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Outputs (122)

Mitochondrial Dynamics in the Neonatal Brain -a potential target following injury? (2022)
Journal Article
Jones, A., & Thornton, C. (2022). Mitochondrial Dynamics in the Neonatal Brain -a potential target following injury?. Bioscience Reports, https://doi.org/10.1042/BSR20211696

The impact of birth asphyxia and its sequelae, hypoxic-ischaemic brain injury, is long lasting and significant, both for the infant and for their family. Treatment options are limited to therapeutic hypothermia, which is not universally successful an... Read More about Mitochondrial Dynamics in the Neonatal Brain -a potential target following injury?.

Position Statement: Minimal criteria for reporting veterinary and animal medicine research for mesenchymal stromal/stem cells in orthopaedic applications. (2022)
Journal Article
Guest, D. J., Dudhia, J., Smith, R. K., Roberts, S., Conzemius, M., Innes, J. F., Fortier, L., & Meeson, R. L. (2022). Position Statement: Minimal criteria for reporting veterinary and animal medicine research for mesenchymal stromal/stem cells in orthopaedic applications. Frontiers in Veterinary Science, https://doi.org/10.3389/fvets.2022.817041

Mesenchymal stromal/stem cells (MSCs) are being used in an increasingly broad range of clinical applications in horses, dogs and cats. In this position statement, we aim to provide guidelines to improve reporting research involving the use of MSCs in... Read More about Position Statement: Minimal criteria for reporting veterinary and animal medicine research for mesenchymal stromal/stem cells in orthopaedic applications..

Training related risk factors for Exercise Induced Pulmonary Haemorrhage in British National Hunt racehorses. (2022)
Journal Article
Cardwell, J., & McGilvray, T. (in press). Training related risk factors for Exercise Induced Pulmonary Haemorrhage in British National Hunt racehorses. Equine Veterinary Journal, https://doi.org/10.1111/evj.13448

Background: Exercise induced pulmonary haemorrhage (EIPH) is an important condition of horses performing high intensity exercise, with reported prevalence among racehorses of up to 95%, based on the detection of blood on tracheobronchoscopy. Previous... Read More about Training related risk factors for Exercise Induced Pulmonary Haemorrhage in British National Hunt racehorses..

A founder mutation in EHD1 presents with tubular proteinuria and deafness (2022)
Journal Article
Russell, C., Issler, N., Afonso, S., Ziegler, C., Weissman, . I., Dumitriu, S., Lowe, M., Jordan, K., Iancu, D., Davies, B., Cebrian-Serrano, A., Tekman, M., Böckenhauer, D., Warth, R., Kleta, R., Zaccai, T. C. . F., Meindl, K., Stanescu, H. C., Dahlke, E., Klootwijk, E. D., …Schilling, A. (online). A founder mutation in EHD1 presents with tubular proteinuria and deafness. Journal of the American Society of Nephrology,

Background:
The endocytic reabsorption of proteins in the proximal tubule requires a complex machinery and defects
can lead to tubular proteinuria. The precise mechanisms of endocytosis and processing of receptors and
cargo are incompletely unders... Read More about A founder mutation in EHD1 presents with tubular proteinuria and deafness.

Effect of theatre temperature on body temperature during anaesthesia for routine neutering of domestic rabbits (Oryctolagus cuniculus) (2021)
Journal Article
Edis, A., Pelligand, L., Baldrey, V., & Hedley, J. (2022). Effect of theatre temperature on body temperature during anaesthesia for routine neutering of domestic rabbits (Oryctolagus cuniculus). Veterinary Anaesthesia and Analgesia, 49(2), 173-181. https://doi.org/10.1016/j.vaa.2021.06.019

Objective: To investigate the effect of theatre temperature on body temperature in rabbits undergoing castration or ovariohysterectomy surgery during general anaesthesia.

Study design: Prospective, clinical study.

Animals: A group of 88 rabbits... Read More about Effect of theatre temperature on body temperature during anaesthesia for routine neutering of domestic rabbits (Oryctolagus cuniculus).

Population Pharmacokinetics of Intravenous Amoxicillin Combined With Clavulanic Acid in Healthy and Critically Ill Dogs (2021)
Journal Article
Vegas Cómitre, M., Cortellini, S., Devreese, M., Roques, B., Bousquet-Melou, A., Toutain, P.-L., & Pelligand, L. (2021). Population Pharmacokinetics of Intravenous Amoxicillin Combined With Clavulanic Acid in Healthy and Critically Ill Dogs. Journal of Veterinary Medicine, https://doi.org/10.3389/fvets.2021.770202

Background – Data regarding antimicrobial pharmacokinetics (PK) in critically ill dogs is lacking and likely differs from healthy dogs.

Hypothesis/Objectives —To describe a population PK model for intravenous amoxicillin clavulanic acid (AMC) in... Read More about Population Pharmacokinetics of Intravenous Amoxicillin Combined With Clavulanic Acid in Healthy and Critically Ill Dogs.

