Spatial relationship between bone formation and mechanical stimulus within cortical bone: Combining 3D fluorochrome mapping and poroelastic finite element modelling (2018)
Journal Article
Carriero, A., Pereira, A. F., Wilson, A. J., Castagno, S., Javaheri, B., Pitsillides, A. A., Marenzana, M., & Shefelbine, S. J. (2018). Spatial relationship between bone formation and mechanical stimulus within cortical bone: Combining 3D fluorochrome mapping and poroelastic finite element modelling. Bone Reports, 8, 72-80. https://doi.org/10.1016/j.bonr.2018.02.003

Bone is a dynamic tissue and adapts its architecture in response to biological and mechanical factors. Here we investigate how cortical bone formation is spatially controlled by the local mechanical environment in the murine tibia axial loading model... Read More about Spatial relationship between bone formation and mechanical stimulus within cortical bone: Combining 3D fluorochrome mapping and poroelastic finite element modelling.

Focus on the Role of D-serine and D-amino Acid Oxidase in Amyotrophic Lateral Sclerosis/Motor Neuron Disease (ALS) (2018)
Journal Article
Kondori, N. R., Paul, P., Robbins, J. P., Liu, K., Hildyard, J. C. W., Wells, D. J., & De Belleroche, J. S. (2018). Focus on the Role of D-serine and D-amino Acid Oxidase in Amyotrophic Lateral Sclerosis/Motor Neuron Disease (ALS). Frontiers in Molecular Biosciences, 5(8), https://doi.org/10.3389/fmolb.2018.00008

Highly pathogenic avian influenza (HPAI) H5N1 virus has been circulating in Vietnam since 2003, while outbreaks of HPAI H5N6 virus are more recent, having only been reported since 2014. Although the spatial distribution of H5N1 outbreaks and risk fac... Read More about Focus on the Role of D-serine and D-amino Acid Oxidase in Amyotrophic Lateral Sclerosis/Motor Neuron Disease (ALS).

Folic Acid Exposure Rescues Spina Bifida Aperta Phenotypes in Human Induced Pluripotent Stem Cell Model (2018)
Journal Article
Sahakyan, V., Duelen, R., Tam, W. L., Roberts, S. J., Grosemans, H., Berckmans, P., Ceccarelli, G., Pelizzo, G., Broccoli, V., Deprest, J., Luyten, F. P., Verfaillie, C. M., & Sampaolesi, M. (2018). Folic Acid Exposure Rescues Spina Bifida Aperta Phenotypes in Human Induced Pluripotent Stem Cell Model. Nature, 8, 2942. https://doi.org/10.1038/s41598-018-21103-8

Neural tube defects (NTDs) are severe congenital abnormalities, caused by failed closure of neural tube during early embryonic development. Periconceptional folic acid (FA) supplementation greatly reduces the risk of NTDs. However, the molecular mech... Read More about Folic Acid Exposure Rescues Spina Bifida Aperta Phenotypes in Human Induced Pluripotent Stem Cell Model.

Biomechanics of predator–prey arms race in lion, zebra, cheetah and impala (2018)
Journal Article
Wilson, A. M., Hubel, T. Y., Wilshin, S. D., Lowe, J. C., Lorenc, M., Dewhirst, O. P., Bartlam-Brooks, H. L. A., Diack, R. A., Bennitt, E., Golabek, K. A., Woledge, R., McNutt, J. W., Curtin, N. A., & West, T. G. (2018). Biomechanics of predator–prey arms race in lion, zebra, cheetah and impala. Nature, 554(7691), 183+. https://doi.org/10.1038/nature25479

The fastest and most manoeuvrable terrestrial animals are found in savannah habitats, where predators chase and capture running prey. Hunt outcome and success rate are critical to survival, so both predator and prey should evolve to be faster and/or... Read More about Biomechanics of predator–prey arms race in lion, zebra, cheetah and impala.

Bone apparent and material densities examined by cone beam computed tomography and the Archimedes technique: comparison of the two methods and their results (2018)
Journal Article
Adams, G. J., Cook, R. B., Hutchinson, J. R., & Ziopos, P. (2018). Bone apparent and material densities examined by cone beam computed tomography and the Archimedes technique: comparison of the two methods and their results. Frontiers in Mechanical Engineering, 3(23), https://doi.org/10.3389/fmech.2017.00023

An understanding of bone apparent and material densities and how they vary within bone at the organ level is of great interest in the understanding of degenerative bone conditions and for biomedical engineering applications. The densities of bone tis... Read More about Bone apparent and material densities examined by cone beam computed tomography and the Archimedes technique: comparison of the two methods and their results.

Structure and collagen crimp patterns of functionally distinct equine tendons, revealed by quantitative polarised light microscopy (qPLM) (2018)
Journal Article
Spiesz, E. M., Thorpe, C. T., Thurner, P. J., & Screen, H. R. C. (2018). Structure and collagen crimp patterns of functionally distinct equine tendons, revealed by quantitative polarised light microscopy (qPLM). Acta Biomaterialia, 70, 281-292. https://doi.org/10.1016/j.actbio.2018.01.034

Structure-function relationships in tendons are directly influenced by the arrangement of collagen fibres. However, the details of such arrangements in functionally distinct tendons remain obscure. This study demonstrates the use of quantitative pola... Read More about Structure and collagen crimp patterns of functionally distinct equine tendons, revealed by quantitative polarised light microscopy (qPLM).

Perturbation of the T cell receptor repertoire occurs with increasing age in dogs (2018)
Journal Article
Holder, A., Mirczuk, S. M., Fowkes, R. C., Palmer, D. B., Aspinall, R., & Catchpole, B. (2018). Perturbation of the T cell receptor repertoire occurs with increasing age in dogs. Developmental and Comparative Immunology, 79, 150-157. https://doi.org/10.1016/j.dci.2017.10.020

Pharmacokinetic–pharmacodynamic integration and modelling of oxytetracycline for the calf pathogens Mannheimia haemolytica and Pasteurella multocida (2018)
Journal Article
Lees, P., Potter, T., Pelligand, L., & Toutain, P. L. (2018). Pharmacokinetic–pharmacodynamic integration and modelling of oxytetracycline for the calf pathogens Mannheimia haemolytica and Pasteurella multocida. Journal of Veterinary Pharmacology and Therapeutics, 41(1), 28-38. https://doi.org/10.1111/jvp.12439

A calf tissue cage model was used to study the pharmacokinetics (PK) and pharmacodynamics (PD) of oxytetracycline in serum, inflamed (exudate) and noninflamed (transudate) tissue cage fluids. After intramuscular administration, the PK was characteriz... Read More about Pharmacokinetic–pharmacodynamic integration and modelling of oxytetracycline for the calf pathogens Mannheimia haemolytica and Pasteurella multocida.

Construction of two whole genome radiation hybrid panels for dromedary (Camelus dromedarius): 5000RAD and 15000RAD (2018)
Journal Article
Perelman, P. L., Pichler, R., Gaggl, A., Larkin, D. M., Raudsepp, T., Alshanbari, F., Holl, H. M., Brooks, S. A., Burger, P. A., & Periasamy, K. (2018). Construction of two whole genome radiation hybrid panels for dromedary (Camelus dromedarius): 5000RAD and 15000RAD. Scientific Reports, 8(1), https://doi.org/10.1038/s41598-018-20223-5

The availability of genomic resources including linkage information for camelids has been very limited. Here, we describe the construction of a set of two radiation hybrid (RH) panels (5000RAD and 15000RAD) for the dromedary (Camelus dromedarius) as... Read More about Construction of two whole genome radiation hybrid panels for dromedary (Camelus dromedarius): 5000RAD and 15000RAD.

