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An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA(2) dependent signalling (2016)
Journal Article
Williams, R. S. B., & Bate, C. (2016). An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA(2) dependent signalling. Neuropharmacology, 101, 566-575. https://doi.org/10.1016/j.neuropharm.2015.06.013

Many neurodegenerative diseases present the loss of synapses as a common pathological feature. Here we have employed an in vitro model for synaptic loss to investigate the molecular mechanism of a therapeutic treatment, valproic acid (VPA). We show t... Read More about An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA(2) dependent signalling.

One Health – an Ecological and Evolutionary Framework for tackling Neglected Zoonotic Diseases (2016)
Journal Article
Webster, J. P., Gower, C. M., Knowles, S. C. L., & Fenton, A. (2016). One Health – an Ecological and Evolutionary Framework for tackling Neglected Zoonotic Diseases. Evolutionary Applications, 9(2), 313-333. https://doi.org/10.1111/eva.12341

Understanding the complex population biology and transmission ecology of multihost parasites has been declared as one of the major challenges of biomedical sciences for the 21st century and the Neglected Zoonotic Diseases (NZDs) are perhaps the most... Read More about One Health – an Ecological and Evolutionary Framework for tackling Neglected Zoonotic Diseases.

The genomic basis of parasitism in the Strongyloides clade of nematodes (2016)
Journal Article
Hunt, V. L., Tsai, I. J., Coghlan, A., Reid, A. J., Holroyd, N., Foth, B. J., Tracey, A., Cotton, J. A., Stanley, E. J., Beasley, H., Bennett, H. M., Brooks, K., Harsha, B., Kajitani, R., Kulkarni, A., Harbecke, D., Nagayasu, E., Nichol, S., Ogura, Y., Quail, M. A., …Berriman, M. (2016). The genomic basis of parasitism in the Strongyloides clade of nematodes. Nature Genetics, 48(3), 299-307. https://doi.org/10.1038/ng.3495

Soil-transmitted nematodes, including the Strongyloides genus, cause one of the most prevalent neglected tropical diseases. Here we compare the genomes of four Strongyloides species, including the human pathogen Strongyloides stercoralis, and their c... Read More about The genomic basis of parasitism in the Strongyloides clade of nematodes.

Consumers' behavior in quantitative microbial risk assessment for pathogens in raw milk: Incorporation of the likelihood of consumption as a function of storage time and temperature (2016)
Journal Article
Crotta, M., Paterlini, F., Rizzi, R., & Guitian, J. (2016). Consumers' behavior in quantitative microbial risk assessment for pathogens in raw milk: Incorporation of the likelihood of consumption as a function of storage time and temperature. Journal of Dairy Science, 99(2), 1029-1038. https://doi.org/10.3168/jds.2015-10175

Vaccination control programs for multiple livestock host species: an age-stratified, seasonal transmission model for brucellosis control in endemic settings (2016)
Journal Article
Beauvais, W., Musallam, I. I., & Guitian, J. (2016). Vaccination control programs for multiple livestock host species: an age-stratified, seasonal transmission model for brucellosis control in endemic settings. https://doi.org/10.1186/s13071-016-1327-6

Brucella melitensis causes production losses in ruminants and febrile disease in humans in Africa, Central Asia, the Middle East and elsewhere. Although traditionally understood to affect primarily sheep and goats, it is also the predominant Brucella... Read More about Vaccination control programs for multiple livestock host species: an age-stratified, seasonal transmission model for brucellosis control in endemic settings.

Complete Genome Sequence of MIDG2331, a Genetically Tractable Serovar 8 Clinical Isolate of Actinobacillus pleuropneumoniae (2016)
Journal Article
Bossé, J. T., Chaudhuri, R. R., Li, Y., Leanse, L. G., Fernandez Crespo, R., Coupland, P., Holden, M. T., Bazzoli, D. M., Maskell, D. J., Tucker, A. W., Wren, B. W., Rycroft, A. N., & Langford, P. R. (2016). Complete Genome Sequence of MIDG2331, a Genetically Tractable Serovar 8 Clinical Isolate of Actinobacillus pleuropneumoniae. Genome Announcements, 4(i), e01667-15. https://doi.org/10.1128/genomeA.01667-15

We report here the complete annotated genome sequence of a clinical serovar 8 isolate Actinobacillus pleuropneumoniae MIDG2331. Unlike the serovar 8 reference strain 405, MIDG2331 is amenable to genetic manipulation via natural transformation as well... Read More about Complete Genome Sequence of MIDG2331, a Genetically Tractable Serovar 8 Clinical Isolate of Actinobacillus pleuropneumoniae.

