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Polyhexamethylene Biguanide Nanoparticles Inhibit Biofilm Formation by Mastitis-Causing Staphylococcus aureus (2025)
Journal Article
Leite, R., Garcia, B., Barbosa, K., Mitsunaga, T., Fidelis, C., Dias, B., de Miranda, R., Zucolotto, V., Good, L., & dos Santos, M. (2025). Polyhexamethylene Biguanide Nanoparticles Inhibit Biofilm Formation by Mastitis-Causing Staphylococcus aureus. Veterinary Sciences, 12(5), https://doi.org/10.3390/vetsci12050507

Staphylococcus aureus is a mastitis pathogen that compromises cow health and causes significant economic losses in the dairy industry. High antimicrobial resistance and biofilm formation by S. aureus limit the efficacy of conventional treatments. Thi... Read More about Polyhexamethylene Biguanide Nanoparticles Inhibit Biofilm Formation by Mastitis-Causing Staphylococcus aureus.

Imported seafood is a reservoir of Enterobacteriaceae carrying CTX-M-encoding genes of high clinical relevance (2025)
Journal Article
Pearce, R., Pirolo, M., Goecke, N., Toppi, V., Good, L., Guitian, J., & Guardabassi, L. (2025). Imported seafood is a reservoir of Enterobacteriaceae carrying CTX-M-encoding genes of high clinical relevance. International Journal of Food Microbiology, 430, https://doi.org/10.1016/j.ijfoodmicro.2025.111063

We determined the frequency, genotypes, phenotypes, and mobility of extended-spectrum beta-lactamase (ESBL)encoding genes in Enterobacteriaceae isolated from retail seafood products. Overall, 288 samples of fresh shrimps, catfish and seabass imported... Read More about Imported seafood is a reservoir of Enterobacteriaceae carrying CTX-M-encoding genes of high clinical relevance.

Efficacy of natural antimicrobial peptides versus peptidomimetic analogues: a systematic review (2022)
Journal Article
Hellewell, L., Gilani, N., Stanton, C., Pelligand, L., Franzyk, H., Guardabassi, L., & Good, L. (in press). Efficacy of natural antimicrobial peptides versus peptidomimetic analogues: a systematic review. Future Medicinal Chemistry, https://doi.org/10.4155/fmc-2022-0160

Aims: This systematic review was carried out to determine whether synthetic peptidomimetics exhibit significant advantages over antimicrobial peptides (AMPs) in terms of in vitro potency. Structural features - molecular weight, charge and length - we... Read More about Efficacy of natural antimicrobial peptides versus peptidomimetic analogues: a systematic review.

Antimicrobial activity of polyhexamethylene biguanide nanoparticles against mastitis-causing Staphylococcus aureus (2021)
Journal Article
Leite, R. F., Gonçalves, J. L., Buanz, A., Febraro, C., Craig, D., Van Winden, S., Good, L., & Santos, M. V. (in press). Antimicrobial activity of polyhexamethylene biguanide nanoparticles against mastitis-causing Staphylococcus aureus. Journal of Dairy Science, https://doi.org/10.3168/jdsc.2021-0114

Polyhexamethylene biguanide (PHMB) nanoparticles (NP) developed for this study presented antimicrobial activity against mastitis-causing Staphylococcus aureus at lower concentrations than PHMB alone, chlorhexidine digluconate, povidone-iodine, and so... Read More about Antimicrobial activity of polyhexamethylene biguanide nanoparticles against mastitis-causing Staphylococcus aureus.

Genetic diversity and risk factors for the transmission of antimicrobial resistance across human, animals and environmental compartments in East Africa: a review. (2020)
Journal Article
Katale, B. Z., Misinzo, G., Mshana, S. E., Chiyangi, H., Campino, S., Clark, T. G., Good, L., Rweyemamu, M. M., & Matee, M. I. (2020). Genetic diversity and risk factors for the transmission of antimicrobial resistance across human, animals and environmental compartments in East Africa: a review. Antimicrobial Resistance and Infection Control, 9(1), 127

BACKGROUND

The emergence and spread of antimicrobial resistance (AMR) present a challenge to disease control in East Africa. Resistance to beta-lactams, which are by far the most used antibiotics worldwide and include the penicillins, cephalospori... Read More about Genetic diversity and risk factors for the transmission of antimicrobial resistance across human, animals and environmental compartments in East Africa: a review..

