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Repeat histopathology and culture of colonic biopsy specimens after treatment for Escherichia coli-associated granulomatous colitis in a cat (2023)
Journal Article
Waite, O., Yaffy, D., & Kathrani, A. (2023). Repeat histopathology and culture of colonic biopsy specimens after treatment for Escherichia coli-associated granulomatous colitis in a cat. Journal of Feline Medicine and Surgery Open Reports, 9(2), https://doi.org/10.1177/20551169231178442

Case summaryA 7.5-year-old neutered male Oriental Shorthair cat presented with an 8-month history of haematochezia, mucoid diarrhoea, tenesmus and vocalisation after a 4-year history of small bowel diarrhoea. Transabdominal ultrasonography confirmed... Read More about Repeat histopathology and culture of colonic biopsy specimens after treatment for Escherichia coli-associated granulomatous colitis in a cat.

Ketogenic diets in healthy dogs induce gut and serum metabolome changes suggestive of anti-tumourigenic effects: A model for human ketotherapy trials (2022)
Journal Article
Allenspach, K., Borcherding, D., Iennarella-Servantez, C., Mosichuk, A., Atherly, T., Sahoo, D., …Mochel, J. (2022). Ketogenic diets in healthy dogs induce gut and serum metabolome changes suggestive of anti-tumourigenic effects: A model for human ketotherapy trials. Clinical and Translational Medicine, 12(9), https://doi.org/10.1002/ctm2.1047

A Preliminary Study of Modulen IBD Liquid Diet in Hospitalized Dogs with Protein-Losing Enteropathy (2022)
Journal Article
Kathrani, A., & Parkes, G. (2022). A Preliminary Study of Modulen IBD Liquid Diet in Hospitalized Dogs with Protein-Losing Enteropathy. Animals, 12(12), https://doi.org/10.3390/ani12121594

Simple Summary Modulen IBD is an oral liquid food that results in remission rates similar to immunosuppressive drugs in children with inflammatory bowel disease. This diet has not been previously investigated in dogs. We aimed to describe the use of... Read More about A Preliminary Study of Modulen IBD Liquid Diet in Hospitalized Dogs with Protein-Losing Enteropathy.

The effect of a hydrolyzed protein diet on the fecal microbiota in cats with chronic enteropathy (2022)
Journal Article
Kathrani, A. (2022). The effect of a hydrolyzed protein diet on the fecal microbiota in cats with chronic enteropathy. Microbiome, https://doi.org/10.1038/s41598-022-06576-y

Background The effect of a hydrolyzed protein diet on the fecal microbiota has not been studied in feline chronic enteropathy (CE). Our study aimed to 1) compare the fecal microbiota of cats with CE to control cats with no gastrointestinal signs and... Read More about The effect of a hydrolyzed protein diet on the fecal microbiota in cats with chronic enteropathy.

The effect of assisted enteral feeding on treatment outcome in dogs with inflammatory protein-losing enteropathy (2021)
Journal Article
Economu, L., Chang, Y., Priestnall, S., & Kathrani, A. (2021). The effect of assisted enteral feeding on treatment outcome in dogs with inflammatory protein-losing enteropathy. Journal of Veterinary Internal Medicine, 35(3), 1297-1305. https://doi.org/10.1111/jvim.16125

Background The effect of assisted enteral feeding on treatment outcome in dogs with protein-losing enteropathy (PLE) is unknown. Objectives To determine if dogs with inflammatory PLE that had an enteral feeding tube placed had better outcome vs dogs... Read More about The effect of assisted enteral feeding on treatment outcome in dogs with inflammatory protein-losing enteropathy.

Gastroesophageal intussusception and extreme esophageal dilatation secondary to bilateral laryngeal paralysis in a cat (2021)
Journal Article
Tayler, S., Mullowney, D., Lataretu, A., Plested, M., Tuan, J., & Kathrani, A. (2021). Gastroesophageal intussusception and extreme esophageal dilatation secondary to bilateral laryngeal paralysis in a cat. Journal of Veterinary Internal Medicine, 35(2), 1088-1092. https://doi.org/10.1111/jvim.16056

Gastroesophageal intussusception, extreme esophageal dilatation, and laryngeal paralysis are individually rare clinical entities in cats and the simultaneous occurrence in a single animal has not been described. We describe these 3 conditions occurri... Read More about Gastroesophageal intussusception and extreme esophageal dilatation secondary to bilateral laryngeal paralysis in a cat.

