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TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control (2014)
Journal Article
Gatliff, J., East, D. A., Crosby, J., Abeti, R., Harvey, R., Craigen, W., Parker, P., & Campanella, M. (2014). TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control. Autophagy, 10(12), 2279-96. https://doi.org/10.4161/15548627.2014.991665

The 18-kDa TSPO (translocator protein) localizes on the outer mitochondrial membrane (OMM) and participates in cholesterol transport. Here, we report that TSPO inhibits mitochondrial autophagy downstream of the PINK1-PARK2 pathway, preventing essenti... Read More about TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control.

Iodine vapor staining for atomic number contrast in backscattered electron and X-ray imaging (2014)
Journal Article
Boyde, A., McCorkell, F. A., Taylor, G. K., Bomphrey, R. J., & Doube, M. (2014). Iodine vapor staining for atomic number contrast in backscattered electron and X-ray imaging. Microscopy Research and Technique, 77(12), 1044-1051. https://doi.org/10.1002/jemt.22435

Iodine imparts strong contrast to objects imaged with electrons and X‐rays due to its high atomic number (53), and is widely used in liquid form as a microscopic stain and clinical contrast agent. We have developed a simple technique which exploits e... Read More about Iodine vapor staining for atomic number contrast in backscattered electron and X-ray imaging.

PMI: A Delta Psi(m) Independent Pharmacological Regulator of Mitophagy (2014)
Journal Article
East, D. A., Fagiani, F., Crosby, J., Georgakopoulos, N. D., Bertrand, H., Schaap, M., Fowkes, A., Wells, G., & Campanella, M. (2014). PMI: A Delta Psi(m) Independent Pharmacological Regulator of Mitophagy. https://doi.org/10.1016/j.chembiol.2014.09.019

Mitophagy is central to mitochondrial and cellular homeostasis and operates via the PINK1/Parkin pathway targeting mitochondria devoid of membrane potential (ΔΨm) to autophagosomes. Although mitophagy is recognized as a fundamental cellular process,... Read More about PMI: A Delta Psi(m) Independent Pharmacological Regulator of Mitophagy.

Mitigating the Goldilocks effect: the effects of different substrate models on track formation potential (2014)
Journal Article
Falkingham, P. L., Hage, J., & Baeker, M. (2014). Mitigating the Goldilocks effect: the effects of different substrate models on track formation potential. Royal Society Open Science, 1(3), 140225. https://doi.org/10.1098/rsos.140225

In ichnology, the Goldilocks effect describes a scenario in which a substrate must be ‘just right’ in order for tracks to form—too soft, the animal will be unable to traverse the area, and too firm, the substrate will not deform. Any given substrate... Read More about Mitigating the Goldilocks effect: the effects of different substrate models on track formation potential.

Don't break a leg: Running birds from quail to ostrich prioritise leg safety and economy in uneven terrain (2014)
Journal Article
Birn-Jeffery, A. V., Hubicki, C. M., Blum, Y., Renjewski, D., Hurst, J. W., & Daley, M. A. (2014). Don't break a leg: Running birds from quail to ostrich prioritise leg safety and economy in uneven terrain. Journal of Experimental Biology, 217(Pt21), 3786-96. https://doi.org/10.1242/jeb.102640

Cursorial ground birds are paragons of bipedal running that span a 500-fold mass range from quail to ostrich. Here we investigate the task-level control priorities of cursorial birds by analysing how they negotiate single-step obstacles that create a... Read More about Don't break a leg: Running birds from quail to ostrich prioritise leg safety and economy in uneven terrain.

Expression of Protease-Activated Receptor 1 and 2 and Anti-Tubulogenic Activity of Protease-Activated Receptor 1 in Human Endothelial Colony-Forming Cells (2014)
Journal Article
Fortunato, T. M., Vara, D. S., Wheeler-Jones, C. P. D., & Pula, G. (2014). Expression of Protease-Activated Receptor 1 and 2 and Anti-Tubulogenic Activity of Protease-Activated Receptor 1 in Human Endothelial Colony-Forming Cells. PLoS ONE, 9(10), https://doi.org/10.1371/journal.pone.0109375

Endothelial colony-forming cells (ECFCs) are obtained from the culture of human peripheral blood mononuclear cell (hPBMNC) fractions and are characterised by high proliferative and pro-vasculogenic potential, which makes them of great interest for ce... Read More about Expression of Protease-Activated Receptor 1 and 2 and Anti-Tubulogenic Activity of Protease-Activated Receptor 1 in Human Endothelial Colony-Forming Cells.

