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Computed tomography of the equine temporohyoid joint: Association between imaging changes and potential risk factors (2025)
Journal Article
Dash, R., Perkins, J., Chang, Y., & Morgan, R. (2025). Computed tomography of the equine temporohyoid joint: Association between imaging changes and potential risk factors. Equine Veterinary Journal, https://doi.org/10.1111/evj.14495

Background: Temporohyoid osteoarthropathy (THO) is characterised by bone proliferation and cartilage ossification caused by infectious and degenerative conditions, amongst others. Objectives: To describe the variable appearance of the temporohyoid jo... Read More about Computed tomography of the equine temporohyoid joint: Association between imaging changes and potential risk factors.

The cholinergic anti-inflammatory pathway inhibits inflammation without lymphocyte relay (2023)
Journal Article
Simon, T., Kirk, J., Dolezalova, N., Guyot, M., Panzolini, C., Bondue, A., Lavergne, J., Hugues, S., Hypolite, N., Saeb-Parsy, K., Perkins, J., Macia, E., Sridhar, A., Vervoordeldonk, M., Glaichenhaus, N., Donega, M., & Blancou, P. (2023). The cholinergic anti-inflammatory pathway inhibits inflammation without lymphocyte relay. Frontiers in Neuroscience, 17, https://doi.org/10.3389/fnins.2023.1125492

The magnitude of innate inflammatory immune responses is dependent on interactions between peripheral neural and immune cells. In particular, a cholinergic anti-inflammatory pathway (CAP) has been identified in the spleen whereby noradrenaline (NA) r... Read More about The cholinergic anti-inflammatory pathway inhibits inflammation without lymphocyte relay.

Bilateral Functional Electrical Stimulation for the Treatment of Presbyphonia in a Sheep Model (2023)
Journal Article
Kirsch, A., Gerstenberger, C., Jakubass, B., Tschernitz, M., Perkins, J., Groselj-Strele, A., Lanmueller, H., Jarvis, J., Kniesburges, S., Doellinger, M., & Gugatschka, M. (2023). Bilateral Functional Electrical Stimulation for the Treatment of Presbyphonia in a Sheep Model. The Laryngoscope, https://doi.org/10.1002/lary.30984

Objectives: The aim of the study was to increase muscle volume and improve phonation characteristics of the aged ovine larynx by functional electrical stimulation (FES) using a minimally invasive surgical procedure. Methods: Stimulation electrodes we... Read More about Bilateral Functional Electrical Stimulation for the Treatment of Presbyphonia in a Sheep Model.

Organotopic organization of the porcine mid-cervical vagus nerve (2023)
Journal Article
Thompson, N., Ravagli, E., Mastitskaya, S., Iacoviello, F., Stathopoulou, T., Perkins, J., Shearing, P., Aristovich, K., & Holder, D. (2023). Organotopic organization of the porcine mid-cervical vagus nerve. Frontiers in Neuroscience, 17, https://doi.org/10.3389/fnins.2023.963503

IntroductionDespite detailed characterization of fascicular organization of somatic nerves, the functional anatomy of fascicles evident in human and large mammal cervical vagus nerve is unknown. The vagus nerve is a prime target for intervention in t... Read More about Organotopic organization of the porcine mid-cervical vagus nerve.

Overcoming temporal dispersion for measurement of activity-related impedance changes in unmyelinated nerves (2022)
Journal Article
Tarotin, I., Mastitskaya, S., Ravagli, E., Perkins, J., Holder, D., & Aristovich, K. (2022). Overcoming temporal dispersion for measurement of activity-related impedance changes in unmyelinated nerves. Journal of Neural Engineering, 19(2), https://doi.org/10.1088/1741-2552/ac669a

Objective. Fast neural electrical impedance tomography is an imaging technique that has been successful in visualising electrically evoked activity of myelinated fibres in peripheral nerves by measurement of the impedance changes (dZ) accompanying ex... Read More about Overcoming temporal dispersion for measurement of activity-related impedance changes in unmyelinated nerves.

