Skip to main content

Research Repository

Advanced Search

Browse


Bilateral Functional Electrical Stimulation for the Treatment of Presbyphonia in a Sheep Model (2023)
Journal Article
Kirsch, A., Gerstenberger, C., Jakubass, B., Tschernitz, M., Perkins, J., Groselj-Strele, A., …Gugatschka, M. (2023). Bilateral Functional Electrical Stimulation for the Treatment of Presbyphonia in a Sheep Model. The Laryngoscope, https://doi.org/10.1002/lary.30984

Objectives: The aim of the study was to increase muscle volume and improve phonation characteristics of the aged ovine larynx by functional electrical stimulation (FES) using a minimally invasive surgical procedure. Methods: Stimulation electrodes we... Read More about Bilateral Functional Electrical Stimulation for the Treatment of Presbyphonia in a Sheep Model.

Cultured dissociated primary dorsal root ganglion neurons from adult horses enable study of axonal transport (2022)
Journal Article
Adalbert, R., Cahalan, S., Hopkins, E., Almuhanna, A., Loreto, A., Por, E., …Piercy, R. (2022). Cultured dissociated primary dorsal root ganglion neurons from adult horses enable study of axonal transport. Journal of Anatomy, https://doi.org/10.1111/joa.13719

Neurological disorders are prevalent in horses, but their study is challenging due to anatomic constraints and the large body size; very few host-specific in vitro models have been established to study these types of diseases, particularly from adult... Read More about Cultured dissociated primary dorsal root ganglion neurons from adult horses enable study of axonal transport.

Model-based geometrical optimisation and in vivo validation of a spatially selective multielectrode cuff array for vagus nerve neuromodulation (2021)
Journal Article
Aristovich, K., Donega, M., Fjordbakk, C., Tarotin, I., Chapman, C., Viscasillas, J., …Holder, D. (2021). Model-based geometrical optimisation and in vivo validation of a spatially selective multielectrode cuff array for vagus nerve neuromodulation. Journal of Neuroscience Methods, 352, https://doi.org/10.1016/j.jneumeth.2021.109079

Background: Neuromodulation by electrical stimulation of the human cervical vagus nerve may be limited by adverse side effects due to stimulation of off-target organs. It may be possible to overcome this by spatially selective stimulation of peripher... Read More about Model-based geometrical optimisation and in vivo validation of a spatially selective multielectrode cuff array for vagus nerve neuromodulation.

Optimisation and validation of immunohistochemical axonal markers for morphological and functional characterisation of equine peripheral nerves (2021)
Journal Article
Almuhanna, A., Cahalan, S., Lane, A., Goodwin, D., Perkins, J., & Piercy, R. (2021). Optimisation and validation of immunohistochemical axonal markers for morphological and functional characterisation of equine peripheral nerves. Equine Veterinary Journal, 53(6), 1188-1198. https://doi.org/10.1111/evj.13403

Background: Horses are affected by various peripheral nerve disorders but defining their aetiology and pathophysiology is hampered by limited understanding of associated morphological and pathological changes and involvement of specific axonal types.... Read More about Optimisation and validation of immunohistochemical axonal markers for morphological and functional characterisation of equine peripheral nerves.

Quantification of clinically applicable stimulation parameters for precision near-organ neuromodulation of human splenic nerves (2020)
Journal Article
Gupta, I., Cassará, A. M., Tarotin, I., Donega, M., Miranda, J. A., Sokal, D. M., …Chew, D. J. (2020). Quantification of clinically applicable stimulation parameters for precision near-organ neuromodulation of human splenic nerves. Communications Biology, 3(1), 577

Abstract: Neuromodulation is a new therapeutic pathway to treat inflammatory conditions by modulating the electrical signalling pattern of the autonomic connections to the spleen. However, targeting this sub-division of the nervous system presents sp... Read More about Quantification of clinically applicable stimulation parameters for precision near-organ neuromodulation of human splenic nerves.

