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Effect of a unilateral hind limb orthotic lift on upper body movement symmetry in the trotting horse (2018)
Journal Article
Vertz, J., Deblanc, D., Rhodin, M., & Pfau, T. (2018). Effect of a unilateral hind limb orthotic lift on upper body movement symmetry in the trotting horse. PLoS ONE, 13(6), e0199447. https://doi.org/10.1371/journal.pone.0199447

In trotting horses, movement asymmetry is associated with ground reaction force asymmetry. In humans, limb length differences influence contralateral force production. Here we investigate whether horses, in immediate reaction to limb length changes,... Read More about Effect of a unilateral hind limb orthotic lift on upper body movement symmetry in the trotting horse.

Bone marrow mesenchymal stem cells do not enhance intra-synovial tendon healing despite engraftment and homing to niches within the synovium (2018)
Journal Article
Khan, M. R., Dudhia, J., David, F. H., De Godoy, R., Mehra, V., Hughes, G., …Smith, R. K. W. (2018). Bone marrow mesenchymal stem cells do not enhance intra-synovial tendon healing despite engraftment and homing to niches within the synovium. https://doi.org/10.1186/s13287-018-0900-7

Intra-synovial tendon injuries display poor healing, which often results in reduced functionality and pain. A lack of effective therapeutic options has led to experimental approaches to augment natural tendon repair with autologous mesenchymal stem c... Read More about Bone marrow mesenchymal stem cells do not enhance intra-synovial tendon healing despite engraftment and homing to niches within the synovium.

A novel kinematics analysis method using quaternion interpolation – a case study in frog jumping (2018)
Journal Article
Richards, C. T., & Porro, L. B. (2018). A novel kinematics analysis method using quaternion interpolation – a case study in frog jumping. Journal of Theoretical Biology, 454, 410-424. https://doi.org/10.1016/j.jtbi.2018.06.010

Spherical Linear Interpolation (SLERP) has long been used in computer animation to interpolate movements between two 3D orientations. We developed a forward kinematics (FK) approach using quaternions and SLERP to predict how frogs modulate jump kinem... Read More about A novel kinematics analysis method using quaternion interpolation – a case study in frog jumping.

Understanding the agility of running birds: Sensorimotor and mechanical factors in avian bipedal locomotion (2018)
Journal Article
Daley, M. A. (2018). Understanding the agility of running birds: Sensorimotor and mechanical factors in avian bipedal locomotion. Integrative and Comparative Biology, https://doi.org/10.1093/icb/icy058

Birds are a diverse and agile lineage of vertebrates that all use bipedal locomotion for at least part of their life. Thus birds provide a valuable opportunity to investigate how biomechanics and sensorimotor control are integrated for agile bipedal... Read More about Understanding the agility of running birds: Sensorimotor and mechanical factors in avian bipedal locomotion.

A review of treatment options for behavioural manifestations of clinical anxiety as a comorbidity in dogs with idiopathic epilepsy (2018)
Journal Article
Watson, F., Rusbridge, C., Packer, R. M. A., Casey, R. A., Heath, S., & Volk, H. A. (2018). A review of treatment options for behavioural manifestations of clinical anxiety as a comorbidity in dogs with idiopathic epilepsy. https://doi.org/10.1016/j.tvjl.2018.06.001

Psychiatric comorbidities affect a large percentage of people with epilepsy and have a detrimental impact on their quality of life. Recently, behavioural comorbidities, with similar characteristics to human psychiatric diseases, have been identified... Read More about A review of treatment options for behavioural manifestations of clinical anxiety as a comorbidity in dogs with idiopathic epilepsy.

Regional diversity in the murine cortical vascular network is revealed by synchrotron X-ray tomography and is amplified with age (2018)
Journal Article
Núñez, J. A., Goring, A., Javaheri, B., Razi, H., Gomez-Nicola, D., Pitsillides, A. A., …Clarkin, C. E. (2018). Regional diversity in the murine cortical vascular network is revealed by synchrotron X-ray tomography and is amplified with age. https://doi.org/10.22203/eCM.v035a20

Cortical bone is permeated by a system of pores, occupied by the blood supply and osteocytes. With ageing, bone mass reduction and disruption of the microstructure are associated with reduced vascular supply. Insight into the regulation of the blood... Read More about Regional diversity in the murine cortical vascular network is revealed by synchrotron X-ray tomography and is amplified with age.

Scaling of avian bipedal locomotion reveals independent effects of body mass and leg posture on gait (2018)
Journal Article
Daley, M. A., & Birn-Jeffery, A. V. (2018). Scaling of avian bipedal locomotion reveals independent effects of body mass and leg posture on gait. Journal of Experimental Biology, 221, https://doi.org/10.1242/jeb.152538

Birds provide an interesting opportunity to study the relationships between body size, limb morphology and bipedal locomotor function. Birds are ecologically diverse and span a large range of body size and limb proportions, yet all use their hindlimb... Read More about Scaling of avian bipedal locomotion reveals independent effects of body mass and leg posture on gait.

