All Outputs (506)

Serological evidence of Rift Valley fever virus infection among domestic ruminant herds in Uganda (2021)
Journal Article
Ndumu, D., Bakamutumaho, B., Miller, E., Nakayima, J., Downing, R., Balinandi, S., …Gonzalez, J. (2021). Serological evidence of Rift Valley fever virus infection among domestic ruminant herds in Uganda. BMC Veterinary Research, 17(1), https://doi.org/10.1186/s12917-021-02867-0

BackgroundPrior to the first recorded outbreak of Rift Valley fever (RVF) in Uganda, in March 2016, earlier studies done until the 1970's indicated the presence of the RVF virus (RVFV) in the country, without any recorded outbreaks in either man or a... Read More about Serological evidence of Rift Valley fever virus infection among domestic ruminant herds in Uganda.

The translocator protein (TSPO) is prodromal to mitophagy loss in neurotoxicity (2021)
Journal Article
Frison, M., Faccenda, D., Abeti, R., Rigon, M., Strobbe, D., England-Rendon, B., …Campanella, M. (2021). The translocator protein (TSPO) is prodromal to mitophagy loss in neurotoxicity. Molecular Psychiatry, 26(7), 2721-2739. https://doi.org/10.1038/s41380-021-01050-z

Dysfunctional mitochondria characterise Parkinson's Disease (PD). Uncovering etiological molecules, which harm the homeostasis of mitochondria in response to pathological cues, is therefore pivotal to inform early diagnosis and therapy in the conditi... Read More about The translocator protein (TSPO) is prodromal to mitophagy loss in neurotoxicity.

Multiscale molecular profiling of pathological bone resolves sexually dimorphic control of extracellular matrix composition (2021)
Journal Article
Sharma, A., Goring, A., Johnson, P., Emery, R., Hesse, E., Boyde, A., …Clarkin, C. (2021). Multiscale molecular profiling of pathological bone resolves sexually dimorphic control of extracellular matrix composition. Disease Models and Mechanisms, 14(3), https://doi.org/10.1242/dmm.048116

Collagen assembly during development is essential for successful matrix mineralisation, which determines bone quality and mechanocompetence. However, the biochemical and structural perturbations that drive pathological skeletal collagen configuration... Read More about Multiscale molecular profiling of pathological bone resolves sexually dimorphic control of extracellular matrix composition.

Diagnosis of Chikungunya Virus in Febrile Patients From a Malaria Holoendemic Area (2021)
Journal Article
Ingoba, L., Adedoja, A., Peko, S., Vairo, F., Haider, N., Kock, R., …Ntoumi, F. (2021). Diagnosis of Chikungunya Virus in Febrile Patients From a Malaria Holoendemic Area. International Journal of Infectious Diseases, 109, 247-252. https://doi.org/10.1016/j.ijid.2021.06.043

Introduction: Accurate diagnosis of chikungunya (CHIK) is essential for effective disease management and surveillance. In a cohort of febrile Congolese patients, available diagnostic methods widely used in CHIK diagnosis were evaluated. In addition,... Read More about Diagnosis of Chikungunya Virus in Febrile Patients From a Malaria Holoendemic Area.

Survey Design to Monitor Drug Efficacy for the Control of Soil-Transmitted Helminthiasis and Schistosomiasis (2021)
Journal Article
Coffeng, L., Levecke, B., Hattendorf, J., Walker, M., & Denwood, M. (2021). Survey Design to Monitor Drug Efficacy for the Control of Soil-Transmitted Helminthiasis and Schistosomiasis. Clinical Infectious Diseases, 72, S195-S202. https://doi.org/10.1093/cid/ciab196

Background. Control of soil-transmitted helminthiasis and schistosomiasis relies heavily on regular preventive chemotherapy. Monitoring drug efficacy is crucial to provide early warning of treatment failures. The World Health Organization (WHO) recom... Read More about Survey Design to Monitor Drug Efficacy for the Control of Soil-Transmitted Helminthiasis and Schistosomiasis.

