Probing Differences in Gene Essentiality Between the Human and Animal Adapted Lineages of the Mycobacterium tuberculosis Complex Using TnSeq

Gibson, AJ; Passmore, IJ; Faulkner, V; Xia, D; Nobeli, I; Stiens, J; Willcocks, S; Clark, TG; Sobkowiak, B; Werling, D; Villarreal-Ramos, B; Wren, BW; Kendall, SL

doi:10.3389/fvets.2021.760717

Gastroesophageal intussusception and extreme esophageal dilatation secondary to bilateral laryngeal paralysis in a cat (2021)
Journal Article
Tayler, S., Mullowney, D., Lataretu, A., Plested, M., Tuan, J., & Kathrani, A. (2021). Gastroesophageal intussusception and extreme esophageal dilatation secondary to bilateral laryngeal paralysis in a cat. Journal of Veterinary Internal Medicine, 35(2), 1088-1092. https://doi.org/10.1111/jvim.16056

Gastroesophageal intussusception, extreme esophageal dilatation, and laryngeal paralysis are individually rare clinical entities in cats and the simultaneous occurrence in a single animal has not been described. We describe these 3 conditions occurri... Read More about Gastroesophageal intussusception and extreme esophageal dilatation secondary to bilateral laryngeal paralysis in a cat.

A highly prevalent SINE mutation in the myostatin (MSTN) gene promoter is associated with low circulating myostatin concentration in Thoroughbred racehorses (2021)
Journal Article
O'Hara, V., Cowan, A., Riddell, D., Massey, C., Martin, J., & Piercy, R. (2021). A highly prevalent SINE mutation in the myostatin (MSTN) gene promoter is associated with low circulating myostatin concentration in Thoroughbred racehorses. Scientific Reports, 11(1), https://doi.org/10.1038/s41598-021-86783-1

Horse racing is a popular and financially important industry worldwide and researchers and horse owners are interested in genetic and training influences that maximise athletic performance. An association has been found between the presence of a shor... Read More about A highly prevalent SINE mutation in the myostatin (MSTN) gene promoter is associated with low circulating myostatin concentration in Thoroughbred racehorses.

Pharmacokinetics of Colistin in the Gastrointestinal Tract of Poultry Following Dosing via Drinking Water and Its Bactericidal Impact on Enteric Escherichia coli (2021)
Journal Article
Mead, A., Richez, P., Azzariti, S., & Pelligand, L. (2021). Pharmacokinetics of Colistin in the Gastrointestinal Tract of Poultry Following Dosing via Drinking Water and Its Bactericidal Impact on Enteric Escherichia coli. Frontiers in Veterinary Science, 8, https://doi.org/10.3389/fvets.2021.698135

Colistin, a last-line antibiotic of major importance in veterinary medicine and of critical importance in human medicine, is authorized to treat gastrointestinal (enteric) infections caused by non-invasive Escherichia coli in multiple veterinary spec... Read More about Pharmacokinetics of Colistin in the Gastrointestinal Tract of Poultry Following Dosing via Drinking Water and Its Bactericidal Impact on Enteric Escherichia coli.

Differential rotational movement and symmetry values of the thoracolumbosacral region in high-level dressage horses when trotting (2021)
Journal Article
MacKechnie-Guire, R., & Pfau, T. (2021). Differential rotational movement and symmetry values of the thoracolumbosacral region in high-level dressage horses when trotting. PLoS ONE, 16(5), https://doi.org/10.1371/journal.pone.0251144

High-level dressage horses regularly perform advanced movements, requiring coordination and force transmission between front and hind limbs across the thoracolumbosacral region. This study aimed at quantifying kinematic differences in dressage horses... Read More about Differential rotational movement and symmetry values of the thoracolumbosacral region in high-level dressage horses when trotting.

