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All Outputs (418)

Exploring mitochondrial cholesterol (mChol) signalling for therapeutic intervention in neurological conditions (2019)
Journal Article
Desai, R., & Campanella, M. (2019). Exploring mitochondrial cholesterol (mChol) signalling for therapeutic intervention in neurological conditions. British Journal of Pharmacology, https://doi.org/10.1111/bph.14697

The pharmacological targeting of cholesterol levels continues to draw interest due to the vast success of therapeutics such as statins in extending life expectancy by modifying the prognosis of diseases associated with the impairment of the lipid met... Read More about Exploring mitochondrial cholesterol (mChol) signalling for therapeutic intervention in neurological conditions.

High-density genotyping reveals signatures of selection related to acclimation and economically important traits in 15 local sheep breeds from Russia (2019)
Journal Article
Yurchenko, A. A., Deniskova, T. E., Yudin, N. S., Dotsev, A. V., Khamiruev, T. N., Selionova, M. I., …Larkin, D. M. (2019). High-density genotyping reveals signatures of selection related to acclimation and economically important traits in 15 local sheep breeds from Russia. BMC Genomics, 20(Suppl 3), https://doi.org/10.1186/s12864-019-5537-0

Domestication and centuries of selective breeding have changed genomes of sheep breeds to respond to environmental challenges and human needs. The genomes of local breeds, therefore, are valuable sources of genomic variants to be used to understand m... Read More about High-density genotyping reveals signatures of selection related to acclimation and economically important traits in 15 local sheep breeds from Russia.

The impact of early structural enrichment on spatial cognition in layer chicks (2019)
Journal Article
Norman, K. I., Adriaense, J., & Nicol, C. J. (2019). The impact of early structural enrichment on spatial cognition in layer chicks. Behavioural Processes, 164, 167-174. https://doi.org/10.1016/j.beproc.2019.05.008

The aim of the study was to determine whether early access to elevated structures affects spatial navigational abilities. Ninety six day-old chicks were reared in 16 pens. Eight pens were provided with A-frame perches with an attached platform and a... Read More about The impact of early structural enrichment on spatial cognition in layer chicks.

Evolutionary parallelisms of pectoral and pelvic network-anatomy from fins to limbs (2019)
Journal Article
Esteve-Altava, B., Pierce, S. E., Molnar, J. L., Johnston, P., Diogo, R., & Hutchinson, J. R. (2019). Evolutionary parallelisms of pectoral and pelvic network-anatomy from fins to limbs. Science Advances, 5(5), https://doi.org/10.1126/sciadv.aau7459

Lobe-fins transformed into limbs during the Devonian period, facilitating the water-to-land transition in tetrapods. We traced the evolution of well-articulated skeletons across the fins-to-limbs transition, using a network-based approach to quantify... Read More about Evolutionary parallelisms of pectoral and pelvic network-anatomy from fins to limbs.

The impact of pelvic lateral rotation on hindlimb kinematics and stride length in the red-legged running frog, Kassina maculata (2019)
Journal Article
Collings, A. J., Porro, L. B., Hill, C., & Richards, C. T. (2019). The impact of pelvic lateral rotation on hindlimb kinematics and stride length in the red-legged running frog, Kassina maculata. Royal Society Open Science, 6, 190060. https://doi.org/10.1098/rsos.190060

Some frog species, such as Kassina maculata (red-legged running frog), use an asynchronous walking/running gait as their primary locomotor mode. Prior comparative anatomy work has suggested that lateral rotation of the pelvis improves walking perform... Read More about The impact of pelvic lateral rotation on hindlimb kinematics and stride length in the red-legged running frog, Kassina maculata.

FBS/BSA media concentration determines CCCP’s ability to depolarize mitochondria and activate PINK1-PRKN mitophagy (2019)
Journal Article
Soutar, M. P. M., Kempthorne, L., Annuario, E., Luft, C., Wray, S., Ketteler, R., …Plun-Favreau, H. (2019). FBS/BSA media concentration determines CCCP’s ability to depolarize mitochondria and activate PINK1-PRKN mitophagy. Autophagy, https://doi.org/10.1080/15548627.2019.1603549

Mitochondrial quality control is essential for maintaining a healthy population of mitochondria. Two proteins associated with Parkinson disease, the kinase PINK1 and the E3 ubiquitin ligase PRKN, play a central role in the selective degradation of he... Read More about FBS/BSA media concentration determines CCCP’s ability to depolarize mitochondria and activate PINK1-PRKN mitophagy.

The architecture of cancellous bone in the hindlimb of moa (Aves: Dinornithiformes), with implications for stance and gait (2019)
Journal Article
Bishop, P. J., Scofield, R. P., & Hocknull, S. A. (2019). The architecture of cancellous bone in the hindlimb of moa (Aves: Dinornithiformes), with implications for stance and gait. https://doi.org/10.1080/03115518.2019.1594380

The extinct, flightless moa of New Zealand included some of the largest birds to have existed and possessed many distinguishing pelvic and hindlimb osteological features. These features may have influenced stance and gait in moa compared with extant... Read More about The architecture of cancellous bone in the hindlimb of moa (Aves: Dinornithiformes), with implications for stance and gait.

