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Type I and III interferons disrupt lung epithelial repair during recovery from viral infection (2020)
Journal Article
Major, J., Crotta, S., Llorian, M., McCabe, T. M., Gad, H. H., Priestnall, S. L., Hartmann, R., & Wack, A. (2020). Type I and III interferons disrupt lung epithelial repair during recovery from viral infection. Science, 369(6504), 712-717. https://doi.org/10.1126/science.abc2061

Interferons (IFNs) are central to antiviral immunity. Viral recognition elicits IFN production, which in turn triggers the transcription of IFN-stimulated genes (ISGs), which engage in various antiviral functions. Type I IFNs (IFN-α and IFN-β) are wi... Read More about Type I and III interferons disrupt lung epithelial repair during recovery from viral infection.

Peritoneal fluid accumulation in the femoral canal as a result of a post‐traumatic femoral hydrocele in a mature Warmblood stallion (2020)
Journal Article
Baldwin, C. M., Priestnall, S. L., & McMaster, M. (2020). Peritoneal fluid accumulation in the femoral canal as a result of a post‐traumatic femoral hydrocele in a mature Warmblood stallion. Equine Veterinary Education, https://doi.org/10.1111/eve.13301

The following case report documents the clinical presentation, ultrasonographic appearance, surgical management and outcome of a horse with a traumatic tear extending from the superficial and deep inguinal rings, across the aponeurosis of the externa... Read More about Peritoneal fluid accumulation in the femoral canal as a result of a post‐traumatic femoral hydrocele in a mature Warmblood stallion.

Equine penile squamous cell carcinoma: expression of biomarker proteins and EcPV2 (2020)
Journal Article
Arthurs, C., Suarez-Bonnet, A., Willis, C., Xie, B., Machulla, N., Mair, T. S., Cao, K., Millar, M., Thrasivoulou, C., Priestnall, S. L., & Ahmed, A. (2020). Equine penile squamous cell carcinoma: expression of biomarker proteins and EcPV2. Scientific Reports, 10(1), https://doi.org/10.1038/s41598-020-64014-3

Equine penile squamous cell carcinoma (EpSCC) is a relatively common cutaneous neoplasm with a poor prognosis. In this study, we aimed to determine the protein expression and colocalisation of FRA1, c-Myc, Cyclin D1, and MMP7 in normal (NT), tumour (... Read More about Equine penile squamous cell carcinoma: expression of biomarker proteins and EcPV2.

Canine Respiratory Coronavirus: A Naturally Occurring Model of COVID-19? (2020)
Journal Article
Priestnall, S. L. (2020). Canine Respiratory Coronavirus: A Naturally Occurring Model of COVID-19?. Veterinary Pathology, https://doi.org/10.1177/0300985820926485

Discovered in 2003 at the Royal Veterinary College, London, canine respiratory coronavirus (CRCoV) is a betacoronavirus of dogs and major cause of canine infectious respiratory disease complex. Generally causing mild clinical signs of persistent coug... Read More about Canine Respiratory Coronavirus: A Naturally Occurring Model of COVID-19?.

Histiocytic sarcoma in miniature schnauzers: 30 cases (2020)
Journal Article
Purzycka, K., Peters, L. M., Elliott, J., Lamb, C. R., Priestnall, S. L., Hardas, A., Johnston, C. A., & Rodriguez‐Piza, I. (2020). Histiocytic sarcoma in miniature schnauzers: 30 cases. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13139

Objectives
To summarise the clinical presentation and outcomes in a series of miniature schnauzers diagnosed with histiocytic sarcoma.

Materials and Methods
Retrospective review of medical records of miniature schnauzers diagnosed with histiocyt... Read More about Histiocytic sarcoma in miniature schnauzers: 30 cases.

Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis (2020)
Journal Article
Moreira-Teixeira, L., Tabone, O., Graham, C. M., Singhania, A., Stavropoulos, E., Redford, P. S., Chakravarty, P., Priestnall, S. L., Suarez-Bonnet, A., Herbert, E., Mayer-Barber, K. D., Sher, A., Fonseca, K. L., Sousa, J., Cá, B., Verma, R., Haldar, P., Saraiva, M., & O’Garra, A. (2020). Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis. Nature Immunology, 21(4), 464-476. https://doi.org/10.1038/s41590-020-0610-z

Although mouse infection models have been extensively used to study the host response to Mycobacterium tuberculosis, their validity in revealing determinants of human tuberculosis (TB) resistance and disease progression has been heavily debated. Here... Read More about Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis.