Magnetic resonance imaging of the caudal portion of the digastric muscle in canine idiopathic facial neuropathy (2021)
Journal Article
McGregor, O., Plested, M., & Beltran, E. (2021). Magnetic resonance imaging of the caudal portion of the digastric muscle in canine idiopathic facial neuropathy. Veterinary Radiology and Ultrasound, 62(4), 455-462. https://doi.org/10.1111/vru.12974

Idiopathic is the most common etiology for acute onset of facial neuropathy in dogs with limited number of studies describing MRI characteristics. A retrospective, observational study was performed using archived records, aiming to describe the MRI f... Read More about Magnetic resonance imaging of the caudal portion of the digastric muscle in canine idiopathic facial neuropathy.

Musculoskeletal magnetic resonance imaging in the DE50-MD dog model of Duchenne muscular dystrophy (2021)
Journal Article
Hornby, N., Drees, R., Harron, R., Chang, R., Wells, D., & Piercy, R. (2021). Musculoskeletal magnetic resonance imaging in the DE50-MD dog model of Duchenne muscular dystrophy. Neuromuscular Disorders, 31(8), 736-751. https://doi.org/10.1016/j.nmd.2021.05.010

The DE50-MD canine model of Duchenne muscular dystrophy (DMD) has a dystrophin gene splice site mutation causing deletion of exon 50, an out-of-frame transcript and absence of dystrophin expression in striated muscles. We hypothesized that the muscul... Read More about Musculoskeletal magnetic resonance imaging in the DE50-MD dog model of Duchenne muscular dystrophy.

Treatment failure in hyperthyroid cats after radioiodine (I-131) injection (2021)
Journal Article
Mullowney, D., Chang, Y., Glanemann, B., & Syme, H. (2021). Treatment failure in hyperthyroid cats after radioiodine (I-131) injection. Journal of Veterinary Internal Medicine, 35(4), 1688-1696. https://doi.org/10.1111/jvim.16161

Background There is limited published information on the outcome for cats where total thyroxine concentration (TT4) remains elevated after treatment with radioactive iodine (RAI). Objective To determine the frequency of, and predictors for, subsequen... Read More about Treatment failure in hyperthyroid cats after radioiodine (I-131) injection.

Differential Rotational Movement of the Thoracolumbosacral Spine in High-Level Dressage Horses Ridden in a Straight Line, in Sitting Trot and Seated Canter Compared to In-Hand Trot (2021)
Journal Article
MacKechnie-Guire, R., & Pfau, T. (2021). Differential Rotational Movement of the Thoracolumbosacral Spine in High-Level Dressage Horses Ridden in a Straight Line, in Sitting Trot and Seated Canter Compared to In-Hand Trot. Animals, 11(3), https://doi.org/10.3390/ani11030888

Simple Summary As part of the investigative process of "loss of athletic performance", quantitative data may help veterinary decision making when assessing equine back dysfunction. Ranges of motion of differential rotational movement were quantified... Read More about Differential Rotational Movement of the Thoracolumbosacral Spine in High-Level Dressage Horses Ridden in a Straight Line, in Sitting Trot and Seated Canter Compared to In-Hand Trot.

Waterhouse-Friderichsen syndrome in a cat with Klebsiella spp. infection (2021)
Journal Article
Cole, L., Hardas, A., Priestnall, S., & Tinson, E. (2021). Waterhouse-Friderichsen syndrome in a cat with Klebsiella spp. infection. Journal of Veterinary Emergency and Critical Care, 31(4), 531-536. https://doi.org/10.1111/vec.13063

Objective To describe a case of Waterhouse-Friderichsen syndrome of adrenocortical failure in a cat with Klebsiella spp. infection. Case Summary A 12-year-old male neutered domestic short-haired cat was referred for respiratory failure requiring mech... Read More about Waterhouse-Friderichsen syndrome in a cat with Klebsiella spp. infection.

