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A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis (2023)
Journal Article
Elliott, J. (2023). A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis. Equine Veterinary Journal, https://doi.org/10.1111/evj.13933

Equine laminitis has both fascinated and frustrated veterinary researchers and clinicians for many years. The recognition that many ponies suffering from pasture associated laminitis have an insulin dysregulated phenotype (endocrinopathic laminitis,... Read More about A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis.

Regional modular responses in different bone compartments to the anabolic effect of PTH (1-34) and axial loading in mice (2023)
Journal Article
Monzem, S., Valkani, D., Evans, L., Chang, Y., & Pitsillides, A. (2023). Regional modular responses in different bone compartments to the anabolic effect of PTH (1-34) and axial loading in mice. BONE, 170, https://doi.org/10.1016/j.bone.2023.116720

Beneficial effects of intermittent parathyroid hormone (PTH) on bone mass and architecture are described to either simply add to, or to synergise with those of mechanical loading. We evaluate whether interaction with in vivo loading is reinforced by... Read More about Regional modular responses in different bone compartments to the anabolic effect of PTH (1-34) and axial loading in mice.

Expert assessment of the impact of ship-strikes on cetacean welfare using the Welfare Assessment Tool for Wild Cetaceans (2023)
Journal Article
Rae, F., Nicol, C., & Simmonds, M. (2023). Expert assessment of the impact of ship-strikes on cetacean welfare using the Welfare Assessment Tool for Wild Cetaceans. Animal Welfare Journal, 32, Article e18. https://doi.org/10.1017/awf.2023.7

Human activities are increasingly impacting our oceans and the focus of attention tends to be on their environmental impacts, rather than consequences for animal welfare. Global shipping density has quadrupled since 1992. Unsurprisingly, increased le... Read More about Expert assessment of the impact of ship-strikes on cetacean welfare using the Welfare Assessment Tool for Wild Cetaceans.

In cats undergoing midline ovariohysterectomy, is the use of local infiltration anaesthesia with bupivacaine associated with a reduction in post-operative pain score? (2023)
Journal Article
Freeman, T., Wisbey, A., Burroughs, K., Gentle, S., Ellis, C., & Batt-Williams, S. (in press). In cats undergoing midline ovariohysterectomy, is the use of local infiltration anaesthesia with bupivacaine associated with a reduction in post-operative pain score?. Veterinary Evidence, https://doi.org/10.18849/ve.v8i1.552

A knowledge Summary for RCVS knowledge - A student assignment to be published with a member of staff as supervisor In cats undergoing midline ovariohysterectomy, is the use of local infiltration anaesthesia with bupivacaine associated with a red... Read More about In cats undergoing midline ovariohysterectomy, is the use of local infiltration anaesthesia with bupivacaine associated with a reduction in post-operative pain score?.

Novel insights on the effect of sclerostin on bone and other organs (2023)
Journal Article
Dreyer, T., Keen, J., Wells, L., & Roberts, S. (2023). Novel insights on the effect of sclerostin on bone and other organs. Journal of Endocrinology, 257(2), https://doi.org/10.1530/JOE-22-0209

As a key regulator of bone homeostasis, sclerostin has garnered a lot of interest over the last two decades. Although sclerostin is primarily expressed by osteocytes and is well known for its role in bone formation and remodelling, it is also express... Read More about Novel insights on the effect of sclerostin on bone and other organs.

Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway (2023)
Journal Article
Rickman, M., Ghim, M., Pang, K., von Huelsen Rocha, A. C., Drudi, E. M., Sureda-Vives, M., …Warboys, C. M. (in press). Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway. Journal of Cell Science, https://doi.org/10.1242/jcs.260449

Multidirectional or disturbed flow promotes endothelial dysfunction and is associated with early atherogenesis. Here we investigated the role of Wnt signalling in flow-mediated endothelial dysfunction. The expression of Frizzled-4 was higher in cultu... Read More about Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway.

Locomotor and postural diversity among reptiles: palaeobiological implications (2023)
Journal Article
Gônet, J., Bardin, J., Girondot, M., Hutchinson, J., & Laurin, M. (2023). Locomotor and postural diversity among reptiles: palaeobiological implications. Journal of Anatomy, https://doi.org/10.1111/joa.13833

The conquest of land by the first tetrapod vertebrates represents a key stage in their evolution. Selection pressures exerted by this new environment on animals led to the emergence of new locomotor and postural strategies that favoured access to dif... Read More about Locomotor and postural diversity among reptiles: palaeobiological implications.

