Outputs (122)

Limb myology and muscle architecture of the Indian rhinoceros Rhinoceros unicornis and the white rhinoceros Ceratotherium simum (Mammalia: Rhinocerotidae) (2021)
Journal Article
Hutchinson, J., Etienne, C., & Houssaye, A. (2021). Limb myology and muscle architecture of the Indian rhinoceros Rhinoceros unicornis and the white rhinoceros Ceratotherium simum (Mammalia: Rhinocerotidae). PeerJ, https://doi.org/10.7717/peerj.11314

Land mammals support and move their body using their musculoskeletal system. Their
musculature usually presents varying adaptations with body mass or mode of locomotion.
Rhinocerotidae is an interesting clade in this regard, as they are heavy anima... Read More about Limb myology and muscle architecture of the Indian rhinoceros Rhinoceros unicornis and the white rhinoceros Ceratotherium simum (Mammalia: Rhinocerotidae).

Future research priorities in canine epilepsy: viewpoints of owners, general practice veterinarians and neurology specialists (2021)
Journal Article
Jones, G., Volk, H., & Packer, R. (in press). Future research priorities in canine epilepsy: viewpoints of owners, general practice veterinarians and neurology specialists. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16144

Background: Epilepsy is the most common chronic neurological disease in dogs that impacts the quality of life (QoL) of affected dogs and their owners. Canine epilepsy research is expanding internationally, but where best to focus limited research tim... Read More about Future research priorities in canine epilepsy: viewpoints of owners, general practice veterinarians and neurology specialists.

Proportion and risk factors for death by euthanasia in dogs in the UK (2021)
Journal Article
O'Neill, D., Pegram, C., Gray, C., Packer, R. M., Richards, Y., Church, D. B., Brodbelt, D. C., & O’Neill, D. G. (2021). Proportion and risk factors for death by euthanasia in dogs in the UK. International Journal of Advanced Scientific Engineering and Technological Research, https://doi.org/10.1038/s41598-021-88342-0

Objectives: To report proportional euthanasia or unassisted death, as well as the demographic and clinical factors associated with euthanasia, in dogs under primary veterinary care in the UK.

Methods: A cohort study design to estimate proportional... Read More about Proportion and risk factors for death by euthanasia in dogs in the UK.

The zebrafish cardiac endothelial cell – roles in development and regeneration (2021)
Journal Article
Pellet-Many, C., Lowe, V., & Wisniewski, L. (2021). The zebrafish cardiac endothelial cell – roles in development and regeneration. Journal of Cardiovascular Development and Disease,

In zebrafish, the spatiotemporal development of the vascular system is well described due to its stereotypical nature. However, the cellular and molecular mechanisms orchestrating post embryonic vascular development, the maintenance of vascular homeo... Read More about The zebrafish cardiac endothelial cell – roles in development and regeneration.

Effect of diet and non-esterified fatty acid levels on global transcriptomic profiles in circulating peripheral blood mononuclear cells in early lactation dairy cows (2021)
Journal Article
Cheng, Z., Wylie, A., Ferris, C., Ingvartsen, K., Wathes, D., & GplusE consortium. (in press). Effect of diet and non-esterified fatty acid levels on global transcriptomic profiles in circulating peripheral blood mononuclear cells in early lactation dairy cows. Journal of Dairy Science,

Integrating protein networks and machine learning for disease stratification in the Hereditary Spastic Paraplegias (2021)
Journal Article
Vavouraki, N., Tomkins, J. E., Kara, E., Houlden, H., Hardy, J., Tindall, M. J., Lewis, P. A., & Manzoni, C. (2021). Integrating protein networks and machine learning for disease stratification in the Hereditary Spastic Paraplegias. iScience, 102484. https://doi.org/10.1016/j.isci.2021.102484

Machine-learning based prediction of Cushing’s syndrome in dogs attending UK primary-care veterinary practice (2021)
Journal Article
Schofield, I., Brodbelt, D. C., Kennedy, N., Niessen, S. J. M., Church, D. B., Geddes, R. F., & O’Neill, D. G. (2021). Machine-learning based prediction of Cushing’s syndrome in dogs attending UK primary-care veterinary practice. Scientific Reports, 11(1), https://doi.org/10.1038/s41598-021-88440-z

Cushing’s syndrome is an endocrine disease in dogs that negatively impacts upon the quality-of-life of affected animals. Cushing’s syndrome can be a challenging diagnosis to confirm, therefore new methods to aid diagnosis are warranted. Four machine-... Read More about Machine-learning based prediction of Cushing’s syndrome in dogs attending UK primary-care veterinary practice.

