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A Functional Single-Nucleotide Polymorphism Upstream of the Collagen Type III Gene Is Associated with Catastrophic Fracture Risk in Thoroughbred Horses (2023)
Journal Article
Lago, E. P., Baird, A., Blott, S. C., Mcphail, R. E., Ross, A. C., Durward-Akhurst, S. A., & Guest, D. J. (2023). A Functional Single-Nucleotide Polymorphism Upstream of the Collagen Type III Gene Is Associated with Catastrophic Fracture Risk in Thoroughbred Horses. Animals, 14(1), 116. https://doi.org/10.3390/ani14010116

Fractures caused by bone overloading are a leading cause of euthanasia in Thoroughbred racehorses. The risk of fatal fracture has been shown to be influenced by both environmental and genetic factors but, to date, no specific genetic mechanisms unde... Read More about A Functional Single-Nucleotide Polymorphism Upstream of the Collagen Type III Gene Is Associated with Catastrophic Fracture Risk in Thoroughbred Horses.

Ear health and quality of life in pet rabbits of differing ear conformations: a UK questionnaire survey of signalment risk factors and effects on rabbit welfare and behaviour (2023)
Journal Article
Chivers, B., Keeler, M., & Burn, C. (2023). Ear health and quality of life in pet rabbits of differing ear conformations: a UK questionnaire survey of signalment risk factors and effects on rabbit welfare and behaviour. PLoS ONE, https://doi.org/10.1371/journal.pone.0285372

The impacts of ear disease on animal welfare and behaviour are little documented. Ear disease may be common in rabbits, but difficult to recognise, and lop-ears have previously been indicated as a risk factor for ear disease. We aimed to better under... Read More about Ear health and quality of life in pet rabbits of differing ear conformations: a UK questionnaire survey of signalment risk factors and effects on rabbit welfare and behaviour.

Exogenous interleukin-1 beta stimulation regulates equine tenocyte function and gene expression in three-dimensional culture which can be rescued by pharmacological inhibition of interleukin 1 receptor, but not nuclear factor kappa B, signaling (2023)
Journal Article
Beaumont, R. E., Smith, E. J., Zhou, L., Marr, N., Thorpe, C. T., & Guest, D. J. (in press). Exogenous interleukin-1 beta stimulation regulates equine tenocyte function and gene expression in three-dimensional culture which can be rescued by pharmacological inhibition of interleukin 1 receptor, but not nuclear factor kappa B, signaling. Molecular and Cellular Biochemistry, https://doi.org/10.1007/s11010-023-04779-z

Ear disease in pet rabbits: owner-reported data from a UK survey 2021-2022 (2023)
Dataset
Chivers, B., Keeler, M., & Burn, C. (in press). Ear disease in pet rabbits: owner-reported data from a UK survey 2021-2022. [Dataset]

Methods, analysis and interpretation of these data are published in Chivers, B. D., Keeler, M. R. D., and Burn, C. C. (2023) Ear health and quality of life in pet rabbits of differing ear conformations: a UK survey of owner-reported signalment risk... Read More about Ear disease in pet rabbits: owner-reported data from a UK survey 2021-2022.

Tumour necrosis factor alpha, Interleukin 1 beta and Interferon gamma have detrimental effects on equine tenocytes that cannot be rescued by IL-1RA or mesenchymal stromal cell-derived factors (2022)
Journal Article
Guest, D., Smith, E., Beaumont, R., McClellan, A., Sze, C., Palomino Lago, E., …Smith, R. (in press). Tumour necrosis factor alpha, Interleukin 1 beta and Interferon gamma have detrimental effects on equine tenocytes that cannot be rescued by IL-1RA or mesenchymal stromal cell-derived factors. Cell and Tissue Research, https://doi.org/10.1007/s00441-022-03726-6

Tendon injuries occur commonly in both human and equine athletes, and poor tendon regeneration leads to functionally deficient scar tissue and an increased frequency of re-injury. Despite evidence suggesting inadequate resolution of inflammation le... Read More about Tumour necrosis factor alpha, Interleukin 1 beta and Interferon gamma have detrimental effects on equine tenocytes that cannot be rescued by IL-1RA or mesenchymal stromal cell-derived factors.

