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Leptospirosis vaccination in dogs attending UK primary care practices: vaccine uptake and factors associated with administration (2022)
Journal Article
Taylor, C., O'Neill, D., Catchpole, B., & Brodbelt, D. (2022). Leptospirosis vaccination in dogs attending UK primary care practices: vaccine uptake and factors associated with administration. BMC Veterinary Research, 18(285), https://doi.org/10.1186/s12917-022-03382-6

Background Leptospirosis is a zoonotic disease that is found globally and affects most mammalian species. Vaccination of dogs against leptospirosis is an important approach to preventing clinical disease, or reducing disease severity, as well as red... Read More about Leptospirosis vaccination in dogs attending UK primary care practices: vaccine uptake and factors associated with administration.

EXPERIMENTALLY INDUCED DISEASE An Experimental Dermal Oedema Model for Apx Toxins of Actinobacillus pleuropneumoniae (2022)
Journal Article
Soutter, F., Priestnall, S. L., Catchpole, B., & Rycroft, A. N. (2022). EXPERIMENTALLY INDUCED DISEASE An Experimental Dermal Oedema Model for Apx Toxins of Actinobacillus pleuropneumoniae. Journal of Comparative Pathology, https://doi.org/10.1016/j.jcpa.2022.04.004

In-vivo models of Actinobacillus pleuropneumoniae (App) infection in pigs are required for the development of vaccines and investigations of pathogenicity. Existing models cause severe respiratory disease with pulmonary oedema, dyspnoea and severe th... Read More about EXPERIMENTALLY INDUCED DISEASE An Experimental Dermal Oedema Model for Apx Toxins of Actinobacillus pleuropneumoniae.

Studying the heterogeneous pathogenesis of canine diabetes: Observational characterization of an island population (2021)
Journal Article
Brito-Casillas, Y., Melian, C., Holder, A., Wiebe, J., Navarro, A., Quesada-Canales, O., …Wagner, A. (2021). Studying the heterogeneous pathogenesis of canine diabetes: Observational characterization of an island population. Veterinary Medicine and Science, 7(4), 1071-1081. https://doi.org/10.1002/vms3.452

Background: Canine diabetes mellitus has mostly been studied in northern European, Australian and American populations, whereas other regions have received less attention. Objectives: We evaluated the epidemiological, clinical and histopathological f... Read More about Studying the heterogeneous pathogenesis of canine diabetes: Observational characterization of an island population.

A genome-wide association study identifies novel candidate genes for susceptibility to diabetes mellitus in non-obese cats (2021)
Journal Article
Catchpole, B., Forcada, Y., Boursnell, M., & Church, D. (2021). A genome-wide association study identifies novel candidate genes for susceptibility to diabetes mellitus in non-obese cats. PLoS ONE, https://doi.org/10.1371/journal.pone.0259939

Diabetes mellitus (DM) is a common feline endocrinopathy, which is similar to human type 2 diabetes (T2DM) in terms of its pathophysiology. T2DM occurs due to peripheral insulin resistance and/or β-cell dysfunction. Several studies have identified ge... Read More about A genome-wide association study identifies novel candidate genes for susceptibility to diabetes mellitus in non-obese cats.

Incidence and demographic risk factors for leptospirosis in dogs in the UK (2021)
Journal Article
Taylor, C., O'Neill, D. G., Catchpole, B., & Brodbelt, D. C. (in press). Incidence and demographic risk factors for leptospirosis in dogs in the UK. Veterinary Record, https://doi.org/10.1002/vetr.512

Objectives To estimate the annual incidence risk of leptospirosis diagnosis in practice-attending dogs in the UK during 2016 and identify risk factors for diagnosis. Methods Incidence of leptospirosis diagnosis in dogs during 2016 was estima... Read More about Incidence and demographic risk factors for leptospirosis in dogs in the UK.

