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Serum 1H nuclear magnetic resonance-based metabolomics of sole lesion development in Holstein cows (2023)
Journal Article
Barden, M., Phelan, M., Hyde, R., Anagnostopoulos, A., Griffiths, B., Bedford, C., Green, M., Psifidi, A., Banos, G., & Oikonomou, G. (2023). Serum 1H nuclear magnetic resonance-based metabolomics of sole lesion development in Holstein cows. Journal of Dairy Science, 106(4), 2667-2684. https://doi.org/10.3168/jds.2022-22681

those with the strongest evidence of being associated with sole lesions corresponded to phenylalanine and 4 unlabeled metabolites. We conclude that the serum metabolome, as characterized by proton nuclear magnetic resonance spectroscopy, does not app... Read More about Serum 1H nuclear magnetic resonance-based metabolomics of sole lesion development in Holstein cows.

Risk factors for upper urinary tract uroliths and ureteral obstruction in cats under referral veterinary care in the United Kingdom (2023)
Journal Article
Geddes, R. F., Davison, L. J., Elliott, J., Syme, H. M., & O'Neill, D. G. (2023). Risk factors for upper urinary tract uroliths and ureteral obstruction in cats under referral veterinary care in the United Kingdom. Journal of Veterinary Internal Medicine, 37(2), 567-577. https://doi.org/10.1111/jvim.16659

Background
Cats presenting with upper urinary tract uroliths (UUTUs) and ureteral obstruction (“obstructive UUTU”) are typically younger than cats with idiopathic CKD that often have incidental nephroliths.

Hypothesis
Cats with upper urinary tra... Read More about Risk factors for upper urinary tract uroliths and ureteral obstruction in cats under referral veterinary care in the United Kingdom.

Metformin and empagliflozin combination modulate macrophage inflammatory gene expression (2023)
Journal Article
Arefin, A., & Gage, M. C. (2023). Metformin and empagliflozin combination modulate macrophage inflammatory gene expression. International Journal of Molecular Sciences, https://doi.org/10.3390/ijms24054785

Type-2 Diabetes Mellitus is a complex, chronic illness characterized by persistent high blood glucose levels. Patients can be described anti diabetes drugs as single agents or in combination depending on the severity of their condition. Metformin and... Read More about Metformin and empagliflozin combination modulate macrophage inflammatory gene expression.

A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis (2023)
Journal Article
Elliott, J., & Bailey, S. (in press). A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis. Equine Veterinary Journal, https://doi.org/10.1111/evj.13933

Equine laminitis has both fascinated and frustrated veterinary researchers and clinicians for many years. The recognition that many ponies suffering from pasture associated laminitis have an insulin dysregulated phenotype (endocrinopathic laminitis,... Read More about A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis.

A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis (2023)
Journal Article
Elliott, J. (2023). A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis. Equine Veterinary Journal, https://doi.org/10.1111/evj.13933

Equine laminitis has both fascinated and frustrated veterinary researchers and clinicians for many years. The recognition that many ponies suffering from pasture associated laminitis have an insulin dysregulated phenotype (endocrinopathic laminitis,... Read More about A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis.

Regional modular responses in different bone compartments to the anabolic effect of PTH (1-34) and axial loading in mice (2023)
Journal Article
Monzem, S., Valkani, D., Evans, L., Chang, Y., & Pitsillides, A. (2023). Regional modular responses in different bone compartments to the anabolic effect of PTH (1-34) and axial loading in mice. BONE, 170, https://doi.org/10.1016/j.bone.2023.116720

Beneficial effects of intermittent parathyroid hormone (PTH) on bone mass and architecture are described to either simply add to, or to synergise with those of mechanical loading. We evaluate whether interaction with in vivo loading is reinforced by... Read More about Regional modular responses in different bone compartments to the anabolic effect of PTH (1-34) and axial loading in mice.

Expert assessment of the impact of ship-strikes on cetacean welfare using the Welfare Assessment Tool for Wild Cetaceans (2023)
Journal Article
Rae, F., Nicol, C., & Simmonds, M. (2023). Expert assessment of the impact of ship-strikes on cetacean welfare using the Welfare Assessment Tool for Wild Cetaceans. Animal Welfare Journal, 32, Article e18. https://doi.org/10.1017/awf.2023.7

Human activities are increasingly impacting our oceans and the focus of attention tends to be on their environmental impacts, rather than consequences for animal welfare. Global shipping density has quadrupled since 1992. Unsurprisingly, increased le... Read More about Expert assessment of the impact of ship-strikes on cetacean welfare using the Welfare Assessment Tool for Wild Cetaceans.