Gene Expression Profiling of B Cell Lymphoma in Dogs Reveals Dichotomous Metabolic Signatures Distinguished by Oxidative Phosphorylation (2020)
Journal Article
Wu, Y., Chang, Y. M., Polton, G., Stell, A. J., Szladovits, B., Macfarlane, M., Peters, L. M., Priestnall, S. L., Bacon, N. J., Kow, K., Stewart, S., Sharma, E., Goulart, M. R., Gribben, J., Xia, D., & Garden, O. A. (2020). Gene Expression Profiling of B Cell Lymphoma in Dogs Reveals Dichotomous Metabolic Signatures Distinguished by Oxidative Phosphorylation. Frontiers in Oncology, 10, https://doi.org/10.3389/fonc.2020.00307

Gene expression profiling has revealed molecular heterogeneity of diffuse large B cell lymphoma (DLBCL) in both humans and dogs. Two DLBCL subtypes based on cell of origin are generally recognized, germinal center B (GCB)-like and activated B cell (A... Read More about Gene Expression Profiling of B Cell Lymphoma in Dogs Reveals Dichotomous Metabolic Signatures Distinguished by Oxidative Phosphorylation.

Avian Papilloma and Squamous Cell Carcinoma: a Histopathological, Immunohistochemical and Virological study (2020)
Journal Article
Jones, A. L., Suárez-Bonnet, A., Mitchell, J. A., Ramirez, G. A., Stidworthy, M. F., & Priestnall, S. L. (2020). Avian Papilloma and Squamous Cell Carcinoma: a Histopathological, Immunohistochemical and Virological study. Journal of Comparative Pathology, 175, 13-23. https://doi.org/10.1016/j.jcpa.2019.11.007

In this retrospective study, we describe the histopathological findings in seven papillomas and 45 squamous cell carcinomas (SCCs) from psittacine birds, raptors and domestic fowl. The age of affected birds ranged from 3 to 40 years, with median age... Read More about Avian Papilloma and Squamous Cell Carcinoma: a Histopathological, Immunohistochemical and Virological study.

Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice (2019)
Journal Article
Ying Wu, Chang, Y. M., Stell, A. J., Priestnall, S. L., Sharma, E., Goulart, M. R., Gribben, J., Xia, D., & Garden, O. A. (2019). Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice. https://doi.org/10.1038/s41598-019-50065-8

Regulatory T cells (Tregs) are a double-edged regulator of the immune system. Aberrations of Tregs correlate with pathogenesis of inflammatory, autoimmune and neoplastic disorders. Phenotypically and functionally distinct subsets of Tregs have been i... Read More about Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice.

Bilateral capital physeal dysplasia in a ferret (Mustela putorius furo) treated with femoral head ostectomy (2019)
Journal Article
Swaffield, M., Hedley, J., Stapleton, N., Priestnall, S. L., Suárez-Bonnet, A., & Baldrey, V. (2019). Bilateral capital physeal dysplasia in a ferret (Mustela putorius furo) treated with femoral head ostectomy. Journal of Exotic Pet Medicine, https://doi.org/10.1053/j.jepm.2019.05.003

A six-month-old male entire ferret presented for investigation of atraumatic bilateral pelvic limb lameness. Radiographic and subsequent histopathological assessment of the femoral heads following bilateral femoral head ostectomy was consistent with... Read More about Bilateral capital physeal dysplasia in a ferret (Mustela putorius furo) treated with femoral head ostectomy.

Canine Ependymoma: Diagnostic Criteria and Common Pitfalls (2019)
Journal Article
Miller, A. D., Koehler, J. W., Donovan, T. A., Stewart, J. E., Porter, B. F., Rissi, D. R., Priestnall, S. L., & Schulman, F. Y. (2019). Canine Ependymoma: Diagnostic Criteria and Common Pitfalls. Veterinary Pathology, 56(6), 860-867. https://doi.org/10.1177/0300985819859872

Reports of canine ependymoma are generally restricted to single case reports with tumor incidence estimated at 2% to 3% of primary central nervous system (CNS) tumors. While most commonly reported in the lateral ventricle, tumors can occur anywhere i... Read More about Canine Ependymoma: Diagnostic Criteria and Common Pitfalls.

Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases (2019)
Journal Article
Singhania, A., Graham, C. M., Gabryšová, L., Moreira-Teixeira, L., Stavropoulos, E., Pitt, J. M., Chakravarty, P., Warnatsch, A., Branchett, W. J., Conejero, L., Lin, J.-W., Davidson, S., Wilson, M. S., Bancroft, G., Langhorne, J., Frickel, E., Sesay, A. K., Priestnall, S. L., Herbert, E., Ioannou, M., …O’Garra, A. (2019). Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases. Nature Communications, 10, https://doi.org/10.1038/s41467-019-10601-6

Understanding how immune challenges elicit different responses is critical for diagnosing and deciphering immune regulation. Using a modular strategy to interpret the complex transcriptional host response in mouse models of infection and inflammation... Read More about Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases.

