Skip to main content

Research Repository

Advanced Search

All Outputs (9758)

Short-term clinical and biochemical responses following treatment with dapagliflozin or ertugliflozin in horses with hyperinsulinemia: A retrospective case series (2024)
Journal Article
Sundra, T., Knowles, E., Rendle, D., Kelty, E., Lester, G., & Rossi, G. (2025). Short-term clinical and biochemical responses following treatment with dapagliflozin or ertugliflozin in horses with hyperinsulinemia: A retrospective case series. Domestic Animal Endocrinology, 90, https://doi.org/10.1016/j.domaniend.2024.106894

The metabolic and lipid profiles of horses treated with sodium-glucose cotransporter 2 inhibitors are not well understood. This retrospective study evaluated blood parameters in hyperinsulinemic horses treated with either ertugliflozin (0.05 mg/kg) o... Read More about Short-term clinical and biochemical responses following treatment with dapagliflozin or ertugliflozin in horses with hyperinsulinemia: A retrospective case series.

Anthropogenic land consolidation intensifies zoonotic host diversity loss and disease transmission in human habitats (2024)
Journal Article
Pei, S., Yu, P., Raghwani, J., Wang, Y., Liu, Z., Li, Y., Cheng, Y., Lin, Q., Song, C., Dharmarajan, G., Faust, C. L., Tian, Y., Xu, Y., Liang, Y., Qu, J., Wei, J., Li, S., Zhang, T., Ma, C., Bharti, N., …Tian, H. (in press). Anthropogenic land consolidation intensifies zoonotic host diversity loss and disease transmission in human habitats. Nature Ecology and Evolution, 9(1), 99-110. https://doi.org/10.1038/s41559-024-02570-x

Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia (2024)
Journal Article
Arber, C., Casey, J., Crawford, S., Rambarack, N., Yaman, U., Wiethoff, S., Augustin, E., Piers, T., Price, M., Rostagno, A., Ghiso, J., Lewis, P., Revesz, T., Hardy, J., Pocock, J., Houlden, H., Schott, J., Salih, D., Lashley, T., & Wray, S. (2024). Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia. Acta Neuropathologica, 148(1), https://doi.org/10.1007/s00401-024-02820-z

Mutations in ITM2B cause familial British, Danish, Chinese, and Korean dementias. In familial British dementia (FBD), a mutation in the stop codon of the ITM2B gene (also known as BRI2) causes a C-terminal cleavage fragment of the ITM2B/BRI2 protein... Read More about Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia.

Preclinical development and characterisation of PP353, a formulation of linezolid for intradiscal administration (2024)
Journal Article
Hagger, G., Guest, S., Birchall, S., Bradley, A., Brindley, C., Corbett, D., Cummings, P., Freire, C., Harris, J., Wise, A., Wood, M., & Czaplewski, L. (2024). Preclinical development and characterisation of PP353, a formulation of linezolid for intradiscal administration. JOR Spine, 7(4), https://doi.org/10.1002/jsp2.70010

IntroductionBacterial infection of the intervertebral disc can lead to vertebral endplate edema known as Modic changes, with associated chronic low back pain. Oral antimicrobial therapy has shown efficacy but relies on prolonged dosing and may not be... Read More about Preclinical development and characterisation of PP353, a formulation of linezolid for intradiscal administration.

A CADASIL NOTCH3 mutation leads to clonal hematopoiesis and expansion of Dnmt3a-R878H hematopoietic clones (2024)
Journal Article
Sánchez-Lanzas, R., Barclay, J., Chardas, A., Kalampalika, F., Jiménez-Pompa, A., Gallipoli, P., & Ganuza, M. (2024). A CADASIL NOTCH3 mutation leads to clonal hematopoiesis and expansion of Dnmt3a-R878H hematopoietic clones. Leukemia, https://doi.org/10.1038/s41375-024-02464-8

Clonal hematopoiesis (CH) is nearly universal in the elderly. The molecular and cellular mechanisms driving CH and the clinical consequences of carrying clonally derived mutant mature blood cells are poorly understood. We recently identified a C223Y... Read More about A CADASIL NOTCH3 mutation leads to clonal hematopoiesis and expansion of Dnmt3a-R878H hematopoietic clones.

Increased susceptibility to diet-induced obesity in female mice impairs ovarian steroidogenesis: The role of elevated leptin signalling on nodal activity inhibition in theca cells (2024)
Journal Article
Wolodko, K., Sentjurc, T., Walewska, E., Laniecka, E., Jura, M., & Galvao, A. (2025). Increased susceptibility to diet-induced obesity in female mice impairs ovarian steroidogenesis: The role of elevated leptin signalling on nodal activity inhibition in theca cells. Molecular Metabolism, 91, https://doi.org/10.1016/j.molmet.2024.102062

Objectives Susceptibility to obesity in humans is driven by the intricate interplay of genetic, environmental and behavioural factors. Moreover, the mechanisms linking maternal obesity to infertility remain largely understudied. In this study, we inv... Read More about Increased susceptibility to diet-induced obesity in female mice impairs ovarian steroidogenesis: The role of elevated leptin signalling on nodal activity inhibition in theca cells.