Differentiation of Cardiac from Noncardiac Pleural Effusions in Cats using Second-Generation Quantitative and Point-of-Care NT-proBNP Measurements (2016)
Journal Article
Hezzell, M. J., Rush, J. E., Humm, K. R., Rozanski, E. A., Sargent, J., Connolly, D. J., Boswood, A., & Oyama, M. A. (2016). Differentiation of Cardiac from Noncardiac Pleural Effusions in Cats using Second-Generation Quantitative and Point-of-Care NT-proBNP Measurements. Journal of Veterinary Internal Medicine, 30(2), 536-542. https://doi.org/10.1111/jvim.13831

Multi-parallel qPCR provides increased sensitivity and diagnostic breadth for gastrointestinal parasites of humans: field-based inferences on the impact of mass deworming (2016)
Journal Article
Easton, A. V., Oliveira, R. G., O'Connell, E. M., Kepha, S., Mwandawiro, C. S., Njenga, S. M., Kihara, J. H., Mwatele, C., Odiere, M. R., Brooker, S. J., Webster, J. P., Anderson, R. M., & Nutman, T. B. (2016). Multi-parallel qPCR provides increased sensitivity and diagnostic breadth for gastrointestinal parasites of humans: field-based inferences on the impact of mass deworming. https://doi.org/10.1186/s13071-016-1314-y

Recovery of chronically lame dairy cows following treatment for claw horn lesions: a randomised controlled trial (2016)
Journal Article
Thomas, H. J., Remnant, J. G., Bollard, N. J., Burrows, A., Whay, H. R., Bell, N. J., Mason, C., & Huxley, J. N. (2016). Recovery of chronically lame dairy cows following treatment for claw horn lesions: a randomised controlled trial. Veterinary Record, 178(5), 116-U54. https://doi.org/10.1136/vr.103394

A positively controlled, randomised controlled trial (RCT) was undertaken to test recovery of cows with claw horn lesions resulting in lameness of greater than two weeks duration. Cows on seven commercial farms were mobility scored fortnightly and se... Read More about Recovery of chronically lame dairy cows following treatment for claw horn lesions: a randomised controlled trial.

Interaction of the tetracyclines with double-stranded RNAs of random base sequence: new perspectives on the target and mechanism of action (2016)
Journal Article
Chukwudi, C. U., & Good, L. (2016). Interaction of the tetracyclines with double-stranded RNAs of random base sequence: new perspectives on the target and mechanism of action. Journal of Antibiotics, 69, 622-630. https://doi.org/10.1038/ja.2015.145

The 16S rRNA binding mechanism proposed for the antibacterial action of the tetracyclines does not explain their mechanism of action against non-bacterial pathogens. In addition, several contradictory base pairs have been proposed as their binding si... Read More about Interaction of the tetracyclines with double-stranded RNAs of random base sequence: new perspectives on the target and mechanism of action.

New approaches to measuring anthelminthic drug efficacy: parasitological responses of childhood schistosome infections to treatment with praziquantel (2016)
Journal Article
Walker, M., Mabud, T., Olliaro, P. L., Coulibaly, J. T., King, C. H., Raso, G., Scherrer, A. U., Stothard, J. R., Sousa-Figueiredo, J. C., Stete, K., Utzinger, J., & Basáñez, M.-G. (2016). New approaches to measuring anthelminthic drug efficacy: parasitological responses of childhood schistosome infections to treatment with praziquantel. https://doi.org/10.1186/s13071-016-1312-0

Exploring the evidence base for national and regional policy interventions to combat resistance (2016)
Journal Article
Dar, F. K., Littmann, J., Rweyemamu, M., Buckley, E. J., Shahid, M., Kock, R. A., Li, H. L., Giha, H., Khan, M., So, A. D., Bindayna, K. M., Kessel, A., Pedersen, H. B., Permanand, G., Zumla, A., Rottingen, J.-A., & Heymann, D. L. (2016). Exploring the evidence base for national and regional policy interventions to combat resistance. https://doi.org/10.1016/S0140-6736%2815%2900520-6

The effectiveness of existing policies to control antimicrobial resistance is not yet fully understood. A strengthened evidence base is needed to inform effective policy interventions across countries with different income levels and the human health... Read More about Exploring the evidence base for national and regional policy interventions to combat resistance.