Cultured dissociated primary dorsal root ganglion neurons from adult horses enable study of axonal transport (2022)
Journal Article
Adalbert, R., Cahalan, S., Hopkins, E., Almuhanna, A., Loreto, A., Por, E., Perkins, J., Coleman, M., & Piercy, R. (2022). Cultured dissociated primary dorsal root ganglion neurons from adult horses enable study of axonal transport. Journal of Anatomy, https://doi.org/10.1111/joa.13719

Neurological disorders are prevalent in horses, but their study is challenging due to anatomic constraints and the large body size; very few host-specific in vitro models have been established to study these types of diseases, particularly from adult... Read More about Cultured dissociated primary dorsal root ganglion neurons from adult horses enable study of axonal transport.

Ex vivo biomechanical evaluation of polyester and polyblend suture techniques to perform equine laryngoplasty (2022)
Journal Article
Pressanto, M., Pascoletti, G., Perkins, J., Zanetti, E., Beccati, F., Santalucia, V., & Pepe, M. (2022). Ex vivo biomechanical evaluation of polyester and polyblend suture techniques to perform equine laryngoplasty. Veterinary Surgery, https://doi.org/10.1111/vsu.13777

Objective To validate the use of a polyblend tape suture in equine laryngoplasty (PL). Study design Experimental study. Animals Thirty-two cadaveric larynges. Methods Each larynx was randomly assigned to 1 of 4 groups: PL with polyblend tape suture (... Read More about Ex vivo biomechanical evaluation of polyester and polyblend suture techniques to perform equine laryngoplasty.

Human-relevant near-organ neuromodulation of the immune via the nerve (2021)
Journal Article
Donega, M., Fjordbakk, C., Kirk, J., Sokal, D., Gupta, I., Hunsberger, G., Crawford, A., Cook, S., Viscasillas, J., Stathopoulou, T., Miranda, J., Dopson, W., Goodwin, D., Rowles, A., McGill, P., McSloy, A., Werling, D., Witherington, J., Chew, D., & Perkins, J. (2021). Human-relevant near-organ neuromodulation of the immune via the nerve. Proceedings of the National Academy of Sciences, 118(20), https://doi.org/10.1073/pnas.2025428118

Neuromodulation of immune function by stimulating the autonomic connections to the spleen has been demonstrated in rodent models. Consequently, neuroimmune modulation has been proposed as a new therapeutic strategy for the treatment of inflammatory c... Read More about Human-relevant near-organ neuromodulation of the immune via the nerve.

Optimisation and validation of immunohistochemical axonal markers for morphological and functional characterisation of equine peripheral nerves (2021)
Journal Article
Almuhanna, A., Cahalan, S., Lane, A., Goodwin, D., Perkins, J., & Piercy, R. (2021). Optimisation and validation of immunohistochemical axonal markers for morphological and functional characterisation of equine peripheral nerves. Equine Veterinary Journal, 53(6), 1188-1198. https://doi.org/10.1111/evj.13403

Background: Horses are affected by various peripheral nerve disorders but defining their aetiology and pathophysiology is hampered by limited understanding of associated morphological and pathological changes and involvement of specific axonal types.... Read More about Optimisation and validation of immunohistochemical axonal markers for morphological and functional characterisation of equine peripheral nerves.

Imaging of focal seizures with Electrical Impedance Tomography and depth electrodes in real time (2021)
Journal Article
Witkowska-Wrobel, A., Aristovich, K., Crawford, A., Perkins, J., & Holder, D. (2021). Imaging of focal seizures with Electrical Impedance Tomography and depth electrodes in real time. NeuroImage, 234, https://doi.org/10.1016/j.neuroimage.2021.117972

A B S T R A C T Intracranial EEG is the current gold standard technique for localizing seizures for surgery, but it can be insen-sitive to tangential dipole or distant sources. Electrical Impedance Tomography (EIT) offers a novel method to improve co... Read More about Imaging of focal seizures with Electrical Impedance Tomography and depth electrodes in real time.