Nonocular Melanocytic Neoplasia in Cats: Characterization and Proposal of a Histologic Classification Scheme to More Accurately Predict Clinical Outcome (2019)
Journal Article
Pittaway, R., Dobromylskyj, M. J., Erles, K., Pittaway, C. E., Suárez-Bonnet, A., Chang, Y. M., & Priestnall, S. L. (2019). Nonocular Melanocytic Neoplasia in Cats: Characterization and Proposal of a Histologic Classification Scheme to More Accurately Predict Clinical Outcome. Veterinary Pathology, 56(6), 868-877. https://doi.org/10.1177/0300985819854435

Nonocular melanocytic neoplasia is considered uncommon in cats yet is routinely encountered in diagnostic pathology and recognized to exhibit a wide variation in biological behavior. Accurate prediction of clinical outcomes is challenging with no wid... Read More about Nonocular Melanocytic Neoplasia in Cats: Characterization and Proposal of a Histologic Classification Scheme to More Accurately Predict Clinical Outcome.

Lymphatic endothelial cell immunohistochemical markers for evaluation of the intestinal lymphatic vasculature in dogs with chronic inflammatory enteropathy (2019)
Journal Article
Wennogle, S. A., Priestnall, S. L., Suárez-Bonnet, A., Soontararak, S., & Webb, C. B. (2019). Lymphatic endothelial cell immunohistochemical markers for evaluation of the intestinal lymphatic vasculature in dogs with chronic inflammatory enteropathy. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.15545

Correlating Gastrointestinal Histopathologic Changes to Clinical Disease Activity in Dogs With Idiopathic Inflammatory Bowel Disease (2019)
Journal Article
Allenspach, K., Mochel, J. P., Du, Y., Priestnall, S. L., Moore, F., Slayter, M., Rodrigues, A., Ackermann, M., Krockenberger, M., Mansell, J., Luckschander, N., Wang, C., Suchodolski, J., Berghoff, N., & Jergens, A. E. (2019). Correlating Gastrointestinal Histopathologic Changes to Clinical Disease Activity in Dogs With Idiopathic Inflammatory Bowel Disease. Veterinary Pathology, 56(3), 435-443. https://doi.org/10.1177/0300985818813090

Prior studies have failed to detect a convincing association between histologic lesions of inflammation and clinical activity in dogs with inflammatory bowel disease (IBD). We hypothesized that use of a simplified histopathologic scoring system would... Read More about Correlating Gastrointestinal Histopathologic Changes to Clinical Disease Activity in Dogs With Idiopathic Inflammatory Bowel Disease.

Malignant Cutaneous Peripheral Nerve Sheath Tumour with Rhabdomyosarcomatous Differentiation (Triton Tumour) in a Domestic Cat (2018)
Journal Article
Stoll, A. L., Suárez-Bonnet, A., Summers, B. A., & Priestnall, S. L. (2018). Malignant Cutaneous Peripheral Nerve Sheath Tumour with Rhabdomyosarcomatous Differentiation (Triton Tumour) in a Domestic Cat. Journal of Comparative Pathology, 165, 1-5. https://doi.org/10.1016/j.jcpa.2018.09.003

Divergent differentiation is encountered frequently within human malignant peripheral nerve sheath tumours (MPNSTs). The new component is often a rhabdomyosarcoma, but in animals this specific form of divergent differentiation within MPNSTs has only... Read More about Malignant Cutaneous Peripheral Nerve Sheath Tumour with Rhabdomyosarcomatous Differentiation (Triton Tumour) in a Domestic Cat.

Observational Study Design in Veterinary Pathology, Part 2: Methodology (2018)
Journal Article
Caswell, J. L., Bassel, L. L., Rothenburger, J. L., Gröne, A., Sargeant, J. M., Beck, A. P., Ekman, S., Gibson-Corley, K. N., Kuiken, T., LaDouceur, E. E. B., Meyerholz, D. K., Origgi, F. C., Posthaus, H., Priestnall, S. L., Ressel, L., Sharkey, L., Teixeira, L. B. C., Uchida, K., Ward, J. M., Webster, J. D., & Yamate, J. (2018). Observational Study Design in Veterinary Pathology, Part 2: Methodology. Veterinary Pathology, 55(6), 774-785. https://doi.org/10.1177/0300985818798121

Observational studies are a basis for much of our knowledge of veterinary pathology, yet considerations for conducting pathology-based observational studies are not readily available. In part 1 of this series, we offered advice on planning and carryi... Read More about Observational Study Design in Veterinary Pathology, Part 2: Methodology.