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The Effect of Visitors on the Behavior of Zoo-Housed Western Lowland Gorillas (Gorilla gorilla gorilla) (2020)
Journal Article
Lewis, R. N., Chang, Y. M., Ferguson, A., Lee, T., Clifforde, L., & Abeyesinghe, S. M. (2020). The Effect of Visitors on the Behavior of Zoo-Housed Western Lowland Gorillas (Gorilla gorilla gorilla). Zoo Biology, https://doi.org/10.1002/zoo.21552

Primates, especially apes, are popular with the public, often attracting large crowds. These crowds could cause behavioral change in captive primates, whether positive, neutral, or negative. We examined the impact of visitors on the behavior of six w... Read More about The Effect of Visitors on the Behavior of Zoo-Housed Western Lowland Gorillas (Gorilla gorilla gorilla).

Identification of Production Chain Risk Factors for Slaughterhouse Condemnation of Broiler Chickens’ (2020)
Journal Article
Buzdugan, S. N., Chang, Y. M., Huntington, B., Rushton, J., Guitian, J., Alarcon, P., & Blake, D. P. (2020). Identification of Production Chain Risk Factors for Slaughterhouse Condemnation of Broiler Chickens’. Preventive Veterinary Medicine, 105036. https://doi.org/10.1016/j.prevetmed.2020.105036

Slaughterhouse condemnation of broiler chickens results from identification of polymorphic pathological conditions during meat inspection from arrival and on theslaughter line. While conditions that result in condemnation are multifactorial, identifi... Read More about Identification of Production Chain Risk Factors for Slaughterhouse Condemnation of Broiler Chickens’.

Gene Expression Profiling of B Cell Lymphoma in Dogs Reveals Dichotomous Metabolic Signatures Distinguished by Oxidative Phosphorylation (2020)
Journal Article
Wu, Y., Chang, Y. M., Polton, G., Stell, A. J., Szladovits, B., Macfarlane, M., Peters, L. M., Priestnall, S. L., Bacon, N. J., Kow, K., Stewart, S., Sharma, E., Goulart, M. R., Gribben, J., Xia, D., & Garden, O. A. (2020). Gene Expression Profiling of B Cell Lymphoma in Dogs Reveals Dichotomous Metabolic Signatures Distinguished by Oxidative Phosphorylation. Frontiers in Oncology, 10, https://doi.org/10.3389/fonc.2020.00307

Gene expression profiling has revealed molecular heterogeneity of diffuse large B cell lymphoma (DLBCL) in both humans and dogs. Two DLBCL subtypes based on cell of origin are generally recognized, germinal center B (GCB)-like and activated B cell (A... Read More about Gene Expression Profiling of B Cell Lymphoma in Dogs Reveals Dichotomous Metabolic Signatures Distinguished by Oxidative Phosphorylation.

Lasting organ-level bone mechanoadaptation is unrelated to local strain (2020)
Journal Article
Javaheri, B., Razi, H., Gohin, S., Wylie, S., Chang, Y. M., Salmon, P., Lee, P. D., & Pitsillides, A. A. (2020). Lasting organ-level bone mechanoadaptation is unrelated to local strain. Science Advances, 6(10), https://doi.org/10.1126/sciadv.aax8301

Bones adapt to mechanical forces according to strict principles predicting straight shape. Most bones are, however, paradoxically curved. To solve this paradox, we used computed tomography–based, four-dimensional imaging methods and computational ana... Read More about Lasting organ-level bone mechanoadaptation is unrelated to local strain.

Pre-analytical factors affecting whole blood and plasma glucose concentrations in loggerhead sea turtles (Caretta caretta) (2020)
Journal Article
Kunze, P. E., Perrault, J. R., Chang, Y. M., Manire, C. A., Clark, S., & Stacy, N. I. (2020). Pre-analytical factors affecting whole blood and plasma glucose concentrations in loggerhead sea turtles (Caretta caretta). PLoS ONE, 15, https://doi.org/10.1371/journal.pone.0229800

Blood glucose is vital for many physiological pathways and can be quantified by clinical chemistry analyzers and in-house point-of-care (POC) devices. Pre-analytical and analytical factors can influence blood glucose measurements. This project aimed... Read More about Pre-analytical factors affecting whole blood and plasma glucose concentrations in loggerhead sea turtles (Caretta caretta).

