Effects of the long-term feeding of diets enriched with inorganic phosphorus on the adult feline kidney and phosphorus metabolism

Alexander, J; Stockman, J; Atwal, J; Butterwick, R; Colyer, A; Elliott, D; Gilham, M; Morris, P; Staunton, R; Renfrew, H; Elliott, J; Watson, P

doi:10.1017/S0007114518002751

Authors

J Alexander

J Stockman

J Atwal

R Butterwick

A Colyer

D Elliott

M Gilham

P Morris

R Staunton

H Renfrew

J Elliott

P Watson

Abstract

Renal disease has a high incidence in cats, and some evidence implicates dietary P as well. To investigate this further, two studies in healthy adult cats were conducted. Study 1 (36 weeks) included forty-eight cats, stratified to control or test diets providing 1·2 or 4·8 g/1000 kcal (4184 kJ) P (0 or approximately 3·6 g/1000 kcal (4184 kJ) inorganic P, Ca:P 1·2, 0·6). Study 2 (29 weeks) included fifty cats, stratified to control or test diets, providing 1·3 or 3·6 g/1000 kcal (4184 kJ) P (0 or approximately 1·5 g/1000 kcal (4184 kJ) inorganic P, Ca:P 1·2, 0·9). Health markers, glomerular filtration rate (GFR) and mineral balance were measured regularly, with abdominal ultrasound. Study 1 was halted after 4 weeks as the test group GFR reduced by 0·4 (95 % CI 0·3, 0·5) ml/min per kg, and ultrasound revealed changes in renal echogenicity. In study 2, at week 28, no change in mean GFR was observed (P >0·05); however, altered renal echogenicity was detected in 36 % of test cats. In agreement with previous studies, feeding a diet with Ca:P

Citation

Alexander, J., Stockman, J., Atwal, J., Butterwick, R., Colyer, A., Elliott, D., …Watson, P. (2019). Effects of the long-term feeding of diets enriched with inorganic phosphorus on the adult feline kidney and phosphorus metabolism. British Journal of Nutrition, 21, 1-21. https://doi.org/10.1017/S0007114518002751

Journal Article Type	Article
Acceptance Date	Aug 29, 2018
Publication Date	Jan 1, 2019
Deposit Date	Jan 12, 2019
Publicly Available Date	Nov 20, 2020
Journal	BRITISH JOURNAL OF NUTRITION
Print ISSN	0007-1145
Publisher	Cambridge University Press
Peer Reviewed	Peer Reviewed
Volume	21
Pages	1-21
DOI	https://doi.org/10.1017/S0007114518002751
Public URL	https://rvc-repository.worktribe.com/output/1384159