White paper formatted for Endocrine Oncology NET models meeting 2024 White Paper: the current state of neuroendocrine tumour research models and our future aspirations (2024)
Journal Article
Hien Ear, P., Marinoni, I., Dayton, T., Guenter, R., Quelle, D. E., Battistella, A., Buishand, F. O., Chittaranjan, S., Du, Y.-C. N., Marques, I., Pellegata, N., Sadowski, S. M., Tirosh, A., April-Monn, S., Aurilia, C., Jaskula-Sztul, R., Jesús, M., Moreno, B., Donati, S., English, K. A., …Schrader, J. (2024). White paper formatted for Endocrine Oncology NET models meeting 2024 White Paper: the current state of neuroendocrine tumour research models and our future aspirations. Endocrine Oncology, https://doi.org/10.1530/EO-24-0055

Cats are not small dogs- assessment and stabilisation of emergency presentation (2024)
Journal Article
O'Byrne, E., & Cole, L. (2024). Cats are not small dogs- assessment and stabilisation of emergency presentation. Veterinary Nurse, 29(11), 2-6

Cats are a common emergency presentation in practice with a wide range of presenting conditions ranging from trauma caused by road traffic accidents (RTAs) or falling from a height, to acute medical conditions or ingestion of toxins. When dealing wit... Read More about Cats are not small dogs- assessment and stabilisation of emergency presentation.

A histopathological study in road-killed European badgers (Meles meles) from the English midlands with isolation of novel non-tuberculous atypical mycobacteria (2024)
Journal Article
Corbetta, D., Grau-Roma, L., Rees, C., Swift, B., O'Cathail, C., Barron, E., Verin, R., Morey-Matamalas, A., Sorley, M., & Bennett, M. (2024). A histopathological study in road-killed European badgers (Meles meles) from the English midlands with isolation of novel non-tuberculous atypical mycobacteria. European Journal of Wildlife Research, 70(6), https://doi.org/10.1007/s10344-024-01866-4

European badgers (Meles meles) play an important role in the epidemiology of bovine tuberculosis (caused by Mycobacterium bovis) in England, but little is known about the prevalence of atypical mycobacteriosis. Badgers are also known to be infected b... Read More about A histopathological study in road-killed European badgers (Meles meles) from the English midlands with isolation of novel non-tuberculous atypical mycobacteria.

Routes of importation and spatial dynamics of SARS-CoV-2 variants during localized interventions in Chile (2024)
Journal Article
Gutierrez, B., Tsui, J., Pullano, G., Mazzoli, M., Gangavarapu, K., Inward, R., Bajaj, S., Pena, R., Busch-Moreno, S., Suchard, M., Pybus, O., Dunner, A., Puentes, R., Ayala, S., Fernandez, J., Araos, R., Ferres, L., Colizza, V., & Kraemer, M. (2024). Routes of importation and spatial dynamics of SARS-CoV-2 variants during localized interventions in Chile. PNAS Nexus, 3(11), https://doi.org/10.1093/pnasnexus/pgae483

Human mobility is strongly associated with the spread of SARS-CoV-2 via air travel on an international scale and with population mixing and the number of people moving between locations on a local scale. However, these conclusions are drawn mostly fr... Read More about Routes of importation and spatial dynamics of SARS-CoV-2 variants during localized interventions in Chile.

A systematic review of the prevalence of post-operative complications after general anaesthesia in adult horses (2000-2023) (2024)
Journal Article
Loomes, K., de Grauw, J., Gozalo-Marcilla, M., Redondo, J., & Bettschart-Wolfensberger, R. (2024). A systematic review of the prevalence of post-operative complications after general anaesthesia in adult horses (2000-2023). Equine Veterinary Journal, https://doi.org/10.1111/evj.14416

Background Equine post-operative morbidity represents a significant concern for both veterinary surgeons and horse owners. Objectives To estimate the prevalence of post-operative complications in horses after elective/non-abdominal surgery or colic s... Read More about A systematic review of the prevalence of post-operative complications after general anaesthesia in adult horses (2000-2023).

Investigating the resistome of haemolytic bacteria in Arctic soils (2024)
Journal Article
Mogrovejo-Arias, D., Hay, M., Edwards, A., Mitchell, A., Steinmann, J., Brill, F., & Neumann, B. (2024). Investigating the resistome of haemolytic bacteria in Arctic soils. Environmental Microbiology Reports, 16(5), https://doi.org/10.1111/1758-2229.70028

Microorganisms inhabiting hostile Arctic environments express a variety of functional phenotypes, some of clinical interest, such as haemolytic ability and antimicrobial resistance. We studied haemolytic bacterial isolates from Arctic habitats, asses... Read More about Investigating the resistome of haemolytic bacteria in Arctic soils.