Model-based geometrical optimisation and in vivo validation of a spatially selective multielectrode cuff array for vagus nerve neuromodulation (2021)
Journal Article
Aristovich, K., Donega, M., Fjordbakk, C., Tarotin, I., Chapman, C., Viscasillas, J., Stathopoulou, T., Crawford, A., Chew, D., Perkins, J., & Holder, D. (2021). Model-based geometrical optimisation and in vivo validation of a spatially selective multielectrode cuff array for vagus nerve neuromodulation. Journal of Neuroscience Methods, 352, https://doi.org/10.1016/j.jneumeth.2021.109079

Background: Neuromodulation by electrical stimulation of the human cervical vagus nerve may be limited by adverse side effects due to stimulation of off-target organs. It may be possible to overcome this by spatially selective stimulation of peripher... Read More about Model-based geometrical optimisation and in vivo validation of a spatially selective multielectrode cuff array for vagus nerve neuromodulation.

Splenic Nerve Neuromodulation Reduces Inflammation and Promotes Resolution in Chronically Implanted Pigs (2021)
Journal Article
Sokal, D., McSloy, A., Donega, M., Kirk, J., Colas, R., Dolezalova, N., Gomez, E., Gupta, I., Fjordbakk, C., Ouchouche, S., Matteucci, P., Schlegel, K., Bashirullah, R., Werling, D., Harman, K., Rowles, A., Yazicioglu, R., Dalli, J., Chew, D., & Perkins, J. (2021). Splenic Nerve Neuromodulation Reduces Inflammation and Promotes Resolution in Chronically Implanted Pigs. Frontiers in Immunology, 12, https://doi.org/10.3389/fimmu.2021.649786

Neuromodulation of the immune system has been proposed as a novel therapeutic strategy for the treatment of inflammatory conditions. We recently demonstrated that stimulation of near-organ autonomic nerves to the spleen can be harnessed to modulate t... Read More about Splenic Nerve Neuromodulation Reduces Inflammation and Promotes Resolution in Chronically Implanted Pigs.

Quantification of clinically applicable stimulation parameters for precision near-organ neuromodulation of human splenic nerves (2020)
Journal Article
Gupta, I., Cassará, A. M., Tarotin, I., Donega, M., Miranda, J. A., Sokal, D. M., Ouchouche, S., Dopson, W., Matteucci, P., Neufeld, E., Schiefer, M. A., Rowles, A., McGill, P., Perkins, J., Dolezalova, N., Saeb-Parsy, K., Kuster, N., Yazicioglu, R. F., Witherington, J., & Chew, D. J. (2020). Quantification of clinically applicable stimulation parameters for precision near-organ neuromodulation of human splenic nerves. Communications Biology, 3(1), 577

Abstract: Neuromodulation is a new therapeutic pathway to treat inflammatory conditions by modulating the electrical signalling pattern of the autonomic connections to the spleen. However, targeting this sub-division of the nervous system presents sp... Read More about Quantification of clinically applicable stimulation parameters for precision near-organ neuromodulation of human splenic nerves.

MicroCT optimisation for imaging fascicular anatomy in peripheral nerves (2020)
Journal Article
Thompson, N., Ravagli, E., Mastitskaya, S., Iacoviello, F., Aristovich, K., Perkins, J. D. M., Shearing, P. R., & Holder, D. (2020). MicroCT optimisation for imaging fascicular anatomy in peripheral nerves. Journal of Neuroscience Methods, 108652. https://doi.org/10.1016/j.jneumeth.2020.108652

Due to the lack of understanding of the fascicular organisation, vagus nerve stimulation (VNS) leads to unwanted off-target effects. Micro-computed tomography (microCT) can be used to trace fascicles from periphery and image fascicular anatomy.
In t... Read More about MicroCT optimisation for imaging fascicular anatomy in peripheral nerves.

