Skip to main content

Research Repository

Advanced Search

All Outputs (2484)

Osteoarthritis-related nociceptive behaviour following mechanical joint loading correlates with cartilage damage (2020)
Journal Article
Ter Heegde, F., Luiz, A. P., Santana-Varela, S., Magnusdottir, R., Hopkinson, M., Chang, Y. M., Poulet, B., Fowkes, R. C., Wood, J. N., & Chenu, C. (2020). Osteoarthritis-related nociceptive behaviour following mechanical joint loading correlates with cartilage damage. Osteoarthritis and Cartilage, 28(3), 383-395. https://doi.org/10.1016/j.joca.2019.12.004

In osteoarthritis (OA), the pain-structure relationship remains complex and poorly understood. Here, we used the mechanical joint loading (MJL) model of OA to investigate both knee pathology and nociceptive behaviour.

Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity (2020)
Journal Article
Staines, K., Hopkinson, M., Dillon, S., Stephen, L., Fleming, R., Sophocleous, A., Buttle, D., Pitsillides, A., & Farquharson, C. (2020). Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity. Bioscience Reports, 40, https://doi.org/10.1042/BSR20190329

E11/Podoplanin (Pdpn) is implicated in early osteocytogenesis and the formation of osteocyte dendrites. This dendritic network is critical for bone modelling/remodelling, through the production of receptor activator of nuclear factor κ B (RANK)-ligan... Read More about Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity.

Minimalist analogue robot discovers animal-like walking gaits (2019)
Journal Article
Smith, B. J. H., & Usherwood, J. R. (2019). Minimalist analogue robot discovers animal-like walking gaits. https://doi.org/10.1088/1748-3190/ab654e

Robots based on simplified or abstracted biomechanical concepts can be a useful tool for investigating how and why animals move the way they do. In this paper we present an extremely simple quadruped robot, which is able to walk with no form of softw... Read More about Minimalist analogue robot discovers animal-like walking gaits.

Divergent evolution of terrestrial locomotor abilities in extant Crocodylia (2019)
Journal Article
Hutchinson, J. R., Felkler, D., Houston, K., Chang, Y. M., Brueggen, J., Kledzik, D., & Vliet, K. A. (2019). Divergent evolution of terrestrial locomotor abilities in extant Crocodylia. https://doi.org/10.1038/s41598-019-55768-6

Extant Crocodylia are exceptional because they employ almost the full range of quadrupedal footfall patterns (“gaits”) used by mammals; including asymmetrical gaits such as galloping and bounding. Perhaps this capacity evolved in stem Crocodylomorpha... Read More about Divergent evolution of terrestrial locomotor abilities in extant Crocodylia.

Association between hyponatremia and neurological dysfunction in hospitalized foals (2019)
Journal Article
Dunkel, B., Dodson, F., Chang, Y. M., & Slovis, N. M. (2019). Association between hyponatremia and neurological dysfunction in hospitalized foals. Journal of Veterinary Emergency and Critical Care, 30(1), 66-73. https://doi.org/10.1111/vec.12906

Hyponatremia and rapid correction of hyponatremia can lead to neurological abnormalities. The objective of the study was to determine whether plasma sodium concentrations (Na+) and speed of correction of hyponatremia are significantly associated with... Read More about Association between hyponatremia and neurological dysfunction in hospitalized foals.

Antimicrobial susceptibility and genetic profile of Mycoplasma hyopneumoniae isolates from Brazil (2019)
Journal Article
Gonzaga, N. F., De Souza, L. F. L., Santos, M. R., Assao, V. S., Rycroft, A. N., Deeney, A. S., Fietto, J. L. R., Bressan, G. C., Moreira, M. A. S., & Silva-Júnior, A. (2019). Antimicrobial susceptibility and genetic profile of Mycoplasma hyopneumoniae isolates from Brazil. https://doi.org/10.1007/s42770-019-00185-0

Mycoplasma hyopneumoniae is the etiologic agent of porcine enzootic pneumonia, responsible for major production losses worldwide. The bacteria have a limited metabolism and need to obtain molecules from the growth environment, which causes multiple d... Read More about Antimicrobial susceptibility and genetic profile of Mycoplasma hyopneumoniae isolates from Brazil.