Genetic diversity and risk factors for the transmission of antimicrobial resistance across human, animals and environmental compartments in East Africa: a review (2020)
Journal Article
Katale, B., Misinzo, G., Mshana, S., Chiyangi, H., Campino, S., Clark, T., Good, L., Rweyemamu, M., & Matee, M. (2020). Genetic diversity and risk factors for the transmission of antimicrobial resistance across human, animals and environmental compartments in East Africa: a review. Antimicrobial Resistance and Infection Control, 9(1), https://doi.org/10.1186/s13756-020-00786-7

The emergence and spread of antimicrobial resistance (AMR) present a challenge to disease control in East Africa. Resistance to beta-lactams, which are by far the most used antibiotics worldwide and include the penicillins, cephalosporins, monobactam... Read More about Genetic diversity and risk factors for the transmission of antimicrobial resistance across human, animals and environmental compartments in East Africa: a review.

Identification of Escherichia coli from broiler chickens in Jordan, their antimicrobial resistance, gene characterization and the associated risk factors (2019)
Journal Article
Ibrahim, R. A., Cryer, T. L., Lafi, S. Q., Basha, E.-A., Good, L., & Tarazi, Y. H. (2019). Identification of Escherichia coli from broiler chickens in Jordan, their antimicrobial resistance, gene characterization and the associated risk factors. BMC Veterinary Research, 15(159), https://doi.org/10.1186/s12917-019-1901-1

Avian pathogenic Escherichia coli (APEC) is the principle cause of colibacillosis affecting poultry. The main challenge to the poultry industry is antimicrobial resistance and the emergence of multidrug resistant bacteria that threaten the safety of... Read More about Identification of Escherichia coli from broiler chickens in Jordan, their antimicrobial resistance, gene characterization and the associated risk factors.

Polyhexamethylene Biguanide: Polyurethane Blend Nanofibrous Membranes for Wound Infection Control (2019)
Journal Article
Worsley, A., Vassileva, K., Tsui, J., Song, W., & Good, L. (2019). Polyhexamethylene Biguanide: Polyurethane Blend Nanofibrous Membranes for Wound Infection Control. Polymers, 11(5), 915. https://doi.org/10.3390/polym11050915

Polyhexamethylene biguanide (PHMB) is a broad-spectrum antiseptic which avoids many efficacy and toxicity problems associated with antimicrobials, in particular, it has a low risk of loss of susceptibility due to acquired antimicrobial resistance. De... Read More about Polyhexamethylene Biguanide: Polyurethane Blend Nanofibrous Membranes for Wound Infection Control.

CD44 targeted delivery of siRNA by using HA-decorated nanotechnologies for KRAS silencing in cancer treatment (2019)
Journal Article
Tirella, A., Kloc-Muniak, K., Good, L., Ridden, J., Ashford, M., Puri, S., & Tirelli, N. (2019). CD44 targeted delivery of siRNA by using HA-decorated nanotechnologies for KRAS silencing in cancer treatment. International Journal of Pharmaceutics, 561, 114-123. https://doi.org/10.1016/j.ijpharm.2019.02.032

KRAS is a small GTPase that regulates cell proliferation and survival. In tumors, the KRAS gene is mutated, and leading to unregulated tumor growth. Despite the recognized importance of KRAS in cancer, attempts to develop small molecule inhibitors ha... Read More about CD44 targeted delivery of siRNA by using HA-decorated nanotechnologies for KRAS silencing in cancer treatment.

Doxycycline inhibits pre-rRNA processing and mature rRNA formation in E. coli (2019)
Journal Article
Chukwudi, C. U., & Good, L. (2019). Doxycycline inhibits pre-rRNA processing and mature rRNA formation in E. coli. Journal of Antibiotics, 72, 225-236. https://doi.org/10.1038/s41429-019-0149-0

In bacteria, RNase III cleaves the initial long primary ribosomal RNA transcripts/precursors (pre-rRNAs), thereby releasing the pre-16S and pre-23S rRNAs for maturation. This cleavage is specified by the double-stranded secondary structures flanking... Read More about Doxycycline inhibits pre-rRNA processing and mature rRNA formation in E. coli.

Polyhexamethylene Biguanide and Nadifloxacin Self-Assembled Nanoparticles: Antimicrobial Effects against Intracellular Methicillin-Resistant Staphylococcus aureus (2018)
Journal Article
Kamaruzzaman, N. F., de Fatima Pina, M., Chivu, A., & Good, L. (2018). Polyhexamethylene Biguanide and Nadifloxacin Self-Assembled Nanoparticles: Antimicrobial Effects against Intracellular Methicillin-Resistant Staphylococcus aureus. Polymers, 10(5), 521. https://doi.org/10.3390/polym10050521

The treatment of skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus (MRSA) remains a challenge, partly due to localization of the bacteria inside the host’s cells, where antimicrobial penetration and efficacy is lim... Read More about Polyhexamethylene Biguanide and Nadifloxacin Self-Assembled Nanoparticles: Antimicrobial Effects against Intracellular Methicillin-Resistant Staphylococcus aureus.