Mineralization can be an incidental ultrasonographic finding in equine tendons and ligaments (2018)
Journal Article
O'Brien, E. J. O., & Smith, R. K. W. (2018). Mineralization can be an incidental ultrasonographic finding in equine tendons and ligaments. https://doi.org/10.1111/vru.12628

Tendon/ligament mineralization is recognized in horses but information regarding its clinical significance is limited. The aims of this observational study were to report the structures most commonly affected by ultrasonographically detectable minera... Read More about Mineralization can be an incidental ultrasonographic finding in equine tendons and ligaments.

A dynamic simulation of musculoskeletal function in the mouse hindlimb during trotting locomotion (2018)
Journal Article
Charles, J. P., Cappellari, I., & Hutchinson, J. R. (2018). A dynamic simulation of musculoskeletal function in the mouse hindlimb during trotting locomotion. Frontiers in Bioengineering and Biotechnology, 6(61), https://doi.org/10.3389/fbioe.2018.00061

Mice are often used as animal models of various human neuromuscular diseases, and analysis of these models often requires detailed gait analysis. However, little is known of the dynamics of the mouse musculoskeletal system during locomotion. In this... Read More about A dynamic simulation of musculoskeletal function in the mouse hindlimb during trotting locomotion.

The grazing gait, and implications of toppling table geometry for primate footfall sequences (2018)
Journal Article
Usherwood, J. R., & Smith, B. J. H. (2018). The grazing gait, and implications of toppling table geometry for primate footfall sequences. Biology Letters, 14(5), https://doi.org/10.1098/rsbl.2018.0137

Many medium and large herbivores locomote forwards very slowly and intermittently when grazing. While the footfall order during grazing is the same as for walking, the relative fore–hind timing—phasing—is quite different. Extended periods of static s... Read More about The grazing gait, and implications of toppling table geometry for primate footfall sequences.

Bidirectional regulation of bone formation by exogenous and osteosarcoma-derived Sema3A (2018)
Journal Article
De Ridder, D., Marino, S., Bishop, R. T., Renema, N., Chenu, C., Heymann, D., & Idris, A. I. (2018). Bidirectional regulation of bone formation by exogenous and osteosarcoma-derived Sema3A. https://doi.org/10.1038/s41598-018-25290-2

Semaphorin 3A (Sema3A), a secreted member of the Semaphorin family, increases osteoblast differentiation, stimulates bone formation and enhances fracture healing. Here, we report a previously unknown role of Sema3A in the regulation of ectopic bone f... Read More about Bidirectional regulation of bone formation by exogenous and osteosarcoma-derived Sema3A.

Postoperative survival and early complications after intracranial surgery in dogs (2018)
Journal Article
Forward, A. K., Volk, H. A., & De Decker, S. (2018). Postoperative survival and early complications after intracranial surgery in dogs. Vector-Borne and Zoonotic Diseases, 47(4), 549-554. https://doi.org/10.1111/vsu.12785

Objective To describe survival and early postoperative outcome after intracranial surgery in dogs. Study design Retrospective case series. Animals Fifty client-owned dogs that underwent intracranial surgery. Methods Records were searched... Read More about Postoperative survival and early complications after intracranial surgery in dogs.

Transient peak-strain matching partially recovers the age-impaired mechanoadaptive cortical bone response (2018)
Journal Article
Javaheri, B., Carriero, A., Wood, M., De Souza, R., Lee, P. D., Shefelbine, S., & Pitsillides, A. A. (2018). Transient peak-strain matching partially recovers the age-impaired mechanoadaptive cortical bone response. https://doi.org/10.1038/s41598-018-25084-6

Mechanoadaptation maintains bone mass and architecture; its failure underlies age-related decline in bone strength. It is unclear whether this is due to failure of osteocytes to sense strain, osteoblasts to form bone or insufficient mechanical stimul... Read More about Transient peak-strain matching partially recovers the age-impaired mechanoadaptive cortical bone response.

Preliminary assessment of cognitive impairments in canine idiopathic epilepsy (2018)
Journal Article
Winter, J., Packer, R. M. A., & Volk, H. A. (2018). Preliminary assessment of cognitive impairments in canine idiopathic epilepsy. Veterinary Record, https://doi.org/10.1136/vr.104603

In humans, epilepsy can induce or accelerate cognitive impairment (CI). There is emerging evidence of CI in dogs with idiopathic epilepsy (IE) from recent epidemiological studies. The aim of our study was to assess CI in dogs with IE using two tests... Read More about Preliminary assessment of cognitive impairments in canine idiopathic epilepsy.