Association between Single Nucleotide Polymorphism in RelA with Somatic Cell Count and Longevity Supports Importance of NF-¦ÊB Signalling in Cattle Health (2019)
Journal Article
Chen, X., Zhang, S., Cheng, Z. R., Pollott, G. E., & Wathes, D. C. (2019). Association between Single Nucleotide Polymorphism in RelA with Somatic Cell Count and Longevity Supports Importance of NF-¦ÊB Signalling in Cattle Health. Open Journal of Animal Sciences, 9(1), 51-64. https://doi.org/10.4236/ojas.2019.91005

Mastitis reduces milk production and causes culling. The NF-κB transcription factor RelA plays a central regulatory role in innate immunity. This study used a candidate gene approach to investigate associations between the synonymous C/G SNP rs480357... Read More about Association between Single Nucleotide Polymorphism in RelA with Somatic Cell Count and Longevity Supports Importance of NF-¦ÊB Signalling in Cattle Health.

GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice (2019)
Journal Article
Puig, B., Altmeppen, H. C., Linsenmeier, L., Chakroun, K., Wegwitz, F., Piontek, U. K., Tatzelt, J., Bate, C., Magnus, T., & Glatzel, M. (2019). GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice. PLoS Pathogens, 15(1), e1007520. https://doi.org/10.1371/journal.ppat.1007520

The cellular prion protein (PrPC) is a cell surface glycoprotein attached to the membrane by a glycosylphosphatidylinositol (GPI)-anchor and plays a critical role in transmissible, neurodegenerative and fatal prion diseases. Alterations in membrane a... Read More about GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice.

Plasticity of Amino Acid Residue 145 Near the Receptor Binding Site of H3 Swine Influenza A Viruses and Its Impact on Receptor Binding and Antibody Recognition (2019)
Journal Article
Santos, J. J. S., Abente, E. J., Obadan, A. O., Thompson, A. J., Ferreri, L., Geiger, G., Gonzalez-Reiche, A. S., Lewis, N. S., Burke, D. F., Rajão, D. S., Paulson, J. C., Vincent, A. L., & Perez, D. R. (2019). Plasticity of Amino Acid Residue 145 Near the Receptor Binding Site of H3 Swine Influenza A Viruses and Its Impact on Receptor Binding and Antibody Recognition. Journal of Virology, 93(2), e01413-18. https://doi.org/10.1128/JVI.01413-18

The hemagglutinin (HA), a glycoprotein on the surface of influenza A virus (IAV), initiates the virus life cycle by binding to terminal sialic acid (SA) residues on host cells. The HA gradually accumulates amino acid substitutions that allow IAV to e... Read More about Plasticity of Amino Acid Residue 145 Near the Receptor Binding Site of H3 Swine Influenza A Viruses and Its Impact on Receptor Binding and Antibody Recognition.

Correlating Gastrointestinal Histopathologic Changes to Clinical Disease Activity in Dogs With Idiopathic Inflammatory Bowel Disease (2019)
Journal Article
Allenspach, K., Mochel, J. P., Du, Y., Priestnall, S. L., Moore, F., Slayter, M., Rodrigues, A., Ackermann, M., Krockenberger, M., Mansell, J., Luckschander, N., Wang, C., Suchodolski, J., Berghoff, N., & Jergens, A. E. (2019). Correlating Gastrointestinal Histopathologic Changes to Clinical Disease Activity in Dogs With Idiopathic Inflammatory Bowel Disease. Veterinary Pathology, 56(3), 435-443. https://doi.org/10.1177/0300985818813090

Prior studies have failed to detect a convincing association between histologic lesions of inflammation and clinical activity in dogs with inflammatory bowel disease (IBD). We hypothesized that use of a simplified histopathologic scoring system would... Read More about Correlating Gastrointestinal Histopathologic Changes to Clinical Disease Activity in Dogs With Idiopathic Inflammatory Bowel Disease.

