Disrupting myeloid-specific LXRa phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation (2018)
Journal Article
Gage, M. C., Becares, N., Louie, R., Waddington, K. E., Zhang, Y., Tittanegro, T. H., Rodriguez-Lorenzo, S., Jathanna, A., Pourcet, B., Pello, O., De La Rosa, J. V., Castrillo, A., & Pineda-Torra, I. (2018). Disrupting myeloid-specific LXRa phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation. https://doi.org/10.1073/pnas.1721245115

Macrophages are key immune cells for the initiation and development of atherosclerotic lesions. However, the macrophage regulatory nodes that determine how lesions progress in response to dietary challenges are not fully understood. Liver X receptors... Read More about Disrupting myeloid-specific LXRa phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation.

Cell specific microvesicles vary with season and disease predisposition in healthy and previously laminitic ponies (2018)
Journal Article
Finding, E. J. T., Lawson, C., Elliott, J., Harris, P. A., & Menzies-Gow, N. J. (2018). Cell specific microvesicles vary with season and disease predisposition in healthy and previously laminitic ponies. Veterinary Immunology and Immunopathology, https://doi.org/10.1016/j.vetimm.2018.06.001

Microvesicles are small (up to 1 μm) vesicles found in plasma and other bodily fluids. They are recognised as part of the normal system of inter-cellular communication but altered numbers are also used as biomarkers of disease. Microvesicles have not... Read More about Cell specific microvesicles vary with season and disease predisposition in healthy and previously laminitic ponies.

Factors That Modify the Risk of Early Pregnancy Loss and Early Conceptus Growth in Thoroughbreds (2018)
Journal Article
Rose, B. V., Chang, Y. M., Wathes, D. C., Verheyen, K. L. P., & De Mestre, A. M. (2018). Factors That Modify the Risk of Early Pregnancy Loss and Early Conceptus Growth in Thoroughbreds. Journal of Equine Veterinary Science, 66(179), https://doi.org/10.1016/j.jevs.2018.05.071

Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies (2018)
Journal Article
Timpson, A., De Mestre, A. M., Elliott, J., Harris, P. A., Cheng, Z. R., Mirczuk, S. M., Callan, L., Rainbow, L., & Menzies-Gow, N. J. (2018). Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies. Journal of Equine Veterinary Science, https://doi.org/10.1016/j.jevs.2018.06.009

The aims of the study were to determine whether adipose tissue global gene expression (i) differs between never laminitic (NL) and previously laminitic (PL) ponies; (ii) is influenced by season and/or a diet designed to simulate spring grass and (iii... Read More about Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies.

Construction of Red Fox Chromosomal Fragments from the Short-Read Genome Assembly (2018)
Journal Article
Rando, H., Farré, M., Robson, M., Won, N., Johnson, J., Buch, R., Bastounes, E., Xiang, X., Feng, S., Liu, S., Xiong, Z., Kim, J., Zhang, G., Trut, L., Larkin, D. M., & Kukekova, A. (2018). Construction of Red Fox Chromosomal Fragments from the Short-Read Genome Assembly. Genes, 9(6), 308. https://doi.org/10.3390/genes9060308

The genome of a red fox (Vulpes vulpes) was recently sequenced and assembled using next-generation sequencing (NGS). The assembly is of high quality, with 94X coverage and a scaffold N50 of 11.8 Mbp, but is split into 676,878 scaffolds, some of which... Read More about Construction of Red Fox Chromosomal Fragments from the Short-Read Genome Assembly.

A novel kinematics analysis method using quaternion interpolation – a case study in frog jumping (2018)
Journal Article
Richards, C. T., & Porro, L. B. (2018). A novel kinematics analysis method using quaternion interpolation – a case study in frog jumping. Journal of Theoretical Biology, 454, 410-424. https://doi.org/10.1016/j.jtbi.2018.06.010

Spherical Linear Interpolation (SLERP) has long been used in computer animation to interpolate movements between two 3D orientations. We developed a forward kinematics (FK) approach using quaternions and SLERP to predict how frogs modulate jump kinem... Read More about A novel kinematics analysis method using quaternion interpolation – a case study in frog jumping.