Seroprevalence and associated risk factors of chikungunya, dengue, and Zika in eight districts in Tanzania (2021)
Journal Article
Mwanyika, G., Sindato, C., Rugarabamu, S., Rumisha, S., Karimuribo, E., Misinzo, G., …Mboera, L. (2021). Seroprevalence and associated risk factors of chikungunya, dengue, and Zika in eight districts in Tanzania. International Journal of Infectious Diseases, 111, 271-280. https://doi.org/10.1016/j.ijid.2021.08.040

Background: This study was conducted to determine the seroprevalence and risk factors of chikungunya (CHIKV), dengue (DENV), and Zika (ZIKV) viruses in Tanzania. Methods: The study covered the districts of Buhigwe, Kalambo, Kilindi, Kinondoni, Kondoa... Read More about Seroprevalence and associated risk factors of chikungunya, dengue, and Zika in eight districts in Tanzania.

Quantifying and Modeling the Acquisition and Retention of Lumpy Skin Disease Virus by Hematophagus Insects Reveals Clinically but Not Subclinically Affected Cattle Are Promoters of Viral Transmission and Key Targets for Control of Disease Outbreaks (2021)
Journal Article
Sanz-Bernardo, B., Haga, I., Wijesiriwardana, N., Basu, S., Larner, W., Diaz, A., …Beard, P. (2021). Quantifying and Modeling the Acquisition and Retention of Lumpy Skin Disease Virus by Hematophagus Insects Reveals Clinically but Not Subclinically Affected Cattle Are Promoters of Viral Transmission and Key Targets for Control of Disease Outbreaks. Journal of Virology, 95(9), https://doi.org/10.1128/JVI.02239-20

Lumpy skin disease virus (LSDV) is a vector-transmitted poxvirus that causes disease in cattle. Vector species involved in LSDV transmission and their ability to acquire and transmit the virus are poorly characterized. Using a highly representative b... Read More about Quantifying and Modeling the Acquisition and Retention of Lumpy Skin Disease Virus by Hematophagus Insects Reveals Clinically but Not Subclinically Affected Cattle Are Promoters of Viral Transmission and Key Targets for Control of Disease Outbreaks.

Bioinformatic Analysis of the Campylobacter jejuni Type VI Secretion System and Effector Prediction (2021)
Journal Article
Robinson, L., Liaw, J., Omole, Z., Xia, D., van Vliet, A., Corcionivoschi, N., …Gundogdu, O. (2021). Bioinformatic Analysis of the Campylobacter jejuni Type VI Secretion System and Effector Prediction. Frontiers in Microbiology, 12, https://doi.org/10.3389/fmicb.2021.694824

The Type VI Secretion System (T6SS) has important roles relating to bacterial antagonism, subversion of host cells, and niche colonisation. Campylobacter jejuni is one of the leading bacterial causes of human gastroenteritis worldwide and is a commen... Read More about Bioinformatic Analysis of the Campylobacter jejuni Type VI Secretion System and Effector Prediction.

Targeted strategies for the management of wildlife diseases: the case of brucellosis in Alpine ibex (2021)
Journal Article
Lambert, S., Thebault, A., Rossi, S., Marchand, P., Petit, E., Toigo, C., & Gilot-Fromont, E. (2021). Targeted strategies for the management of wildlife diseases: the case of brucellosis in Alpine ibex. Veterinary Record, 52(1), https://doi.org/10.1186/s13567-021-00984-0

The management of infectious diseases in wildlife reservoirs is challenging and faces several limitations. However, detailed knowledge of host-pathogen systems often reveal heterogeneity among the hosts' contribution to transmission. Management strat... Read More about Targeted strategies for the management of wildlife diseases: the case of brucellosis in Alpine ibex.

Genetic Determinants of Receptor-Binding Preference and Zoonotic Potential of H9N2 Avian Influenza Viruses (2021)
Journal Article
Peacock, T., Sealy, J., Harvey, W., Benton, D., Reeve, R., & Iqbal, M. (2021). Genetic Determinants of Receptor-Binding Preference and Zoonotic Potential of H9N2 Avian Influenza Viruses. Journal of Virology, 95(5), https://doi.org/10.1128/JVI.01651-20

Receptor recognition and binding is the first step of viral infection and a key determinant of host specificity. The inability of avian influenza viruses to effectively bind human-like sialylated receptors is a major impediment to their efficient tra... Read More about Genetic Determinants of Receptor-Binding Preference and Zoonotic Potential of H9N2 Avian Influenza Viruses.

