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All Outputs (21)

Distinctive seizure signature in the first video case-control study of a naturally-occurring feline autoimmune encephalitis model (2025)
Journal Article
Binks, S., Crawford, A., Ives, E., Davison, L., Fox, H., Fower, A., Kaczmarska, A., Woodhall, M., Waters, P., Handel, A., Irani, S., Quintana, R. G., Chowdhury, F., Eriksson, S., & Pakozdy, A. (2025). Distinctive seizure signature in the first video case-control study of a naturally-occurring feline autoimmune encephalitis model. Brain, Behavior, and Immunity, https://doi.org/10.1016/j.bbi.2025.02.018

Whole genome sequencing identifies novel candidate genetic variants in canine stomatocytosis (2025)
Journal Article
Wallace, M., Falcone, S., Castillo, D., Williams, T., & Davison, L. (2025). Whole genome sequencing identifies novel candidate genetic variants in canine stomatocytosis. Gene, 149314. https://doi.org/10.1016/j.gene.2025.149314

Abstract
Stomatocytosis is a rare spectrum of red blood cell (RBC) disorders. In humans, stomatocytosis is typically caused by genetic changes in specific ion exchange and transport genes. Stomatocytosis has been identified in dogs, however the unde... Read More about Whole genome sequencing identifies novel candidate genetic variants in canine stomatocytosis.

Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes (2024)
Journal Article
Hill, T. G., Gao, R., Benrick, A., Kothegala, L., Rorsman, N., Santos, C., Acreman, S., Briant, L. J., Dou, H., Gandasi, N. R., Guida, C., Haythorne, E., Wallace, M., Knudsen, J. G., Miranda, C., Tolö, J., Clark, A., Davison, L., Størling, J., Tarasov, A., …Zhang, Q. (2024). Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes. Nature Metabolism, https://doi.org/10.1038/s42255-024-01139-z

A Novel Macrophage Subpopulation Conveys Increased Genetic Risk of Coronary Artery Disease (2024)
Journal Article
Jiang, J., Hiron, T. K., Agbaedeng, T., Malhotra, Y., Drydale, E., Bancroft, J., Ng, E., Reschen, M. E., Davison, L. J., & O’Callaghan, C. A. (2024). A Novel Macrophage Subpopulation Conveys Increased Genetic Risk of Coronary Artery Disease. Circulation Research, 135(1), 6-25. https://doi.org/10.1161/circresaha.123.324172

BACKGROUND:

Coronary artery disease (CAD), the leading cause of death worldwide, is influenced by both environmental and genetic factors. Although over 250 genetic risk loci have been identified through genome-wide association studies, the specifi... Read More about A Novel Macrophage Subpopulation Conveys Increased Genetic Risk of Coronary Artery Disease.

Characterisation of Canine Intestinal MicroRNA Expression in Inflammatory Bowel Disease and T-Cell Lymphoma (2023)
Journal Article
Williams, J., Werling, D., Davison, L., Hiron, T., & Xia, D. (in press). Characterisation of Canine Intestinal MicroRNA Expression in Inflammatory Bowel Disease and T-Cell Lymphoma. Journal of Comparative Pathology, https://doi.org/10.1016/j.jcpa.2023.03.186

Differentiating between canine inflammatory bowel disease and intestinal T-cell lymphoma via histopathological examination of endoscopically-derived intestinal biopsies can be challenging and involves an invasive procedure requiring specialised equip... Read More about Characterisation of Canine Intestinal MicroRNA Expression in Inflammatory Bowel Disease and T-Cell Lymphoma.

Assessment of glucocorticoid and antibiotic exposure as risk factors for diabetes mellitus in selected dog breeds attending UK primary-care clinics (2023)
Journal Article
Davison, L., O'Neill, D., Brodbelt, D., Church, D., & Heeley, A. (in press). Assessment of glucocorticoid and antibiotic exposure as risk factors for diabetes mellitus in selected dog breeds attending UK primary-care clinics. Veterinary Record, https://doi.org/10.1002/vetr.2785

Background: Diabetes mellitus (DM) is an important endocrine disorder in dogs resulting from interactions between both genetic (non-environmental) and environmental factors. This study aimed to explore prior exposure to glucocorticoid or antibiotic t... Read More about Assessment of glucocorticoid and antibiotic exposure as risk factors for diabetes mellitus in selected dog breeds attending UK primary-care clinics.

