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Pilot study to determine the effect of feeding a commercial feedstuff on gastric squamous gastric disease (ESGD) healing and prevention of recurrence. (2024)
Journal Article
Menzies-Gow, N. (in press). Pilot study to determine the effect of feeding a commercial feedstuff on gastric squamous gastric disease (ESGD) healing and prevention of recurrence. Journal of Equine Veterinary Science, https://doi.org/10.1016/j.jevs.2024.105015

Feedstuffs are often recommended to mitigate potential damage from acid associated with equine squamous gastric disease (ESGD). In acidic conditions, pectin alters its structure to one like mucus and binds the stomach mucosa, whilst alfalfa has a str... Read More about Pilot study to determine the effect of feeding a commercial feedstuff on gastric squamous gastric disease (ESGD) healing and prevention of recurrence..

Short-term induced hyperinsulinaemia and dexamethasone challenge do not affect circulating total adiponectin concentrations in insulin-sensitive ponies (2023)
Journal Article
Barnabé, M., Elliott, J., Harris, P., & Menzies-Gow, N. (2023). Short-term induced hyperinsulinaemia and dexamethasone challenge do not affect circulating total adiponectin concentrations in insulin-sensitive ponies. Equine Veterinary Journal, https://doi.org/10.1111/evj.14012

BackgroundHypoadiponectinaemia is a risk factor for endocrinopathic laminitis, but the directionality and nature of its association with insulin dysregulation is unclear.ObjectivesTo investigate the effects of short-term induced hyperinsulinaemia and... Read More about Short-term induced hyperinsulinaemia and dexamethasone challenge do not affect circulating total adiponectin concentrations in insulin-sensitive ponies.

BEVA primary care clinical guidelines: Diagnosis and management of equine pituitary pars intermedia dysfunction (2023)
Journal Article
Menzies-Gow, N., Knowles, E., & Hart, N. (in press). BEVA primary care clinical guidelines: Diagnosis and management of equine pituitary pars intermedia dysfunction. Equine Veterinary Journal, https://doi.org/10.1111/evj.14009

Background: Pituitary pars intermedia dysfunction (PPID) is a prevalent, age-related chronic disorder in equids. Diagnosis of PPID can be challenging because of its broad spectrum of clinical presentations and disparate published diagnostic criteria,... Read More about BEVA primary care clinical guidelines: Diagnosis and management of equine pituitary pars intermedia dysfunction.

Factors associated with insulin responses to oral sugars in a mixed-breed cohort of ponies (2023)
Journal Article
Knowles, E., Harris, P., Elliott, J., Chang, Y., & Menzies-Gow, N. (2023). Factors associated with insulin responses to oral sugars in a mixed-breed cohort of ponies. Equine Veterinary Journal, https://doi.org/10.1111/evj.13983

Background: Serum insulin concentration at 60 min (InsulinT60) during an oral sugar test (OST) indicates future laminitis risk and insulin dysregulation (ID). Associations between InsulinT60 and physical and owner-reported variables may help clinicia... Read More about Factors associated with insulin responses to oral sugars in a mixed-breed cohort of ponies.

Short Communication: Identification of equine corticotropin-like intermediate lobe peptide (CLIP) binding to an adrenocortipcotrophic hormone (ACTH) assay capture antibody (2023)
Journal Article
Knowles, E., Hyde, C., Harris, P., Elliott, J., & Menzies-Gow, N. (2023). Short Communication: Identification of equine corticotropin-like intermediate lobe peptide (CLIP) binding to an adrenocortipcotrophic hormone (ACTH) assay capture antibody. Domestic Animal Endocrinology, https://doi.org/10.1016/j.domaniend.2023.106785

A chemiluminescent immunoassay is commonly employed to measure adrenocorticotrophic hormone (ACTH) concentrations to assist pituitary pars intermedia dysfunction diagnosis. In a previous study, seasonally dependent assay cross-reactivity to endogenou... Read More about Short Communication: Identification of equine corticotropin-like intermediate lobe peptide (CLIP) binding to an adrenocortipcotrophic hormone (ACTH) assay capture antibody.

Relationships between total adiponectin concentrations and obesity in native-breed ponies in England (2023)
Journal Article
Barnabe, M., Elliott, J., Harris, P., & Menzies-Gow, N. (in press). Relationships between total adiponectin concentrations and obesity in native-breed ponies in England. Equine Veterinary Journal, https://doi.org/10.1111/evj.14013

Background: Equine metabolic syndrome is a collection of risk factors associated with an increased risk of endocrinopathic laminitis. All affected animals display insulin dysregulation and some may show adiponectin dysregulation and/or excessive adip... Read More about Relationships between total adiponectin concentrations and obesity in native-breed ponies in England.

Predictors of laminitis development in a cohort of nonlaminitic ponies (2023)
Journal Article
Knowles, E., Elliott, J., Harris, P., Chang, Y., & Menzies-Gow, N. (2023). Predictors of laminitis development in a cohort of nonlaminitic ponies. Equine Veterinary Journal, https://doi.org/10.1111/evj.13572

Background Quantifying risk factors for laminitis development requires improvement. Objectives To identify the most useful physical examination, metabolic and management factors to predict laminitis development in client-owned, nonlaminitic ponies. S... Read More about Predictors of laminitis development in a cohort of nonlaminitic ponies.

Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies. (2022)
Journal Article
Finding, E., Elliott, J., Harris, P., & Menzies-Gow, N. (2022). Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies. Research in Veterinary Science, https://doi.org/10.1016/j.rvsc.2022.05.012

Previously laminitic (PL) ponies are reported to have higher blood pressure than non laminitic (NL) ponies. This relative hypertension may be related to endothelial cell dysfunction, similar to humans with metabolic syndrome. To investigate the relat... Read More about Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies..

Influence of endocrine disease on l-lactate concentrations in blood of ponies (2021)
Journal Article
Dunkel, B., Knowles, E., Chang, Y., & Menzies-Gow, N. (2021). Influence of endocrine disease on l-lactate concentrations in blood of ponies. Journal of Veterinary Internal Medicine, 35(3), 1582-1588. https://doi.org/10.1111/jvim.16079

Background Blood l-lactate concentrations are higher in people with developing or established diabetes mellitus and insulin resistance. Objectives To investigate whether blood l-lactate concentrations are positively correlated with measures of insuli... Read More about Influence of endocrine disease on l-lactate concentrations in blood of ponies.

Predictors of laminitis development in a cohort of non-laminitic ponies (2021)
Journal Article
Knowles, E., Elliott, J., Harris, P., Chang, R., & Menzies-Gow, N. (2021). Predictors of laminitis development in a cohort of non-laminitic ponies. Equine Veterinary Journal, https://doi.org/10.1111/evj.31_13492

Background: Quantifying the risk of laminitis development requires improvement.
Objectives: To identify the most useful physical examination, metabolic and management factors to predict future laminitis development in client-owned, non-laminitic pon... Read More about Predictors of laminitis development in a cohort of non-laminitic ponies.

The effect of strip grazing on physical activity and behaviour in ponies (2021)
Journal Article
Cameron, A., Longland, A., Pfau, T., Pinnegar, S., Brackston, I., Hockenhull, J., Harris, P. A., & Menzies-Gow, N. J. (2021). The effect of strip grazing on physical activity and behaviour in ponies. Journal of Equine Veterinary Science, 103745. https://doi.org/10.1016/j.jevs.2021.103745

This work aimed to determine the effect of strip grazing on physical activity in ponies using behavioural observations alongside accelerometers positioned at the poll. In study one, ten British native breed ponies were randomly assigned to paddock A... Read More about The effect of strip grazing on physical activity and behaviour in ponies.

Pergolide dosing compliance and factors affecting the laboratory control of equine pituitary pars intermedia dysfunction (2021)
Journal Article
Menzies-Gow, N., Hague, N., & Durham, A. (2021). Pergolide dosing compliance and factors affecting the laboratory control of equine pituitary pars intermedia dysfunction. Veterinary Record, https://doi.org/10.1002/vetr.142

Background: Equine pituitary pars intermedia dysfunction (PPID) is treated with daily pergolide therapy. Owner compliance and its effect on PPID control has not been previously investigated.
Methods: Clinical records were searched to identify the sa... Read More about Pergolide dosing compliance and factors affecting the laboratory control of equine pituitary pars intermedia dysfunction.

Pergolide dosing compliance and factors affecting the laboratory control of equine pituitary pars intermedia dysfunction (2021)
Journal Article
Menzies-Gow, N. (2021). Pergolide dosing compliance and factors affecting the laboratory control of equine pituitary pars intermedia dysfunction. Veterinary Record,

Background: Equine pituitary pars intermedia dysfunction (PPID) is treated with daily pergolide therapy. Owner compliance and its effect on PPID control has not been previously investigated.
Methods: Clinical records were searched to identify the sa... Read More about Pergolide dosing compliance and factors affecting the laboratory control of equine pituitary pars intermedia dysfunction.

Physics of Animal Health: On the mechano-biology of hoof growth and form (2019)
Journal Article
Al-Agele, R., Paul, E., Taylor, S., Watson, C., Sturrock, C., Drakopoulos, M., Atwood, R. C., Rutland, C. S., Menzies-Gow, N. J., Knowles, E., Elliott, J., Harris, P., & Rauch, C. (2019). Physics of Animal Health: On the mechano-biology of hoof growth and form. https://doi.org/10.1098/rsif.2019.0214

Global inequalities in economic access and agriculture productivity imply that a large number of developing countries rely on working equids for transport/agriculture/mining. Therefore, the understanding of hoof conditions/shape variations affecting... Read More about Physics of Animal Health: On the mechano-biology of hoof growth and form.

Prevalence of and risk factors for acute laminitis in horses treated with corticosteroids (2019)
Journal Article
Potter, K., Stevens, K. B., & Menzies-Gow, N. J. (2019). Prevalence of and risk factors for acute laminitis in horses treated with corticosteroids. Veterinary Record, 85(82), https://doi.org/10.1136/vr.105378

A retrospective treated versus untreated study (study 1) and multicentre prospective cohort study (study 2) were undertaken to determine the prevalence of, and risk factors associated with, acute laminitis in horses treated with corticosteroids. All... Read More about Prevalence of and risk factors for acute laminitis in horses treated with corticosteroids.