Mineralisation of collagen rich soft tissues and osteocyte lacunae in Enpp1-/- mice (2014)
Journal Article
Hajjawi, M. O. R., MacRae, V. E., Huesa, C., Boyde, A., Millan, J. L., Arnett, T. R., & Orriss, I. R. (2014). Mineralisation of collagen rich soft tissues and osteocyte lacunae in Enpp1-/- mice. BONE, 69, 139-147. https://doi.org/10.1016/j.bone.2014.09.016

Ecto-nucleotide pyrophosphatase/phosphodiesterases (NPPs) hydrolyse nucleotide triphosphates to the corresponding nucleotide monophosphates and the mineralisation inhibitor, pyrophosphate (PPi). This study examined the role of NPP1 in osteocytes, ost... Read More about Mineralisation of collagen rich soft tissues and osteocyte lacunae in Enpp1-/- mice.

The immediate effects of foot orthoses on hip and knee kinematics and muscle activity during a functional step-up task in individuals with patellofemoral pain (2014)
Journal Article
Lack, S., Barton, C., Woledge, R. C., Laupheimer, M. W., & Morrissey, D. (2014). The immediate effects of foot orthoses on hip and knee kinematics and muscle activity during a functional step-up task in individuals with patellofemoral pain. Clinical Biomechanics, 29(9), https://doi.org/10.1016/j.clinbiomech.2014.08.005

Calcium Homeostasis in Myogenic Differentiation Factor 1 (MyoD)-Transformed, Virally-Transduced, Skin-Derived Equine Myotubes (2014)
Journal Article
Fernandez-Fuente, M., Terracciano, C. M., Martin-Duque, P., Brown, S. C., Vassaux, G., & Piercy, R. J. (2014). Calcium Homeostasis in Myogenic Differentiation Factor 1 (MyoD)-Transformed, Virally-Transduced, Skin-Derived Equine Myotubes. PLoS ONE, 9(8), e105971. https://doi.org/10.1371/journal.pone.0105971

Dysfunctional skeletal muscle calcium homeostasis plays a central role in the pathophysiology of several human and animal skeletal muscle disorders, in particular, genetic disorders associated with ryanodine receptor 1 (RYR1) mutations, such as malig... Read More about Calcium Homeostasis in Myogenic Differentiation Factor 1 (MyoD)-Transformed, Virally-Transduced, Skin-Derived Equine Myotubes.

High-fat meals rich in EPA plus DHA compared with DHA only have differential effects on postprandial lipemia and plasma 8-isoprostane F-2 alpha concentrations relative to a control high-oleic acid meal: a randomized controlled trial (2014)
Journal Article
Purcell, R., Latham, S. H., Botham, K. M., Hall, W. L., & Wheeler-Jones, C. P. D. (2014). High-fat meals rich in EPA plus DHA compared with DHA only have differential effects on postprandial lipemia and plasma 8-isoprostane F-2 alpha concentrations relative to a control high-oleic acid meal: a randomized controlled trial. American Journal of Clinical Nutrition, 100(4), 1019-1028. https://doi.org/10.3945/ajcn.114.091223

Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated-skeletal muscle insulin resistance (2014)
Journal Article
Talbot, N. A., Wheeler-Jones, C. P. D., & Cleasby, M. E. (2014). Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated-skeletal muscle insulin resistance. Molecular and Cellular Endocrinology, 393(1-2), 129-142. https://doi.org/10.1016/j.mce.2014.06.010

Obesity and saturated fatty acid (SFA) treatment are both associated with skeletal muscle insulin resistance (IR) and increased macrophage infiltration. However, the relative effects of SFA and unsaturated fatty acid (UFA)-activated macrophages on mu... Read More about Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated-skeletal muscle insulin resistance.

SMAD1/5 signaling in the early equine placenta regulates trophoblast differentiation and chorionic gonadotropin secretion (2014)
Journal Article
Cabrera-Sharp, V., Read, J. E., Richardson, S., Kowalski, A. A., Antczak, D. F., Cartwright, J. E., Mukherjee, A., & De Mestre, A. M. (2014). SMAD1/5 signaling in the early equine placenta regulates trophoblast differentiation and chorionic gonadotropin secretion. Endocrinology, 155(8), 3054-64. https://doi.org/10.1210/en.2013-2116

TGFβ superfamily proteins, acting via SMAD (Sma- and Mad-related protein)2/3 pathways, regulate placental function; however, the role of SMAD1/5/8 pathway in the placenta is unknown. This study investigated the functional role of bone morphogenetic p... Read More about SMAD1/5 signaling in the early equine placenta regulates trophoblast differentiation and chorionic gonadotropin secretion.