On the importance of integrating comparative anatomy and One Health perspectives in anatomy education (2021)
Journal Article
Bhattacharjee, S., Davies, D. C., Mcgonnell, I. M., Holmes, J. M., Kilroy, D., Holland, J. C., & Reynolds, A. L. (2022). On the importance of integrating comparative anatomy and One Health perspectives in anatomy education. Journal of Anatomy, 240(3), 429-446. https://doi.org/10.1111/joa

As a result of many factors, including climate change, unrestricted population growth, widespread deforestation and intensive agriculture, a new pattern of diseases in humans is emerging. With increasing encroachment by human societies into wild doma... Read More about On the importance of integrating comparative anatomy and One Health perspectives in anatomy education.

Effect of topical antimicrobial therapy and household cleaning on meticillin-resistant Staphylococcus pseudintermedius carriage in dogs (2021)
Journal Article
Frosini, S. M., Bond, R., King, R., Feudi, C., Schwarz, S., & Loeffler, A. (2021). Effect of topical antimicrobial therapy and household cleaning on meticillin-resistant Staphylococcus pseudintermedius carriage in dogs. BMJ Open, https://doi.org/10.1002/vetr.937

Abstract
MRSP is a multidrug-resistant, zoonotic canine pathogen. This study investigated MRSP carriage and clearance through topical antimicrobial therapy and household cleaning in dogs recovered from MRSP infection.
Dogs were swabbed for MRSP c... Read More about Effect of topical antimicrobial therapy and household cleaning on meticillin-resistant Staphylococcus pseudintermedius carriage in dogs.

S1P in the development of atherosclerosis: roles of haemodynamic wall shear stress and endothelial permeability (2021)
Journal Article
Warboys, C. M., & Weinberg, P. D. (2021). S1P in the development of atherosclerosis: roles of haemodynamic wall shear stress and endothelial permeability. Tissue Barriers, https://doi.org/10.1080/21688370.2021.1959243

Atherosclerosis is characterised by focal accumulations of lipid within the arterial wall, thought to arise from effects of haemodynamic wall shear stress (WSS) on endothelial permeability. Identifying pathways that mediate effects of shear on permea... Read More about S1P in the development of atherosclerosis: roles of haemodynamic wall shear stress and endothelial permeability.

Cross sectional study to identify prevalence of and factors associated with laminitis in UK donkeys (2021)
Journal Article
Menzies‐Gow, N., Wakeel, F., Little, H., Buil, J., & Rickards, K. (in press). Cross sectional study to identify prevalence of and factors associated with laminitis in UK donkeys. Journal of Equine Veterinary Science, https://doi.org/10.1111/evj.13505

Background
Laminitis causes lameness in donkeys, but its prevalence and factors associated with disease remain uncertain.

Objectives
To determine the prevalence of and identify factors associated with laminitis in donkeys.

Study design
Retro... Read More about Cross sectional study to identify prevalence of and factors associated with laminitis in UK donkeys.

Predictors of laminitis development in a cohort of non-laminitic ponies (2021)
Journal Article
Knowles, E., Elliott, J., Harris, P., Chang, R., & Menzies-Gow, N. (2021). Predictors of laminitis development in a cohort of non-laminitic ponies. Equine Veterinary Journal, https://doi.org/10.1111/evj.31_13492

Background: Quantifying the risk of laminitis development requires improvement.
Objectives: To identify the most useful physical examination, metabolic and management factors to predict future laminitis development in client-owned, non-laminitic pon... Read More about Predictors of laminitis development in a cohort of non-laminitic ponies.

Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor (2021)
Journal Article
Pang, K. T., Ghim, M., Liu, C., Tay, H. M., Fhu, C. W., Chia, R. N., Qiu, B., Sarathchandra, P., Chester, A. H., Yacoub, M. H., Wilkinson, F. L., Weston, R., Warboys, C. M., Hou, H. W., Weinberg, P. D., & Wang, X. (2021). Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor. Frontiers in Cell and Developmental Biology, 9, https://doi.org/10.3389/fcell.2021.706143

Elevated serum concentrations of leucine-rich α-2-glycoprotein (LRG1) have been reported in patients with inflammatory, autoimmune, and cardiovascular diseases. This study aims to investigate the role of LRG1 in endothelial activation. LRG1 in endoth... Read More about Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor.