Sustainable veterinary anaesthesia: single centre audit of oxygen and inhaled anaesthetic consumption and comparisons to a hypothetical model (2021)
Journal Article
McMillan, M. (2021). Sustainable veterinary anaesthesia: single centre audit of oxygen and inhaled anaesthetic consumption and comparisons to a hypothetical model. Journal of Small Animal Practice, 62(6), 420-427. https://doi.org/10.1111/jsap.13316

Objectives Single centre carbon footprint audit of oxygen and inhaled anaesthetic agent consumption. Study design: Retrospective audit with hypothetical intervention. Materials and Methods Records of 100 consecutive anaesthetics were examined. Consum... Read More about Sustainable veterinary anaesthesia: single centre audit of oxygen and inhaled anaesthetic consumption and comparisons to a hypothetical model.

Influence of endocrine disease on l-lactate concentrations in blood of ponies (2021)
Journal Article
Dunkel, B., Knowles, E., Chang, Y., & Menzies-Gow, N. (2021). Influence of endocrine disease on l-lactate concentrations in blood of ponies. Journal of Veterinary Internal Medicine, 35(3), 1582-1588. https://doi.org/10.1111/jvim.16079

Background Blood l-lactate concentrations are higher in people with developing or established diabetes mellitus and insulin resistance. Objectives To investigate whether blood l-lactate concentrations are positively correlated with measures of insuli... Read More about Influence of endocrine disease on l-lactate concentrations in blood of ponies.

Optimisation and validation of immunohistochemical axonal markers for morphological and functional characterisation of equine peripheral nerves (2021)
Journal Article
Almuhanna, A., Cahalan, S., Lane, A., Goodwin, D., Perkins, J., & Piercy, R. (2021). Optimisation and validation of immunohistochemical axonal markers for morphological and functional characterisation of equine peripheral nerves. Equine Veterinary Journal, 53(6), 1188-1198. https://doi.org/10.1111/evj.13403

Background: Horses are affected by various peripheral nerve disorders but defining their aetiology and pathophysiology is hampered by limited understanding of associated morphological and pathological changes and involvement of specific axonal types.... Read More about Optimisation and validation of immunohistochemical axonal markers for morphological and functional characterisation of equine peripheral nerves.

Anaesthetic and perioperative management of a dog with biventricular congestive heart failure and advanced second-degree atrioventricular block (2021)
Journal Article
Foster, A., Seo, J., & Veres-Nyeki, K. (2021). Anaesthetic and perioperative management of a dog with biventricular congestive heart failure and advanced second-degree atrioventricular block. Vet Record Case Reports, 9(3), https://doi.org/10.1002/vrc2.94

A 7-year-old male neutered Cocker Spaniel presented with a 6-h history of severe tachypnoea. Cardiac evaluation revealed advanced second-degree atrioventricular block (2AVB) and biventricular congestive heart failure (CHF). Due to concerns of impendi... Read More about Anaesthetic and perioperative management of a dog with biventricular congestive heart failure and advanced second-degree atrioventricular block.

Acquired cervical scoliosis in two dogs with inflammatory central nervous system disease (2021)
Journal Article
Poad, L., De Decker, S., & Fenn, J. (2021). Acquired cervical scoliosis in two dogs with inflammatory central nervous system disease. Journal of Veterinary Internal Medicine, 35(5), 2421-2426. https://doi.org/10.1111/jvim.16257

Acquired cervical scoliosis previously has been reported in dogs as a clinical sign associated with Chiari-like malformation and syringomyelia but has not been described with inflammatory central nervous system disease. A 9-month-old Flat-Coated Retr... Read More about Acquired cervical scoliosis in two dogs with inflammatory central nervous system disease.

Cardiac auscultation skills in final year veterinary students and recent veterinary graduates, referral hospital veterinary surgeons and veterinary cardiologists or cardiology residents (2021)
Journal Article
Deirdre, M., Fuentes, V., & Barfield, D. (2021). Cardiac auscultation skills in final year veterinary students and recent veterinary graduates, referral hospital veterinary surgeons and veterinary cardiologists or cardiology residents. Veterinary Record, 189(6), https://doi.org/10.1002/vetr.305

Background: Cardiac auscultation is an important part of the physical examination. This study evaluated cardiac auscultation skills in veterinary students and compared their abilities to recent veterinary graduates, referral hospital veterinary surge... Read More about Cardiac auscultation skills in final year veterinary students and recent veterinary graduates, referral hospital veterinary surgeons and veterinary cardiologists or cardiology residents.

