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Multihost Transmission of Schistosoma mansoni in Senegal, 2015–2018

Catalano, S; Léger, E; Fall, C B; Borlase, A; Diop, S D; Berger, D; Webster, B L; Faye, B; Diouf, N D; Rollinson, D; Sène, M; Bâ, Kh; Webster, J P


S Catalano

E Léger

C B Fall

A Borlase

S D Diop

D Berger

B L Webster

B Faye

N D Diouf

D Rollinson

M Sène

Kh Bâ

J P Webster


In West Africa, Schistosoma spp. are capable of infecting multiple definitive hosts, a lifecycle feature that may complicate schistosomiasis control. We characterized the evolutionary relationships among multiple Schistosoma mansoni isolates collected from snails (intermediate hosts), humans (definitive hosts), and rodents (definitive hosts) in Senegal. On a local scale, diagnosis of S. mansoni infection ranged 3.8%–44.8% in school-aged children, 1.7%–52.6% in Mastomys huberti mice, and 1.8%–7.1% in Biomphalaria pfeifferi snails. Our phylogenetic framework confirmed the presence of multiple S. mansoni lineages that could infect both humans and rodents; divergence times of these lineages varied (0.13–0.02 million years ago). We propose that extensive movement of persons across West Africa might have contributed to the establishment of these various multihost S. mansoni clades. High S. mansoni prevalence in rodents at transmission sites frequented by humans further highlights the implications that alternative hosts could have on future public health interventions.


Catalano, S., Léger, E., Fall, C. B., Borlase, A., Diop, S. D., Berger, D., …Webster, J. P. (2020). Multihost Transmission of Schistosoma mansoni in Senegal, 2015–2018. Emerging Infectious Disease, 26(6),

Journal Article Type Article
Acceptance Date May 1, 2020
Publication Date May 7, 2020
Deposit Date May 12, 2020
Publicly Available Date Aug 7, 2020
Journal Emerging Infectious Diseases
Print ISSN 1080-6040
Publisher Centers for Disease Control and Prevention
Peer Reviewed Peer Reviewed
Volume 26
Issue 6
Public URL


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