Hypercoagulability in dogs with chronic enteropathy and association with serum albumin concentration (2021)
Journal Article
Dixon, A., Hall, E., Adamantos, S., Kathrani, A., McGrath, C., & Black, V. (2021). Hypercoagulability in dogs with chronic enteropathy and association with serum albumin concentration. Journal of Veterinary Internal Medicine, 35(2), 860-866. https://doi.org/10.1111/jvim.16044

Background: Dogs with protein-losing enteropathy (PLE) are at risk of developing a hypercoagulable state, but the prevalence of hypercoagulability in dogs with chronic enteropathies (CE) and normal serum albumin concentration is unknown. Hypothesis:... Read More about Hypercoagulability in dogs with chronic enteropathy and association with serum albumin concentration.

Histopathologic Concordance Of Concurrent Duodenal And Ileal Biopsy Specimens In Dogs With Inflammatory Or Neoplastic Disease Blinded (2021)
Journal Article
Kathrani, A., Priestnall, S., & Caulfield, S. (2021). Histopathologic Concordance Of Concurrent Duodenal And Ileal Biopsy Specimens In Dogs With Inflammatory Or Neoplastic Disease Blinded. Journal of Veterinary Internal Medicine, https://doi.org/10.3390/ani11102938

Background Histopathologic discordance between intestinal locations in canine chronic enteropathy has prompted recommendations to biopsy both duodenal and ileal sites to minimize lesion oversight. Further evaluation is required for dogs with non-chr... Read More about Histopathologic Concordance Of Concurrent Duodenal And Ileal Biopsy Specimens In Dogs With Inflammatory Or Neoplastic Disease Blinded.

Dietary and Nutritional Approaches to the Management of Chronic Enteropathy in Dogs and Cats (2021)
Journal Article
Kathrani, A. (2021). Dietary and Nutritional Approaches to the Management of Chronic Enteropathy in Dogs and Cats. Veterinary Clinics of North America: Small Animal Practice, 51(1), 123-136. https://doi.org/10.1016/j.cvsm.2020.09.005

Nutrition can influence those functions of the gastrointestinal tract that can be adversely affected in chronic enteropathy, such as microbiota, mucosal immune system, intestinal permeability, and motility. Diet serves as a possible risk factor in di... Read More about Dietary and Nutritional Approaches to the Management of Chronic Enteropathy in Dogs and Cats.

Blood taurine concentrations in dogs with exocrine pancreatic insufficiency (2020)
Journal Article
Tayler, S., Seo, J., Connolly, D. J., & Kathrani, A. (2020). Blood taurine concentrations in dogs with exocrine pancreatic insufficiency. American Journal of Veterinary Research, 81(12), 958-963. https://doi.org/10.2460/ajvr.81.12.958

Objective: To determine whether blood taurine concentrations in dogs with exocrine pancreatic insufficiency (EPI) were lower than the reference interval (200 to 350 nmol/mL) or the cutoff used to indicate taurine deficiency (< 150 nmol/mL). Animal... Read More about Blood taurine concentrations in dogs with exocrine pancreatic insufficiency.

The use of hydrolysed diets for vomiting and/or diarrhoea in cats in primary veterinary practice (2020)
Journal Article
Kathrani, A., Church, D. B., Brodbelt, D. C., Pegram, C., & O'Neill, D. G. (2020). The use of hydrolysed diets for vomiting and/or diarrhoea in cats in primary veterinary practice. Journal of Small Animal Practice, 61(21), https://doi.org/10.1111/jsap.13214

Objective To describe responses of cats prescribed a hydrolysed diet with or without concurrent medication for chronic vomiting and/or diarrhoea of undetermined aetiology. Materials and Methods Anonymised records of 512,213 cats under UK veterinary c... Read More about The use of hydrolysed diets for vomiting and/or diarrhoea in cats in primary veterinary practice.

Serological markers of gluten sensitivity in Border terriers with gall bladder mucocoeles (2020)
Journal Article
Barker, L., Tivers, M. S., Kathrani, A., Allerton, F., Powell, R., Stam, L., & Black, V. (2020). Serological markers of gluten sensitivity in Border terriers with gall bladder mucocoeles. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13211

Objectives To evaluate serological markers of gluten sensitivity in conjunction with cholecystokinin measurement in Border terriers with gall bladder mucocoeles. Materials and Methods Medical records from two referral hospitals were obtained... Read More about Serological markers of gluten sensitivity in Border terriers with gall bladder mucocoeles.

