Prednisolone-induced diabetes mellitus in the cat: a historical cohort

Nerhagen, S; Moberg, HL; Boge, GS; Glanemann, B

Abstract

Objectives
Prednisolone is a commonly used drug in cats and potential adverse effects include hyperglycaemia and diabetes mellitus. The aims of this study were to evaluate the frequency and investigate potential predisposing risk factors for the development of prednisolone-induced diabetes mellitus (PIDM) in cats.

Methods
The electronic records of a tertiary referral centre were searched for cats receiving prednisolone at a starting dose of ⩾1.9 mg/kg/day, for >3 weeks and with follow-up data available for >3 months between January 2007 and July 2019. One hundred and forty-three cats were included in the study.

Results
Of the 143 cats, 14 cats (9.7%) were diagnosed with PIDM. Twelve out of 14 cats (85.7%) developed diabetes within 3 months of the initiation of therapy.

Conclusions and relevance
Cats requiring high-dose prednisolone therapy should be closely monitored over the first 3 months of therapy for the development of PIDM.

Citation

Nerhagen, S., Moberg, H., Boge, G., & Glanemann, B. (2020). Prednisolone-induced diabetes mellitus in the cat: a historical cohort. Journal of Feline Medicine and Surgery, 1098612X2094352. https://doi.org/10.1177/1098612x20943522

• Journal Article Type: Article
• Acceptance Date: Jun 18, 2020
• Publication Date: Jul 27, 2020
• Deposit Date: Aug 18, 2020
• Publicly Available Date: Aug 18, 2020
• Journal: Journal of Feline Medicine and Surgery
• Print ISSN: 1098-612X
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Pages: 1098612X2094352
• DOI: https://doi.org/10.1177/1098612x20943522
• Public URL: https://rvc-repository.worktribe.com/output/1376609
• Publisher URL: https://doi.org/10.1177/1098612x20943522