Genotyping and Whole-Genome Resequencing of Welsh Sheep Breeds Reveal Candidate Genes and Variants for Adaptation to Local Environment and Socioeconomic Traits (2021)
Journal Article
Sweet-Jones, J., Lenis, V. P., Yurchenko, A. A., Yudin, N. S., Swain, M., & Larkin, D. M. (2021). Genotyping and Whole-Genome Resequencing of Welsh Sheep Breeds Reveal Candidate Genes and Variants for Adaptation to Local Environment and Socioeconomic Traits. Frontiers in Genetics, 12, https://doi.org/10.3389/fgene.2021.612492

Background: Advances in genetic tools applied to livestock breeding has prompted research into the previously neglected breeds adapted to harsh local environments. One such group is the Welsh mountain sheep breeds, which can be farmed at altitudes of... Read More about Genotyping and Whole-Genome Resequencing of Welsh Sheep Breeds Reveal Candidate Genes and Variants for Adaptation to Local Environment and Socioeconomic Traits.

Associations between behaviour and health outcomes in conventional and slow-growing breeds of broiler chicken (2021)
Journal Article
Abeyesinghe, S., Abeyesinghe, S., Chancellor, N., Hernandez Moore, D., Chang, Y.-M., Pearce, J., Demmers, T., & Nicol, C. (2021). Associations between behaviour and health outcomes in conventional and slow-growing breeds of broiler chicken. animal, 15(7), Article 100261. https://doi.org/10.1016/j.animal.2021.100261

Broiler chickens are prone to a range of complex health and welfare issues. To support informed selection of welfare traits whilst minimising impact on production efficiency and to address a major gap in understanding, we systematically explored asso... Read More about Associations between behaviour and health outcomes in conventional and slow-growing breeds of broiler chicken.

Global transcriptomic profiles of circulating leucocytes in early lactation cows with clinical or subclinical mastitis (2021)
Journal Article
Cheng, Z., Buggiotti, L., Salavati, M., Marchitelli, C., Palma-Vera, S., Wylie, A., Takeda, H., Tang, L., Crowe, M., Wathes, D., & GplusE Consortium. (in press). Global transcriptomic profiles of circulating leucocytes in early lactation cows with clinical or subclinical mastitis. Molecular Biology Reports,

Bovine mastitis is an inflammatory disease of the mammary gland, which is classified as subclinical or clinical. Circulating neutrophils are recruited to the udder to help combat infection. We compared the transcriptomic profiles in circulating leuko... Read More about Global transcriptomic profiles of circulating leucocytes in early lactation cows with clinical or subclinical mastitis.

An ethical framework for the use of horses in competitive sport: theory and function (2021)
Journal Article
Campbell, M. (2021). An ethical framework for the use of horses in competitive sport: theory and function. Animals, https://doi.org/10.3390/ani11061725

Growing ethical concern about equestrian sport is reflected in publications by regulatory authorities, animal charities, and the lay press; and in government debate and social media. However, attempts by regulators and stakeholders to address ethica... Read More about An ethical framework for the use of horses in competitive sport: theory and function.

The evolutionary biomechanics of locomotor function in giant land animals (2021)
Journal Article
Hutchinson, J. (2021). The evolutionary biomechanics of locomotor function in giant land animals. Journal of Experimental Biology, https://doi.org/10.1242/jeb.217463

Giant land vertebrates have evolved more than 30 times, notably in dinosaurs and mammals. The evolutionary and biomechanical perspectives considered here unify data from extant and extinct species, assessing current theory regarding how the locomotor... Read More about The evolutionary biomechanics of locomotor function in giant land animals.

Intra-operative Raman spectroscopy and ex vivo Raman mapping for assessment of cartilage degradation (2021)
Journal Article
Gaifulina, R., Nunn, A. D. G., Draper, E. R. C., Strachan, R. K., Blake, N., Firth, S., Thomas, G. M. H., Mcmillan, P. F., Dudhia, J., & 6ap, U. K. (2021). Intra-operative Raman spectroscopy and ex vivo Raman mapping for assessment of cartilage degradation. Applied Spectroscopy, https://doi.org/10.1016/j.clispe.2021.100012

The development of a label-free, non-destructive and safe analytical method such as Raman spectroscopy for assessing cartilage degradation is highly desirable. Compared to non-optical imaging modalities, Raman mapping offers a more sensitive means of... Read More about Intra-operative Raman spectroscopy and ex vivo Raman mapping for assessment of cartilage degradation.

The pen is milder than the blade: Identification marking mice using ink on the tail appears more humane than ear-punching even with local anaesthetic (2021)
Journal Article
Burn, C., Mazlan, N.-H., Chancellor, N., & Wells, D. (2021). The pen is milder than the blade: Identification marking mice using ink on the tail appears more humane than ear-punching even with local anaesthetic. Animals, 11, Article 1664. https://doi.org/10.3390/ani11061664

Identification marking mice commonly involves ear-punching with or without anaesthetic, or tail-marking with ink. To identify which is most humane, we marked male BALB/c mice using ear-punching (EP), ear-punching with anaesthetic EMLATM cream (EP+A),... Read More about The pen is milder than the blade: Identification marking mice using ink on the tail appears more humane than ear-punching even with local anaesthetic.