Tracking progress: an update on animal models for Duchenne muscular dystrophy (2018)
Journal Article
Wells, D. J. (2018). Tracking progress: an update on animal models for Duchenne muscular dystrophy. Disease Models and Mechanisms, 11, https://doi.org/10.1242/dmm.035774

Understanding the agility of running birds: Sensorimotor and mechanical factors in avian bipedal locomotion (2018)
Journal Article
Daley, M. A. (2018). Understanding the agility of running birds: Sensorimotor and mechanical factors in avian bipedal locomotion. Integrative and Comparative Biology, https://doi.org/10.1093/icb/icy058

Birds are a diverse and agile lineage of vertebrates that all use bipedal locomotion for at least part of their life. Thus birds provide a valuable opportunity to investigate how biomechanics and sensorimotor control are integrated for agile bipedal... Read More about Understanding the agility of running birds: Sensorimotor and mechanical factors in avian bipedal locomotion.

Risk of introduction of lumpy skin disease in France by the import of vectors in animal trucks (2018)
Journal Article
Saegerman, C., Bertagnoli, S., Meyer, G., Ganière, J.-P., Caufour, P., De Clercq, K., Jacquiet, P., Fournié, G., Hautefeuille, C., Etore, F., & Casal, J. (2018). Risk of introduction of lumpy skin disease in France by the import of vectors in animal trucks. PLoS ONE, 13(6), e0198506. https://doi.org/10.1371/journal.pone.0198506

a-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease (2018)
Journal Article
Ludtmann, M. H. R., Angelova, P. R., Horrocks, M. H., Choi, M. L., Rodrigues, M., Baev, A. Y., Berezhnov, A. V., Yao, Z., Little, D., Banushi, B., Al-Menhali, A. S., Ranasinghe, R. T., Whiten, D. R., Yapom, R., Dolt, K. S., Devine, M. J., Gissen, P., Kunath, T., Jaganjac, M., Pavlov, E. V., …Gandhi, S. (2018). a-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease. Nature Communications, 9, 2293. https://doi.org/10.1038/s41467-018-04422-2

Protein aggregation causes α-synuclein to switch from its physiological role to a pathological toxic gain of function. Under physiological conditions, monomeric α-synuclein improves ATP synthase efficiency. Here, we report that aggregation of monomer... Read More about a-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease.

Reduction of the ATPase inhibitory factor 1 (IF1) leads to visual impairment in vertebrates (2018)
Journal Article
Martin-Jimenez, R., Faccenda, D., Allen, E., Reichel, H. B., Arcos, L., Ferraina, C., Strobbe, D., Russell, C., & Campanella, M. (2018). Reduction of the ATPase inhibitory factor 1 (IF1) leads to visual impairment in vertebrates. https://doi.org/10.1038/s41419-018-0578-x

In vertebrates, mitochondria are tightly preserved energy producing organelles, which sustain nervous system development and function. The understanding of proteins that regulate their homoeostasis in complex animals is therefore critical and doing s... Read More about Reduction of the ATPase inhibitory factor 1 (IF1) leads to visual impairment in vertebrates.

The effects & mechanisms of increasing running step rate: A feasibility study in a mixed-sex group of runners with patellofemoral pain (2018)
Journal Article
Neal, B. S., Barton, C. J., Birn-Jeffery, A. V., Daley, M. A., & Morrissey, D. (2018). The effects & mechanisms of increasing running step rate: A feasibility study in a mixed-sex group of runners with patellofemoral pain. Physical Therapy in Sport, 32, 244-251. https://doi.org/10.1016/j.ptsp.2018.05.018

Integrative transcriptome and proteome analyses define marked differences between Neospora caninum isolates throughout the tachyzoite lytic cycle (2018)
Journal Article
Horcajo, P., Xia, D., Randle, N., Collantes-Fernández, E., Wastling, J., Ortega-Mora, L. M., & Regidor-Cerrillo, J. (2018). Integrative transcriptome and proteome analyses define marked differences between Neospora caninum isolates throughout the tachyzoite lytic cycle. Journal of Proteomics, 180, 108-119. https://doi.org/10.1016/j.jprot.2017.11.007

Neospora caninum is one of the main causes of transmissible abortion in cattle. Intraspecific variations in virulence have been widely shown among N. caninum isolates. However, the molecular basis governing such variability have not been elucidated t... Read More about Integrative transcriptome and proteome analyses define marked differences between Neospora caninum isolates throughout the tachyzoite lytic cycle.

Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation (2018)
Journal Article
Martinez, M., Gehring, R., Mochel, J. P., Pade, D., & Pelligand, L. (2018). Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation. Journal of Veterinary Pharmacology and Therapeutics, 41(4), E-68. https://doi.org/10.1111/jvp.12666

During the 2017 Biennial meeting, the American Academy of Veterinary Pharmacology and Therapeutics hosted a 1‐day session on the influence of population variability on dose‐exposure‐response relationships. In Part I, we highlighted some of the source... Read More about Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation.

