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Short-term induced hyperinsulinaemia and dexamethasone challenge do not affect circulating total adiponectin concentrations in insulin-sensitive ponies (2023)
Journal Article
Barnabé, M., Elliott, J., Harris, P., & Menzies-Gow, N. (2023). Short-term induced hyperinsulinaemia and dexamethasone challenge do not affect circulating total adiponectin concentrations in insulin-sensitive ponies. Equine Veterinary Journal, https://doi.org/10.1111/evj.14012

BackgroundHypoadiponectinaemia is a risk factor for endocrinopathic laminitis, but the directionality and nature of its association with insulin dysregulation is unclear.ObjectivesTo investigate the effects of short-term induced hyperinsulinaemia and... Read More about Short-term induced hyperinsulinaemia and dexamethasone challenge do not affect circulating total adiponectin concentrations in insulin-sensitive ponies.

Factors associated with insulin responses to oral sugars in a mixed-breed cohort of ponies (2023)
Journal Article
Knowles, E., Harris, P., Elliott, J., Chang, Y., & Menzies-Gow, N. (2023). Factors associated with insulin responses to oral sugars in a mixed-breed cohort of ponies. Equine Veterinary Journal, https://doi.org/10.1111/evj.13983

Background: Serum insulin concentration at 60 min (InsulinT60) during an oral sugar test (OST) indicates future laminitis risk and insulin dysregulation (ID). Associations between InsulinT60 and physical and owner-reported variables may help clinicia... Read More about Factors associated with insulin responses to oral sugars in a mixed-breed cohort of ponies.

Short Communication: Identification of equine corticotropin-like intermediate lobe peptide (CLIP) binding to an adrenocortipcotrophic hormone (ACTH) assay capture antibody (2023)
Journal Article
Knowles, E., Hyde, C., Harris, P., Elliott, J., & Menzies-Gow, N. (2023). Short Communication: Identification of equine corticotropin-like intermediate lobe peptide (CLIP) binding to an adrenocortipcotrophic hormone (ACTH) assay capture antibody. Domestic Animal Endocrinology, https://doi.org/10.1016/j.domaniend.2023.106785

A chemiluminescent immunoassay is commonly employed to measure adrenocorticotrophic hormone (ACTH) concentrations to assist pituitary pars intermedia dysfunction diagnosis. In a previous study, seasonally dependent assay cross-reactivity to endogenou... Read More about Short Communication: Identification of equine corticotropin-like intermediate lobe peptide (CLIP) binding to an adrenocortipcotrophic hormone (ACTH) assay capture antibody.

Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies. (2022)
Journal Article
Finding, E., Elliott, J., Harris, P., & Menzies-Gow, N. (2022). Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies. Research in Veterinary Science, https://doi.org/10.1016/j.rvsc.2022.05.012

Previously laminitic (PL) ponies are reported to have higher blood pressure than non laminitic (NL) ponies. This relative hypertension may be related to endothelial cell dysfunction, similar to humans with metabolic syndrome. To investigate the relat... Read More about Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies..

Predictors of laminitis development in a cohort of non-laminitic ponies (2021)
Journal Article
Knowles, E., Elliott, J., Harris, P., Chang, R., & Menzies-Gow, N. (2021). Predictors of laminitis development in a cohort of non-laminitic ponies. Equine Veterinary Journal, https://doi.org/10.1111/evj.31_13492

Background: Quantifying the risk of laminitis development requires improvement. Objectives: To identify the most useful physical examination, metabolic and management factors to predict future laminitis development in client-owned, non-laminitic pon... Read More about Predictors of laminitis development in a cohort of non-laminitic ponies.

The effect of strip grazing on physical activity and behaviour in ponies (2021)
Journal Article
Cameron, A., Longland, A., Pfau, T., Pinnegar, S., Brackston, I., Hockenhull, J., …Menzies-Gow, N. J. (2021). The effect of strip grazing on physical activity and behaviour in ponies. Journal of Equine Veterinary Science, 103745. https://doi.org/10.1016/j.jevs.2021.103745

This work aimed to determine the effect of strip grazing on physical activity in ponies using behavioural observations alongside accelerometers positioned at the poll. In study one, ten British native breed ponies were randomly assigned to paddock A... Read More about The effect of strip grazing on physical activity and behaviour in ponies.

Pergolide dosing compliance and factors affecting the laboratory control of equine pituitary pars intermedia dysfunction (2021)
Journal Article
Menzies-Gow, N., Hague, N., & Durham, A. (2021). Pergolide dosing compliance and factors affecting the laboratory control of equine pituitary pars intermedia dysfunction. Veterinary Record, https://doi.org/10.1002/vetr.142

Background: Equine pituitary pars intermedia dysfunction (PPID) is treated with daily pergolide therapy. Owner compliance and its effect on PPID control has not been previously investigated. Methods: Clinical records were searched to identify the sa... Read More about Pergolide dosing compliance and factors affecting the laboratory control of equine pituitary pars intermedia dysfunction.