Spatio-temporal distribution and agroecological factors associated with canine leptospirosis in Great Britain (2021)
Journal Article
Taylor, C., Brodbelt, D. C., Dobson, B. A., Catchpole, B., O'neill, D. G., & Stevens, K. B. (2021). Spatio-temporal distribution and agroecological factors associated with canine leptospirosis in Great Britain. Preventive Veterinary Medicine, 193, https://doi.org/10.1016/j.prevetmed.2021.105407

Leptospirosis is an important global zoonotic disease that affects a wide range of mammalian species. Canine leptospirosis outbreaks have been reported after flooding (eg. in Brazil and the United States of America) suggesting an environmental associ... Read More about Spatio-temporal distribution and agroecological factors associated with canine leptospirosis in Great Britain.

Dog leucocyte antigen (DLA) class II haplotypes and risk of canine diabetes mellitus in specific dog breeds (2020)
Journal Article
Denyer, A. L., Massey, J. P., Davison, L. J., Ollier, W. E. R., Catchpole, B., & Kennedy, L. J. (2020). Dog leucocyte antigen (DLA) class II haplotypes and risk of canine diabetes mellitus in specific dog breeds. Canine Medicine and Genetics, 7(1), 15. https://doi.org/10.1186/s40575-020-00093-9

Abstract: Background: Canine diabetes mellitus (DM) is a common endocrine disease in domestic dogs. A number of pathological mechanisms are thought to contribute to the aetiopathogenesis of relative or absolute insulin deficiency, including immune-me... Read More about Dog leucocyte antigen (DLA) class II haplotypes and risk of canine diabetes mellitus in specific dog breeds.

Polymorphisms in the CTLA4 promoter sequence are associated with canine hypoadrenocorticism (2020)
Journal Article
Boag, A. M., Short, A., Kennedy, L. J., Syme, H., Graham, P. A., & Catchpole, B. (2020). Polymorphisms in the CTLA4 promoter sequence are associated with canine hypoadrenocorticism. Canine Medicine and Genetics, 7(2), https://doi.org/10.1186/s40575-020-0081-4

Canine hypoadrenocorticism is an immune-mediated endocrinopathy that shares both clinical and pathophysiological similarities with Addison’s disease in humans. Several dog breeds are overrepresented in the disease population, suggesting that a geneti... Read More about Polymorphisms in the CTLA4 promoter sequence are associated with canine hypoadrenocorticism.

An investigation of polymorphisms in innate and adaptive immune response genes in canine leishmaniosis (2019)
Journal Article
Soutter, F., Solano-Gallego, L., Attipa, C., Gradoni, L., Fiorentino, E., Foglia Manzillo, V., …Catchpole, B. (2019). An investigation of polymorphisms in innate and adaptive immune response genes in canine leishmaniosis. Veterinary Parasitology, 269, 34-41. https://doi.org/10.1016/j.vetpar.2019.04.011

The outcome of infection with Leishmania infantum in dogs is variable, which is thought to be due to the nature of the immune response mounted by the host. As a consequence, the clinical signs and severity of canine leishmaniosis vary between individ... Read More about An investigation of polymorphisms in innate and adaptive immune response genes in canine leishmaniosis.

A longitudinal study of autoantibodies against cytochrome P450 side-chain cleavage enzyme in dogs (Canis lupus familiaris) affected with hypoadrenocorticism (Addison’s disease) (2018)
Journal Article
Boag, A. M., Christie, M. R., McLaughlin, K. A., Syme, H. M., Graham, P., & Catchpole, B. (2018). A longitudinal study of autoantibodies against cytochrome P450 side-chain cleavage enzyme in dogs (Canis lupus familiaris) affected with hypoadrenocorticism (Addison’s disease). Veterinary Immunology and Immunopathology, 202, 41-45. https://doi.org/10.1016/j.vetimm.2018.05.013

Autoantibodies directed against the P450 side chain cleavage enzyme (P450scc) have been recently described in dogs affected with hypoadrenocorticism, consistent with an immune-mediated pathogenesis of this endocrinopathy. In human autoimmune Addison’... Read More about A longitudinal study of autoantibodies against cytochrome P450 side-chain cleavage enzyme in dogs (Canis lupus familiaris) affected with hypoadrenocorticism (Addison’s disease).