Epidemiology of Bovine Tuberculosis and Its Zoonotic Implication in Addis Ababa Milkshed, Central Ethiopia (2021)
Journal Article
Tulu, B., Zewede, A., Belay, M., Zeleke, M., Girma, M., Tegegn, M., …Ameni, G. (2021). Epidemiology of Bovine Tuberculosis and Its Zoonotic Implication in Addis Ababa Milkshed, Central Ethiopia. Frontiers in Veterinary Science, 8, https://doi.org/10.3389/fvets.2021.595511

Bovine tuberculosis (bTB) continues to be one of the most widely distributed chronic infectious diseases of zoonotic importance, which causes a significant economic loss in animal production. A cross-sectional study was conducted to estimate the prev... Read More about Epidemiology of Bovine Tuberculosis and Its Zoonotic Implication in Addis Ababa Milkshed, Central Ethiopia.

Characterization of contemporary 2010.1 H3N2 swine influenza A viruses circulating in United States pigs (2021)
Journal Article
Powell, J., Abente, E., Chang, J., Souza, C., Rajao, D., Anderson, T., …Vincent, A. (2021). Characterization of contemporary 2010.1 H3N2 swine influenza A viruses circulating in United States pigs. Journal of Virology, 553, 94-101. https://doi.org/10.1016/j.virol.2020.11.006

In 2012, swine influenza surveillance detected a novel reassorted influenza A virus (IAV) strain containing human-seasonal hemagglutinin (HA) and neuraminidase (NA). Subsequently, these viruses reassorted, maintaining only the human-origin H3, which... Read More about Characterization of contemporary 2010.1 H3N2 swine influenza A viruses circulating in United States pigs.

Risk Factors for Middle East Respiratory Syndrome Coronavirus Infection among Camel Populations, Southern Jordan, 2014-2018 (2021)
Journal Article
Holloway, P., Gibson, M., van Doremalen, N., Nash, S., Holloway, T., Letko, M., …Guitian, J. (2021). Risk Factors for Middle East Respiratory Syndrome Coronavirus Infection among Camel Populations, Southern Jordan, 2014-2018. Emerging Infectious Disease, 27(9), 2301-2311. https://doi.org/10.3201/eid2709.203508

After the first detection of Middle East respiratory syndrome coronavirus (MERS-CoV) in camels in Jordan in 2013, we conducted 2 consecutive surveys in 2014-2015 and 2017-2018 investigating risk factors for MERS-CoV infection among camel populations... Read More about Risk Factors for Middle East Respiratory Syndrome Coronavirus Infection among Camel Populations, Southern Jordan, 2014-2018.

Age and Sex Differences in Load-Induced Tibial Cortical Bone Surface Strain Maps (2021)
Journal Article
Carriero, A., Javaheri, B., Kazeruni, N., Pitsillides, A., & Shefelbine, S. (2021). Age and Sex Differences in Load-Induced Tibial Cortical Bone Surface Strain Maps. JBMR Plus, 5(3), https://doi.org/10.1002/jbm4.10467

Bone adapts its architecture to the applied load; however, it is still unclear how bone mechano-adaptation is coordinated and why potential for adaptation adjusts during the life course. Previous animal models have suggested strain as the mechanical... Read More about Age and Sex Differences in Load-Induced Tibial Cortical Bone Surface Strain Maps.

Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon (2021)
Journal Article
Finney, L., Glanville, N., Farne, H., Aniscenko, J., Fenwick, P., Kemp, S., …Singanayagam, A. (2021). Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon. Journal of Allergy and Clinical Immunology, 147(2), 510-+. https://doi.org/10.1016/j.jaci.2020.09.034

Background: The mechanisms underlying altered susceptibility and propensity to severe Coronavirus disease 2019 (COVID-19) disease in at-risk groups such as patients with chronic obstructive pulmonary disease (COPD) are poorly understood. Inhaled cort... Read More about Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon.