Aging and Mechanoadaptive Responsiveness of Bone (2019)
Journal Article
Javaheri, B., & Pitsillides, A. A. (2019). Aging and Mechanoadaptive Responsiveness of Bone. Current Osteoporosis Reports, 17(6), 560-569. https://doi.org/10.1007/s11914-019-00553-7

Osteoporosis is an age-related disorder characterized by bone loss and increased fracture susceptibility. Whether this is due to reduced loading in less active elderly individuals or inherent modifications in bone cells is uncertain. We suppose that... Read More about Aging and Mechanoadaptive Responsiveness of Bone.

Variation in limb loading magnitude and timing in tetrapods (2019)
Journal Article
Granatosky, M. C., McElroy, E. J., Lemelin, P., Reilly, S. M., Nyakatura, J. A., Andrada, E., Kilbourne, B. M., Allen, V. R., Butcher, M. T., Blob, R. W., & Ross, C. F. (2019). Variation in limb loading magnitude and timing in tetrapods. Journal of Experimental Biology, https://doi.org/10.1242/jeb.201525

Comparative analyses of locomotion in tetrapods reveal two patterns of stride cycle variability. Tachymetabolic tetrapods (birds and mammals) have lower inter-cycle variation in stride duration than bradymetabolic tetrapods (amphibians, lizards, turt... Read More about Variation in limb loading magnitude and timing in tetrapods.

The contribution of multicellular model organisms to Neuronal Ceroid Lipofuscinosis research (2019)
Journal Article
Russell, C., Huber, R., Hughes, S., Wenfei Liu, Morgan, A., & Tuxworth, R. (2019). The contribution of multicellular model organisms to Neuronal Ceroid Lipofuscinosis research. https://doi.org/10.1016/j.bbadis.2019.165614

The NCLs (neuronal ceroid lipofuscinosis) are forms of neurodegenerative disease that affect people of all ages and ethnicities but are most prevalent in children. Commonly known as Batten disease, this debilitating neurological disorder is comprised... Read More about The contribution of multicellular model organisms to Neuronal Ceroid Lipofuscinosis research.

Raman spectroscopy links differentiating osteoblast matrix signatures to pro-angiogenic potential (2019)
Journal Article
Sharma, A., Goring, A., Staines, K. A., Emery, R., Pitsillides, A. A., Oreffo, R. O. C., Mahajan, S., & Clarkin, C. E. (2019). Raman spectroscopy links differentiating osteoblast matrix signatures to pro-angiogenic potential. Matrix Biology, 5, https://doi.org/10.1016/j.mbplus.2019.100018

Mineralization of bone is achieved by the sequential maturation of the immature amorphous calcium phase to mature hydroxyapatite and is central to the process of bone development and repair. To study normal and dysregulated mineralization in vitro, s... Read More about Raman spectroscopy links differentiating osteoblast matrix signatures to pro-angiogenic potential.

A decade of optimizing drug development for rare neuromuscular disorders through TACT (2019)
Journal Article
Wagner, K. R., De Luca, A., Caizergues, D., Dowling, J., Goemans, N., Gordish-Dressman, H., Grounds, M. D., Kelly, M., Mayhew, A., McNally, E. M., Zoetis, T., Lee, J., Turner, C., Wells, D. J., Csimma, C., & Straub, V. (2019). A decade of optimizing drug development for rare neuromuscular disorders through TACT. Nature Reviews Drug Discovery, 19(1-2), https://doi.org/10.1038/d41573-019-00199-1

The role of chick Ebf genes in the mediolateral patterning of the somites (2019)
Journal Article
EL-Magd, M. A., Elsayed, S. A., El-Shetry, E. S., Abdelfattah-Hassan, A., Saleh, A. A., Allen, S., McGonnell, I. M., & Patel, K. (2019). The role of chick Ebf genes in the mediolateral patterning of the somites. https://doi.org/10.1002/dvg.23339

This study was conducted to check whether the three chick Early B‐cell Factor (Ebf) genes, particularly cEbf1, would be targets for Shh and Bmp signals during somites mediolateral (ML) patterning. Tissue manipulations and gain and loss of function ex... Read More about The role of chick Ebf genes in the mediolateral patterning of the somites.

