post-transcriptional regulation by microRNA 185 (2018)
Journal Article
Holder, A. L., Jones, G., Soutter, F., Palmer, D. B., Aspinall, R., & Catchpole, B. (2018). Polymorphisms in the canine IL7R 3 ' UTR are associated with thymic output in Labrador retriever dogs and influence post-transcriptional regulation by microRNA 185. Developmental and Comparative Immunology, 81, 244-251. https://doi.org/10.1016/j.dci.2017.12.008

Interleukin-7 (IL-7) and its receptor (IL-7R) are essential for T cell development in the thymus, and changes in the IL-7/IL-7R pathway have been implicated in age-associated thymic involution which results in a reduction of naïve T cell output. The... Read More about Polymorphisms in the canine IL7R 3 ' UTR are associated with thymic output in Labrador retriever dogs and influence post-transcriptional regulation by microRNA 185.

A probabilistic approach to the interpretation of milk antibody results for diagnosis of Johne’s disease in dairy cattle (2018)
Journal Article
Meyer, A., Bond, K., Van Winden, S. C. L., Green, M., & Guitian, J. (2018). A probabilistic approach to the interpretation of milk antibody results for diagnosis of Johne’s disease in dairy cattle. Preventive Veterinary Medicine, 150, 30-37. https://doi.org/10.1016/j.prevetmed.2017.11.016

Johne’s disease is a serious wasting disease of ruminants that is of high economic importance for the dairy sector in particular. The chronic nature of the disease, the fluctuations in antibody levels and the limited ability of diagnostic tests to id... Read More about A probabilistic approach to the interpretation of milk antibody results for diagnosis of Johne’s disease in dairy cattle.

Identification of production challenges and benefits using value chain mapping of egg food systems in Nairobi, Kenya (2018)
Journal Article
Onono, J. O., Alarcon, P., Karani, M., Muinde, P., Akoko, J. M., Maud, C., Fèvre, E. M., Haesler, B., & Rushton, J. (2018). Identification of production challenges and benefits using value chain mapping of egg food systems in Nairobi, Kenya. Agricultural Systems, 159, 1-8. https://doi.org/10.1016/j.agsy.2017.10.001

Commercial layer and indigenous chicken farming in Nairobi and associated activities in the egg value chains are a source of livelihood for urban families. A value chain mapping framework was used to describe types of inputs and outputs from chicken... Read More about Identification of production challenges and benefits using value chain mapping of egg food systems in Nairobi, Kenya.

Valproic acid and its congener propylisopropylacetic acid reduced the amount of soluble amyloid-ß oligomers released from 7PA2 cells (2018)
Journal Article
Williams, R. S. B., & Bate, C. (2018). Valproic acid and its congener propylisopropylacetic acid reduced the amount of soluble amyloid-ß oligomers released from 7PA2 cells. Neuropharmacology, 128, 54-62. https://doi.org/10.1016/j.neuropharm.2017.09.031

The amyloid hypothesis of Alzheimer's disease suggests that synaptic degeneration and pathology is caused by the accumulation of amyloid-β (Aβ) peptides derived from the amyloid precursor protein (APP). Subsequently, soluble Aβ oligomers cause the lo... Read More about Valproic acid and its congener propylisopropylacetic acid reduced the amount of soluble amyloid-ß oligomers released from 7PA2 cells.

Electroencephalographic assessment of concussive non-penetrative captive bolt stunning of turkeys (2017)
Journal Article
Gibson, T. J., Rebelo, C. B., Gowers, T. A., & Chancellor, N. M. (2017). Electroencephalographic assessment of concussive non-penetrative captive bolt stunning of turkeys. British Poultry Science, 59(1), 13-20. https://doi.org/10.1080/00071668.2017.1401215

1. The aim of this study was to evaluate the electroencephalographic (EEG) and behavioural responses of turkeys stunned with three different concussive non-penetrative captive-bolt guns prior to slaughter.

2. A total of 31 slaughter weight ex-bree... Read More about Electroencephalographic assessment of concussive non-penetrative captive bolt stunning of turkeys.

Interpreting ambiguous ‘trace’ results in Schistosoma mansoni CCA Tests: Estimating sensitivity and specificity of ambiguous results with no gold standard (2017)
Journal Article
Clements, M. N., Donnelly, C. A., Fenwick, A., Kabatereine, N. B., Knowles, S. C. L., Meité, A., N'Goran, E. K., Nalule, Y., Nogaro, S., Phillips, A. E., Tukahebwa, E. M., & Fleming, F. M. (2017). Interpreting ambiguous ‘trace’ results in Schistosoma mansoni CCA Tests: Estimating sensitivity and specificity of ambiguous results with no gold standard. PLoS Neglected Tropical Diseases, https://doi.org/10.1371/journal.pntd.0006102

Zoonotic potential of Salmonella enterica carried by pet tortoises (2017)
Journal Article
Bruce, H. L., Barrow, P. A., & Rycroft, A. N. (2017). Zoonotic potential of Salmonella enterica carried by pet tortoises. Veterinary Record, 182(5), 141. https://doi.org/10.1136/vr.104457

The prevalence of Salmonella in chelonians is not known in the UK and it is not clear whether such Salmonella strains would be pathogenic for human beings. Some strains, such as members of the Arizonae subgroup, may be unable to cause anything more t... Read More about Zoonotic potential of Salmonella enterica carried by pet tortoises.

Breaking the Cycle, Cholesterol Cycling, and Synapse Damage in Response to Amyloid-ß (2017)
Journal Article
Bate, C. (2017). Breaking the Cycle, Cholesterol Cycling, and Synapse Damage in Response to Amyloid-ß. Journal of Experimental Neuroscience, 11, https://doi.org/10.1177/1179069517733096

Soluble amyloid-β (Aβ) oligomers, a key driver of pathogenesis in Alzheimer disease, bind to cellular prion proteins (PrPC) expressed on synaptosomes resulting in increased cholesterol concentrations, movement of cytoplasmic phospholipase A2 (cPLA2)... Read More about Breaking the Cycle, Cholesterol Cycling, and Synapse Damage in Response to Amyloid-ß.

Student experiences and perceptions of compulsory research projects: a veterinary perspective (2017)
Journal Article
Cardwell, J. M., Magnier, K., Kinnison, T., & Silva-Fletcher, A. T. (2017). Student experiences and perceptions of compulsory research projects: a veterinary perspective. Veterinary Record Open, 4, e000243. https://doi.org/10.1136/vetreco-2017-000243

Background Although research underpins clinical work, many students training to be clinicians are not inherently interested in developing research skills.

Aim To characterise and understand veterinary student experiences and perceptions of compuls... Read More about Student experiences and perceptions of compulsory research projects: a veterinary perspective.

Linking disease epidemiology and livestock productivity: The case of bovine respiratory disease in France (2017)
Journal Article
Delabouglise, A., James, A., Valarcher, J. F., Haggluend, S., Raboisson, D., & Rushton, J. (2017). Linking disease epidemiology and livestock productivity: The case of bovine respiratory disease in France. PLoS ONE, 12, e0189090. https://doi.org/10.1371/journal.pone.0189090

Concerns are growing over the impact of livestock farming on environment and public health. The livestock industry is faced with the double constraint of limiting its use of natural resources and antimicrobials while ensuring its economic sustainabil... Read More about Linking disease epidemiology and livestock productivity: The case of bovine respiratory disease in France.

Phenotypic and genotypic monitoring of Schistosoma mansoni in Tanzanian schoolchildren five years into a preventative chemotherapy national control programme (2017)
Journal Article
Gower, C. M., Gehre, F., Marques, S. R., Lamberton, P. H. L., Lwambo, N. J., & Webster, J. P. (2017). Phenotypic and genotypic monitoring of Schistosoma mansoni in Tanzanian schoolchildren five years into a preventative chemotherapy national control programme. https://doi.org/10.1186/s13071-017-2533-6

We conducted combined in vitro PZQ efficacy testing with population genetic analyses of S. mansoni collected from children from two schools in 2010, five years after the introduction of a National Control Programme. Children at one school had receive... Read More about Phenotypic and genotypic monitoring of Schistosoma mansoni in Tanzanian schoolchildren five years into a preventative chemotherapy national control programme.