Predictive Simulations of Musculoskeletal Function and Jumping Performance in a Generalized Bird (2021)
Journal Article
Bishop, P., Falisse, A., De Groote, F., & Hutchinson, J. (in press). Predictive Simulations of Musculoskeletal Function and Jumping Performance in a Generalized Bird. Integrative Organismal Biology, https://doi.org/10.1093/iob/obab006

Jumping is a common, but demanding, behavior that many animals employ during everyday activity. In contrast to jump-specialists such as anurans and some primates, jumping biomechanics and the factors that influence performance remains little studied... Read More about Predictive Simulations of Musculoskeletal Function and Jumping Performance in a Generalized Bird.

A Retrospective Case Study into the Effect of Hoof Lesions on the Lying Behaviour of Holstein–Friesian in a Loose-Housed System (2021)
Journal Article
Ji, K., Booth, R., & Blackie, N. (in press). A Retrospective Case Study into the Effect of Hoof Lesions on the Lying Behaviour of Holstein–Friesian in a Loose-Housed System. Animals, https://doi.org/10.3390/ani11041120

The association between hoof lesions and lying behaviour was assessed on a Holstein–Friesian dairy farm in England. Twenty-nine cows were included in the study. Cows with claw horn disruption lesions (CHDL, n = 8), soft tissue lesions (STL, n = 6), a... Read More about A Retrospective Case Study into the Effect of Hoof Lesions on the Lying Behaviour of Holstein–Friesian in a Loose-Housed System.

Comparison of the Ability of High and Low Virulence Strains of noncytopathic Bovine Viral Diarrhoea Virus-1 to Modulate Expression of Interferon Tau Stimulated Genes in Bovine Endometrium (2021)
Journal Article
Cheng, Z., Wang, K., Thomas, C., Zhang, S., & Wathes, D. C. (2021). Comparison of the Ability of High and Low Virulence Strains of noncytopathic Bovine Viral Diarrhoea Virus-1 to Modulate Expression of Interferon Tau Stimulated Genes in Bovine Endometrium. Frontiers in Veterinary Science,

Bovine Viral Diarrhoea virus (BVDV) is a pestivirus with a single-stranded, positive sense RNA genome. It is endemic in many cattle populations, causing major economic losses in part due to reduced fertility. BVDV exhibits great genetic diversity an... Read More about Comparison of the Ability of High and Low Virulence Strains of noncytopathic Bovine Viral Diarrhoea Virus-1 to Modulate Expression of Interferon Tau Stimulated Genes in Bovine Endometrium.

Computational modelling of muscle fibre operating ranges in the hindlimb of a small ground bird (Eudromia elegans), with implications for modelling locomotion in extinct species (2021)
Journal Article
Hutchinson, J. R., Allen, V. R., Bishop, P. J., Michel, K. B., Falisse, A., De Groote, F., & Cuff, A. R. (in press). Computational modelling of muscle fibre operating ranges in the hindlimb of a small ground bird (Eudromia elegans), with implications for modelling locomotion in extinct species. PLoS Computational Biology, 17(4), e1008843. https://doi.org/10.1371/journal.pcbi.1008843

Demographic History, Adaptation, and NRAP Convergent Evolution at Amino Acid Residue 100 in the World Northernmost Cattle from Siberia (2021)
Journal Article
Buggiotti, L., Yurchenko, A. A., Yudin, N. S., Jagt, C. J. V., Vorobieva, N. V., Kusliy, M. F., Vasiliev, S. K., Rodionov, A. N., Boronetskaya, O. I., Zinovieva, N. A., Graphodatsky, A. S., Daetwyler, H. D., & Larkin, D. M. (2021). Demographic History, Adaptation, and NRAP Convergent Evolution at Amino Acid Residue 100 in the World Northernmost Cattle from Siberia. Molecular Biology and Evolution,

Native cattle breeds represent an important cultural heritage. They are a reservoir of genetic variation useful for properly responding to agriculture needs in the light of ongoing climate changes. Evolutionary processes that occur in response to ext... Read More about Demographic History, Adaptation, and NRAP Convergent Evolution at Amino Acid Residue 100 in the World Northernmost Cattle from Siberia.

Frequency, breed predisposition and demographic risk factors for overweight status in dogs in the UK (2021)
Journal Article
Pegram, C., Raffan, E., White, E., Ashworth, A., Brodbelt, D., Church, D., & O'Neill, D. (2021). Frequency, breed predisposition and demographic risk factors for overweight status in dogs in the UK. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13325

Objectives: To evaluate the prevalence and risk factors for overweight status in dogs under primary veterinary care in the UK.
Methods: A retrospective study design was used to estimate the one-year (2016) period prevalence of overweight status. The... Read More about Frequency, breed predisposition and demographic risk factors for overweight status in dogs in the UK.