Comparison of environment quality measurements between 3 types of calf housing in the United Kingdom (2023)
Journal Article
Mahendran, S., Blackie, N., wathes, C., & booth, R. (in press). Comparison of environment quality measurements between 3 types of calf housing in the United Kingdom. Journal of Dairy Science, https://doi.org/10.3168/jds.2022-22613

Pre-weaned calves are kept in a range of housing types which offer variable protection against the weather and provide differing internal environments. This cross-sectional observational study assessed the influence of housing type (shed, polytunnel... Read More about Comparison of environment quality measurements between 3 types of calf housing in the United Kingdom.

Thin and hypokinetic myocardial segments in cats with cardiomyopathy (2023)
Journal Article
Matos, J., Sargent, J., Silva, J., Payne, J., Seo, J., Spalla, I., …Fuentes, V. (2023). Thin and hypokinetic myocardial segments in cats with cardiomyopathy. Journal of Veterinary Cardiology, 46, 5-17. https://doi.org/10.1016/j.jvc.2023.02.002

Introduction/objectives: Thin and hypokinetic myocardial segments (THyMS) represent adverse ventricular (LV) remodeling in human hypertrophic car-diomyopathy. We describe the echocardiographic features and outcome in cats with THyMS, and in a subpopu... Read More about Thin and hypokinetic myocardial segments in cats with cardiomyopathy.

The impact of age-related increase in passive muscle stiffness on simulated upper limb reaching (2023)
Journal Article
Murtola, T., & Richards, C. (2023). The impact of age-related increase in passive muscle stiffness on simulated upper limb reaching. Royal Society Open Science, 10, Article 221453. https://doi.org/10.1098/rsos.221453

Ageing changes the musculoskeletal and neural systems, potentially affecting a person's ability to perform daily living activities. One of these changes is increased passive stiffness of muscles, but its contribution to performance is difficult to se... Read More about The impact of age-related increase in passive muscle stiffness on simulated upper limb reaching.

Pharma-cartography: Navigating the complexities of antibiotic supply to rural livestock in West Bengal, India, through value chain and power dynamic analysis (2023)
Journal Article
Hennessey, M., Ebata, A., Samanta, I., Mateus, A., Arnold, J., Day, D., …Alarcon, P. (in press). Pharma-cartography: Navigating the complexities of antibiotic supply to rural livestock in West Bengal, India, through value chain and power dynamic analysis. PLoS ONE, 18(2), e0281188. https://doi.org/10.1371/journal.pone.0281188

Antibiotic resistance threatens provision of healthcare and livestock production worldwide with predicted negative socioeconomic impact. Antibiotic stewardship can be considered of importance to people living in rural communities, many of which depen... Read More about Pharma-cartography: Navigating the complexities of antibiotic supply to rural livestock in West Bengal, India, through value chain and power dynamic analysis.

Clinical presentation, diagnostic investigations, treatment protocols and outcomes of dogs diagnosed with tick-borne diseases living in the United Kingdom: 76 cases (2005-2019) Animal Health Trust, Newmarket, UK † † (2023)
Journal Article
Silvestrini, P., Lloyd-Bradley, B., Glanemann, B., Barker, E. N., Badham, H., Tappin, S., …Piviani, M. (2023). Clinical presentation, diagnostic investigations, treatment protocols and outcomes of dogs diagnosed with tick-borne diseases living in the United Kingdom: 76 cases (2005-2019) Animal Health Trust, Newmarket, UK † †. Journal of Small Animal Practice, 1-9. https://doi.org/10.1111/jsap.13592

Objectives: To report the presence of tick-borne diseases in dogs living in the United Kingdom. Materials and MethOds: Dogs with a final diagnosis of tick-borne diseases made between January 2005 and August 2019 at seven referral institutions in the... Read More about Clinical presentation, diagnostic investigations, treatment protocols and outcomes of dogs diagnosed with tick-borne diseases living in the United Kingdom: 76 cases (2005-2019) Animal Health Trust, Newmarket, UK † †.

Shear-mediated ALK5 expression regulates endothelial activation (2023)
Journal Article
Pang, K. T., Ghim, M., Sarathchandra, P., Warboys, C. M., Yacoub, M. H., Chester, A. H., & Weinberg, P. D. (2023). Shear-mediated ALK5 expression regulates endothelial activation. Biochemical and Biophysical Research Communications, 642, 90-96. https://doi.org/10.1016/j.bbrc.2022.12.058

Calcific aortic valve disease affects the aortic side of the valve, exposed to low magnitude multidirectional (“disturbed) blood flow, more than it affects the ventricular side, exposed to high magnitude uniaxial flow. Overt disease is preceded by en... Read More about Shear-mediated ALK5 expression regulates endothelial activation.