The effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult mice (2016)
Journal Article
Heppolette, C. A. A., Chen, J.-H., Carr, S. K., Palmer, D. B., & Ozanne, S. E. (2016). The effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult mice. Oncotarget, 7(6), 6398-6409. https://doi.org/10.18632/oncotarget.7176

Environmental factors such as nutrition during early life can influence long-term health, a concept termed developmental programming. Initial research was focused towards the effects on metabolic health but more recent studies have demonstrated effec... Read More about The effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult mice.

The genomic basis of parasitism in the Strongyloides clade of nematodes (2016)
Journal Article
Hunt, V. L., Tsai, I. J., Coghlan, A., Reid, A. J., Holroyd, N., Foth, B. J., Tracey, A., Cotton, J. A., Stanley, E. J., Beasley, H., Bennett, H. M., Brooks, K., Harsha, B., Kajitani, R., Kulkarni, A., Harbecke, D., Nagayasu, E., Nichol, S., Ogura, Y., Quail, M. A., …Berriman, M. (2016). The genomic basis of parasitism in the Strongyloides clade of nematodes. Nature Genetics, 48(3), 299-307. https://doi.org/10.1038/ng.3495

Soil-transmitted nematodes, including the Strongyloides genus, cause one of the most prevalent neglected tropical diseases. Here we compare the genomes of four Strongyloides species, including the human pathogen Strongyloides stercoralis, and their c... Read More about The genomic basis of parasitism in the Strongyloides clade of nematodes.

The fast and forceful kicking strike of the secretary bird (2016)
Journal Article
Portugal, S. J., Murn, C. P., Sparkes, E. L., & Daley, M. A. (2016). The fast and forceful kicking strike of the secretary bird. Current Biology, 26(2), R58-R59. https://doi.org/10.1016/j.cub.2015.12.004

The extinct, giant giraffid Sivatherium giganteum: skeletal reconstruction and body mass estimation (2016)
Journal Article
Basu, C. K., Falkingham, P. L., & Hutchinson, J. R. (2016). The extinct, giant giraffid Sivatherium giganteum: skeletal reconstruction and body mass estimation. Biology Letters, 12(1), https://doi.org/10.1098/rsbl.2015.0940

Microvesicles and exosomes: new players in metabolic and cardiovascular disease (2016)
Journal Article
Lawson, C., Vicencio, J. M., Yellon, D. M., & Davidson, S. M. (2016). Microvesicles and exosomes: new players in metabolic and cardiovascular disease. Journal of Endocrinology, 228(2), R57-71. https://doi.org/10.1530/joe-15-0201

Fascicles and the interfascicular matrix show adaptation for fatigue resistance in energy storing tendons (2016)
Journal Article
Thorpe, C. T., Riley, G. P., Birch, H. L., Clegg, P. D., & Screen, H. R. C. (2016). Fascicles and the interfascicular matrix show adaptation for fatigue resistance in energy storing tendons. Acta Biomaterialia, 42, 308-315. https://doi.org/10.1016/j.actbio.2016.06.012

Tendon is composed of rope-like fascicles, bound together by interfascicular matrix (IFM). Our previous work shows that the IFM is critical for tendon function, facilitating sliding between fascicles to allow tendons to stretch. This function is part... Read More about Fascicles and the interfascicular matrix show adaptation for fatigue resistance in energy storing tendons.

Anatomy, morphology and evolution of the patella in squamate lizards and tuatara (Sphenodon punctatus) (2016)
Journal Article
Regnault, S., Jones, M. E. H., Pitsillides, A. A., & Hutchinson, J. R. (2016). Anatomy, morphology and evolution of the patella in squamate lizards and tuatara (Sphenodon punctatus). Journal of Anatomy, 228, 864-876. https://doi.org/10.1111/joa.12435