Bats actively modulate membrane compliance to control camber and reduce drag (2022)
Journal Article
Cheney, J., Rehm, J., Swartz, S., & Breuer, K. (in press). Bats actively modulate membrane compliance to control camber and reduce drag. Journal of Experimental Biology, https://doi.org/10.1242/jeb.243974

Bat wing skin is exceptionally compliant and cambers significantly during flight. Plagiopatagiales proprii, arrays of small muscles embedded in the armwing membrane, are activated during flight and are hypothesized to modulate membrane tension. We ex... Read More about Bats actively modulate membrane compliance to control camber and reduce drag.

Position Statement: Minimal criteria for reporting veterinary and animal medicine research for mesenchymal stromal/stem cells in orthopaedic applications. (2022)
Journal Article
Guest, D. J., Dudhia, J., Smith, R. K., Roberts, S., Conzemius, M., Innes, J. F., …Meeson, R. L. (2022). Position Statement: Minimal criteria for reporting veterinary and animal medicine research for mesenchymal stromal/stem cells in orthopaedic applications. Frontiers in Veterinary Science, https://doi.org/10.3389/fvets.2022.817041

Mesenchymal stromal/stem cells (MSCs) are being used in an increasingly broad range of clinical applications in horses, dogs and cats. In this position statement, we aim to provide guidelines to improve reporting research involving the use of MSCs in... Read More about Position Statement: Minimal criteria for reporting veterinary and animal medicine research for mesenchymal stromal/stem cells in orthopaedic applications..

The evolutionary biomechanics of locomotor function in giant land animals (2021)
Journal Article
Hutchinson, J. (2021). The evolutionary biomechanics of locomotor function in giant land animals. Journal of Experimental Biology, https://doi.org/10.1242/jeb.217463

Giant land vertebrates have evolved more than 30 times, notably in dinosaurs and mammals. The evolutionary and biomechanical perspectives considered here unify data from extant and extinct species, assessing current theory regarding how the locomotor... Read More about The evolutionary biomechanics of locomotor function in giant land animals.

Intra-operative Raman spectroscopy and ex vivo Raman mapping for assessment of cartilage degradation (2021)
Journal Article
Gaifulina, R., Nunn, A. D. G., Draper, E. R. C., Strachan, R. K., Blake, N., Firth, S., …6ap, U. K. (2021). Intra-operative Raman spectroscopy and ex vivo Raman mapping for assessment of cartilage degradation. Applied Spectroscopy, https://doi.org/10.1016/j.clispe.2021.100012

The development of a label-free, non-destructive and safe analytical method such as Raman spectroscopy for assessing cartilage degradation is highly desirable. Compared to non-optical imaging modalities, Raman mapping offers a more sensitive means of... Read More about Intra-operative Raman spectroscopy and ex vivo Raman mapping for assessment of cartilage degradation.

Limb myology and muscle architecture of the Indian rhinoceros Rhinoceros unicornis and the white rhinoceros Ceratotherium simum (Mammalia: Rhinocerotidae) (2021)
Journal Article
Hutchinson, J., Etienne, C., & Houssaye, A. (2021). Limb myology and muscle architecture of the Indian rhinoceros Rhinoceros unicornis and the white rhinoceros Ceratotherium simum (Mammalia: Rhinocerotidae). PeerJ, https://doi.org/10.7717/peerj.11314

Land mammals support and move their body using their musculoskeletal system. Their musculature usually presents varying adaptations with body mass or mode of locomotion. Rhinocerotidae is an interesting clade in this regard, as they are heavy anima... Read More about Limb myology and muscle architecture of the Indian rhinoceros Rhinoceros unicornis and the white rhinoceros Ceratotherium simum (Mammalia: Rhinocerotidae).

