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All Outputs (20)

A Preliminary Study Assessing a Transfer Learning Approach to Intestinal Image Analysis to Help Determine Treatment Response in Canine Protein-Losing Enteropathy (2024)
Journal Article
Kathrani, A., Trewin, I., Ancheta, K., Psifidi, A., Le Calvez, S., & Williams, J. (in press). A Preliminary Study Assessing a Transfer Learning Approach to Intestinal Image Analysis to Help Determine Treatment Response in Canine Protein-Losing Enteropathy. Veterinary Sciences, 11(3), 129. https://doi.org/10.3390/vetsci11030129

Characterisation of Canine Intestinal MicroRNA Expression in Inflammatory Bowel Disease and T-Cell Lymphoma (2023)
Journal Article
Williams, J., Werling, D., Davison, L., Hiron, T., & Xia, D. (in press). Characterisation of Canine Intestinal MicroRNA Expression in Inflammatory Bowel Disease and T-Cell Lymphoma. Journal of Comparative Pathology, https://doi.org/10.1016/j.jcpa.2023.03.186

Differentiating between canine inflammatory bowel disease and intestinal T-cell lymphoma via histopathological examination of endoscopically-derived intestinal biopsies can be challenging and involves an invasive procedure requiring specialised equip... Read More about Characterisation of Canine Intestinal MicroRNA Expression in Inflammatory Bowel Disease and T-Cell Lymphoma.

Nfkb2 deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa (2022)
Journal Article
Papoutsopoulou, S., Tang, J., Elramli, A. H., Williams, J. M., Gupta, N., Ikuomola, F. I., Sheibani-Tezerji, R., Alam, M. T., Hernández-Fernaud, J. R., Caamaño, J. H., Probert, C. S., Muller, W., Duckworth, C. A., & Pritchard, D. M. (2022). Nfkb2 deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa. American Journal of Physiology - Gastrointestinal and Liver Physiology, 323(4), G306-G317. https://doi.org/10.1152/ajpgi.00037.2022

Background & aims: The alternative (non-canonical) nuclear factor-kB (NF-kB) signalling pathway predominantly regulates the function of the p52/RelB heterodimer. Germline Nfkb2 deficiency in mice leads to loss of p100/p52 protein and offers protectio... Read More about Nfkb2 deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa.

Interleukin-10 Deficiency Impacts on TNF-Induced NFκB Regulated Responses In Vivo (2022)
Journal Article
Papoutsopoulou, S., Pollock, L., Williams, J. M., Abdul-Mahdi, M. M. L. F., Dobbash, R., Duckworth, C. A., & Campbell, B. J. (in press). Interleukin-10 Deficiency Impacts on TNF-Induced NFκB Regulated Responses In Vivo. Biology, 11(10), 1377. https://doi.org/10.3390/biology11101377

Interleukin-10 (IL-10) is an anti-inflammatory cytokine that has a major protective role against intestinal inflammation. We recently revealed that intestinal epithelial cells in vitro regulate NFκB-driven transcriptional responses to TNF via an auto... Read More about Interleukin-10 Deficiency Impacts on TNF-Induced NFκB Regulated Responses In Vivo.

Differential expression of microRNAs in the caecal content and faeces of broiler chickens experimentally infected with Eimeria (2022)
Journal Article
Williams, J., Blake, D., & Xia, D. (2022). Differential expression of microRNAs in the caecal content and faeces of broiler chickens experimentally infected with Eimeria. Avian Pathology, https://doi.org/10.1080/03079457.2022.2076581

Differential expression of microRNAs in the caecal content and faeces of broiler chickens experimentally infected with Eimeria

Vetreccr R1 Text Final AL 27May21 (2021)
Journal Article
Loeffler, A., Boone, J., Boone, J., Fountain, K., Williams, J., Lloyd, D. H., Killick, R., Rodriguez Barbón, A., Stidworthy, M. F., & Loeffler, A. (in press). Vetreccr R1 Text Final AL 27May21. Veterinary Record,

Pinnae are vital structures for echolocation and survival in many species of bats. Pinnal lesions have been described as common in captive bats, but information on specific diseases affecting the pinnae is scarce. A collection of histological section... Read More about Vetreccr R1 Text Final AL 27May21.

Surgical management of a sinonasal angiomatous polyp and associated cyst involving the paranasal sinuses and nasal cavity via standing axial rhinotomy (2020)
Journal Article
Rowley, K. J., Fiske-Jackson, A. R., Williams, J. M., Jones, A. L., & Townsend, N. B. (2020). Surgical management of a sinonasal angiomatous polyp and associated cyst involving the paranasal sinuses and nasal cavity via standing axial rhinotomy. Equine Veterinary Education, https://doi.org/10.1111/eve.13261

This case report describes the successful surgical management of a sinonasal angiomatous polyp involving the dorsal conchal bullae, dorsal conchal sinus, ventral conchal sinus, ventral conchal bullae and ventral conchal recess of the left nasal cavit... Read More about Surgical management of a sinonasal angiomatous polyp and associated cyst involving the paranasal sinuses and nasal cavity via standing axial rhinotomy.

