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Urinary active transforming growth factor ß in feline chronic kidney disease (2016)
Journal Article
Lawson, J. S., Syme, H. M., Wheeler-Jones, C. P. D., & Elliott, J. (2016). Urinary active transforming growth factor ß in feline chronic kidney disease. https://doi.org/10.1016/j.tvjl.2016.02.004

The cytokine transforming growth factor beta 1 (TGF-β1) has been widely implicated in the development and progression of renal fibrosis in chronic kidney disease (CKD) in humans and in experimental models. The aims of this study were to assess the as... Read More about Urinary active transforming growth factor ß in feline chronic kidney disease.

Lipopolysaccharide and toll-like receptor 4 in dogs with congenital portosystemic shunts (2015)
Journal Article
Tivers, M. S., Lipscomb, V. J., Smith, K. C., Wheeler-Jones, C. P. D., & House, A. K. (2015). Lipopolysaccharide and toll-like receptor 4 in dogs with congenital portosystemic shunts. https://doi.org/10.1016/j.tvjl.2015.07.006

Surgical attenuation of a congenital portosystemic shunt (CPSS) results in increased portal vein perfusion, liver growth and clinical improvement. Portal lipopolysaccharide (LPS) is implicated in liver regeneration via toll-like receptor (TLR) 4 medi... Read More about Lipopolysaccharide and toll-like receptor 4 in dogs with congenital portosystemic shunts.

Expression of Protease-Activated Receptor 1 and 2 and Anti-Tubulogenic Activity of Protease-Activated Receptor 1 in Human Endothelial Colony-Forming Cells (2014)
Journal Article
Fortunato, T. M., Vara, D. S., Wheeler-Jones, C. P. D., & Pula, G. (2014). Expression of Protease-Activated Receptor 1 and 2 and Anti-Tubulogenic Activity of Protease-Activated Receptor 1 in Human Endothelial Colony-Forming Cells. PLoS ONE, 9(10), https://doi.org/10.1371/journal.pone.0109375

Endothelial colony-forming cells (ECFCs) are obtained from the culture of human peripheral blood mononuclear cell (hPBMNC) fractions and are characterised by high proliferative and pro-vasculogenic potential, which makes them of great interest for ce... Read More about Expression of Protease-Activated Receptor 1 and 2 and Anti-Tubulogenic Activity of Protease-Activated Receptor 1 in Human Endothelial Colony-Forming Cells.

High-fat meals rich in EPA plus DHA compared with DHA only have differential effects on postprandial lipemia and plasma 8-isoprostane F-2 alpha concentrations relative to a control high-oleic acid meal: a randomized controlled trial (2014)
Journal Article
Purcell, R., Latham, S. H., Botham, K. M., Hall, W. L., & Wheeler-Jones, C. P. D. (2014). High-fat meals rich in EPA plus DHA compared with DHA only have differential effects on postprandial lipemia and plasma 8-isoprostane F-2 alpha concentrations relative to a control high-oleic acid meal: a randomized controlled trial. American Journal of Clinical Nutrition, 100(4), 1019-1028. https://doi.org/10.3945/ajcn.114.091223

Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated-skeletal muscle insulin resistance (2014)
Journal Article
Talbot, N. A., Wheeler-Jones, C. P. D., & Cleasby, M. E. (2014). Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated-skeletal muscle insulin resistance. Molecular and Cellular Endocrinology, 393(1-2), 129-142. https://doi.org/10.1016/j.mce.2014.06.010

Obesity and saturated fatty acid (SFA) treatment are both associated with skeletal muscle insulin resistance (IR) and increased macrophage infiltration. However, the relative effects of SFA and unsaturated fatty acid (UFA)-activated macrophages on mu... Read More about Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated-skeletal muscle insulin resistance.

Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes (2014)
Journal Article
Thompson, I. R., Mirczuk, S. M., Smith, L., Lessey, A. J., Simbi, B., Sunters, A., Baxter, G. F., Lipscomb, V. J., McGonnell, I. M., Wheeler-Jones, C. P. D., Mukherjee, A., Roberson, M. S., McArdle, C. A., & Fowkes, R. C. (2014). Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes. Cell and Tissue Research, 355(2), 425-36. https://doi.org/10.1007/s00441-013-1763-y

The guanylyl cyclases, GC-A and GC-B, are selective receptors for atrial and C-type natriuretic peptides (ANP and CNP, respectively). In the anterior pituitary, CNP and GC-B are major regulators of cGMP production in gonadotropes and yet mouse models... Read More about Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes.

