Skip to main content

Research Repository

Advanced Search

Time lapse: A glimpse into prehistoric genomics (2019)
Journal Article
Griffin, D. K., Larkin, D. M., & O'Connor, R. E. (2019). Time lapse: A glimpse into prehistoric genomics. European Journal of Medical Genetics, https://doi.org/10.1016/j.ejmg.2019.03.004

For the purpose of this review, ‘time-lapse’ refers to the reconstruction of ancestral (in this case dinosaur) karyotypes using genome assemblies of extant species. Such reconstructions are only usually possible when genomes are assembled to ‘chromos... Read More about Time lapse: A glimpse into prehistoric genomics.

Vascular white matter lesions negatively correlate with brain metastases in malignant melanoma - results from a retrospective comparative analysis (2019)
Journal Article
Berk, B. A., Hering, K., Kortmann, R.-D., Hoffmann, K.-T., Ziemer, M., & Seidel, C. (2019). Vascular white matter lesions negatively correlate with brain metastases in malignant melanoma - results from a retrospective comparative analysis. Clinical Neurology and Neurosurgery, 180, 117-121. https://doi.org/10.1016/j.clineuro.2019.03.016

Brain metastasis (BM) is a major complication of different cancers. There is increasing evidence for influence of vascular factors on BM in patients with non-small cell lung cancer (NSCLC). It is not known if the same is true for other tumors that mi... Read More about Vascular white matter lesions negatively correlate with brain metastases in malignant melanoma - results from a retrospective comparative analysis.

Genome-wide association study and scan for signatures of selection point to candidate genes for body temperature maintenance under the cold stress in Siberian cattle populations (2019)
Journal Article
Igoshin, A. V., Yurchenko, A. A., Belonogova, N. M., Petrovsky, D. V., Aitnazarov, R. B., Soloshenko, V. A., Yudin, N. S., & Larkin, D. M. (2019). Genome-wide association study and scan for signatures of selection point to candidate genes for body temperature maintenance under the cold stress in Siberian cattle populations. BMC Genomics, 20(Suppl 1), https://doi.org/10.1186/s12863-019-0725-0

Design of new highly productive livestock breeds, well-adapted to local climatic conditions is one of the aims of modern agriculture and breeding. The genetics underlying economically important traits in cattle are widely studied, whereas our knowled... Read More about Genome-wide association study and scan for signatures of selection point to candidate genes for body temperature maintenance under the cold stress in Siberian cattle populations.

Smooth muscle cell-specific knockout of neuropilin-1 impairs postnatal lung development and pathological vascular smooth muscle cell accumulation (2019)
Journal Article
Mahmoud, M., Evans, I. M., Mehta, V., Pellet-Many, C., Paliashvili, K., & Zachary, I. (2019). Smooth muscle cell-specific knockout of neuropilin-1 impairs postnatal lung development and pathological vascular smooth muscle cell accumulation. https://doi.org/10.1152/ajpcell.00405.2018

Neuropilin 1 (NRP1) is important for neuronal and cardiovascular development due to its role in conveying class 3 semaphorin and vascular endothelial growth factor signaling, respectively. NRP1 is expressed in smooth muscle cells (SMCs) and mediates... Read More about Smooth muscle cell-specific knockout of neuropilin-1 impairs postnatal lung development and pathological vascular smooth muscle cell accumulation.

Relating neuromuscular control to functional anatomy of limb muscles in extant archosaurs (2019)
Journal Article
Cuff, A. R., Daley, M. A., Michel, K. B., Allen, V. R., Lamas, L. P., Adami, C., Monticelli, P., Pelligand, L., & Hutchinson, J. R. (2019). Relating neuromuscular control to functional anatomy of limb muscles in extant archosaurs. Journal of Morphology, 280(5), 666-680. https://doi.org/10.1002/jmor.20973

Electromyography (EMG) is used to understand muscle activity patterns in animals. Understanding how much variation exists in muscle activity patterns in homologous muscles across animal clades during similar behaviours is important for evaluating the... Read More about Relating neuromuscular control to functional anatomy of limb muscles in extant archosaurs.

