Vitamin K catabolite inhibition of ovariectomy-induced bone loss: Structure–activity relationship considerations

Soper, R J; Oguz, C; Emery, R; Pitsillides, A A; Hodges, S J

Abstract

The potential benefit of vitamin K as a therapeutic in osteoporosis is controversial and the vitamin K regimen being used clinically (45 mg/day) employs doses that are many times higher than required to ensure maximal gamma‐carboxylation of the vitamin K‐dependent bone proteins. We therefore tested the hypothesis that vitamin K catabolites, 5‐carbon (CAN5C) and 7‐carbon carboxylic acid (CAN7C) aliphatic side‐chain derivatives of the naphthoquinone moiety exert an osteotrophic role consistent with the treatment of osteoporosis.

Citation

Soper, R. J., Oguz, C., Emery, R., Pitsillides, A. A., & Hodges, S. J. (2014). Vitamin K catabolite inhibition of ovariectomy-induced bone loss: Structure–activity relationship considerations. Molecular Nutrition & Food Research, 58(8), 1658-1666. https://doi.org/10.1002/mnfr.201400063

• Journal Article Type: Article
• Acceptance Date: Jun 3, 2014
• Publication Date: Jul 14, 2014
• Deposit Date: Nov 11, 2014
• Publicly Available Date: Feb 8, 2019
• Journal: Molecular Nutrition & Food Research
• Print ISSN: 1613-4125
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 58
• Issue: 8
• Pages: 1658-1666
• DOI: https://doi.org/10.1002/mnfr.201400063
• Public URL: https://rvc-repository.worktribe.com/output/1405225
• Additional Information: Corporate Creators : Imperial College London