The effect of assisted enteral feeding on treatment outcome in dogs with inflammatory protein-losing enteropathy (2021)
Journal Article
Economu, L., Chang, Y., Priestnall, S., & Kathrani, A. (2021). The effect of assisted enteral feeding on treatment outcome in dogs with inflammatory protein-losing enteropathy. Journal of Veterinary Internal Medicine, 35(3), 1297-1305. https://doi.org/10.1111/jvim.16125

Background The effect of assisted enteral feeding on treatment outcome in dogs with protein-losing enteropathy (PLE) is unknown. Objectives To determine if dogs with inflammatory PLE that had an enteral feeding tube placed had better outcome vs dogs... Read More about The effect of assisted enteral feeding on treatment outcome in dogs with inflammatory protein-losing enteropathy.

A Cohort Study Risk Factor Analysis for Endemic Disease in Pre-Weaned Dairy Heifer Calves (2021)
Journal Article
Johnson, K., Chancellor, N., & Wathes, D. (2021). A Cohort Study Risk Factor Analysis for Endemic Disease in Pre-Weaned Dairy Heifer Calves. Animals, 11(2), https://doi.org/10.3390/ani11020378

Simple Summary Most dairy heifer calves are removed from their dam and reared on milk from birth until weaning at around nine weeks of age. During this period they are susceptible to diseases which reduce their welfare and later performance in the da... Read More about A Cohort Study Risk Factor Analysis for Endemic Disease in Pre-Weaned Dairy Heifer Calves.

Equine squamous gastric disease: prevalence, impact and management (2021)
Journal Article
Hewetson, M., & Tallon, R. (2021). Equine squamous gastric disease: prevalence, impact and management. Veterinary Medicine: Research and Reports, https://doi.org/10.2147/VMRR.S235258

This narrative review explores the etiopathogenesis, clinical signs, diagnosis and treatment of ESGD (Equine Squamous Gastric Disease) and discusses the impact of this commonly encountered condition on the equine industry. ESGD refers specifically to... Read More about Equine squamous gastric disease: prevalence, impact and management.

Challenges in defining the functional, non‐coding, expressed genome of members of the Mycobacterium tuberculosis complex (2021)
Journal Article
Stiens, J., Arnvig, K. B., Kendall, S. L., & Nobeli, I. (2022). Challenges in defining the functional, non‐coding, expressed genome of members of the Mycobacterium tuberculosis complex. Molecular Microbiology, 117(1), 20-31. https://doi.org/10.1111/mmi.14862

A definitive transcriptome atlas for the non-coding expressed elements of the members of the Mycobacterium tuberculosis complex (MTBC) does not exist. Incomplete lists of non-coding transcripts can be obtained for some of the reference genomes (e.g.,... Read More about Challenges in defining the functional, non‐coding, expressed genome of members of the Mycobacterium tuberculosis complex.

Probing Differences in Gene Essentiality Between the Human and Animal Adapted Lineages of the Mycobacterium tuberculosis Complex Using TnSeq (2021)
Journal Article
Gibson, A., Passmore, I., Faulkner, V., Xia, D., Nobeli, I., Stiens, J., …Kendall, S. (2021). Probing Differences in Gene Essentiality Between the Human and Animal Adapted Lineages of the Mycobacterium tuberculosis Complex Using TnSeq. Frontiers in Veterinary Science, 8, https://doi.org/10.3389/fvets.2021.760717

Members of the Mycobacterium tuberculosis complex (MTBC) show distinct host adaptations, preferences and phenotypes despite being >99% identical at the nucleic acid level. Previous studies have explored gene expression changes between the members, ho... Read More about Probing Differences in Gene Essentiality Between the Human and Animal Adapted Lineages of the Mycobacterium tuberculosis Complex Using TnSeq.

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