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All Outputs (10)

Analysis of lower urinary tract signs and bacteriuria in cats with subcutaneous ureteral bypass systems (2023)
Journal Article
Djoneva, L., Lawson, J., Rutherford, L., & Geddes, R. (2023). Analysis of lower urinary tract signs and bacteriuria in cats with subcutaneous ureteral bypass systems. Vet Record Open, 10(2), https://doi.org/10.1002/vro2.69

ObjectivesDistinguishing bacterial cystitis from subclinical bacteriuria is necessary for feline treatment protocols and antimicrobial stewardship. This can be challenging in cats with subcutaneous ureteral bypass (SUB) systems because they may prese... Read More about Analysis of lower urinary tract signs and bacteriuria in cats with subcutaneous ureteral bypass systems.

Renal Senescence, Telomere Shortening and Nitrosative Stress in Feline Chronic Kidney Disease (2021)
Journal Article
Quimby, J., Erickson, A., Mcleland, S., Cianciolo, R., Maranon, D., Lunn, K., …Bailey, S. (2021). Renal Senescence, Telomere Shortening and Nitrosative Stress in Feline Chronic Kidney Disease. Veterinary Sciences, 8(12), https://doi.org/10.3390/vetsci8120314

Kidney tissues from cats with naturally occurring chronic kidney disease (CKD) and adult and senior cats without CKD were assessed to determine whether telomere shortening and nitrosative stress are associated with senescence in feline CKD. The histo... Read More about Renal Senescence, Telomere Shortening and Nitrosative Stress in Feline Chronic Kidney Disease.

Investigation of the transforming growth factor-beta 1 signalling pathway as a possible link between hyperphosphataemia and renal fibrosis in feline chronic kidney disease (2020)
Journal Article
Lawson, J., Syme, H., Wheeler-Jones, C., & Elliott, J. (2020). Investigation of the transforming growth factor-beta 1 signalling pathway as a possible link between hyperphosphataemia and renal fibrosis in feline chronic kidney disease. The Veterinary Journal, 267, 105582. https://doi.org/10.1016/j.tvjl.2020.105582

Chronic kidney disease (CKD) is common in geriatric cats, and is characterised in the majority of cases by tubulointerstitial inflammation and fibrosis. Hyperphosphataemia is a frequent complication of CKD and is independently associated with severit... Read More about Investigation of the transforming growth factor-beta 1 signalling pathway as a possible link between hyperphosphataemia and renal fibrosis in feline chronic kidney disease.

Characterisation of Crandell-Rees Feline Kidney (CRFK) cells as mesenchymal in phenotype (2019)
Journal Article
Lawson, J. S., Syme, H. M., Wheeler-Jones, C. P. D., & Elliott, J. (2019). Characterisation of Crandell-Rees Feline Kidney (CRFK) cells as mesenchymal in phenotype. Research in Veterinary Science, 127, 99-102. https://doi.org/10.1016/j.rvsc.2019.10.012

The Crandell-Rees Feline Kidney Cell (CRFK) is an immortalised cell line derived from the feline kidney that is utilised for the growth of certain vaccinal viruses. Confusion exists as to whether CRFK are epithelial or mesenchymal in phenotype. The a... Read More about Characterisation of Crandell-Rees Feline Kidney (CRFK) cells as mesenchymal in phenotype.

The cat as a naturally occurring model of renal interstitial fibrosis: Characterisation of primary feline proximal tubular epithelial cells and comparative pro-fibrotic effects of TGF-ß1 (2018)
Journal Article
Lawson, J. S., Liu, H., Syme, H. M., Purcell, R., Wheeler-Jones, C. P. D., & Elliott, J. (2018). The cat as a naturally occurring model of renal interstitial fibrosis: Characterisation of primary feline proximal tubular epithelial cells and comparative pro-fibrotic effects of TGF-ß1. PLoS ONE, 13(8), e0202577. https://doi.org/10.1371/journal.pone.0202577

Chronic kidney disease (CKD) is common in both geriatric cats and aging humans, and is pathologically characterised by chronic tubulointerstitial inflammation and fibrosis in both species. Cats with CKD may represent a spontaneously occurring, non-ro... Read More about The cat as a naturally occurring model of renal interstitial fibrosis: Characterisation of primary feline proximal tubular epithelial cells and comparative pro-fibrotic effects of TGF-ß1.

Characterisation of feline renal cortical fibroblast cultures and their transcriptional response to transforming growth factor beta 1 (2018)
Journal Article
Lawson, J. S., Syme, H. M., Wheeler-Jones, C. P. D., & Elliott, J. (2018). Characterisation of feline renal cortical fibroblast cultures and their transcriptional response to transforming growth factor beta 1. BMC Veterinary Research, 14, 76. https://doi.org/10.1186/s12917-018-1387-2

Chronic kidney disease (CKD) is common in geriatric cats, and the most prevalent pathology is chronic tubulointerstitial inflammation and fibrosis. The cell type predominantly responsible for the production of extra-cellular matrix in renal fibrosis... Read More about Characterisation of feline renal cortical fibroblast cultures and their transcriptional response to transforming growth factor beta 1.

Urinary active transforming growth factor ß in feline chronic kidney disease (2016)
Journal Article
Lawson, J. S., Syme, H. M., Wheeler-Jones, C. P. D., & Elliott, J. (2016). Urinary active transforming growth factor ß in feline chronic kidney disease. https://doi.org/10.1016/j.tvjl.2016.02.004

The cytokine transforming growth factor beta 1 (TGF-β1) has been widely implicated in the development and progression of renal fibrosis in chronic kidney disease (CKD) in humans and in experimental models. The aims of this study were to assess the as... Read More about Urinary active transforming growth factor ß in feline chronic kidney disease.

Renal fibrosis in feline chronic kidney disease: known mediators and mechanisms of injury (2015)
Journal Article
Lawson, J. S., Elliott, J., Wheeler-Jones, C. P. D., Syme, H. M., & Jepson, R. E. (2015). Renal fibrosis in feline chronic kidney disease: known mediators and mechanisms of injury. https://doi.org/10.1016/j.tvjl.2014.10.009

Chronic kidney disease (CKD) is a common medical condition of ageing cats. In most cases the underlying aetiology is unknown, but the most frequently reported pathological diagnosis is renal tubulointerstitial fibrosis. Renal fibrosis, characterised... Read More about Renal fibrosis in feline chronic kidney disease: known mediators and mechanisms of injury.