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Successful management of fipronil toxicosis in two pet rabbits

D'Ovidio, Dario; Cortellini, Stefano


Dario D'Ovidio

Stefano Cortellini


Background: Antiparasitic drug toxicosis is commonly described in dogs and cats, but reports on the management of antiparasitic drug toxicities in pet rabbits are scarce. Here, we describe the successful clinical management of two pet rabbits with fipronil toxicosis.
Cases Description: The first case was a 5-month-old, intact female, rabbit that presented with the acute onset of seizures, obtunded mentation, and in lateral recumbency, while the second rabbit was a 1-year-old, intact male, rabbit that presented with anorexia and lethargy. In both cases, the owners reported to have administered a 0.5 ml fipronil vial topically on the skin as an antiparasitic drug between 4 and 6 hours prior to presentation. Complete blood count and serum biochemistry were unremarkable and both rabbits tested negative on Encephalitozoon cuniculi serology. Both animals were decontaminated by bathing with tepid water and dishwashing soap. The rabbit with seizures received on admission intravenous midazolam. In both cases, overnight hospitalization, intravenous isotonic crystalloid fluids, and assisted-feeding by oral syringe were provided until voluntary feeding was resumed. Both rabbits rapidly improved approximately 12 hours of initiating supportive care. Complete resolution of clinical signs and return of normal appetite and defecation occurred within 24 hours of hospitalization in both animals. No recurrence of neurological signs was reported in the rabbit presenting with seizures on a follow-up period of 1 month.
Conclusion: The outcome of these cases suggests that supportive treatment of fipronil toxicity in pet rabbits can be successful if administered promptly.


D'Ovidio, D., & Cortellini, S. (2022). Successful management of fipronil toxicosis in two pet rabbits. Open Veterinary Journal, 12(4), 508-510.

Journal Article Type Article
Acceptance Date Jul 14, 2022
Online Publication Date Aug 5, 2022
Publication Date Aug 5, 2022
Deposit Date Aug 30, 2022
Publicly Available Date Sep 27, 2022
Journal Open Veterinary Journal
Print ISSN 2218-6050
Publisher University of Tripoli
Peer Reviewed Peer Reviewed
Volume 12
Issue 4
Pages 508-510
Series ISSN ISSN: 2226-4485 (Print)/ ISSN: 2218-6050 (Online)
Keywords General Veterinary
Publisher URL


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