Comparison of outcomes in dogs undergoing hiatal hernia repair with and without use of a gastropexy: 41 cases (2012-2022) (2024)
Journal Article
Watkins, M., Shales, C., Thomas, G., Rossanese, M., Sparks, T., & White, R. (2024). Comparison of outcomes in dogs undergoing hiatal hernia repair with and without use of a gastropexy: 41 cases (2012-2022). Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13797

Objectives: To determine the difference in complication rate, gastrointestinal grade and requirement for ongoing medical and/or surgical management following hiatal hernia repair in dogs with and without gastropexy. Materials and methods: Clinical re... Read More about Comparison of outcomes in dogs undergoing hiatal hernia repair with and without use of a gastropexy: 41 cases (2012-2022).

Spontaneous hepatocellular and gastric tumours in African clawed frogs (Xenopus laevis) (2024)
Journal Article
Martí-García, B., Priestnall, S., Torres, Y., & Suárez-Bonnet, A. (2024). Spontaneous hepatocellular and gastric tumours in African clawed frogs (Xenopus laevis). Laboratory Animals, https://doi.org/10.1177/00236772241273060

Three seven-year-old African clawed frogs (Xenopus laevis) from an animal research facility showed weight loss, coelomic distention and an abnormal swimming gait were euthanised on welfare grounds. A complete necropsy of each animal showed a focal, f... Read More about Spontaneous hepatocellular and gastric tumours in African clawed frogs (Xenopus laevis).

Somatic GNAQ, CTNNB1, and CACNA1C Mutations in Cat Aldosterone-Secreting Tumors (2024)
Journal Article
Watson, A., Syme, H., & Brown, M. (2024). Somatic GNAQ, CTNNB1, and CACNA1C Mutations in Cat Aldosterone-Secreting Tumors. Hypertension, 81(12), 2489-2500. https://doi.org/10.1161/HYPERTENSIONAHA.124.23501

BACKGROUND:Primary aldosteronism (PA) is a common cause of human hypertension. Somatic mutations in KCNJ5, CACNA1D, ATP1A1, and ATP2B3 are found in at least 80% of aldosterone-producing adenomas, which cause unilateral PA in humans. Somatic mutations... Read More about Somatic GNAQ, CTNNB1, and CACNA1C Mutations in Cat Aldosterone-Secreting Tumors.

Comparison of CHOP-19 and CHOP-25 for treatment of peripheral nodal B-cell lymphoma in dogs: A European multicenter retrospective cohort study (2024)
Journal Article
Hawkes, C., Morris, J., Bavcar, S., Wilkie, C., Ray, S., Auquier, C., Benjamin, S., Masso, J., Bottin, S., Davies, O., Desmas-Bazelle, I., Einhorn, A., Figueroa-Gonzalez, C., Holenova, K., Kritsotalaki, E., Peak, K., Smallwood, K., Treggiari, E., Valenti, P., de la Virgen, M., & Fournier, Q. (2024). Comparison of CHOP-19 and CHOP-25 for treatment of peripheral nodal B-cell lymphoma in dogs: A European multicenter retrospective cohort study. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.17222

BackgroundPeripheral nodal B-cell lymphomas (PNBCL) represent the most common presentation of lymphomas in dogs. Multiagent CHOP (C = cyclophosphamide, H = hydroxydaunorubicin [Doxorubicin], O = Oncovin, P = prednisolone)-based chemotherapy protocols... Read More about Comparison of CHOP-19 and CHOP-25 for treatment of peripheral nodal B-cell lymphoma in dogs: A European multicenter retrospective cohort study.

Antimicrobial resistance in plant endophytes associated with poultry-manure application revealed by selective culture and whole genome sequencing (2024)
Journal Article
Tripathi, A., Jaiswal, A., Kumar, D., Chavda, P., Pandit, R., Joshi, M., Blake, D., Tomley, F., Joshi, C., & Dubey, S. (2024). Antimicrobial resistance in plant endophytes associated with poultry-manure application revealed by selective culture and whole genome sequencing. Journal of Hazardous Materials, 480, https://doi.org/10.1016/j.jhazmat.2024.136166

Poultry manure is widely used as organic fertilizer in agriculture during the cultivation of crops, but the persistent high-level use of antibiotics in poultry production has raised concerns about the selection for reservoirs of antimicrobial resista... Read More about Antimicrobial resistance in plant endophytes associated with poultry-manure application revealed by selective culture and whole genome sequencing.