TSPO: kaleidoscopic 18-kDa amid biochemical pharmacology, control and targeting of mitochondria (2016)
Journal Article
Gatliff, J., & Campanella, M. (2016). TSPO: kaleidoscopic 18-kDa amid biochemical pharmacology, control and targeting of mitochondria. Biochemical Journal, 473(2), 107-21. https://doi.org/10.1042/bj20150899

A method for isolating and culturing placental cells from failed early equine pregnancies (2016)
Journal Article
Rose, B. V., Cabrera-Sharp, V., Firth, M. J., Barrelet, F. E., Bate, S., Cameron, I. J., Crabtree, J. R., Crowhurst, J., McGladdery, A. J., Neal, H., Pynn, J., Pynn, O. D., Smith, C., Wise, Z., Verheyen, K. L. P., Wathes, D. C., & De Mestre, A. M. (2016). A method for isolating and culturing placental cells from failed early equine pregnancies. Placenta, 38, 107-111. https://doi.org/10.1016/j.placenta.2015.12.014

Early pregnancy loss occurs in 6–10% of equine pregnancies making it the main cause of reproductive wastage. Despite this, reasons for the losses are known in only 16% of cases. Lack of viable conceptus material has inhibited investigations of many p... Read More about A method for isolating and culturing placental cells from failed early equine pregnancies.

Neuroprotective coordination of cell mitophagy by the ATPase Inhibitory Factor 1 (2016)
Journal Article
Matic, I., Cocco, S., Ferraina, C., Martin-Jimenez, R., Florenzano, F., Crosby, J., Lupi, R., Amadoro, G., Russell, C., Pignataro, G., Annunziato, L., Abramov, A. Y., & Campanella, M. (2016). Neuroprotective coordination of cell mitophagy by the ATPase Inhibitory Factor 1. Pharmacological Research, 103(1), 56-68. https://doi.org/10.1016/j.phrs.2015.10.010

The mitochondrial ATPase Inhibitory Factor 1 (hereafter referred to as IF1) blocks the reversal of the F1Fo-ATPsynthase to prevent detrimental consumption of cellular ATP and associated demise. Herein, we infer further its molecular physiology by ass... Read More about Neuroprotective coordination of cell mitophagy by the ATPase Inhibitory Factor 1.

Endochondral growth defect and deployment of transient chondrocyte behaviours underlie osteoarthritis onset in a natural murine model (2016)
Journal Article
Staines, K. A., Madi, K., Mirczuk, S. M., Parker, S., Burleigh, A., Poulet, B., Hopkinson, M., Bodey, A. J., Fowkes, R. C., Farquharson, C., Lee, P. D., & Pitsillides, A. A. (2016). Endochondral growth defect and deployment of transient chondrocyte behaviours underlie osteoarthritis onset in a natural murine model. https://doi.org/10.1002/art.39508

Expression of Sulf1 and Sulf2 in cartilage, bone and endochondral fracture healing (2016)
Journal Article
Zaman, G., Staines, K. A., Farquharson, C., Newton, P. T., Dudhia, J., Chenu, C., Pitsillides, A. A., & Dhoot, G. K. (2016). Expression of Sulf1 and Sulf2 in cartilage, bone and endochondral fracture healing. Histochemistry and Cell Biology, 145(1), 67-79. https://doi.org/10.1007/s00418-015-1365-8

Digital preparation and osteology of the skull of Lesothosaurus diagnosticus (Ornithischia: Dinosauria) (2015)
Journal Article
Porro, L. B., Witmer, L. M., & Barrett, P. M. (2015). Digital preparation and osteology of the skull of Lesothosaurus diagnosticus (Ornithischia: Dinosauria). https://doi.org/10.7717/peerj.1494

Several skulls of the ornithischian dinosaur Lesothosaurus diagnosticus (Lower Jurassic, southern Africa) are known, but all are either incomplete, deformed, or incompletely prepared. This has hampered attempts to provide a comprehensive description... Read More about Digital preparation and osteology of the skull of Lesothosaurus diagnosticus (Ornithischia: Dinosauria).

MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR (2015)
Journal Article
Singh, Y., Garden, O. A., Lang, F., & Cobb, B. S. (2015). MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR. Journal of Immunology, 195(12), 5667-5677. https://doi.org/10.4049/jimmunol.1401875

CD4(+) regulatory T cells (Tregs) are essential for controlling immune responses and preventing autoimmunity. Their development requires regulation of gene expression by microRNAs (miRNAs). To understand miRNA function in Treg development, we searche... Read More about MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR.

Effect of Cyclooxygenase(COX)-1 and COX-2 inhibition on furosemide-induced renal responses and isoform immunolocalization in the healthy cat kidney (2015)
Journal Article
Pelligand, L., Suemanotham, N., King, J. N., Seewald, W., Syme, H. M., Smith, K. C., Lees, P., & Elliott, J. (2015). Effect of Cyclooxygenase(COX)-1 and COX-2 inhibition on furosemide-induced renal responses and isoform immunolocalization in the healthy cat kidney. BMC Veterinary Research, 11(296), https://doi.org/10.1186/s12917-015-0598-z

The interfascicular matrix enables fascicle sliding and recovery in tendon, and behaves more elastically in energy storing tendons (2015)
Journal Article
Thorpe, C. T., Godinho, M. S. C., Riley, G. P., Birch, H. L., Clegg, P. D., & Screen, H. R. C. (2015). The interfascicular matrix enables fascicle sliding and recovery in tendon, and behaves more elastically in energy storing tendons. Journal of the Mechanical Behavior of Biomedical Materials, 52, 85-94. https://doi.org/10.1016/j.jmbbm.2015.04.009

ANP-ing Up Diabetes: Impaired Natriuretic Peptide Action in Muscle Forms a Mechanistic Link Between Obesity and Diabetes (2015)
Journal Article
Cleasby, M. E. (2015). ANP-ing Up Diabetes: Impaired Natriuretic Peptide Action in Muscle Forms a Mechanistic Link Between Obesity and Diabetes. Diabetes, 64(12), 3978-3980. https://doi.org/10.2337/dbi15-0017

The Emerging Role of Disturbed CoQ Metabolism in Nonalcoholic Fatty Liver Disease Development and Progression (2015)
Journal Article
Botham, K. M., Napolitano, M., & Bravo, E. (2015). The Emerging Role of Disturbed CoQ Metabolism in Nonalcoholic Fatty Liver Disease Development and Progression. Nutrients, 7(12), 9834-46. https://doi.org/10.3390/nu7125501

Although non-alcoholic fatty liver disease (NAFLD), characterised by the accumulation of triacylglycerol in the liver, is the most common liver disorder, the causes of its development and progression to the more serious non-alcoholic steatohepatitis... Read More about The Emerging Role of Disturbed CoQ Metabolism in Nonalcoholic Fatty Liver Disease Development and Progression.

A homeostatic function of CXCR2 signalling in articular cartilage (2015)
Journal Article
Sherwood, J., Bertrand, J., Nalesso, G., Poulet, B., Pitsillides, A. A., Brandolini, L., Karystinou, A., De Bari, C., Luyten, F. P., Pitzalis, C., Pap, T., & Dell'Accio, F. (2015). A homeostatic function of CXCR2 signalling in articular cartilage. Annals of the Rheumatic Diseases, 74(12), 2207-2215. https://doi.org/10.1136/annrheumdis-2014-205546

A CFD-informed quasi-steady model of flapping-wing aerodynamics (2015)
Journal Article
Nakata, T., Liu, H., & Bomphrey, R. J. (2015). A CFD-informed quasi-steady model of flapping-wing aerodynamics. Journal of Fluid Mechanics, 783, 323-343. https://doi.org/10.1017/jfm.2015.537

Aerodynamic performance and agility during flapping flight are determined by the combination of wing shape and kinematics. The degree of morphological and kinematic optimization is unknown and depends upon a large parameter space. Aimed at providing... Read More about A CFD-informed quasi-steady model of flapping-wing aerodynamics.