Propagation phase-contrast micro-computed tomography allows laboratory-based three-dimensional imaging of articular cartilage down to the cellular level (2019)
Journal Article
Clark, J. N., Garbout, A., Ferreira, S. A., Javaheri, B., Pitsillides, A. A., Rankin, S. M., Jeffers, J. R. T., & Hansen, U. (2019). Propagation phase-contrast micro-computed tomography allows laboratory-based three-dimensional imaging of articular cartilage down to the cellular level. Osteoarthritis and Cartilage, 28, 102-111. https://doi.org/10.1016/j.joca.2019.10.007

High-resolution non-invasive three-dimensional (3D) imaging of chondrocytes in articular cartilage remains elusive. The aim of this study was to explore whether laboratory micro-computed tomography (micro-CT) permits imaging cells within articular ca... Read More about Propagation phase-contrast micro-computed tomography allows laboratory-based three-dimensional imaging of articular cartilage down to the cellular level.

Comparative Chromosome Mapping of Musk Ox and the X Chromosome among Some Bovidae Species (2019)
Journal Article
Proskuryakova, A. A., Kulemzina, A. I., Perelman, P. L., Yudkin, D. V., Lemskaya, N. A., Okhlopkov, I. M., Kirillin, E. V., Farré, M., Larkin, D. M., Roelke-Parker, M. E., O'Brien, S. J., Bush, M., & Graphodatsky, A. S. (2019). Comparative Chromosome Mapping of Musk Ox and the X Chromosome among Some Bovidae Species. Genes, 10(11), 857. https://doi.org/10.3390/genes10110857

Bovidae, the largest family in Pecora infraorder, are characterized by a striking variability in diploid number of chromosomes between species and among individuals within a species. The bovid X chromosome is also remarkably variable, with several mo... Read More about Comparative Chromosome Mapping of Musk Ox and the X Chromosome among Some Bovidae Species.

Hormonal Regulation of Glucocorticoid Inactivation and Reactivation in aT3-1 and LßT2 Gonadotroph Cells (2019)
Journal Article
Michael, A. E., Thurston, L. M., & Fowkes, R. C. (2019). Hormonal Regulation of Glucocorticoid Inactivation and Reactivation in aT3-1 and LßT2 Gonadotroph Cells. Biology, 8(4), 81. https://doi.org/10.3390/biology8040081

The regulation of reproductive function by glucocorticoids occurs at all levels of the hypothalamo-pituitary-gonadal axis. Within the pituitary, glucocorticoids have been shown to directly alter gene expression in gonadotrophs, indicating that these... Read More about Hormonal Regulation of Glucocorticoid Inactivation and Reactivation in aT3-1 and LßT2 Gonadotroph Cells.

Dysregulated cell signalling and reduced satellite cell potential in ageing muscle (2019)
Journal Article
Patel, K., Simbi, B. H., Ritvos, O., Vaiyapuri, S., & Dhoot, G. K. (2019). Dysregulated cell signalling and reduced satellite cell potential in ageing muscle. Experimental Cell Research, 385(2), https://doi.org/10.1016/j.yexcr.2019.111685

Aberrant activation of signalling pathways has been postulated to promote age related changes in skeletal muscle. Cell signalling activation requires not only the expression of ligands and receptors but also an appropriate environment that facilitate... Read More about Dysregulated cell signalling and reduced satellite cell potential in ageing muscle.

Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice (2019)
Journal Article
Ying Wu, Chang, Y. M., Stell, A. J., Priestnall, S. L., Sharma, E., Goulart, M. R., Gribben, J., Xia, D., & Garden, O. A. (2019). Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice. https://doi.org/10.1038/s41598-019-50065-8

Regulatory T cells (Tregs) are a double-edged regulator of the immune system. Aberrations of Tregs correlate with pathogenesis of inflammatory, autoimmune and neoplastic disorders. Phenotypically and functionally distinct subsets of Tregs have been i... Read More about Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice.