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Population Pharmacokinetics and Pharmacodynamics Modeling of Torasemide and Furosemide After Oral Repeated Administration in Healthy Dogs (2020)
Journal Article
Pelligand, L., Guillot, E., Geneteau, A., Guyonnet, J., Magnier, R., Elliott, J., Peyrou, M., & Jacobs, M. (2020). Population Pharmacokinetics and Pharmacodynamics Modeling of Torasemide and Furosemide After Oral Repeated Administration in Healthy Dogs. Frontiers in Veterinary Science, 7, https://doi.org/10.3389/fvets.2020.00151

Torasemide is a loop diuretic licensed in dogs for cardiogenic pulmonary oedema. The aim of this pharmacokinetic-pharmacodynamic (PK/PD) study was to define an optimally effective dosage regimen based on preclinical data. In a first study, 5 dogs rec... Read More about Population Pharmacokinetics and Pharmacodynamics Modeling of Torasemide and Furosemide After Oral Repeated Administration in Healthy Dogs.

Spatial and temporal overlaps between leopards ( Panthera pardus ) and their competitors in the African large predator guild (2020)
Journal Article
Rafiq, K., Hayward, M. W., Wilson, A. M., Meloro, C., Jordan, N. R., Wich, S. A., McNutt, J. W., & Golabek, K. A. (2020). Spatial and temporal overlaps between leopards ( Panthera pardus ) and their competitors in the African large predator guild. Journal of Zoology, 311(4), 246-259

Understanding the mechanisms facilitating coexistence within species assemblages is a key consideration for conservation as intact assemblages are necessary for maintaining full ecosystem function. The African large predator guild represents one of t... Read More about Spatial and temporal overlaps between leopards ( Panthera pardus ) and their competitors in the African large predator guild.

Spatial and temporal overlaps between leopards (Panthera pardus ) and their competitors in the African large predator guild (2020)
Journal Article
Rafiq, K., Hayward, M. W., Wilson, A. M., Meloro, C., Jordan, N. R., Wich, S. A., McNutt, J. W., & Golabek, K. A. (2020). Spatial and temporal overlaps between leopards (Panthera pardus ) and their competitors in the African large predator guild. Journal of Zoology, https://doi.org/10.1111/jzo.12781

Understanding the mechanisms facilitating coexistence within species assemblages is a key consideration for conservation as intact assemblages are necessary for maintaining full ecosystem function. The African large predator guild represents one of t... Read More about Spatial and temporal overlaps between leopards (Panthera pardus ) and their competitors in the African large predator guild.

In vitro-virtual-reality: an anatomically explicit musculoskeletal simulation powered by in vitro muscle using closed loop tissue-software interaction (2020)
Journal Article
Richards, C. T., & Eberhard, E. A. (2020). In vitro-virtual-reality: an anatomically explicit musculoskeletal simulation powered by in vitro muscle using closed loop tissue-software interaction. Journal of Experimental Biology, https://doi.org/10.1242/jeb.210054

Muscle force-length dynamics are governed by intrinsic contractile properties, motor stimulation and mechanical load. Although intrinsic properties are well-characterised, physiologists lack in vitro instrumentation accounting for combined effects of... Read More about In vitro-virtual-reality: an anatomically explicit musculoskeletal simulation powered by in vitro muscle using closed loop tissue-software interaction.

Minimally Invasive Markers of Stress and Production Parameters in Dairy Cows before and after the Installation of a Voluntary Milking System (2020)
Journal Article
Jerram, L. J., Van Winden, S. C. L., & Fowkes, R. C. (2020). Minimally Invasive Markers of Stress and Production Parameters in Dairy Cows before and after the Installation of a Voluntary Milking System. Animals, 10(4), 589. https://doi.org/10.3390/ani10040589

Automatic milking systems (AMS) are a low-labour alternative to conventional parlours, with previous studies demonstrating that cows vary in their ability to cope with the change to AMS. Cortisol expression can be combined with other measures to asse... Read More about Minimally Invasive Markers of Stress and Production Parameters in Dairy Cows before and after the Installation of a Voluntary Milking System.

Toxicokinetics of bisphenol-S and its glucuronide in plasma and urine following oral and dermal exposure in volunteers for the interpretation of biomonitoring data (2020)
Journal Article
Khmiri, I., Côté, J., Mantha, M., Khemiri, R., Lacroix, M., Gely, C., Toutain, P.-L., Picard-Hagen, N., Gayrard, V., & Bouchard, M. (2020). Toxicokinetics of bisphenol-S and its glucuronide in plasma and urine following oral and dermal exposure in volunteers for the interpretation of biomonitoring data. Environment International, 138, 105644. https://doi.org/10.1016/j.envint.2020.105644

The measurement of bisphenol-S (BPS) and its glucurono-conjugate (BPSG) in urine may be used for the biomonitoring of exposure in populations. However, this requires a thorough knowledge of their toxicokinetics. The time courses of BPS and BPSG were... Read More about Toxicokinetics of bisphenol-S and its glucuronide in plasma and urine following oral and dermal exposure in volunteers for the interpretation of biomonitoring data.

Toxicokinetics of bisphenol-S and its glucuronide in plasma and urine following oral and dermal exposure in volunteers for the interpretation of biomonitoring data (2020)
Journal Article
Khmiri, I., Côté, J., Mantha, M., Khemiri, R., Lacroix, M., Gely, C., Toutain, P.-L., Picard-Hagen, N., Gayrard, M., & Bouchard, M. (2020). Toxicokinetics of bisphenol-S and its glucuronide in plasma and urine following oral and dermal exposure in volunteers for the interpretation of biomonitoring data. Environment International, 138, https://doi.org/10.1016/j.envint.2020.105644

The measurement of bisphenol-S (BPS) and its glucurono-conjugate (BPSG) in urine may be used for the biomonitoring of exposure in populations. However, this requires a thorough knowledge of their toxicokinetics. The time courses of BPS and BPSG were... Read More about Toxicokinetics of bisphenol-S and its glucuronide in plasma and urine following oral and dermal exposure in volunteers for the interpretation of biomonitoring data.

Applied mechanical loading to mouse hindlimb acutely increases skeletal perfusion and chronically enhanced vascular porosity (2020)
Journal Article
Gohin, S., Javaheri, B., Hopkinson, M., Pitsillides, A. A., Arnett, T. R., & Chenu, C. (2020). Applied mechanical loading to mouse hindlimb acutely increases skeletal perfusion and chronically enhanced vascular porosity. Journal of Applied Physiology,

Blood supply is essential for osteogenesis, yet its relationship to load-related increases in bone mass is poorly defined. Herein, we aim to investigate the link between load-induced osteogenesis and the blood supply (bone perfusion and vascular poro... Read More about Applied mechanical loading to mouse hindlimb acutely increases skeletal perfusion and chronically enhanced vascular porosity.

Recent progress on the flight of dragonflies and damselflies (2020)
Journal Article
Nakata, T., Henningsson, P., Lin, H.-T., & Bomphrey, R. J. (2020). Recent progress on the flight of dragonflies and damselflies. International Journal of Odonatology, 23(1), 41-49. https://doi.org/10.1080/13887890.2019.1688502

Remarkable flight performance is key to the survival of adult Odonata. They integrate varied three-dimensional architectures and kinematics of the wings, unsteady aerodynamics, and sensory feedback control in order to achieve agile flight. Therefore,... Read More about Recent progress on the flight of dragonflies and damselflies.

Lasting organ-level bone mechanoadaptation is unrelated to local strain (2020)
Journal Article
Javaheri, B., Razi, H., Gohin, S., Wylie, S., Chang, Y. M., Salmon, P., Lee, P. D., & Pitsillides, A. A. (2020). Lasting organ-level bone mechanoadaptation is unrelated to local strain. Science Advances, 6(10), https://doi.org/10.1126/sciadv.aax8301

Bones adapt to mechanical forces according to strict principles predicting straight shape. Most bones are, however, paradoxically curved. To solve this paradox, we used computed tomography–based, four-dimensional imaging methods and computational ana... Read More about Lasting organ-level bone mechanoadaptation is unrelated to local strain.

Aldosterone and the mineralocorticoid receptor in renal injury: A potential therapeutic target in feline chronic kidney disease (2020)
Journal Article
Spencer, S., Wheeler-Jones, C. P. D., & Elliott, J. (2020). Aldosterone and the mineralocorticoid receptor in renal injury: A potential therapeutic target in feline chronic kidney disease. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.12848

There is a growing body of experimental and clinical evidence supporting mineralocorticoid receptor (MR) activation as a powerful mediator of renal damage in laboratory animals and humans. Multiple pathophysiological mechanisms are proposed, with the... Read More about Aldosterone and the mineralocorticoid receptor in renal injury: A potential therapeutic target in feline chronic kidney disease.