From the raw bar to the bench: Bivalves as models for human health (2019)
Journal Article
Fernández Robledo, J. A., Yadavalli, R., Allam, B., Pales Espinosa, E., Gerdol, M., Greco, S., Stevick, R. J., Gómez-Chiarri, M., Zhang, Y., Heil, C. A., Tracy, A. N., Bishop-Bailey, D., & Metzger, M. J. (2019). From the raw bar to the bench: Bivalves as models for human health. Developmental and Comparative Immunology, 92, 260-282. https://doi.org/10.1016/j.dci.2018.11.020

Bivalves, from raw oysters to steamed clams, are popular choices among seafood lovers and once limited to the coastal areas. The rapid growth of the aquaculture industry and improvement in the preservation and transport of seafood have enabled them t... Read More about From the raw bar to the bench: Bivalves as models for human health.

Comparison of the diagnostic value of symmetric dimethylarginine, cystatin C, and creatinine for detection of decreased glomerular filtration rate in dogs (2019)
Journal Article
Pelander, L., Häggström, J., Larsson, A., Syme, H. M., Elliott, J., Heiene, R., & Ljungvall, I. (2019). Comparison of the diagnostic value of symmetric dimethylarginine, cystatin C, and creatinine for detection of decreased glomerular filtration rate in dogs. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.15445

Terrestrial mammalian wildlife responses to Unmanned Aerial Systems approaches (2019)
Journal Article
Bennitt, E., Bartlam-Brooks, H. L. A., Hubel, T. Y., & Wilson, A. M. (2019). Terrestrial mammalian wildlife responses to Unmanned Aerial Systems approaches. https://doi.org/10.1038/s41598-019-38610-x

Unmanned Aerial Systems (UAS) are increasingly being used recreationally, commercially and for wildlife research, but very few studies have quantified terrestrial mammalian reactions to UAS approaches. We used two Vertical Take-off and Landing (VTOL)... Read More about Terrestrial mammalian wildlife responses to Unmanned Aerial Systems approaches.

Evolution of gene regulation in ruminants differs between evolutionary breakpoint regions and homologous synteny blocks (2019)
Journal Article
Farre Belmonte, M., Kim, J., Proskuryakova, A. A., Zhang, Y., Kulemzina, A. I., Li, Q., Xiong, Y., Johnson, J. L., Perelman, P. L., Johnson, W. E., Warren, W., Kukekova, A. V., Zhang, G., O'Brien, S. J., Ryder, O. A., Graphodatsky, A. S., Ma, J., Lewin, H. A., & Larkin, D. M. (2019). Evolution of gene regulation in ruminants differs between evolutionary breakpoint regions and homologous synteny blocks. Genome Research, 29, 576-589. https://doi.org/10.1101/gr.239863.118

The role of chromosome rearrangements in driving evolution has been a long-standing question of evolutionary biology. Here we focused on ruminants as a model to assess how rearrangements may have contributed to the evolution of gene regulation. Using... Read More about Evolution of gene regulation in ruminants differs between evolutionary breakpoint regions and homologous synteny blocks.

The running kinematics of free-roaming giraffes, measured using a low cost unmanned aerial vehicle (UAV) (2019)
Journal Article
Basu, C. K., Deacon, F., Hutchinson, J. R., & Wilson, A. M. (2019). The running kinematics of free-roaming giraffes, measured using a low cost unmanned aerial vehicle (UAV). PeerJ, 7, e6312. https://doi.org/10.7717/peerj.6312

The study of animal locomotion can be logistically challenging, especially in the case of large or unhandleable animals in uncontrolled environments. Here we demonstrate the utility of a low cost unmanned aerial vehicle (UAV) in measuring two-dimensi... Read More about The running kinematics of free-roaming giraffes, measured using a low cost unmanned aerial vehicle (UAV).

Parsimonious test of dynamic interaction (2019)
Journal Article
Chisholm, S., Stein, A. B., Jordan, N. R., Hubel, T. Y., Shawe-Taylor, J., Fearn, T., McNutt, J. W., Wilson, A. M., & Hailes, S. (2019). Parsimonious test of dynamic interaction. Ecology and Evolution, https://doi.org/10.1002/ece3.4805

In recent years, there have been significant advances in the technology used to collect data on the movement and activity patterns of humans and animals. GPS units, which form the primary source of location data, have become cheaper, more accurate, l... Read More about Parsimonious test of dynamic interaction.

Isolation and generation of osteoblasts (2019)
Book Chapter
Perpetuo, I. P., Bourne, L. E., & Orriss, I. R. (2019). Isolation and generation of osteoblasts. In Bone Research Protocols. Humana Press. https://doi.org/10.1007/978-1-4939-8997-3_2

This chapter describes the isolation, culture, and staining of osteoblasts. The key advantages of this assay are that it allows direct measurement of bone matrix deposition and mineralization, as well as yielding good quantities of osteoblasts at def... Read More about Isolation and generation of osteoblasts.