Hybridized Zoonotic Schistosoma Infections Result in Hybridized Morbidity Profiles: A Clinical Morbidity Study amongst Co-Infected Human Populations of Senegal (2021)
Journal Article
Fall, C., Lambert, S., Leger, E., Yasenev, L., Garba, A., Diop, S., …Webster, J. (2021). Hybridized Zoonotic Schistosoma Infections Result in Hybridized Morbidity Profiles: A Clinical Morbidity Study amongst Co-Infected Human Populations of Senegal. Microorganisms, 9(8), https://doi.org/10.3390/microorganisms9081776

Hybridization of infectious agents is a major emerging public and veterinary health concern at the interface of evolution, epidemiology, and control. Whilst evidence of the extent of hybridization amongst parasites is increasing, their impact on morb... Read More about Hybridized Zoonotic Schistosoma Infections Result in Hybridized Morbidity Profiles: A Clinical Morbidity Study amongst Co-Infected Human Populations of Senegal.

Avian Influenza Risk Environment: Live Bird Commodity Chains in Chattogram, Bangladesh (2021)
Journal Article
Hog, E., Fournie, G., Hoque, M., Mahmud, R., Pfeiffer, D., & Barnett, T. (2021). Avian Influenza Risk Environment: Live Bird Commodity Chains in Chattogram, Bangladesh. Frontiers in Veterinary Science, 8, https://doi.org/10.3389/fvets.2021.694753

In this paper, we identify behaviours in live bird commodity chains in Chattogram, Bangladesh, which may influence the risk of pathogen emergence and transmission: the nature of poultry trade, value appropriation and selling sick or infected birds. E... Read More about Avian Influenza Risk Environment: Live Bird Commodity Chains in Chattogram, Bangladesh.

Activation of Dendritic Cells in Tonsils Is Associated with CD8 T Cell Responses following Vaccination with Live Attenuated Classical Swine Fever Virus (2021)
Journal Article
Soldevila, F., Edwards, J., Graham, S., Crooke, H., Werling, D., & Steinbach, F. (2021). Activation of Dendritic Cells in Tonsils Is Associated with CD8 T Cell Responses following Vaccination with Live Attenuated Classical Swine Fever Virus. International Journal of Molecular Sciences, 22(16), https://doi.org/10.3390/ijms22168795

Classical swine fever (CSF) is a highly contagious disease caused by the classical swine fever virus (CSFV). The live attenuated C-strain vaccine is highly efficacious, initiating protection within several days of delivery. The vaccine strain is dete... Read More about Activation of Dendritic Cells in Tonsils Is Associated with CD8 T Cell Responses following Vaccination with Live Attenuated Classical Swine Fever Virus.

Diverging patterns of introgression from Schistosoma bovis across S. haematobium African lineages (2021)
Journal Article
Rey, O., Toulza, E., Chaparro, C., Allienne, J., Kincaid-Smith, J., Mathieu-Begne, E., …Boissier, J. (2021). Diverging patterns of introgression from Schistosoma bovis across S. haematobium African lineages. PLoS Pathogens, 17(2), https://doi.org/10.1371/journal.ppat.1009313

Author summary Hybridization is a fascinating evolutionary phenomenon that raises the question of how species maintain their integrity. Inter-species hybridization occurs between certain Schistosoma species that can cause important public health and... Read More about Diverging patterns of introgression from Schistosoma bovis across S. haematobium African lineages.

Splenic Nerve Neuromodulation Reduces Inflammation and Promotes Resolution in Chronically Implanted Pigs (2021)
Journal Article
Sokal, D., McSloy, A., Donega, M., Kirk, J., Colas, R., Dolezalova, N., …Perkins, J. (2021). Splenic Nerve Neuromodulation Reduces Inflammation and Promotes Resolution in Chronically Implanted Pigs. Frontiers in Immunology, 12, https://doi.org/10.3389/fimmu.2021.649786

Neuromodulation of the immune system has been proposed as a novel therapeutic strategy for the treatment of inflammatory conditions. We recently demonstrated that stimulation of near-organ autonomic nerves to the spleen can be harnessed to modulate t... Read More about Splenic Nerve Neuromodulation Reduces Inflammation and Promotes Resolution in Chronically Implanted Pigs.