Predictive Simulations of Musculoskeletal Function and Jumping Performance in a Generalized Bird (2021)
Journal Article
Bishop, P., Falisse, A., De Groote, F., & Hutchinson, J. (in press). Predictive Simulations of Musculoskeletal Function and Jumping Performance in a Generalized Bird. Integrative Organismal Biology, https://doi.org/10.1093/iob/obab006

Jumping is a common, but demanding, behavior that many animals employ during everyday activity. In contrast to jump-specialists such as anurans and some primates, jumping biomechanics and the factors that influence performance remains little studied... Read More about Predictive Simulations of Musculoskeletal Function and Jumping Performance in a Generalized Bird.

Computational modelling of muscle fibre operating ranges in the hindlimb of a small ground bird (Eudromia elegans), with implications for modelling locomotion in extinct species (2021)
Journal Article
Hutchinson, J. R., Allen, V. R., Bishop, P. J., Michel, K. B., Falisse, A., De Groote, F., & Cuff, A. R. (in press). Computational modelling of muscle fibre operating ranges in the hindlimb of a small ground bird (Eudromia elegans), with implications for modelling locomotion in extinct species. PLoS Computational Biology, 17(4), e1008843. https://doi.org/10.1371/journal.pcbi.1008843

Limb work and joint work minimization reveal an energetic benefit to the elbows-back, knees-forward limb design in parasagittal quadrupeds (2020)
Journal Article
Usherwood, J. R., & Granatosky, M. C. (2020). Limb work and joint work minimization reveal an energetic benefit to the elbows-back, knees-forward limb design in parasagittal quadrupeds. Proceedings of the Royal Society B: Biological Sciences, 287(1940), 20201517. https://doi.org/10.1098/rspb.2020.1517

Quadrupedal animal locomotion is energetically costly. We explore two forms of mechanical work that may be relevant in imposing these physiological demands. Limb work, due to the forces and velocities between the stance foot and the centre of mass, c... Read More about Limb work and joint work minimization reveal an energetic benefit to the elbows-back, knees-forward limb design in parasagittal quadrupeds.

Dual neutralisation of IL-17F and IL-17A with bimekizumab blocks inflammation-driven osteogenic differentiation of human periosteal cells (2020)
Journal Article
Shah, M., Maroof, A., Gikas, P., Mittal, G., Keen, R., Baeten, D., …Roberts, S. J. (2020). Dual neutralisation of IL-17F and IL-17A with bimekizumab blocks inflammation-driven osteogenic differentiation of human periosteal cells. RMD Open, 6(2), e001306. https://doi.org/10.1136/rmdopen-2020-001306

Objectives Interleukin (IL)-17 signalling has been shown to be a key regulator of disease in ankylosing spondylitis (AS) with several IL-17 blockers currently clinically approved. Despite this, the role of IL-17 in bone pathology is poorly understo... Read More about Dual neutralisation of IL-17F and IL-17A with bimekizumab blocks inflammation-driven osteogenic differentiation of human periosteal cells.

Single-transcript multiplex in situ hybridisation reveals unique patterns of dystrophin isoform expression in the developing mammalian embryo (2020)
Journal Article
Hildyard, J. C. W., Crawford, A. H., Rawson, F., Riddell, D. O., Harron, R. C. M., & Piercy, R. J. (2020). Single-transcript multiplex in situ hybridisation reveals unique patterns of dystrophin isoform expression in the developing mammalian embryo. Wellcome Open Research, 5, 76. https://doi.org/10.12688/wellcomeopenres.15762.2

Background: The dystrophin gene has multiple isoforms: full-length dystrophin (dp427) is principally known for its expression in skeletal and cardiac muscle, but is also expressed in the brain, and several internal promoters give rise to shorter, N-t... Read More about Single-transcript multiplex in situ hybridisation reveals unique patterns of dystrophin isoform expression in the developing mammalian embryo.