Giardia secretome highlights secreted tenascins as a key component of pathogenesis (2018)
Journal Article
Dubourg, A., Xia, D., Winpenny, J. P., Al Naimi, S., Bouzid, M., Sexton, D. W., Wastling, J. M., Hunter, P. R., & Tyler, K. M. (2018). Giardia secretome highlights secreted tenascins as a key component of pathogenesis. GigaScience, 7(3), 1-13. https://doi.org/10.1093/gigascience/giy003

Moving in the Anthropocene: Global reductions in terrestrial mammalian movements (2018)
Journal Article
Tucker, M. A., Bohning-Gaese, K., Fagan, W. F., Fryxell, J. M., Van Moorter, B., Alberts, S. C., Ali, A. H., Allen, A. . M., Attias, N., Avgar, T., Bartlam-Brooks, H. L. A., Bayarbaatar, B., Belant, J. L., Bertassoni, A., Beyer, D., Bidner, L., Van Beest, F. M., Blake, S., Blaum, N., Bracis, C., …Kauffman, M. (2018). Moving in the Anthropocene: Global reductions in terrestrial mammalian movements. Science, 359(6374), 466-469. https://doi.org/10.1126/science.aam9712

Anatomical network analysis of the musculoskeletal system reveals integration loss and parcellation boost during the fins-to-limbs transition (2018)
Journal Article
Esteve-Altava, B., Molnar, J. L., Johnston, P., Hutchinson, J. R., & Diogo, R. (2018). Anatomical network analysis of the musculoskeletal system reveals integration loss and parcellation boost during the fins-to-limbs transition. Evolution, https://doi.org/10.1111/evo.13430

Tetrapods evolved from within the lobe-finned fishes around 370 Ma. The evolution of limbs from lobe-fins entailed a major re-organization of the skeletal and muscular anatomy of appendages in early tetrapods. Concurrently, a degree of similarity bet... Read More about Anatomical network analysis of the musculoskeletal system reveals integration loss and parcellation boost during the fins-to-limbs transition.

FGF-2 promotes osteocyte differentiation through increased E11/podoplanin expression (2018)
Journal Article
Ikpegbu, E., Basta, L., Clements, D. N., Fleming, R., Vincent, T. L., Buttle, D. J., Pitsillides, A. A., Staines, K. A., & Farquharson, C. (2018). FGF-2 promotes osteocyte differentiation through increased E11/podoplanin expression. Journal of Cellular Physiology, 233(7), 5334-5347. https://doi.org/10.1002/jcp.26345

E11/podoplanin is critical in the early stages of osteoblast-to-osteocyte transitions (osteocytogenesis), however, the upstream events which regulate E11 expression are unknown. The aim of this study was to examine the effects of FGF-2 on E11-mediate... Read More about FGF-2 promotes osteocyte differentiation through increased E11/podoplanin expression.

Occurrence of preterm calving in Great Britain and associations with milk production and reproductive performance in dairy cattle (2018)
Journal Article
Damaso, A. F., Velasova, M., Van Winden, S. C. L., Chang, Y. M., & Guitian, J. (2018). Occurrence of preterm calving in Great Britain and associations with milk production and reproductive performance in dairy cattle. Veterinary Record Open, 5, e000221. https://doi.org/10.1136/vetreco-2017-000221

This study describes the occurrence of preterm calving in Great Britain and evaluates its associations with subsequent milk production and reproductive performances and survival on farm of dairy cows. A total of 53 British dairy farms and 5759 animal... Read More about Occurrence of preterm calving in Great Britain and associations with milk production and reproductive performance in dairy cattle.