Implementation of Genomic Surveillance of SARS-CoV-2 in the Caribbean: Lessons Learned for Sustainability in Resource-Limited Settings (2023)
Journal Article
Sahadeo, N. S. D., Nicholls, S., Moreira, F. R. R., O'Toole, Á., Ramkissoon, V., Whittaker, C., Hill, V., McCrone, J. T., Mohammed, N., Ramjag, A., Brown-Jordan, A., Hill, S. C., Singh, R., Nathaniel-Girdharrie, S.-M., Hinds, A., Ramkissoon, N., Parag, K. V., Nandram, N., Parasram, R., Khan-Mohammed, Z., …Carrington, C. V. F. (2023). Implementation of Genomic Surveillance of SARS-CoV-2 in the Caribbean: Lessons Learned for Sustainability in Resource-Limited Settings. The Lancet Global Health, https://doi.org/10.1371/journal.pgph.0001455

In cats undergoing midline ovariohysterectomy, is the use of local infiltration anaesthesia with bupivacaine associated with a reduction in post-operative pain score? (2023)
Journal Article
Freeman, T., Wisbey, A., Burroughs, K., Gentle, S., Ellis, C., & Batt-Williams, S. (in press). In cats undergoing midline ovariohysterectomy, is the use of local infiltration anaesthesia with bupivacaine associated with a reduction in post-operative pain score?. Veterinary Evidence, https://doi.org/10.18849/ve.v8i1.552

A knowledge Summary for RCVS knowledge - A student assignment to be published with a member of staff as supervisor


In cats undergoing midline ovariohysterectomy, is the use of local infiltration anaesthesia with bupivacaine associated with a red... Read More about In cats undergoing midline ovariohysterectomy, is the use of local infiltration anaesthesia with bupivacaine associated with a reduction in post-operative pain score?.

Novel insights on the effect of sclerostin on bone and other organs (2023)
Journal Article
Dreyer, T., Keen, J., Wells, L., & Roberts, S. (2023). Novel insights on the effect of sclerostin on bone and other organs. Journal of Endocrinology, 257(2), https://doi.org/10.1530/JOE-22-0209

As a key regulator of bone homeostasis, sclerostin has garnered a lot of interest over the last two decades. Although sclerostin is primarily expressed by osteocytes and is well known for its role in bone formation and remodelling, it is also express... Read More about Novel insights on the effect of sclerostin on bone and other organs.

Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway (2023)
Journal Article
Rickman, M., Ghim, M., Pang, K., von Huelsen Rocha, A. C., Drudi, E. M., Sureda-Vives, M., Ayoub, N., Tajadura-Ortega, V., George, S. J., Weinberg, P. D., & Warboys, C. M. (in press). Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway. Journal of Cell Science, https://doi.org/10.1242/jcs.260449

Multidirectional or disturbed flow promotes endothelial dysfunction and is associated with early atherogenesis. Here we investigated the role of Wnt signalling in flow-mediated endothelial dysfunction. The expression of Frizzled-4 was higher in cultu... Read More about Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway.

Locomotor and postural diversity among reptiles: palaeobiological implications (2023)
Journal Article
Gônet, J., Bardin, J., Girondot, M., Hutchinson, J., & Laurin, M. (2023). Locomotor and postural diversity among reptiles: palaeobiological implications. Journal of Anatomy, https://doi.org/10.1111/joa.13833

The conquest of land by the first tetrapod vertebrates represents a key stage in their evolution. Selection pressures exerted by this new environment on animals led to the emergence of new locomotor and postural strategies that favoured access to dif... Read More about Locomotor and postural diversity among reptiles: palaeobiological implications.

Assessment of peritubular capillary rarefaction in kidneys of cats with chronic kidney disease (2023)
Journal Article
Paschall, R., Quimby, J., Cianciolo, R., McLeland, S., Lunn, K., & Elliott, J. (2023). Assessment of peritubular capillary rarefaction in kidneys of cats with chronic kidney disease. Journal of Veterinary Internal Medicine, 37(2), 556-566. https://doi.org/10.1111/jvim.16656

BackgroundHypoxia is a key driver of fibrosis and is associated with capillary rarefaction in humans. ObjectivesCharacterize capillary rarefaction in cats with chronic kidney disease (CKD). AnimalsArchival kidney tissue from 58 cats with CKD, 20 unaf... Read More about Assessment of peritubular capillary rarefaction in kidneys of cats with chronic kidney disease.