Potential of milk mid-IR spectra to predict metabolic status of cows through blood components and an innovative clustering approach (2019)
Journal Article
Grelet, C., Vanlierde, A., Hostens, M., Foldager, L., Salavati, M., Ingvartsen, K. L., Crowe, M., Sorensen, M. T., Froidmont, E., Ferris, C. P., Marchitelli, C., Becker, F., Larsen, T., Carter, F., Dehareng, F., McLoughlin, N., Fahey, A., Matthews, E., Santoro, A., Byrne, C., …GplusE Consortium. (2019). Potential of milk mid-IR spectra to predict metabolic status of cows through blood components and an innovative clustering approach. animal, 13(3), 649-658. https://doi.org/10.1017/S1751731118001751

Unbalanced metabolic status in the weeks after calving predisposes dairy cows to metabolic and infectious diseases. Blood glucose, IGF-I, non-esterified fatty acids (NEFA) and β-hydroxybutyrate (BHB) are used as indicators of the metabolic status of... Read More about Potential of milk mid-IR spectra to predict metabolic status of cows through blood components and an innovative clustering approach.

Factors associated with disease progression in dogs with presumed preclinical degenerative mitral valve disease attending primary care veterinary practices in the United Kingdom (2019)
Journal Article
Mattin, M. J., Brodbelt, D. C., Church, D. B., & Boswood, A. (2019). Factors associated with disease progression in dogs with presumed preclinical degenerative mitral valve disease attending primary care veterinary practices in the United Kingdom. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.15390

Differential susceptibility to tetracycline, oxytetracycline and doxycycline of the calf pathogens Mannheimia haemolytica and Pasteurella multocida in three growth media (2019)
Journal Article
Mead, A., Lees, P., Mitchell, J., Rycroft, A. N., Standing, J. F., Toutain, P. L., & Pelligand, L. (2019). Differential susceptibility to tetracycline, oxytetracycline and doxycycline of the calf pathogens Mannheimia haemolytica and Pasteurella multocida in three growth media. Journal of Veterinary Pharmacology and Therapeutics, 42(1), 52-59. https://doi.org/10.1111/jvp.12719

For clinical isolates of bovine Mannheimia haemolytica and Pasteurella multocida, this study reports minimum inhibitory concentration (MIC) differences for tetracycline, oxytetracycline and doxycycline between cation‐adjusted Mueller‐Hinton broth (CA... Read More about Differential susceptibility to tetracycline, oxytetracycline and doxycycline of the calf pathogens Mannheimia haemolytica and Pasteurella multocida in three growth media.

Monkeypox — Enhancing public health preparedness for an emerging lethal human zoonotic epidemic threat in the wake of the smallpox post-eradication era (2019)
Journal Article
Petersen, E., Abubakar, I., Ihekweazu, C., Heymann, D., Ntoumi, F., Blumberg, L., Asogun, D., Mukonka, V., Lule, S. A., Bates, M., Honeyborne, I., Mfinanga, S., Mwaba, P., Dar, O., Vairo, F., Mukhtar, M., Kock, R. A., McHugh, T. D., Ippolito, G., & Zumla, A. (2019). Monkeypox — Enhancing public health preparedness for an emerging lethal human zoonotic epidemic threat in the wake of the smallpox post-eradication era. International Journal of Infectious Diseases, 78, 78-84. https://doi.org/10.1016/j.ijid.2018.11.008

The identification of monkeypox in 3 separate patients in the United Kingdom in September raised media and political attention on an emerging public health threat. Nigeria, whose last confirmed case of monkeypox was in 1978, is currently experiencing... Read More about Monkeypox — Enhancing public health preparedness for an emerging lethal human zoonotic epidemic threat in the wake of the smallpox post-eradication era.

Rapid integrated assessment of food safety and nutrition related to pork consumption of regular consumers and mothers with young children in Vietnam (2019)
Journal Article
Nguyen-Viet, H., Dang-Xuan, S., Pham-Duc, P., Roesel, K., Huong, N. M., Luu-Quoc, T., Van Hung, P., Thi Duong Nga, N., Lapar, L., Unger, F., Haesler, B., & Grace, D. (2019). Rapid integrated assessment of food safety and nutrition related to pork consumption of regular consumers and mothers with young children in Vietnam. Global Food Security, 20, 37-44. https://doi.org/10.1016/j.gfs.2018.12.003

Pork is the most common and widely consumed meat product in Vietnam. The study aimed to assess nutrition and food safety risks and opportunities associated with pork value chains in Vietnam. Twenty-nine focus group discussions (FGD) were conducted in... Read More about Rapid integrated assessment of food safety and nutrition related to pork consumption of regular consumers and mothers with young children in Vietnam.

