A Suárez-Bonnet
Aberrant Expression of Cell Cycle Regulator 14-3-3-σ and E-Cadherin in a Metastatic Cholangiocarcinoma in a Vervet Monkey (Chlorocebus pygerythrus).
Suárez-Bonnet, A; Priestnall, S L; Ramírez, G A; Molín, J; Jaber, J R
Authors
S L Priestnall
G A Ramírez
J Molín
J R Jaber
Abstract
We present a unique case of metastatic cholangiocarcinoma with concurrent abdominal cestodiasis in an African green monkey (Chlorocebus pygerythrus) that presented with respiratory insufficiency and abdominal discomfort. There were multiple white-grey masses in the liver and colonic serosa alongside intra-abdominal parasitic cysts. Histopathologically, the liver masses were composed of poorly-differentiated epithelial cells that formed densely cellular solid areas and trabeculae. The neoplastic cells were strongly immunopositive for CK7 but negative for Hep-Par1 antigen, which confirmed a diagnosis of cholangiocarcinoma. Interestingly, there was strong and diffuse neoexpression in the tumour of the cell cycle regulator 14-3-3σ, which is not constitutively expressed in normal liver. There was aberrantly strong expression of E-cadherin, a key cell-cell adhesion protein, in neoplastic cells with evidence of cytoplasmic internalization. This is the first immunohistochemical analysis of 14-3-3σ and E-cadherin in a liver neoplasm in an animal species and the use of these markers requires further investigation in animal liver neoplasms. [Abstract copyright: Copyright © 2020 Elsevier Ltd. All rights reserved.]
Citation
Suárez-Bonnet, A., Priestnall, S. L., Ramírez, G. A., Molín, J., & Jaber, J. R. (2020). Aberrant Expression of Cell Cycle Regulator 14-3-3-σ and E-Cadherin in a Metastatic Cholangiocarcinoma in a Vervet Monkey (Chlorocebus pygerythrus). Journal of Comparative Pathology, 179, 25-30
Journal Article Type | Article |
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Acceptance Date | Jul 1, 2020 |
Publication Date | Aug 8, 2020 |
Deposit Date | Oct 7, 2020 |
Publicly Available Date | Oct 8, 2020 |
Journal | Journal of Comparative Pathology |
Print ISSN | 0021-9975 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 179 |
Pages | 25-30 |
Keywords | 14-3-3σ, E-cadherin, cholangiocarcinoma, non-human primate |
Public URL | https://rvc-repository.worktribe.com/output/1376254 |
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