NF-κB2 signalling in enteroids modulates enterocyte responses to secreted factors from bone marrow-derived dendritic cells (2019)
Journal Article
Jones, L. G., Vaisa, A., Thompson, L. M., Ikuomola, F. I., Caamaño, J. H., Burkitt, M. D., Miyajima, F., Williams, J. M., Campbell, B. J., Pritchard, D. M., & Duckworth, C. A. (2019). NF-κB2 signalling in enteroids modulates enterocyte responses to secreted factors from bone marrow-derived dendritic cells. https://doi.org/10.1038/s41419-019-2129-5

Alternative pathway NF-κB signalling regulates susceptibility towards developing inflammatory bowel disease (IBD), colitis-associated cancer and sepsis-associated intestinal epithelial cell apoptosis and shedding. However, the cell populations respon... Read More about NF-κB2 signalling in enteroids modulates enterocyte responses to secreted factors from bone marrow-derived dendritic cells.

Potential role of fecal volatile organic compounds as biomarkers of chemically induced intestinal inflammation in mice (2019)
Journal Article
Reade, S., Williams, J. M., Aggio, R., Duckworth, C. A., Mahalhal, A., Hough, R., Pritchard, D. M., & Probert, C. S. (2019). Potential role of fecal volatile organic compounds as biomarkers of chemically induced intestinal inflammation in mice. FASEB Journal, 33(3), 3129-3136. https://doi.org/10.1096/fj.201800076RR

Metabolomics studies have the potential to discover biomarkers. Fecal volatile organic compounds (VOCs) have been found to differ in patients with inflammatory bowel disease and irritable bowel syndrome. Murine models of colitis offer an alternative... Read More about Potential role of fecal volatile organic compounds as biomarkers of chemically induced intestinal inflammation in mice.

Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models (2017)
Journal Article
Burkitt, M. D., Duckworth, C. A., Williams, J. M., & Pritchard, D. M. (2017). Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models. Disease Models and Mechanisms, 10(2), 89-104. https://doi.org/10.1242/dmm.027649

Gastric colonization with Helicobacter pylori induces diverse human pathological conditions, including superficial gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric adenocarcinoma and its precursors. The... Read More about Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models.

Intestinal Preparation Techniques for Histological Analysis in the Mouse (2016)
Journal Article
Williams, J. M., Duckworth, C. A., Vowell, K., Burkitt, M. D., & Pritchard, D. M. (2016). Intestinal Preparation Techniques for Histological Analysis in the Mouse. https://doi.org/10.1002/cpmo.2

The murine intestinal tract represents a difficult organ system to study due to its long convoluted tubular structure, narrow diameter, and delicate mucosa which undergoes rapid changes after sampling prior to fixation. These features do not make for... Read More about Intestinal Preparation Techniques for Histological Analysis in the Mouse.

bak deletion stimulates gastric epithelial proliferation and enhances Helicobacter felis-induced gastric atrophy and dysplasia in mice (2015)
Journal Article
Duckworth, C. A., Abuderman, A. A., Burkitt, M. D., Williams, J. M., O'Reilly, L. A., & Pritchard, D. M. (2015). bak deletion stimulates gastric epithelial proliferation and enhances Helicobacter felis-induced gastric atrophy and dysplasia in mice. https://doi.org/10.1152/ajpgi.00404.2014

Helicobacter infection causes a chronic superficial gastritis that in some cases progresses via atrophic gastritis to adenocarcinoma. Proapoptotic bak has been shown to regulate radiation-induced apoptosis in the stomach and colon and also susceptibi... Read More about bak deletion stimulates gastric epithelial proliferation and enhances Helicobacter felis-induced gastric atrophy and dysplasia in mice.

Epithelial cell shedding and barrier function: a matter of life and death at the small intestinal villus tip (2015)
Journal Article
Williams, J. M., Duckworth, C. A., Burkitt, M. D., Watson, A. J., Campbell, B. J., & Pritchard, D. M. (2015). Epithelial cell shedding and barrier function: a matter of life and death at the small intestinal villus tip. Veterinary Pathology, 523(3), 445-55. https://doi.org/10.1177/0300985814559404

The intestinal epithelium is a critical component of the gut barrier. Composed of a single layer of intestinal epithelial cells (IECs) held together by tight junctions, this delicate structure prevents the transfer of harmful microorganisms, antigens... Read More about Epithelial cell shedding and barrier function: a matter of life and death at the small intestinal villus tip.

Dietary supplementation with soluble plantain non-starch polysaccharides inhibits intestinal invasion of salmonella typhimurium in the chicken (2014)
Journal Article
Parsons, B. N., Wigley, P., Simpson, H., Williams, J. M., Humphrey, S., Salisbury, A.-M., Watson, A. J. M., Fry, S. C., O'Brien, D., Roberts, C. L., O'Kennedy, N., Keita, A. V., Soderholm, J. D., Rhodes, J. M., & Campbell, B. J. (2014). Dietary supplementation with soluble plantain non-starch polysaccharides inhibits intestinal invasion of salmonella typhimurium in the chicken. PLoS ONE, https://doi.org/10.1371/journal.pone.0087658

Soluble fibres (non-starch polysaccharides, NSP) from edible plants but particularly plantain banana (Musa spp.), have been shown in vitro and ex vivo to prevent various enteric pathogens from adhering to, or translocating across, the human intestina... Read More about Dietary supplementation with soluble plantain non-starch polysaccharides inhibits intestinal invasion of salmonella typhimurium in the chicken.