Production diseases in smallholder pig systems in rural Lao PDR (2019)
Journal Article
Holt, H. R., Inthavong, P., Blaszak, K., Keokamphe, C., Phongmany, A., Blacksell, S. D., Durr, P. A., Graham, K., Allen, J., Donnelly, B., Newberry, K., Grace, D., Alonso, S., Gilbert, J., & Unger, F. (2019). Production diseases in smallholder pig systems in rural Lao PDR. Preventive Veterinary Medicine, 162, 110-116. https://doi.org/10.1016/j.prevetmed.2018.11.012

Pigs in Lao People’s Democratic Republic are important for income and food security, particularly in rural households. The majority of pigs are reared in smallholder systems, which may challenge the implementation of any disease control strategies. T... Read More about Production diseases in smallholder pig systems in rural Lao PDR.

Multivariable analysis to determine risk factors associated with early pregnancy loss in thoroughbred broodmares (2019)
Journal Article
De Mestre, A. M., Rose, V. B., Chang, Y. M., Wathes, D. C., & Verheyen, K. L. P. (2019). Multivariable analysis to determine risk factors associated with early pregnancy loss in thoroughbred broodmares. Theriogenology, 124, 18-23. https://doi.org/10.1016/j.theriogenology.2018.10.008

Early pregnancy loss (EPL) between days 15–65 after breeding has been shown to occur in 7.9% of equine pregnancies with substantial economical, welfare and safety implications. Whilst maternal age has been recognised as an important risk factor in re... Read More about Multivariable analysis to determine risk factors associated with early pregnancy loss in thoroughbred broodmares.

Space-use patterns highlight behavioural differences linked to lameness, parity, and days in milk in barn-housed dairy cows (2018)
Journal Article
Vázquez Diosdado, J. A., Barker, Z. E., Hodges, H. R., Amory, J. R., Croft, D. P., Bell, N. J., & Codling, E. A. (2018). Space-use patterns highlight behavioural differences linked to lameness, parity, and days in milk in barn-housed dairy cows. PLoS ONE, 13(12), e0208424. https://doi.org/10.1371/journal.pone.0208424

Lameness is a key health and welfare issue affecting commercial herds of dairy cattle, with potentially significant economic impacts due to the expense of treatment and lost milk production. Existing lameness detection methods can be time-intensive,... Read More about Space-use patterns highlight behavioural differences linked to lameness, parity, and days in milk in barn-housed dairy cows.

A study of tuberculosis in road traffic-killed badgers on the edge of the British bovine TB epidemic area (2018)
Journal Article
Sandoval Barron, E., Swift, B. M. C., Chantrey, J., Christley, R., Gardner, R., Jewell, C., McGrath, I., Mitchell, A., O'Cathail, C., Prosser, A., Ridout, S., Sanchez-Cabezudo, G., Smith, N., Timofte, D., Williams, N., & Bennett, M. (2018). A study of tuberculosis in road traffic-killed badgers on the edge of the British bovine TB epidemic area. https://doi.org/10.1038/s41598-018-35652-5

The role of badgers in the geographic expansion of the bovine tuberculosis (bTB) epidemic in England is unknown: indeed there have been few published studies of bTB in badgers outside of the Southwest of England where the infection is now endemic in... Read More about A study of tuberculosis in road traffic-killed badgers on the edge of the British bovine TB epidemic area.

Incidence and clinical signs of owner-reported equine laminitis in a cohort of horses and ponies in Great Britain (2018)
Journal Article
Pollard, D., Wylie, C. E., Newton, J. R., & Verheyen, K. L. P. (2018). Incidence and clinical signs of owner-reported equine laminitis in a cohort of horses and ponies in Great Britain. Equine Veterinary Journal, 51(5), 587-594. https://doi.org/10.1111/evj.13059

Comparison of 2016–17 and Previous Epizootics of Highly Pathogenic Avian Influenza H5 Guangdong Lineage in Europe (2018)
Journal Article
Alarcon, P., Brouwer, A., Vekatesh, D., Duncan, D., Dovas, C. I., Georgiades, G., Monne, I., Fusaro, A., Dan, A., Smietanka, K., Ragias, V., Breed, A. C., Chassalevris, T., Hjulsager, C. K., Ryan, E., Sanchez, A., Niqueux, E., Tammiranta, N., Zohari, S., Stroud, D. A., …Brown, I. H. (2018). Comparison of 2016–17 and Previous Epizootics of Highly Pathogenic Avian Influenza H5 Guangdong Lineage in Europe. https://doi.org/10.3201/eid2412.171860

We analyzed the highly pathogenic avian influenza (HPAI) H5 epizootic of 2016–17 in Europe by epidemiologic and genetic characteristics and compared it with 2 previous epizootics caused by the same H5 Guangdong lineage. The 2016–17 epizootic was the... Read More about Comparison of 2016–17 and Previous Epizootics of Highly Pathogenic Avian Influenza H5 Guangdong Lineage in Europe.