Feasibility of kilohertz frequency alternating current neuromodulation of carotid sinus nerve activity in the pig (2019)
Journal Article
Fjordbakk, C. T., Miranda, J. A., Sokal, D., Donegà, M., Viscasillas, J., Stathopoulou, T., …Perkins, J. D. M. (2019). Feasibility of kilohertz frequency alternating current neuromodulation of carotid sinus nerve activity in the pig. https://doi.org/10.1038/s41598-019-53566-8

Recent research supports that over-activation of the carotid body plays a key role in metabolic diseases like type 2 diabetes. Supressing carotid body signalling through carotid sinus nerve (CSN) modulation may offer a therapeutic approach for treati... Read More about Feasibility of kilohertz frequency alternating current neuromodulation of carotid sinus nerve activity in the pig.

Investigation into pathophysiology of naturally occurring palatal instability and intermittent dorsal displacement of the soft palate (DDSP) in racehorses: Thyro-hyoid muscles fatigue during exercise (2019)
Journal Article
Cercone, M., Olsen, E., Perkins, J. D. M., Cheetham, J., Mitchell, L. M., & Ducharme, N. G. (2019). Investigation into pathophysiology of naturally occurring palatal instability and intermittent dorsal displacement of the soft palate (DDSP) in racehorses: Thyro-hyoid muscles fatigue during exercise. PLoS ONE, 14, https://doi.org/10.1371/journal.pone.0224524

Exercise induced intermittent dorsal displacement of the soft palate (DDSP) is a common cause of airway obstruction and poor performance in racehorses. The definite etiology is still unclear, but through an experimental model, a role in the developme... Read More about Investigation into pathophysiology of naturally occurring palatal instability and intermittent dorsal displacement of the soft palate (DDSP) in racehorses: Thyro-hyoid muscles fatigue during exercise.

Assessing pathological changes within the nucleus ambiguus of horses with Recurrent Laryngeal Neuropathy: an extreme, length-dependent axonopathy (2019)
Journal Article
Draper, A. C. E., Cahalan, S. D., Goodwin, D., Perkins, J. D. M., & Piercy, R. J. (2019). Assessing pathological changes within the nucleus ambiguus of horses with Recurrent Laryngeal Neuropathy: an extreme, length-dependent axonopathy. Muscle & Nerve, https://doi.org/10.1002/mus.26699

Equine recurrent laryngeal neuropathy (RLN) is a naturally occurring model of length?dependent axonopathy characterised by asymmetrical degeneration of recurrent laryngeal nerve axons (RLn). Distal RLn degeneration is marked, however it is unclear wh... Read More about Assessing pathological changes within the nucleus ambiguus of horses with Recurrent Laryngeal Neuropathy: an extreme, length-dependent axonopathy.

Immunohistochemical and morphological characterisation of equine recurrent laryngeal and distal limb nerves supports classification of recurrent laryngeal neuropathy as a polyneuropathy (2019)
Journal Article
Almuhanna, A. H., Cahalan, S., Goodwin, D., Perkins, J. D. M., & Piercy, R. J. (2019). Immunohistochemical and morphological characterisation of equine recurrent laryngeal and distal limb nerves supports classification of recurrent laryngeal neuropathy as a polyneuropathy. Equine Veterinary Journal, 51(S53), 27. https://doi.org/10.1111/evj.46_13152

Ex vivo investigation of the effect of the transverse arytenoid ligament on abduction of the arytenoid cartilage when performing equine laryngoplasty (2019)
Journal Article
Chesworth, M., Brandenberger, O., Cheetham, J., Windley, Z., Schumacher, J., Cochran, K., …Perkins, J. D. M. (2019). Ex vivo investigation of the effect of the transverse arytenoid ligament on abduction of the arytenoid cartilage when performing equine laryngoplasty. New Zealand Veterinary Journal, 67(5), 264-269. https://doi.org/10.1080/00480169.2019.1635538