High aerodynamic lift from the tail reduces drag in gliding raptors (2020)
Journal Article
Usherwood, J. R., Cheney, J. A., Song, J., Windsor, S. P., Stevenson, J. P. J., Dierksheide, U., Nila, A., & Bomphrey, R. J. (2020). High aerodynamic lift from the tail reduces drag in gliding raptors. Journal of Experimental Biology, 223, https://doi.org/10.1242/jeb.214809

Many functions have been postulated for the aerodynamic role of the avian tail during steady-state flight. By analogy with conventional aircraft, the tail might provide passive pitch stability if it produced very low or negative lift. Alternatively,... Read More about High aerodynamic lift from the tail reduces drag in gliding raptors.

Improving translatability of preclinical studies for neuromuscular disorders: lessons from the TREAT-NMD Advisory Committee for Therapeutics (TACT) (2020)
Journal Article
Willmann, R., Lee, J., Turner, C., Nagaraju, K., Aartsma-Rus, A., Wells, D. J., Wagner, K. R., Csimma, C., Straub, V., Grounds, M. D., & De Luca, A. (2020). Improving translatability of preclinical studies for neuromuscular disorders: lessons from the TREAT-NMD Advisory Committee for Therapeutics (TACT). Disease Models and Mechanisms, 13(2), https://doi.org/10.1242/dmm.042903

Clinical trials for rare neuromuscular diseases imply, among other investments, a high emotional burden for the whole disease community. Translation of data from preclinical studies to justify any clinical trial must be carefully pondered in order to... Read More about Improving translatability of preclinical studies for neuromuscular disorders: lessons from the TREAT-NMD Advisory Committee for Therapeutics (TACT).

Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice (2020)
Journal Article
Galea, G., Delisser, P., Meakin, L., Price, J., & Windahl, S. (2020). Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice. BONE, 133, 115255. https://doi.org/10.1016/j.bone.2020.115255

The primary aim of osteoanabolic therapies is to strategically increase bone mass in skeletal regions likely to experience high strains. In the young healthy skeleton, this is primarily achieved by bone's adaptation to loading. This adaptation appear... Read More about Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice.

Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice (2020)
Journal Article
Galea, G., Delisser, P., Meakin, L., Price, J., & Windahl, S. (2020). Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice. BONE, 133, 115255. https://doi.org/10.1016/j.bone.2020.115255

The primary aim of osteoanabolic therapies is to strategically increase bone mass in skeletal regions likely to experience high strains. In the young healthy skeleton, this is primarily achieved by bone's adaptation to loading. This adaptation appear... Read More about Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice.

Network Analysis for Complex Neurodegenerative Diseases (2020)
Journal Article
Manzoni, C., Lewis, P. A., & Ferrari, R. (2020). Network Analysis for Complex Neurodegenerative Diseases. Current Genetic Medicine Reports, https://doi.org/10.1007/s40142-020-00181-z

Biomedicine is witnessing a paradigm shift in the way complex disorders are investigated. In particular, the need for big data interpretation has led to the development of pipelines that require the cooperation of different fields of expertise, inclu... Read More about Network Analysis for Complex Neurodegenerative Diseases.

Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2 (2020)
Journal Article
Galea, G., Paradise, C., Meakin, L., Camilleri, E., Taipaleenmaki, H., Stein, G., Lanyon, L., Price, J., van Wijnen, A., & Dudakovic, A. (2020). Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2. https://doi.org/10.1016/j.gene.2020.100027

Mechanical loading-related strains trigger bone formation by osteoblasts while suppressing resorption by osteoclasts, uncoupling the processes of formation and resorption. Osteocytes may orchestrate this process in part by secreting sclerostin (SOST)... Read More about Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2.

Extracellular pyrophosphate: The body's “water softener” (2020)
Journal Article
Orriss, I. R. (2020). Extracellular pyrophosphate: The body's “water softener”. BONE, https://doi.org/10.1016/j.bone.2020.115243

Extracellular pyrophosphate (ePPi) was first identified as a key endogenous inhibitor of mineralisation in the 1960's by Fleisch and colleagues. The main source of ePPi seems to be extracellular ATP which is continually released from cells in a contr... Read More about Extracellular pyrophosphate: The body's “water softener”.