Dissecting the Genomic Architecture of Resistance to Eimeria maxima Parasitism in the Chicken (2018)
Journal Article
Boulton, K., Nolan, M. J., Wu, Z., Riggio, V., Matika, O., Harman, K., Hocking, P. M., Bumstead, N., Hesketh, P., Archer, A., Bishop, S. C., Kaiser, P., Tomley, F. M., Hume, D. A., Smith, A. L., Blake, D. P., & Psifidi, A. (2018). Dissecting the Genomic Architecture of Resistance to Eimeria maxima Parasitism in the Chicken. Frontiers in Genetics, 9, https://doi.org/10.3389/fgene.2018.00528

Coccidiosis in poultry, caused by protozoan parasites of the genus Eimeria, is an intestinal disease with substantial economic impact. With the use of anticoccidial drugs under public and political pressure, and the comparatively higher cost of live-... Read More about Dissecting the Genomic Architecture of Resistance to Eimeria maxima Parasitism in the Chicken.

Hepatozoon canis in three imported dogs: a new tickborne disease reaching the United Kingdom (2018)
Journal Article
Attipa, C., Maguire, D., Solano-Gallego, L., Szladovits, B., Barker, E. N., Farr, A., Baneth, G., & Tasker, S. (2018). Hepatozoon canis in three imported dogs: a new tickborne disease reaching the United Kingdom. Veterinary Record, 183(716), https://doi.org/10.1136/vr.105087

An increasing number of non-endemic vectorborne pathogens have been described in dogs imported to the UK in the past two decades. Recently, an outbreak of canine babesiosis in south-east England has raised veterinary awareness with regard to the impa... Read More about Hepatozoon canis in three imported dogs: a new tickborne disease reaching the United Kingdom.

Draft genome assembly of the poultry red mite, Dermanyssus gallinae (2018)
Journal Article
Burgess, S. T. G., Bartley, K., Nunn, F., Wright, H. W., Hughes, M., Gemmell, M., Haldenby, S., Paterson, S., Rombauts, S., Tomley, F. M., Blake, D. P., Pritchard, J., Schicht, S., Strube, C., Øines, Ø., Van Leeuwen, T., Van De Peer, Y., & Nisbet, A. J. (2018). Draft genome assembly of the poultry red mite, Dermanyssus gallinae. Microbiology Resource Announcements, 7(18), https://doi.org/10.1128/MRA.01221-18

The poultry red mite, Dermanyssus gallinae, is a major worldwide concern in the egg-laying industry. Here, we report the first draft genome assembly and gene prediction of Dermanyssus gallinae, based on combined PacBio and MinION long-read de novo se... Read More about Draft genome assembly of the poultry red mite, Dermanyssus gallinae.

The impact of agricultural input subsidies on food and nutrition security: a systematic review (2018)
Journal Article
Walls, H. L., Johnston, D., Tak, M., Dixon, J., Hanefeld, J., Hull, E., & Smith, R. D. (2018). The impact of agricultural input subsidies on food and nutrition security: a systematic review. Food Security, 10(6), 1425-1436. https://doi.org/10.1007/s12571-018-0857-5

Agricultural input subsidies, a form of social protection, are often considered an important means of improving agricultural productivity in low- and middle-income countries. However, their effectiveness and efficiency remains contentious with respec... Read More about The impact of agricultural input subsidies on food and nutrition security: a systematic review.

Repurposing azithromycin and rifampicin against Gram-negative pathogens by combination with peptide potentiators (2018)
Journal Article
Baker, K. R., Jana, B., Hansen, A. M., Vissing, K. J., Nielsen, H. M., Franzyk, H., & Guardabassi, L. (2018). Repurposing azithromycin and rifampicin against Gram-negative pathogens by combination with peptide potentiators. International Journal of Antimicrobial Agents, 53(6), 868-872. https://doi.org/10.1016/j.ijantimicag.2018.10.025

Gram-negative bacterial pathogens are intrinsically resistant to several antibiotics that are not able to penetrate the cell envelope barrier. The aim of this study was to identify peptides that at low concentrations induce susceptibility to these an... Read More about Repurposing azithromycin and rifampicin against Gram-negative pathogens by combination with peptide potentiators.