Efficacy of a Topical Formulation Containing Emodepside and Praziquantel (Profender®, Bayer) against Nematodes in Captive Tortoises (2017)
Journal Article
Tang, P. K., Pellett, S., Blake, D. P., & Hedley, J. (2017). Efficacy of a Topical Formulation Containing Emodepside and Praziquantel (Profender®, Bayer) against Nematodes in Captive Tortoises. Journal of Herpetological Medicine and Surgery, 27(3-4), 116-122. https://doi.org/10.5818/17-04-107.1

Gastrointestinal parasites are commonly diagnosed in captive tortoises. In response, fenbendazole has traditionally been used as an anthelmintic, either in single or repeated doses. However, fenbendazole requires oral administration and the process c... Read More about Efficacy of a Topical Formulation Containing Emodepside and Praziquantel (Profender®, Bayer) against Nematodes in Captive Tortoises.

Retrospective evaluation of COX-2 expression, histological and clinical factors as prognostic indicators in dogs with renal cell carcinomas undergoing nephrectomy (2017)
Journal Article
Carvalho, S., Stoll, A. L., Priestnall, S. L., Suárez-Bonnet, A., Rassnick, K., Lynch, S., Schoepper, I., Romanelli, G., Buracco, P., Atherton, M., De Merlo, E., & Lara-Garcia, A. (2017). Retrospective evaluation of COX-2 expression, histological and clinical factors as prognostic indicators in dogs with renal cell carcinomas undergoing nephrectomy. Veterinary and Comparative Oncology, 15(4), 1280-1294. https://doi.org/10.1111/vco.12264

Prospective cohort study to assess rates of contagious disease in pre-weaned UK dairy heifers: management practices, passive transfer of immunity and associated calf health (2017)
Journal Article
Johnson, K. F., Chancellor, N., Burn, C. C., & Wathes, D. C. (2017). Prospective cohort study to assess rates of contagious disease in pre-weaned UK dairy heifers: management practices, passive transfer of immunity and associated calf health. Veterinary Record Open, 4, e000226. https://doi.org/10.1136/vetreco-2017-000226

Economics of One Health: Costs and benefits of integrated West Nile virus surveillance in Emilia-Romagna (2017)
Journal Article
Paternoster, G., Babo Martins, S., Mattivi, A., Cagarelli, R., Angelini, P., Bellini, R., Santi, A., Galletti, G., Pupella, S., Marano, G., Copello, F., Rushton, J., Staerk, K. D. C., & Tamba, M. (2017). Economics of One Health: Costs and benefits of integrated West Nile virus surveillance in Emilia-Romagna. PLoS ONE, 12(11), e0188156. https://doi.org/10.1371/journal.pone.0188156

Since 2013 in Emilia-Romagna, Italy, surveillance information generated in the public health and in the animal health sectors has been shared and used to guide public health interventions to mitigate the risk of West Nile virus (WNV) transmission via... Read More about Economics of One Health: Costs and benefits of integrated West Nile virus surveillance in Emilia-Romagna.

Border Terriers under primary veterinary care in England: demography and disorders (2017)
Journal Article
O'Neill, D. G., Darwent, E. C., Church, D. B., & Brodbelt, D. C. (2017). Border Terriers under primary veterinary care in England: demography and disorders. Canine Genetics and Epidemiology, 4(15), https://doi.org/10.1186/s40575-017-0055-3

The Border Terrier is a working terrier type that is generally considered to be a relatively healthy and hardy breed. This study aimed to characterise the demography and common disorders of Border Terriers receiving veterinary care in England using d... Read More about Border Terriers under primary veterinary care in England: demography and disorders.

Analysis of pre-weaning feeding policies and other risk factors influencing growth rates in calves on 11 commercial dairy farms (2017)
Journal Article
Johnson, K., Chancellor, N., Burn, C. C., & Wathes, D. C. (2017). Analysis of pre-weaning feeding policies and other risk factors influencing growth rates in calves on 11 commercial dairy farms. animal, https://doi.org/10.1017/S1751731117003160

Growth rates in pre-weaned calves influence their health, age at first calving and lifetime productivity. Many farms restrict milk rations to encourage solid feed intake and facilitate early weaning, but this can compromise growth. This study determi... Read More about Analysis of pre-weaning feeding policies and other risk factors influencing growth rates in calves on 11 commercial dairy farms.