Inconsistent MHC class II association in Beagles experimentally infected with Leishmania infantum (2018)
Journal Article
Soutter, F., Martorell, S., Solano-Gallego, L., & Catchpole, B. (2018). Inconsistent MHC class II association in Beagles experimentally infected with Leishmania infantum. https://doi.org/10.1016/j.tvjl.2018.03.001

The clinical outcome of Leishmania infantum infection in dogs varies from subclinical infection to severe disease. Researchers attribute this variability in clinical manifestations to the ability of the immune response to limit pathogen multiplicatio... Read More about Inconsistent MHC class II association in Beagles experimentally infected with Leishmania infantum.

Polymorphisms in the canine IL7R 3 ' UTR are associated with thymic output in Labrador retriever dogs and influence post-transcriptional regulation by microRNA 185 (2018)
Journal Article
Holder, A. L., Jones, G., Soutter, F., Palmer, D. B., Aspinall, R., & Catchpole, B. (2018). Polymorphisms in the canine IL7R 3 ' UTR are associated with thymic output in Labrador retriever dogs and influence post-transcriptional regulation by microRNA 185. Developmental and Comparative Immunology, 81, 244-251. https://doi.org/10.1016/j.dci.2017.12.008

Interleukin-7 (IL-7) and its receptor (IL-7R) are essential for T cell development in the thymus, and changes in the IL-7/IL-7R pathway have been implicated in age-associated thymic involution which results in a reduction of naïve T cell output. The... Read More about Polymorphisms in the canine IL7R 3 ' UTR are associated with thymic output in Labrador retriever dogs and influence post-transcriptional regulation by microRNA 185.

Feline hypersomatotropism and acromegaly tumorigenesis: a potential role for the AIP gene (2017)
Journal Article
Scudder, C. J., Niessen, S. J. M., Catchpole, B., Fowkes, R. C., Church, D. B., & Forcada, Y. (2017). Feline hypersomatotropism and acromegaly tumorigenesis: a potential role for the AIP gene. Domestic Animal Endocrinology, 59, 134-139. https://doi.org/10.1016/j.domaniend.2016.11.005

Acromegaly in humans is usually sporadic, however up to 20% of familial isolated pituitary adenomas are caused by germline sequence variants of the aryl-hydrocarbon-receptor interacting protein (AIP) gene. Feline acromegaly has similarities to human... Read More about Feline hypersomatotropism and acromegaly tumorigenesis: a potential role for the AIP gene.

An Age-Associated Decline in Thymic Output Differs in Dog Breeds According to Their Longevity (2016)
Journal Article
Holder, A., Mella, S., Palmer, D. B., Aspinall, R., & Catchpole, B. (2016). An Age-Associated Decline in Thymic Output Differs in Dog Breeds According to Their Longevity. PLoS ONE, 11, e0165968. https://doi.org/10.1371/journal.pone.0165968

The age associated decline in immune function is preceded in mammals by a reduction in thymic output. Furthermore, there is increasing evidence of a link between immune competence and lifespan. One approach to determining thymic output is to quantify... Read More about An Age-Associated Decline in Thymic Output Differs in Dog Breeds According to Their Longevity.

Single Nucleotide Polymorphisms in Major histocompatibility class II haplotypes are associated with potential resistance to inflammatory bowel disease in German shepherd dogs (2016)
Journal Article
Peiravan, A., Allenspach, K., Boag, A. M., Soutter, F., Holder, A. L., Catchpole, B., …Procoli, F. (2016). Single Nucleotide Polymorphisms in Major histocompatibility class II haplotypes are associated with potential resistance to inflammatory bowel disease in German shepherd dogs. Veterinary Immunology and Immunopathology, 182, 101-105. https://doi.org/10.1016/j.vetimm.2016.10.012