Feasibility of kilohertz frequency alternating current neuromodulation of carotid sinus nerve activity in the pig (2019)
Journal Article
Fjordbakk, C. T., Miranda, J. A., Sokal, D., Donegà, M., Viscasillas, J., Stathopoulou, T.-R., Chew, D. J., & Perkins, J. D. M. (2019). Feasibility of kilohertz frequency alternating current neuromodulation of carotid sinus nerve activity in the pig. https://doi.org/10.1038/s41598-019-53566-8

Recent research supports that over-activation of the carotid body plays a key role in metabolic diseases like type 2 diabetes. Supressing carotid body signalling through carotid sinus nerve (CSN) modulation may offer a therapeutic approach for treati... Read More about Feasibility of kilohertz frequency alternating current neuromodulation of carotid sinus nerve activity in the pig.

Investigation into pathophysiology of naturally occurring palatal instability and intermittent dorsal displacement of the soft palate (DDSP) in racehorses: Thyro-hyoid muscles fatigue during exercise (2019)
Journal Article
Cercone, M., Olsen, E., Perkins, J. D. M., Cheetham, J., Mitchell, L. M., & Ducharme, N. G. (2019). Investigation into pathophysiology of naturally occurring palatal instability and intermittent dorsal displacement of the soft palate (DDSP) in racehorses: Thyro-hyoid muscles fatigue during exercise. PLoS ONE, 14, https://doi.org/10.1371/journal.pone.0224524

Exercise induced intermittent dorsal displacement of the soft palate (DDSP) is a common cause of airway obstruction and poor performance in racehorses. The definite etiology is still unclear, but through an experimental model, a role in the developme... Read More about Investigation into pathophysiology of naturally occurring palatal instability and intermittent dorsal displacement of the soft palate (DDSP) in racehorses: Thyro-hyoid muscles fatigue during exercise.

Assessing pathological changes within the nucleus ambiguus of horses with Recurrent Laryngeal Neuropathy: an extreme, length-dependent axonopathy (2019)
Journal Article
Draper, A. C. E., Cahalan, S. D., Goodwin, D., Perkins, J. D. M., & Piercy, R. J. (2019). Assessing pathological changes within the nucleus ambiguus of horses with Recurrent Laryngeal Neuropathy: an extreme, length-dependent axonopathy. Muscle & Nerve, https://doi.org/10.1002/mus.26699

Equine recurrent laryngeal neuropathy (RLN) is a naturally occurring model of length‐dependent axonopathy characterised by asymmetrical degeneration of recurrent laryngeal nerve axons (RLn). Distal RLn degeneration is marked, however it is unclear wh... Read More about Assessing pathological changes within the nucleus ambiguus of horses with Recurrent Laryngeal Neuropathy: an extreme, length-dependent axonopathy.

Ex vivo investigation of the effect of the transverse arytenoid ligament on abduction of the arytenoid cartilage when performing equine laryngoplasty (2019)
Journal Article
Chesworth, M., Brandenberger, O., Cheetham, J., Windley, Z., Schumacher, J., Cochran, K., Piercy, R. J., & Perkins, J. D. M. (2019). Ex vivo investigation of the effect of the transverse arytenoid ligament on abduction of the arytenoid cartilage when performing equine laryngoplasty. New Zealand Veterinary Journal, 67(5), 264-269. https://doi.org/10.1080/00480169.2019.1635538

Functional Electrical Stimulation following nerve injury in a Large Animal Model (2019)
Journal Article
Cercone, M., Jarvis, J., Ducharme, N., Perkins, J. D. M., Piercy, R. J., Willand, M., Mitchell, L., Sledziona, M., Soderholm, L. V., & Cheetham, J. (2019). Functional Electrical Stimulation following nerve injury in a Large Animal Model. Muscle & Nerve, 59(6), 717-725. https://doi.org/10.1002/mus.26460

Introduction: Controversy exists over the effects of functional electrical stimulation (FES) on reinnervation. We hypothesized that intramuscular FES would not delay reinnervation after recurrent laryngeal nerve (RLn) axonotmesis. Methods: RLn cryo‐i... Read More about Functional Electrical Stimulation following nerve injury in a Large Animal Model.