Unique skull network complexity of Tyrannosaurus rex among land vertebrates (2019)
Journal Article
Werneburg, I., Esteve-Altava, B., Bruno, J., Torres Ladeira, M., & Diogo, R. (2019). Unique skull network complexity of Tyrannosaurus rex among land vertebrates. https://doi.org/10.1038/s41598-018-37976-8

Like other diapsids, Tyrannosaurus rex has two openings in the temporal skull region. In addition, like in other dinosaurs, its snout and lower jaw show large cranial fenestrae. In T. rex, they are thought to decrease skull weight, because, unlike mo... Read More about Unique skull network complexity of Tyrannosaurus rex among land vertebrates.

A Near Chromosome Assembly of the Dromedary Camel Genome (2019)
Journal Article
Ruvinskiy, D., Larkin, D. M., & Farré, M. (2019). A Near Chromosome Assembly of the Dromedary Camel Genome. Frontiers in Genetics, 10(32), https://doi.org/10.3389/fgene.2019.00032

The dromedary camel is an economically and socially important species of livestock in many parts of the world, being used for transport and the production of milk and meat. Much like cattle and horses, the camel may be found in industrial farming con... Read More about A Near Chromosome Assembly of the Dromedary Camel Genome.

Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment (2019)
Journal Article
Betts, C. A., McClorey, G., Healicon, R., Hammond, S. M., Manzano, R., Muses, S., Ball, V., Godfrey, C., Merritt, T. M., Westering, T., O'Donovan, L., Wells, K. E., Gait, M. J., Wells, D. J., Tyler, D., & Wood, M. J. (2019). Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment. Human Molecular Genetics, 28(3), 396-406. https://doi.org/10.1093/hmg/ddy346

Duchenne muscular dystrophy (DMD) is caused by loss of dystrophin protein, leading to progressive muscle weakness and premature death due to respiratory and/or cardiac complications. Cardiac involvement is characterized by progressive dilated cardiom... Read More about Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment.

Identification of qPCR reference genes suitable for normalizing gene expression in the mdx mouse model of Duchenne muscular dystrophy (2019)
Journal Article
Hildyard, J. C. W., Finch, A. M., & Wells, D. J. (2019). Identification of qPCR reference genes suitable for normalizing gene expression in the mdx mouse model of Duchenne muscular dystrophy. PLoS ONE, 14(1), e0211384. https://doi.org/10.1371/journal.pone.0211384

The mdx mouse is the most widely-used animal model of the human disease Duchenne muscular dystrophy, and quantitative PCR analysis of gene expression in the muscles of this animal plays a key role in the study of pathogenesis and disease progression... Read More about Identification of qPCR reference genes suitable for normalizing gene expression in the mdx mouse model of Duchenne muscular dystrophy.

LIPID MEDIATORS IN IMMUNE REGULATION AND RESOLUTION (2019)
Journal Article
Gilroy, D. W., & Bishop-Bailey, D. (2019). LIPID MEDIATORS IN IMMUNE REGULATION AND RESOLUTION. British Journal of Pharmacology, 176(8), https://doi.org/10.1111/bph.14587

We are all too familiar with the events that follow a bee sting – heat, redness, swelling and pain. These are Celsus’ four cardinal signs of inflammation that are driven by very well defined signals and hormones; in fact targeting the factors that dr... Read More about LIPID MEDIATORS IN IMMUNE REGULATION AND RESOLUTION.

Comparison of in vitro static and dynamic assays to evaluate the efficacy of an antimicrobial drug combination against Staphylococcus aureus (2019)
Journal Article
Broussou, D. C., Toutain, P.-L., Woehrlé, F., El Garch, F., Bousquet-Mélou, A., & Ferran, A. A. (2019). Comparison of in vitro static and dynamic assays to evaluate the efficacy of an antimicrobial drug combination against Staphylococcus aureus. PLoS ONE, 14(1), e0211214. https://doi.org/10.1371/journal.pone.0211214

An easily implementable strategy to reduce treatment failures in severe bacterial infections is to combine already available antibiotics. However, most in vitro combination assays are performed by exposing standard bacterial inocula to constant conce... Read More about Comparison of in vitro static and dynamic assays to evaluate the efficacy of an antimicrobial drug combination against Staphylococcus aureus.