Regulation of UDP-Glucose Dehydrogenase Is Sufficient to Modulate Hyaluronan Production and Release, Control Sulfated GAG Synthesis, and Promote Chondrogenesis
Journal Article
Clarkin, C. E., Allen, S., Kuiper, N. J., Wheeler, B. T., Wheeler-Jones, C. P. D., & Pitsillides, A. A. Regulation of UDP-Glucose Dehydrogenase Is Sufficient to Modulate Hyaluronan Production and Release, Control Sulfated GAG Synthesis, and Promote Chondrogenesis. Journal of Cellular Physiology, 226(3), 749-761. https://doi.org/10.1002/jcp.22393

Expression of guanylyl cyclase-B (GC-B/NPR2) receptors in normal human fetal pituitaries and human pituitary adenomas implicates a regulatory role for C-type natriuretic peptide
Journal Article
Thompson, I. R., Chand, A. N., King, P. J., Ansorge, O., Karavitaki, N., Jones, C. A., Rahmutula, D., Gardner, D. G., Zivkovic, V., Wheeler-Jones, C. P. D., McGonnell, I. M., Korbonits, M., Anderson, R. A., Wass, J. A. H., McNeilly, A. S., & Fowkes, R. C. Expression of guanylyl cyclase-B (GC-B/NPR2) receptors in normal human fetal pituitaries and human pituitary adenomas implicates a regulatory role for C-type natriuretic peptide. Endocrine-Related Cancer, 19(4), 497-508. https://doi.org/10.1530/ERC-12-0129

Cytokine upregulation of proteinase-activated-receptors 2 and 4 expression mediated by p38 MAP kinase and inhibitory kappa B kinase beta in human endothelial cells
Journal Article
Ritchie, E., Saka, M., MacKenzie, C., Drummond, R., Wheeler-Jones, C. P. D., Kanke, T., & Plevin, R. Cytokine upregulation of proteinase-activated-receptors 2 and 4 expression mediated by p38 MAP kinase and inhibitory kappa B kinase beta in human endothelial cells. British Journal of Pharmacology, 150(8), 1044-1054. https://doi.org/10.1038/sj.bjp.0707150

Triacylglycerol-rich lipoproteins derived from healthy donors fed different olive oils modulate cytokine secretion and cyclooxygenase-2 expression in macrophages: the potential role of oleanolic acid
Journal Article
Graham, V. S., Lawson, C., Wheeler-Jones, C. P. D., Perona, J. S., Ruiz-Gutierrez, V., & Botham, K. M. Triacylglycerol-rich lipoproteins derived from healthy donors fed different olive oils modulate cytokine secretion and cyclooxygenase-2 expression in macrophages: the potential role of oleanolic acid. European Journal of Nutrition, 51(3), 301-309. https://doi.org/10.1007/s00394-011-0215-2

Vascular Endothelial Growth Factor (VEGF) and VEGF Receptor Expression in Biopsy Samples of Liver from Dogs with Congenital Portosystemic Shunts
Journal Article
Tivers, M. S., Lipscomb, V. J., Scase, T. J., Priestnall, S. L., House, A. K., Gates, H., Wheeler-Jones, C. P. D., & Smith, K. C. Vascular Endothelial Growth Factor (VEGF) and VEGF Receptor Expression in Biopsy Samples of Liver from Dogs with Congenital Portosystemic Shunts. Journal of Comparative Pathology, 147(1), 55-61. https://doi.org/10.1016/j.jcpa.2011.09.001

Celecoxib activates PI-3K/Akt and mitochondrial redox signaling to enhance heme oxygenase-1-mediated anti-inflammatory activity in vascular endothelium
Journal Article
Hamdulay, S. S., Wang, B. F., Birdsey, G. M., Ali, F., Dumont, O., Evans, P. C., Haskard, D. O., Wheeler-Jones, C. P. D., & Mason, J. C. Celecoxib activates PI-3K/Akt and mitochondrial redox signaling to enhance heme oxygenase-1-mediated anti-inflammatory activity in vascular endothelium. Free Radical Biology and Medicine, 48(8), 1013-1023. https://doi.org/10.1016/j.freeradbiomed.2010.01.017

The effect of estradiol on COX-2, EP2, and EP4 mRNA expression and the extracellular matrix in the cervix of the hypogonadotrophic, ovariectomized ewe
Journal Article
Kershaw-Young, C. M., Scaramuzzi, R. J., McGowan, M. R., Pitsillides, A. A., Wheeler-Jones, C. P. D., & Khalid, M. The effect of estradiol on COX-2, EP2, and EP4 mRNA expression and the extracellular matrix in the cervix of the hypogonadotrophic, ovariectomized ewe. Theriogenology, 73(5), 620-628. https://doi.org/10.1016/j.theriogenology.2009.10.018