Neurological signs and MRI findings in 12 dogs with multiple myeloma (2019)
Journal Article
Wyatt, S. E., De Risio, L., Driver, C. J., José-López, R., Pivetta, M., & Beltran, E. (2019). Neurological signs and MRI findings in 12 dogs with multiple myeloma. https://doi.org/10.1111/vru.12759

Vertebral lesions and associated neurological signs occur in dogs with multiple myeloma, however, veterinary literature describing MRI findings is currently lacking. The objective of this multicenter, retrospective, case series study was to describe... Read More about Neurological signs and MRI findings in 12 dogs with multiple myeloma.

Polyunsaturated fatty acids influence offspring sex ratio in cows (2019)
Journal Article
Marei, W. F. A., Khalil, W. A., Pushpakumara, P. G. A., El-Harairy, M. A., Abo El-Atta, A. M. A., Wathes, D. C., & Fouladi-Nashta, A. A. (2019). Polyunsaturated fatty acids influence offspring sex ratio in cows. https://doi.org/10.1016/j.ijvsm.2018.01.006

Dietary polyunsaturated fatty acids (PUFAs) can influence fertility in farm animals. Some evidence in mice and sheep have suggested that PUFAs may influence offspring sex ratio, which may have significant value for cattle production. To test this hyp... Read More about Polyunsaturated fatty acids influence offspring sex ratio in cows.

Detecting false-positive disease references in veterinary clinical notes without manual annotations (2019)
Journal Article
Kennedy, N., Brodbelt, D. C., Church, D. B., & O'Neill, D. G. (2019). Detecting false-positive disease references in veterinary clinical notes without manual annotations. https://doi.org/10.1038/s41746-019-0108-y

Clinicians often include references to diseases in clinical notes, which have not been diagnosed in their patients. For some diseases terms, the majority of disease references written in the patient notes may not refer to true disease diagnosis. Thes... Read More about Detecting false-positive disease references in veterinary clinical notes without manual annotations.

The effect of cadmium on the bovine in vitro oocyte maturation and early embryo development (2019)
Journal Article
Akar, Y., Ahmad, N., & Khalid, M. (2019). The effect of cadmium on the bovine in vitro oocyte maturation and early embryo development. https://doi.org/10.1016/j.ijvsm.2018.03.001

Common pollutants such as heavy metals and cadmium is among those with high environmental concerns. In vivo studies had shown that cadmium (Cd) causes oocyte degeneration and embryo mortality, and lowers pregnancy rates in mammals. However, there is... Read More about The effect of cadmium on the bovine in vitro oocyte maturation and early embryo development.

Reduced antimicrobial prescribing during autogenous staphylococcal bacterin therapy: a retrospective study in dogs with pyoderma (2019)
Journal Article
Wilson, A., Allers, N., Lloyd, D. H., Bond, R., & Loeffler, A. (2019). Reduced antimicrobial prescribing during autogenous staphylococcal bacterin therapy: a retrospective study in dogs with pyoderma. Veterinary Record, 184(24), https://doi.org/10.1136/vr.105223

Autogenous staphylococcal bacterins are commonly mentioned as treatment for canine recurrent pyoderma but little is known about their efficacy. This retrospective study describes use and assesses efficacy of an autogenous Staphylococcus (pseud)interm... Read More about Reduced antimicrobial prescribing during autogenous staphylococcal bacterin therapy: a retrospective study in dogs with pyoderma.

Cine balanced fast field echo magnetic resonance imaging of canine spinal arachnoid diverticulae pulsation (2019)
Journal Article
Shivapour, S. K., Volk, H. A., Watts, V., & De Decker, S. (2019). Cine balanced fast field echo magnetic resonance imaging of canine spinal arachnoid diverticulae pulsation. https://doi.org/10.1016/j.tvjl.2019.04.014

Canine spinal arachnoid diverticulae (SAD) are characterised by focal cerebrospinal fluid dilatations within the subarachnoid space, most commonly associated with nonpainful paresis and ataxia secondary to chronic compressive myelopathy. Numerous ima... Read More about Cine balanced fast field echo magnetic resonance imaging of canine spinal arachnoid diverticulae pulsation.

Zebrafish as a model for kidney function and disease (2019)
Journal Article
Outtandy, P., Russell, C., Kleta, R., & Brockenhauer, D. (2019). Zebrafish as a model for kidney function and disease. Pediatric Nephrology, 34(5), 751-762. https://doi.org/10.1007/s00467-018-3921-7

Kidney disease is a global problem with around three million people diagnosed in the UK alone and the incidence is rising. Research is critical to develop better treatments. Animal models can help to better understand the pathophysiology behind the v... Read More about Zebrafish as a model for kidney function and disease.

Analysis of neurofilament concentration in healthy adult horses and utility in the diagnosis of equine protozoal myeloencephalitis and equine motor neuron disease (2019)
Journal Article
Morales Gómez, A. M., Zhu, S., Palmer, S., Olsen, E., Ness, S. L., Divers, T. J., …Mohammed, H. O. (2019). Analysis of neurofilament concentration in healthy adult horses and utility in the diagnosis of equine protozoal myeloencephalitis and equine motor neuron disease. Research in Veterinary Science, 125, 1-6. https://doi.org/10.1016/j.rvsc.2019.04.018

Neurofilaments (NFs) are structural proteins of neurons that are released in significant quantities in the cerebrospinal fluid and blood as a result of neuronal degeneration or axonal damage. Therefore, NFs have potential as biomarkers for neurologic... Read More about Analysis of neurofilament concentration in healthy adult horses and utility in the diagnosis of equine protozoal myeloencephalitis and equine motor neuron disease.