Phenotypic indications of FtsZ inhibition in hok/sok-induced bacterial growth changes and stress response (2018)
Journal Article
Chukwudi, C. U., & Good, L. (2018). Phenotypic indications of FtsZ inhibition in hok/sok-induced bacterial growth changes and stress response. Microbial Pathogenesis, 114, 393-401. https://doi.org/10.1016/j.micpath.2017.12.023

The hok/sok locus has been shown to enhance the growth of bacteria in adverse growth conditions such as high temperature, low starting-culture densities and antibiotic treatment. This is in addition to their well-established plasmid-stabilization eff... Read More about Phenotypic indications of FtsZ inhibition in hok/sok-induced bacterial growth changes and stress response.

Bactericidal and Anti-biofilm Effects of Polyhexamethylene Biguanide in Models of Intracellular and Biofilm of Staphylococcus aureus Isolated from Bovine Mastitis (2017)
Journal Article
Kamaruzzaman, N. F., Chong, S. Q. Y., Edmondson-Brown, K. M., Ntow-Boahene, W., Bardiau, M., & Good, L. (2017). Bactericidal and Anti-biofilm Effects of Polyhexamethylene Biguanide in Models of Intracellular and Biofilm of Staphylococcus aureus Isolated from Bovine Mastitis. Frontiers in Microbiology, 11(8), 1518. https://doi.org/10.3389/fmicb.2017.01518

Staphylococcus aureus infection is a common cause of mastitis, reducing milk yield, affecting animal welfare and causing huge economic losses within the dairy industry. In addition to the problem of acquired drug resistance, bacterial invasion into u... Read More about Bactericidal and Anti-biofilm Effects of Polyhexamethylene Biguanide in Models of Intracellular and Biofilm of Staphylococcus aureus Isolated from Bovine Mastitis.

Towards an integrated food safety surveillance system: a simulation study to explore the potential of combining genomic and epidemiological metadata (2017)
Journal Article
Hill, A. A., Crotta, M., Wall, B., Good, L., O'Brien, S. J., & Guitian, J. (2017). Towards an integrated food safety surveillance system: a simulation study to explore the potential of combining genomic and epidemiological metadata. Royal Society Open Science, 4, https://doi.org/10.1098/rsos.160721

Foodborne infection is a result of exposure to complex, dynamic food systems. The efficiency of foodborne infection is driven by ongoing shifts in genetic machinery. Next-generation sequencing technologies can provide high-fidelity data about the gen... Read More about Towards an integrated food safety surveillance system: a simulation study to explore the potential of combining genomic and epidemiological metadata.

Disruption of Higher Order DNA Structures in Friedreich's Ataxia (GAA)n Repeats by PNA or LNA Targeting (2016)
Journal Article
Bergquist, H., Rocha, C. S., Alvarez-Asencio, R., Nguyen, C. H., Rutland, M. W., Smith, C. I., Good, L., Nielsen, P. E., & Zain, R. (2016). Disruption of Higher Order DNA Structures in Friedreich's Ataxia (GAA)n Repeats by PNA or LNA Targeting. PLoS ONE, 15(11), e0165788. https://doi.org/10.1371/journal.pone.0165788

Expansion of (GAA)n repeats in the first intron of the Frataxin gene is associated with reduced mRNA and protein levels and the development of Friedreich’s ataxia. (GAA)n expansions form non-canonical structures, including intramolecular triplex (H-D... Read More about Disruption of Higher Order DNA Structures in Friedreich's Ataxia (GAA)n Repeats by PNA or LNA Targeting.

Biomarkers of browning of white adipose tissue and their regulation during exercise- and diet-induced weight loss (2016)
Journal Article
Nakhuda, A., Josse, A. R., Gburcik, V., Crossland, H., Raymond, F., Metairon, S., Good, L., Atherton, P. J., Phillips, S. M., & Timmons, J. A. (2016). Biomarkers of browning of white adipose tissue and their regulation during exercise- and diet-induced weight loss. American Journal of Clinical Nutrition, 104(3), 557-565. https://doi.org/10.3945/ajcn.116.132563

Interaction of the tetracyclines with double-stranded RNAs of random base sequence: new perspectives on the target and mechanism of action (2016)
Journal Article
Chukwudi, C. U., & Good, L. (2016). Interaction of the tetracyclines with double-stranded RNAs of random base sequence: new perspectives on the target and mechanism of action. Journal of Antibiotics, 69, 622-630. https://doi.org/10.1038/ja.2015.145

The 16S rRNA binding mechanism proposed for the antibacterial action of the tetracyclines does not explain their mechanism of action against non-bacterial pathogens. In addition, several contradictory base pairs have been proposed as their binding si... Read More about Interaction of the tetracyclines with double-stranded RNAs of random base sequence: new perspectives on the target and mechanism of action.