Proteomic Analysis Reveals Age-related Changes in Tendon Matrix Composition, with Age- and Injury-specific Matrix Fragmentation (2014)
Journal Article
Peffers, M. J., Thorpe, C. T., Collins, J. A., Eong, R., Wei, T. K., Screen, H. R., & Clegg, P. D. (2014). Proteomic Analysis Reveals Age-related Changes in Tendon Matrix Composition, with Age- and Injury-specific Matrix Fragmentation. Journal of Biological Chemistry, 289(37), 25867-78. https://doi.org/10.1074/jbc.M114.566554

Energy storing tendons, such as the human Achilles and equine superficial digital flexor tendon (SDFT), are highly prone to injury, the incidence of which increases with aging. The cellular and molecular mechanisms that result in increased injury in... Read More about Proteomic Analysis Reveals Age-related Changes in Tendon Matrix Composition, with Age- and Injury-specific Matrix Fragmentation.

Vitamin K catabolite inhibition of ovariectomy-induced bone loss: Structure–activity relationship considerations (2014)
Journal Article
Soper, R. J., Oguz, C., Emery, R., Pitsillides, A. A., & Hodges, S. J. (2014). Vitamin K catabolite inhibition of ovariectomy-induced bone loss: Structure–activity relationship considerations. Molecular Nutrition & Food Research, 58(8), 1658-1666. https://doi.org/10.1002/mnfr.201400063

The potential benefit of vitamin K as a therapeutic in osteoporosis is controversial and the vitamin K regimen being used clinically (45 mg/day) employs doses that are many times higher than required to ensure maximal gamma‐carboxylation of the vitam... Read More about Vitamin K catabolite inhibition of ovariectomy-induced bone loss: Structure–activity relationship considerations.

STAT1-induced ASPP2 transcription identifies a link between neuroinflammation, cell polarity, and tumor suppression (2014)
Journal Article
Turnquist, C., Wang, Y., Severson, D. T., Zhong, S., Sun, B., Ma, J., Constaninescu, S. N., Ansorge, O., Stolp, H. B., Molnár, Z., Szele, F. G., & Lu, X. (2014). STAT1-induced ASPP2 transcription identifies a link between neuroinflammation, cell polarity, and tumor suppression. https://doi.org/10.1073/pnas.1407898111

Inflammation and loss of cell polarity play pivotal roles in neurodegeneration and cancer. A central question in both diseases is how the loss of cell polarity is sensed by cell death machinery. Here, we identify apoptosis-stimulating protein of p53... Read More about STAT1-induced ASPP2 transcription identifies a link between neuroinflammation, cell polarity, and tumor suppression.

Anatomical and biomechanical traits of broiler chickens across ontogeny. Part I. Anatomy of the musculoskeletal respiratory apparatus and changes in organ size (2014)
Journal Article
Tickle, P. G., Paxton, H. P., Rankin, J. W., Hutchinson, J. R., & Codd, J. R. (2014). Anatomical and biomechanical traits of broiler chickens across ontogeny. Part I. Anatomy of the musculoskeletal respiratory apparatus and changes in organ size. https://doi.org/10.7717/peerj.432

Genetic selection for improved meat yields, digestive efficiency and growth rates have transformed the biology of broiler chickens. Modern birds undergo a 50-fold multiplication in body mass in just six weeks, from hatching to slaughter weight. Howev... Read More about Anatomical and biomechanical traits of broiler chickens across ontogeny. Part I. Anatomy of the musculoskeletal respiratory apparatus and changes in organ size.

Swing-leg trajectory of running guinea fowl suggest task-level priority of force regulation rather than disturbance rejection (2014)
Journal Article
Blum, Y., Vejdani, H. R., Birn-Jeffery, A. V., Hubicki, C. M., Hurst, J. W., & Daley, M. A. (2014). Swing-leg trajectory of running guinea fowl suggest task-level priority of force regulation rather than disturbance rejection. PLoS ONE, 9(6), e100399. https://doi.org/10.1371/journal.pone.0100399

To achieve robust and stable legged locomotion in uneven terrain, animals must effectively coordinate limb swing and stance phases, which involve distinct yet coupled dynamics. Recent theoretical studies have highlighted the critical influence of swi... Read More about Swing-leg trajectory of running guinea fowl suggest task-level priority of force regulation rather than disturbance rejection.

Cardiovascular effects of dietary salt intake in aged healthy cats: a 2-year prospective randomized, blinded, and controlled study (2014)
Journal Article
Chetboul, V., Reynolds, B. S., Trehiou-Sechi, E., Nguyen, P., Concordet, D., Sampedrano, C. C., Testault, I., Elliott, J., Abadie, J., Biourge, V., & Lefebvre, H. P. (2014). Cardiovascular effects of dietary salt intake in aged healthy cats: a 2-year prospective randomized, blinded, and controlled study. PLoS ONE, 9(6), e97862. https://doi.org/10.1371/journal.pone.0097862

High salt dry expanded diets are commercially available for cats to increase water intake and urine volume, as part of the prevention or treatment of naturally occurring urinary stone formation (calcium oxalates and struvites). However, chronic high... Read More about Cardiovascular effects of dietary salt intake in aged healthy cats: a 2-year prospective randomized, blinded, and controlled study.