Outputs (2485)

Initiation of a conserved trophectoderm program in human, cow and mouse embryos (2020)
Journal Article
Gerri, C., McCarthy, A., Alanis-Lobato, G., Demtschenko, A., Bruneau, A., Loubersac, S., …Niakan, K. K. (2020). Initiation of a conserved trophectoderm program in human, cow and mouse embryos. Nature, https://doi.org/10.1038/s41586-020-2759-x

Current understandings of cell specification in early mammalian pre-implantation development are based mainly on mouse studies. The first lineage differentiation event occurs at the morula stage, with outer cells initiating a trophectoderm (TE) place... Read More about Initiation of a conserved trophectoderm program in human, cow and mouse embryos.

3D hindlimb joint mobility of the stem-archosaur Euparkeria capensis with implications for postural evolution within Archosauria. (2020)
Journal Article
Demuth, O. E., Rayfield, E. J., & Hutchinson, J. R. (2020). 3D hindlimb joint mobility of the stem-archosaur Euparkeria capensis with implications for postural evolution within Archosauria. Scientific Reports, 10(1), 15357

Triassic archosaurs and stem-archosaurs show a remarkable disparity in their ankle and pelvis morphologies. However, the implications of these different morphologies for specific functions are still poorly understood. Here, we present the first quant... Read More about 3D hindlimb joint mobility of the stem-archosaur Euparkeria capensis with implications for postural evolution within Archosauria..

The ATPase Inhibitory Factor 1 (IF1) regulates the expression of the mitochondrial Ca2+ uniporter (MCU) via the AMPK/CREB pathway (2020)
Journal Article
Faccenda, D., Gorini, G., Jones, A., Thornton, C., Baracca, A., Solaini, G., & Campanella, M. (2020). The ATPase Inhibitory Factor 1 (IF1) regulates the expression of the mitochondrial Ca2+ uniporter (MCU) via the AMPK/CREB pathway

•IF1 regulates MCU-dependent mitochondrial Ca2+ uptake. •IF1 loss induces MCU upregulation through activation of the AMPK/CREB pathway. •OMA1 depletion restores physiological MCU levels and mitochondrial Ca2+ entry.

Proteomic Characterization of Host-Pathogen Interactions during Bovine Trophoblast Cell Line Infection by Neospora caninum (2020)
Journal Article
Regidor-Cerrillo, J., Xia, D., Jiménez-Pelayo, L., García-Sánchez, M., Collantes-Fernández, E., Randle, N., …Horcajo, P. (2020). Proteomic Characterization of Host-Pathogen Interactions during Bovine Trophoblast Cell Line Infection by Neospora caninum. Pathogens, 9(9), 749

Despite the importance of bovine neosporosis, relevant knowledge gaps remain concerning the pathogenic mechanisms of Neospora caninum. Infection of the placenta is a crucial event in the pathogenesis of the disease; however, very little is known abou... Read More about Proteomic Characterization of Host-Pathogen Interactions during Bovine Trophoblast Cell Line Infection by Neospora caninum.

Proteomic Characterization of Host-Pathogen Interactions during Bovine Trophoblast Cell Line Infection by (2020)
Journal Article
Regidor-Cerrillo, J., Xia, D., Jiménez-Pelayo, L., García-Sánchez, M., Collantes-Fernández, E., Randle, N., …Horcajo, P. (2020). Proteomic Characterization of Host-Pathogen Interactions during Bovine Trophoblast Cell Line Infection by. Pathogens, 9(9),

Despite the importance of bovine neosporosis, relevant knowledge gaps remain concerning the pathogenic mechanisms of . Infection of the placenta is a crucial event in the pathogenesis of the disease; however, very little is known about the relation... Read More about Proteomic Characterization of Host-Pathogen Interactions during Bovine Trophoblast Cell Line Infection by.

Mitochondria Regulate Inflammatory Paracrine Signalling in Neurodegeneration. (2020)
Journal Article
Faccenda, D., & Campanella, M. (2020). Mitochondria Regulate Inflammatory Paracrine Signalling in Neurodegeneration. Journal of Neuroimmune Pharmacology,

Mitochondrial dysfunction occurs in most neurodegenerative diseases, contributing to both their onset and progression. A recent breakthrough unveiled that propagation of the inflammatory response and subsequent neuronal injury are also mediated extra... Read More about Mitochondria Regulate Inflammatory Paracrine Signalling in Neurodegeneration..

Biomechanics of the mandible of Macaca mulatta during the power stroke of mastication: Loading, deformation, and strain regimes and the impact of food type (2020)
Journal Article
Panagiotopoulou, O., Iriarte-Diaz, J., Mehari Abraha, H., Taylor, A. B., Wilshin, S., Dechow, P. C., & Ross, C. F. (2020). Biomechanics of the mandible of Macaca mulatta during the power stroke of mastication: Loading, deformation, and strain regimes and the impact of food type. Journal of Human Evolution, 147, 102865. https://doi.org/10.1016/j.jhevol.2020.102865

Mandible morphology has yet to yield definitive information on primate diet, probably because of poor understanding of mandibular loading and strain regimes, and overreliance on simple beam models of mandibular mechanics. We used a finite element mod... Read More about Biomechanics of the mandible of Macaca mulatta during the power stroke of mastication: Loading, deformation, and strain regimes and the impact of food type.

Evolution of the patella and patelloid in marsupial mammals (2020)
Journal Article
Denyer, A. L., Regnault, S., & Hutchinson, J. R. (2020). Evolution of the patella and patelloid in marsupial mammals. PeerJ, 8, e9760

The musculoskeletal system of marsupial mammals has numerous unusual features beyond the pouch and epipubic bones. One example is the widespread absence or reduction (to a fibrous “patelloid”) of the patella (“kneecap”) sesamoid bone, but prior studi... Read More about Evolution of the patella and patelloid in marsupial mammals.

Whole genome analysis reveals aneuploidies in early pregnancy loss in the horse (2020)
Journal Article
Shilton, C. A., Kahler, A., Davis, B. W., Crabtree, J. R., Crowhurst, J., McGladdery, A. J., …de Mestre, A. M. (2020). Whole genome analysis reveals aneuploidies in early pregnancy loss in the horse. Scientific Reports, 10(1), https://doi.org/10.1038/s41598-020-69967-z

The first 8 weeks of pregnancy is a critical time, with the majority of pregnancy losses occurring during this period. Abnormal chromosome number (aneuploidy) is a common finding in human miscarriage, yet is rarely reported in domestic animals. Equin... Read More about Whole genome analysis reveals aneuploidies in early pregnancy loss in the horse.

Artificial mass loading disrupts stable social order in pigeon dominance hierarchies (2020)
Journal Article
Portugal, S. J., Usherwood, J. R., White, C. R., Sankey, D. W. E., & Wilson, A. M. (2020). Artificial mass loading disrupts stable social order in pigeon dominance hierarchies. Biology Letters, 16(8), 20200468

Dominance hierarchies confer benefits to group members by decreasing the incidences of physical conflict, but may result in certain lower ranked individuals consistently missing out on access to resources. Here, we report a linear dominance hierarchy... Read More about Artificial mass loading disrupts stable social order in pigeon dominance hierarchies.