Functional Electrical Stimulation following nerve injury in a Large Animal Model (2019)
Journal Article
Cercone, M., Jarvis, J., Ducharme, N., Perkins, J. D. M., Piercy, R. J., Willand, M., …Cheetham, J. (2019). Functional Electrical Stimulation following nerve injury in a Large Animal Model. Muscle & Nerve, 59(6), 717-725. https://doi.org/10.1002/mus.26460

Introduction: Controversy exists over the effects of functional electrical stimulation (FES) on reinnervation. We hypothesized that intramuscular FES would not delay reinnervation after recurrent laryngeal nerve (RLn) axonotmesis. Methods: RLn cryo?i... Read More about Functional Electrical Stimulation following nerve injury in a Large Animal Model.

Electrode fabrication and interface optimization for imaging of evoked peripheral nervous system activity with electrical impedance tomography (EIT) (2019)
Journal Article
Chapman, C. A. R., Aristovich, K., Donega, M., Fjordbakk, C. T., Stathopoulou, T., Viscasillas, J., …Holder, D. (2019). Electrode fabrication and interface optimization for imaging of evoked peripheral nervous system activity with electrical impedance tomography (EIT). Journal of Neural Engineering, 16, 016001. https://doi.org/10.1088/1741-2552/aae868

Objective. Non-invasive imaging techniques are undoubtedly the ideal methods for continuous monitoring of neural activity. One such method, fast neural electrical impedance tomography (EIT) has been developed over the past decade in order to image ne... Read More about Electrode fabrication and interface optimization for imaging of evoked peripheral nervous system activity with electrical impedance tomography (EIT).

Reversing Age Related Changes of the Laryngeal Muscles by Chronic Electrostimulation of the Recurrent Laryngeal Nerve (2016)
Journal Article
Karbiener, M., Jarvis, J. C., Perkins, J. D. M., Lanmueller, H., Schmoll, M., Rode, H. S., …Gugatschka, M. (2016). Reversing Age Related Changes of the Laryngeal Muscles by Chronic Electrostimulation of the Recurrent Laryngeal Nerve. PLoS ONE, 11(11), https://doi.org/10.1371/journal.pone.0167367

Age related atrophy of the laryngeal muscles -mainly the thyroarytenoid muscle (TAM)- leads to a glottal gap and consequently to a hoarse and dysphonic voice that significantly affects quality of life. The aim of our study was to reverse this atrophy... Read More about Reversing Age Related Changes of the Laryngeal Muscles by Chronic Electrostimulation of the Recurrent Laryngeal Nerve.

Feasibility, repeatability, and safety of ultrasound-guided stimulation of the first cervical nerve at the alar foramen in horses (2016)
Journal Article
Mespoulhés-Riviére, C., Brandenberger, O., Rossignol, F., Robert, C., Perkins, J. D. M., Marie, J. P., & Ducharme, N. (2016). Feasibility, repeatability, and safety of ultrasound-guided stimulation of the first cervical nerve at the alar foramen in horses. American Journal of Veterinary Research, 77(11), 1245-1451. https://doi.org/10.2460/ajvr.77.11.1245

Effects of Functional Electrical Stimulation on Denervated Laryngeal Muscle in a Large Animal Model (2015)
Journal Article
Cheetham, J., Perkins, J. D. M., Jarvis, J. C., Cercone, M., Maw, M., Hermanson, J. W., …Ducharme, N. G. (2015). Effects of Functional Electrical Stimulation on Denervated Laryngeal Muscle in a Large Animal Model. Artificial Organs, 39(10), 876-885. https://doi.org/10.1111/aor.12624

Bilateral vocal fold paralysis (BVCP) is a life?threatening condition that follows injury to the Recurrent Laryngeal nerve (RLn) and denervation of the intrinsic laryngeal musculature. Functional electrical stimulation (FES) enables restoration and c... Read More about Effects of Functional Electrical Stimulation on Denervated Laryngeal Muscle in a Large Animal Model.