The evolution of pelvic limb muscle moment arms in bird-line archosaurs (2021)
Journal Article
Allen, V. R., Kilbourne, B. M., & Hutchinson, J. R. (2021). The evolution of pelvic limb muscle moment arms in bird-line archosaurs. Science Advances, 7(12), eabe2778. https://doi.org/10.1126/sciadv.abe2778

Global network analysis in Schizosaccharomyces pombe reveals three distinct consequences of the common 1-kb deletion causing juvenile CLN3 disease (2021)
Journal Article
Russell, C., Minnis, C. J., Townsend, S., Petschnigg, J., Tinelli, E., Bähler, J., Russell, C., & Mole, S. E. (2021). Global network analysis in Schizosaccharomyces pombe reveals three distinct consequences of the common 1-kb deletion causing juvenile CLN3 disease. Scientific Reports,

Juvenile CLN3 disease is a recessively inherited paediatric neurodegenerative disorder, with most patients homozygous for a 1-kb intragenic deletion in CLN3. The btn1 gene is the Schizosaccharomyces pombe orthologue of CLN3. Here, we have extended th... Read More about Global network analysis in Schizosaccharomyces pombe reveals three distinct consequences of the common 1-kb deletion causing juvenile CLN3 disease.

Dog breeds and body conformations with predisposition to osteosarcoma in the UK: a case-control study (2021)
Journal Article
Edmunds, G. L., Smalley, M. J., Beck, S., Errington, R. J., Gould, S., Winter, H., Brodbelt, D. C., & O’Neill, D. G. (2021). Dog breeds and body conformations with predisposition to osteosarcoma in the UK: a case-control study. Canine Medicine and Genetics, 8(1), https://doi.org/10.1186/s40575-021-00100-7

A Grand Challenge for Animal Science: Multiple Goals – Convergent and Divergent (2021)
Journal Article
Nicol, C. (2021). A Grand Challenge for Animal Science: Multiple Goals – Convergent and Divergent. Frontiers in Animal Science, 2, https://doi.org/10.3389/fanim.2021.640503

People want safe, affordable, high quality animal-derived foods, produced in ways that protect rural livelihoods and cultures and which are derived from animals that lived healthy and happy lives. These aspirations must be set alongside the overarchi... Read More about A Grand Challenge for Animal Science: Multiple Goals – Convergent and Divergent.

Sensitivity of the Natriuretic Peptide/cGMP System to Hyperammonaemia in Rat C6 Glioma Cells and GPNT Brain Endothelial Cells (2021)
Journal Article
Regan, J., Mirczuk, S., Scudder, C., Stacey, E., Khan, S., Powles, T., Dennis-Berron, J. S., Ginley-Hidinger, M., Mcgonnell, I., Volk, H., Strickland, R., Tivers, M., Lawson, C., Lipscomb, V., & Fowkes, R. (2021). Sensitivity of the Natriuretic Peptide/cGMP System to Hyperammonaemia in Rat C6 Glioma Cells and GPNT Brain Endothelial Cells. Cells, https://doi.org/10.3390/cells10020398

C-type natriuretic peptide (CNP) is the major natriuretic peptide of the central nervous system and acts via its selective guanylyl cyclase-B (GC-B) receptor to regulate cGMP production in neurons, astrocytes and endothelial cells. CNP is implicated... Read More about Sensitivity of the Natriuretic Peptide/cGMP System to Hyperammonaemia in Rat C6 Glioma Cells and GPNT Brain Endothelial Cells.

Pituitary Neoplasm Nomenclature Workshop: Does Adenoma Stand the Test of Time? (2021)
Journal Article
Ho, K., Fleseriu, M., Kaiser, U., Salvatori, R., Brue, T., Lopes, M. B., Kunz, P., Molitch, M., Camper, S. A., Gadelha, M., Syro, L. V., Laws, E., Reincke, M., Nishioka, H., Grossman, A., Barkan, A., Casanueva, F., Wass, J., Mamelak, A., Katznelson, L., …Melmed, S. (2021). Pituitary Neoplasm Nomenclature Workshop: Does Adenoma Stand the Test of Time?. Journal of the Endocrine Society, 5(3), https://doi.org/10.1210/jendso/bvaa205

The WHO Classification of Endocrine Tumours designates pituitary neoplasms as adenomas. A proposed nomenclature change to pituitary neuroendocrine tumors (PitNETs) has been met with concern by some stakeholder groups. The Pituitary Society coordinate... Read More about Pituitary Neoplasm Nomenclature Workshop: Does Adenoma Stand the Test of Time?.

Systematic analysis reveals that colony housing aligns gait profiles and strengthens link between 1 histological and micro-CT bone markers in rat models of osteoarthritis 2 Short running title: Colony housing strengthens osteoarthritis research (2021)
Journal Article
Chang, Y.-M., Menges, S., Westhof, A., Kleinschmidt-Doerr, K., Brenneis, C., Pitsillides, A. A., & Chang, Y.-M. (in press). Systematic analysis reveals that colony housing aligns gait profiles and strengthens link between 1 histological and micro-CT bone markers in rat models of osteoarthritis 2 Short running title: Colony housing strengthens osteoarthritis research. FASEB Journal, -. https://doi.org/10.1096/fj.202002009R