Impacts of UVB provision on serum vitamin D3, pigmentation, growth rates and total body mineral content in Mallorcan midwife toad larvae (Alytes muletensis) (2020)
Journal Article
Whatley, C., Tapley, B., Chang, Y. M., Newton-Yowens, J., McKendry, D., & Michaels, C. (2020). Impacts of UVB provision on serum vitamin D3, pigmentation, growth rates and total body mineral content in Mallorcan midwife toad larvae (Alytes muletensis). https://doi.org/10.19227/jzar.v8i1.434

The health of amphibians in captive breeding programmes can be compromised by nutritional metabolic bone disease and secondary hyperparathyroidism, which is a result of poor calcium metabolism or an inverse calcium:phosphorus ratio in the blood. UVB... Read More about Impacts of UVB provision on serum vitamin D3, pigmentation, growth rates and total body mineral content in Mallorcan midwife toad larvae (Alytes muletensis).

Osteoarthritis-related nociceptive behaviour following mechanical joint loading correlates with cartilage damage (2020)
Journal Article
Ter Heegde, F., Luiz, A. P., Santana-Varela, S., Magnusdottir, R., Hopkinson, M., Chang, Y. M., Poulet, B., Fowkes, R. C., Wood, J. N., & Chenu, C. (2020). Osteoarthritis-related nociceptive behaviour following mechanical joint loading correlates with cartilage damage. Osteoarthritis and Cartilage, 28(3), 383-395. https://doi.org/10.1016/j.joca.2019.12.004

In osteoarthritis (OA), the pain-structure relationship remains complex and poorly understood. Here, we used the mechanical joint loading (MJL) model of OA to investigate both knee pathology and nociceptive behaviour.

Association between hyponatremia and neurological dysfunction in hospitalized foals (2019)
Journal Article
Dunkel, B., Dodson, F., Chang, Y. M., & Slovis, N. M. (2019). Association between hyponatremia and neurological dysfunction in hospitalized foals. Journal of Veterinary Emergency and Critical Care, 30(1), 66-73. https://doi.org/10.1111/vec.12906

Hyponatremia and rapid correction of hyponatremia can lead to neurological abnormalities. The objective of the study was to determine whether plasma sodium concentrations (Na+) and speed of correction of hyponatremia are significantly associated with... Read More about Association between hyponatremia and neurological dysfunction in hospitalized foals.

Divergent evolution of terrestrial locomotor abilities in extant Crocodylia (2019)
Journal Article
Hutchinson, J. R., Felkler, D., Houston, K., Chang, Y. M., Brueggen, J., Kledzik, D., & Vliet, K. A. (2019). Divergent evolution of terrestrial locomotor abilities in extant Crocodylia. https://doi.org/10.1038/s41598-019-55768-6

Extant Crocodylia are exceptional because they employ almost the full range of quadrupedal footfall patterns (“gaits”) used by mammals; including asymmetrical gaits such as galloping and bounding. Perhaps this capacity evolved in stem Crocodylomorpha... Read More about Divergent evolution of terrestrial locomotor abilities in extant Crocodylia.

Decision tree machine learning applied to bovine tuberculosis risk factors to aid disease control decision making (2019)
Journal Article
Romero, M. P., Chang, Y. M., Brunton, L. A., Parry, J., Prosser, A., Upton, P., Rees, E., Tearne, O., Arnold, M., Stevens, K., & Drewe, J. A. (2019). Decision tree machine learning applied to bovine tuberculosis risk factors to aid disease control decision making. Preventive Veterinary Medicine, https://doi.org/10.1016/j.prevetmed.2019.104860

Identifying and understanding the risk factors for endemic bovine tuberculosis (TB) in cattle herds is critical for the control of this disease. Exploratory machine learning techniques can uncover complex non-linear relationships and interactions wit... Read More about Decision tree machine learning applied to bovine tuberculosis risk factors to aid disease control decision making.

Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice (2019)
Journal Article
Ying Wu, Chang, Y. M., Stell, A. J., Priestnall, S. L., Sharma, E., Goulart, M. R., Gribben, J., Xia, D., & Garden, O. A. (2019). Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice. https://doi.org/10.1038/s41598-019-50065-8

Regulatory T cells (Tregs) are a double-edged regulator of the immune system. Aberrations of Tregs correlate with pathogenesis of inflammatory, autoimmune and neoplastic disorders. Phenotypically and functionally distinct subsets of Tregs have been i... Read More about Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice.