Regional diversity in the murine cortical vascular network is revealed by synchrotron X-ray tomography and is amplified with age (2018)
Journal Article
Núñez, J. A., Goring, A., Javaheri, B., Razi, H., Gomez-Nicola, D., Pitsillides, A. A., Thurner, P. J., Gomez-Nicola, D., Schneider, P., & Clarkin, C. E. (2018). Regional diversity in the murine cortical vascular network is revealed by synchrotron X-ray tomography and is amplified with age. https://doi.org/10.22203/eCM.v035a20

Cortical bone is permeated by a system of pores, occupied by the blood supply and osteocytes. With ageing, bone mass reduction and disruption of the microstructure are associated with reduced vascular supply. Insight into the regulation of the blood... Read More about Regional diversity in the murine cortical vascular network is revealed by synchrotron X-ray tomography and is amplified with age.

Scaling of avian bipedal locomotion reveals independent effects of body mass and leg posture on gait (2018)
Journal Article
Daley, M. A., & Birn-Jeffery, A. V. (2018). Scaling of avian bipedal locomotion reveals independent effects of body mass and leg posture on gait. Journal of Experimental Biology, 221, https://doi.org/10.1242/jeb.152538

Birds provide an interesting opportunity to study the relationships between body size, limb morphology and bipedal locomotor function. Birds are ecologically diverse and span a large range of body size and limb proportions, yet all use their hindlimb... Read More about Scaling of avian bipedal locomotion reveals independent effects of body mass and leg posture on gait.

Reconstruction of the diapsid ancestral genome permits chromosome evolution tracing in avian and non-avian dinosaurs (2018)
Journal Article
O'Connor, R. E., Romanov, M. N., Kiazim, L. G., Barrett, P. M., Farre Belmonte, M., Damas, J., Ferguson-Smith, M., Valenzuela, N., Larkin, D. M., & Griffin, D. K. (2018). Reconstruction of the diapsid ancestral genome permits chromosome evolution tracing in avian and non-avian dinosaurs. Nature Communications, 9(1), 1883. https://doi.org/10.1038/s41467-018-04267-9

Genomic organisation of extinct lineages can be inferred from extant chromosome-level genome assemblies. Here, we apply bioinformatic and molecular cytogenetic approaches to determine the genomic structure of the diapsid common ancestor. We then infe... Read More about Reconstruction of the diapsid ancestral genome permits chromosome evolution tracing in avian and non-avian dinosaurs.

Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017 (2018)
Journal Article
Clayton, A., Buschmann, D., Byrd, J. B., Carter, D. R. F., Cheng, L., Compton, C., Daaboul, G., Devitt, A., Falcón-Perez, J. M., Gardiner, C., Gustafson, D., Harrison, P., Helmbrecht, C., Hendrix, A., Hill, A., Hoffman, A., Jones, J. C., Kalluri, R., Kang, J. Y., Kirchner, B., …Nieuwland, R. (2018). Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017. Journal of Extracellular Vesicles, 7(1), 1473707. https://doi.org/10.1080/20013078.2018.1473707

The grazing gait, and implications of toppling table geometry for primate footfall sequences (2018)
Journal Article
Usherwood, J. R., & Smith, B. J. H. (2018). The grazing gait, and implications of toppling table geometry for primate footfall sequences. Biology Letters, 14(5), https://doi.org/10.1098/rsbl.2018.0137

Many medium and large herbivores locomote forwards very slowly and intermittently when grazing. While the footfall order during grazing is the same as for walking, the relative fore–hind timing—phasing—is quite different. Extended periods of static s... Read More about The grazing gait, and implications of toppling table geometry for primate footfall sequences.

A dynamic simulation of musculoskeletal function in the mouse hindlimb during trotting locomotion (2018)
Journal Article
Charles, J. P., Cappellari, I., & Hutchinson, J. R. (2018). A dynamic simulation of musculoskeletal function in the mouse hindlimb during trotting locomotion. Frontiers in Bioengineering and Biotechnology, 6(61), https://doi.org/10.3389/fbioe.2018.00061

Mice are often used as animal models of various human neuromuscular diseases, and analysis of these models often requires detailed gait analysis. However, little is known of the dynamics of the mouse musculoskeletal system during locomotion. In this... Read More about A dynamic simulation of musculoskeletal function in the mouse hindlimb during trotting locomotion.