A preliminary study assessing cytokine production following ex vivo stimulation of whole blood with diet in dogs with chronic enteropathy (2019)
Journal Article
Kathrani, A., & Hall, E. (2019). A preliminary study assessing cytokine production following ex vivo stimulation of whole blood with diet in dogs with chronic enteropathy. BMC Veterinary Research, 15(185), https://doi.org/10.1186/s12917-019-1940-7

Ex vivo whole blood stimulation assays (WBSA) have been used to characterize the cytokine response to diet in cats. The present study aimed to use this assay to determine the cytokine response to diets being fed at the time of diagnosis to dogs with... Read More about A preliminary study assessing cytokine production following ex vivo stimulation of whole blood with diet in dogs with chronic enteropathy.

Indoleamine-pyrrole 2,3-dioxygenase-1 (IDO-1) mRNA is over-expressed in the duodenal mucosa and is negatively correlated with serum tryptophan concentrations in dogs with protein-losing enteropathy (2019)
Journal Article
Kathrani, A., Lezcano, V., Hall, E. J., Jergens, A. E., Seo, Y., Mochel, J. P., …Allenspach, K. (2019). Indoleamine-pyrrole 2,3-dioxygenase-1 (IDO-1) mRNA is over-expressed in the duodenal mucosa and is negatively correlated with serum tryptophan concentrations in dogs with protein-losing enteropathy. PLoS ONE, 14(6), e0218218. https://doi.org/10.1371/journal.pone.0218218

Exploring early life events including diet in cats presenting for gastrointestinal signs in later life (2019)
Journal Article
Kathrani, A., Blackwell, E. J., Williams, J. L., Gruffydd-Jones, T. J., Murray, J. K., Hezzell, M., & Hall, E. J. (2019). Exploring early life events including diet in cats presenting for gastrointestinal signs in later life. Veterinary Record, https://doi.org/10.1136/vr.105040

Our study aimed to determine if certain early life events were more prevalent in cats presenting to veterinary practices specifically for gastrointestinal signs on at least two occasions between six months and 30 months of age. Data from an owner-com... Read More about Exploring early life events including diet in cats presenting for gastrointestinal signs in later life.

A descriptive pilot study of cytokine production following stimulation of ex-vivo whole blood with commercial therapeutic feline hydrolyzed diets in individual healthy immunotolerant cats (2017)
Journal Article
Kathrani, A., Larsen, J. A., Cortopassi, G., Datta, S., & Fascetti, A. J. (2017). A descriptive pilot study of cytokine production following stimulation of ex-vivo whole blood with commercial therapeutic feline hydrolyzed diets in individual healthy immunotolerant cats. BMC Veterinary Research, 13(1), 297. https://doi.org/10.1186/s12917-017-1219-9

Effect of short-term probiotic Enterococcus faecium SF68 dietary supplementation in overweight and obese cats without comorbidities (2016)
Journal Article
Kathrani, A., Larsen, J. A., Kass, P. H., & Fascetti, A. J. (2016). Effect of short-term probiotic Enterococcus faecium SF68 dietary supplementation in overweight and obese cats without comorbidities. Veterinary Record Open, 3(1), e000164. https://doi.org/10.1136/vetreco-2015-000164

Obesity in cats is associated with metabolic abnormalities and increased susceptibility to diseases such as diabetes mellitus. Studies in mouse models and human beings have shown that probiotics can reduce food intake, promote weight loss and improve... Read More about Effect of short-term probiotic Enterococcus faecium SF68 dietary supplementation in overweight and obese cats without comorbidities.

Association between nucleotide oligomerisation domain two(Nod2) gene polymorphisms and canine inflammatory bowel disease (2014)
Journal Article
Kathrani, A., Lee, H., White, C., Catchpole, B., Murphy, A. M., German, A., …Allenspach, K. (2014). Association between nucleotide oligomerisation domain two(Nod2) gene polymorphisms and canine inflammatory bowel disease. Veterinary Immunology and Immunopathology, 161(1-2), 32-41. https://doi.org/10.1016/j.vetimm.2014.06.003

The most important genetic associations that have been implicated to play a role in the etiology of Crohn's disease (CD) in humans are single nucleotide polymorphisms (SNPs) in nucleotide oligomerisation domain 2 (NOD2). The aim of this study was to... Read More about Association between nucleotide oligomerisation domain two(Nod2) gene polymorphisms and canine inflammatory bowel disease.