Pegbovigrastim treatment in vivo does not affect granulocyte ability to migrate to endometrial cells and kill bacteria in vitro in healthy cows (2019)
Journal Article
Tombacz, K., Peters, L. M., Chang, Y. M., Steele, M., Werling, D., & Gibson, A. J. (2019). Pegbovigrastim treatment in vivo does not affect granulocyte ability to migrate to endometrial cells and kill bacteria in vitro in healthy cows. Journal of Dairy Science, 102(10), 9389-9395. https://doi.org/10.3168/jds.2019-16563

In periparturient dairy cows, immune suppression, resulting in decreased neutrophil numbers and function, leads to increased susceptibility to postpartum conditions such as mastitis, retained placenta, and metritis. Administration of polyethylene gly... Read More about Pegbovigrastim treatment in vivo does not affect granulocyte ability to migrate to endometrial cells and kill bacteria in vitro in healthy cows.

Pregabalin for the treatment of syringomyelia-associated neuropathic pain in dogs: A randomised, placebo-controlled, double-masked clinical trial (2019)
Journal Article
Sanchis-Mora, S., Chang, Y. M., Abeyesinghe, S. M., Fisher, A., Upton, N., Volk, H. A., & Pelligand, L. (2019). Pregabalin for the treatment of syringomyelia-associated neuropathic pain in dogs: A randomised, placebo-controlled, double-masked clinical trial. https://doi.org/10.1016/j.tvjl.2019.06.006

Pregabalin is the first-line treatment for neuropathic pain (NeP) in humans. Dogs with Chiari-like malformation and syringomyelia (CM/SM) associated with NeP could benefit from pregabalin. The aim of this study was to evaluate the efficacy of pregaba... Read More about Pregabalin for the treatment of syringomyelia-associated neuropathic pain in dogs: A randomised, placebo-controlled, double-masked clinical trial.

Nonocular Melanocytic Neoplasia in Cats: Characterization and Proposal of a Histologic Classification Scheme to More Accurately Predict Clinical Outcome (2019)
Journal Article
Pittaway, R., Dobromylskyj, M. J., Erles, K., Pittaway, C. E., Suárez-Bonnet, A., Chang, Y. M., & Priestnall, S. L. (2019). Nonocular Melanocytic Neoplasia in Cats: Characterization and Proposal of a Histologic Classification Scheme to More Accurately Predict Clinical Outcome. Veterinary Pathology, 56(6), 868-877. https://doi.org/10.1177/0300985819854435

Nonocular melanocytic neoplasia is considered uncommon in cats yet is routinely encountered in diagnostic pathology and recognized to exhibit a wide variation in biological behavior. Accurate prediction of clinical outcomes is challenging with no wid... Read More about Nonocular Melanocytic Neoplasia in Cats: Characterization and Proposal of a Histologic Classification Scheme to More Accurately Predict Clinical Outcome.

Retrospective evaluation of the association between admission blood glucose and l-lactate concentrations in ponies and horses with gastrointestinal disease (2008-2016): 545 cases (2019)
Journal Article
Dunkel, B., Mason, C. J., & Chang, Y. M. (2019). Retrospective evaluation of the association between admission blood glucose and l-lactate concentrations in ponies and horses with gastrointestinal disease (2008-2016): 545 cases. Journal of Veterinary Emergency and Critical Care, https://doi.org/10.1111/vec.12851

A recent study described increased l‐lactate concentrations in ponies with gastrointestinal disease compared to horses, but blood glucose (BG) concentrations were not considered. The study tested the hypothesis that BG and l‐lactate concentrations ar... Read More about Retrospective evaluation of the association between admission blood glucose and l-lactate concentrations in ponies and horses with gastrointestinal disease (2008-2016): 545 cases.

Chronic kidney disease in cats attending primary care practice in the UK: a VetCompassTM study (2019)
Journal Article
Conroy, M. C., Brodbelt, D. C., O'Neill, D. G., Chang, Y. M., & Elliott, J. (2019). Chronic kidney disease in cats attending primary care practice in the UK: a VetCompassTM study. Veterinary Record, 184(17), https://doi.org/10.1136/vr.105100

Chronic kidney disease (CKD) is a frequent diagnosis in cats attending primary care practice and the most frequent cause of death in cats aged over five years, yet there is limited published research for CKD in cats attending primary care practice. T... Read More about Chronic kidney disease in cats attending primary care practice in the UK: a VetCompassTM study.