Pergolide dosing compliance and factors affecting the laboratory control of equine pituitary pars intermedia dysfunction (2021)
Journal Article
Menzies-Gow, N. (2021). Pergolide dosing compliance and factors affecting the laboratory control of equine pituitary pars intermedia dysfunction. Veterinary Record,

Background: Equine pituitary pars intermedia dysfunction (PPID) is treated with daily pergolide therapy. Owner compliance and its effect on PPID control has not been previously investigated. Methods: Clinical records were searched to identify the sa... Read More about Pergolide dosing compliance and factors affecting the laboratory control of equine pituitary pars intermedia dysfunction.

Physics of Animal Health: On the mechano-biology of hoof growth and form (2019)
Journal Article
Al-Agele, R., Paul, E., Taylor, S., Watson, C., Sturrock, C., Drakopoulos, M., …Rauch, C. (2019). Physics of Animal Health: On the mechano-biology of hoof growth and form. https://doi.org/10.1098/rsif.2019.0214

Global inequalities in economic access and agriculture productivity imply that a large number of developing countries rely on working equids for transport/agriculture/mining. Therefore, the understanding of hoof conditions/shape variations affecting... Read More about Physics of Animal Health: On the mechano-biology of hoof growth and form.

Prevalence of and risk factors for acute laminitis in horses treated with corticosteroids (2019)
Journal Article
Potter, K., Stevens, K. B., & Menzies-Gow, N. J. (2019). Prevalence of and risk factors for acute laminitis in horses treated with corticosteroids. Veterinary Record, 85(82), https://doi.org/10.1136/vr.105378

A retrospective treated versus untreated study (study 1) and multicentre prospective cohort study (study 2) were undertaken to determine the prevalence of, and risk factors associated with, acute laminitis in horses treated with corticosteroids. All... Read More about Prevalence of and risk factors for acute laminitis in horses treated with corticosteroids.

Cell specific microvesicles vary with season and disease predisposition in healthy and previously laminitic ponies (2018)
Journal Article
Finding, E. J. T., Lawson, C., Elliott, J., Harris, P. A., & Menzies-Gow, N. J. (2018). Cell specific microvesicles vary with season and disease predisposition in healthy and previously laminitic ponies. Veterinary Immunology and Immunopathology, https://doi.org/10.1016/j.vetimm.2018.06.001

Microvesicles are small (up to 1 μm) vesicles found in plasma and other bodily fluids. They are recognised as part of the normal system of inter-cellular communication but altered numbers are also used as biomarkers of disease. Microvesicles have not... Read More about Cell specific microvesicles vary with season and disease predisposition in healthy and previously laminitic ponies.

Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies (2018)
Journal Article
Timpson, A., De Mestre, A. M., Elliott, J., Harris, P. A., Cheng, Z. R., Mirczuk, S. M., …Menzies-Gow, N. J. (2018). Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies. Journal of Equine Veterinary Science, https://doi.org/10.1016/j.jevs.2018.06.009

The aims of the study were to determine whether adipose tissue global gene expression (i) differs between never laminitic (NL) and previously laminitic (PL) ponies; (ii) is influenced by season and/or a diet designed to simulate spring grass and (iii... Read More about Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies.

Effect of varying the dose of corn syrup on the insulin and glucose response to the oral sugar test (2018)
Journal Article
Jocelyn, N. A., Harris, P. A., & Menzies-Gow, N. J. (2018). Effect of varying the dose of corn syrup on the insulin and glucose response to the oral sugar test. Equine Veterinary Journal, 50(6), 836-841. https://doi.org/10.1111/evj.12826

After an overnight fast, in a three‐way randomised crossover study with a 7‐day washout, 0.15, 0.3 or 0.45 mL/kg bwt corn syrup was administered orally to eight ponies (5 PL and 3 NL) and blood obtained between 0 and 120 min. Serum [insulin] and [glu... Read More about Effect of varying the dose of corn syrup on the insulin and glucose response to the oral sugar test.

Plasma adrenocorticotropic hormone (ACTH) concentrations in ponies measured by two different assays suggests seasonal cross reactivity or interference (2018)
Journal Article
Knowles, E. J., Moreton-Clack, M. C., Shaw, S., Harris, P. A., Elliott, J., & Menzies-Gow, N. J. (2018). Plasma adrenocorticotropic hormone (ACTH) concentrations in ponies measured by two different assays suggests seasonal cross reactivity or interference. Equine Veterinary Journal, 50(5), 672-677. https://doi.org/10.1111/evj.12797