Risk factors for upper urinary tract uroliths and ureteral obstruction in cats under referral veterinary care in the United Kingdom (2023)
Journal Article
Geddes, R. F., Davison, L. J., Elliott, J., Syme, H. M., & O'Neill, D. G. (2023). Risk factors for upper urinary tract uroliths and ureteral obstruction in cats under referral veterinary care in the United Kingdom. Journal of Veterinary Internal Medicine, 37(2), 567-577. https://doi.org/10.1111/jvim.16659

Background
Cats presenting with upper urinary tract uroliths (UUTUs) and ureteral obstruction (“obstructive UUTU”) are typically younger than cats with idiopathic CKD that often have incidental nephroliths.

Hypothesis
Cats with upper urinary tra... Read More about Risk factors for upper urinary tract uroliths and ureteral obstruction in cats under referral veterinary care in the United Kingdom.

Agreeing Language in Veterinary Endocrinology (ALIVE): Diabetes mellitus - a modified Delphi-method-based system to create consensus disease definitions (2022)
Journal Article
ESVE SCE Membership, Niessen, S., Bjornvad, C., Church, D., Davison, L., Esteban-Saltiveri, D., Fleeman, L., Forcada, Y., Fracassi, F., Gilor, C., Hanson, J., Herrtage, M., Lathan, P., Leal, R., Loste, A., Reusch, C., Schermerhorn, T., Stengel, C., Thoresen, S., & Thuroczy, J. (2022). Agreeing Language in Veterinary Endocrinology (ALIVE): Diabetes mellitus - a modified Delphi-method-based system to create consensus disease definitions. The Veterinary Journal, 289, https://doi.org/10.1016/j.tvjl.2022.105910

Insulin expression in beta cells is reduced within islets before islet loss in diabetic cats (2022)
Journal Article
Bergomi, V., Beck, S., Dobromylskya, M., Davison, L., Wills, J., & Hughes, K. (in press). Insulin expression in beta cells is reduced within islets before islet loss in diabetic cats. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13541

Objectives Diabetes mellitus is a common condition that requires intensive treatment and markedly impacts the welfare of affected cats. The aim of this study was to identify diabetes mellitus-associated perturbations in the feline pancreatic islet mi... Read More about Insulin expression in beta cells is reduced within islets before islet loss in diabetic cats.

Diabetes mellitus in dogs attending UK primary-care practices: frequency, risk factors and survival (2020)
Journal Article
Heeley, A., O’Neill, D., Davison, L., Church, D., Corless, E., & Brodbelt, D. (2020). Diabetes mellitus in dogs attending UK primary-care practices: frequency, risk factors and survival. Canine Medicine and Genetics, 7(1), https://doi.org/10.1186/s40575-020-00087-7

Background: Diabetes mellitus (DM) is an important endocrine disorder of dogs. The objectives of this study were to estimate prevalence and incidence of DM in dogs, and to explore risk factors for DM and the survival of DM cases in primary-care clini... Read More about Diabetes mellitus in dogs attending UK primary-care practices: frequency, risk factors and survival.

Diabetes mellitus in dogs attending UK primary-care practices: frequency, risk factors and survival (2020)
Data
Heeley, A. M., O'Neill, D. G., Davison, L. J., Church, D. B., Corless, E. K., & Brodbelt, D. C. Diabetes mellitus in dogs attending UK primary-care practices: frequency, risk factors and survival. [Data]. https://doi.org/10.34840/61sf-9x25

This study used data made available through VetCompass™ to investigate the prevalence, incidence, risk factors and survival for dogs diagnosed with diabetes mellitus in primary-care practice in the UK. This data set provides the anonymised individual... Read More about Diabetes mellitus in dogs attending UK primary-care practices: frequency, risk factors and survival.