Effect of melatonin supplementation in the long-term preservation of the sheep ovaries at different temperatures and subsequent in vitro embryo production (2018)
Journal Article
Goodarzi, A., Zare Shahneh, A., Kohram, H., Sadeghi, M., Moazenizadeh, M. H., Fouladi-Nashta, A. A., & Dadashpour Davachi, N. (2018). Effect of melatonin supplementation in the long-term preservation of the sheep ovaries at different temperatures and subsequent in vitro embryo production. Theriogenology, 106, 265-270. https://doi.org/10.1016/j.theriogenology.2017.10.009

Investigations in the past decades have shown that oocytes developmental competence following in vitro fertilization is greatly influenced by an interval between isolation of the ovaries immediately after death/slaughter and oocytes recovery from the... Read More about Effect of melatonin supplementation in the long-term preservation of the sheep ovaries at different temperatures and subsequent in vitro embryo production.

Lipopolysaccharide-induced alteration of mitochondrial morphology induces a metabolic shift in microglia modulating the inflammatory response in vitro and in vivo (2018)
Journal Article
Nair, S., Sobotka, K. S., Joshi, P., Gressens, P., Fleiss, B., Thornton, C., Mallard, C., & Hagberg, H. (2018). Lipopolysaccharide-induced alteration of mitochondrial morphology induces a metabolic shift in microglia modulating the inflammatory response in vitro and in vivo. Glia, https://doi.org/10.1002/glia.23587

Accumulating evidence suggests that changes in the metabolic signature of microglia underlie their response to inflammation. We sought to increase our knowledge of how pro‐inflammatory stimuli induce metabolic changes. Primary microglia exposed to li... Read More about Lipopolysaccharide-induced alteration of mitochondrial morphology induces a metabolic shift in microglia modulating the inflammatory response in vitro and in vivo.

Mitochondrial calcium imbalance in Parkinson's disease (2018)
Journal Article
Ludtmann, M. H. R., & Abramov, A. Y. (2018). Mitochondrial calcium imbalance in Parkinson's disease. Neuroscience Letters, 663, 8690. https://doi.org/10.1016/j.neulet.2017.08.044

Multiple factors are involved in the mechanism(s) of neuronal loss in neurodegenerative disorders whilst mitochondria are thought to play a central role in neurodegeneration of Parkinson’s disease. Mitochondria are vital to cellular functions by supp... Read More about Mitochondrial calcium imbalance in Parkinson's disease.

Modulation of foraging strategy in response to distinct prey items and their scents in the aquatic frog Xenopus longipes (Anura: Pipidae) (2018)
Journal Article
Michaels, C. J., Das, S., Chang, Y. M., & Tapley, B. (2018). Modulation of foraging strategy in response to distinct prey items and their scents in the aquatic frog Xenopus longipes (Anura: Pipidae)

Aquatic predators must forage for prey in a complex three-dimensional environment where the availability of different prey types with different spatial niches may vary. Aquatic predators have evolved a number of ways in which they may respond to this... Read More about Modulation of foraging strategy in response to distinct prey items and their scents in the aquatic frog Xenopus longipes (Anura: Pipidae).

Hip joint articular soft tissues of non-dinosaurian Dinosauromorpha and early Dinosauria: evolutionary and biomechanical implications for Saurischia (2018)
Journal Article
Tsai, H. P., Middleton, K. M., Hutchinson, J. R., & Holliday, C. M. (2018). Hip joint articular soft tissues of non-dinosaurian Dinosauromorpha and early Dinosauria: evolutionary and biomechanical implications for Saurischia. Journal of Vertebrate Paleontology, 38(1), https://doi.org/10.1080/02724634.2017.1427593

Dinosauromorphs evolved a wide diversity of hind limb skeletal morphologies, suggesting highly divergent articular soft tissue anatomies. However, poor preservation of articular soft tissues in fossils has hampered any follow-on functional inferences... Read More about Hip joint articular soft tissues of non-dinosaurian Dinosauromorpha and early Dinosauria: evolutionary and biomechanical implications for Saurischia.

Polymorphisms in the canine IL7R 3 ' UTR are associated with thymic output in Labrador retriever dogs and influence post-transcriptional regulation by microRNA 185 (2018)
Journal Article
Holder, A. L., Jones, G., Soutter, F., Palmer, D. B., Aspinall, R., & Catchpole, B. (2018). Polymorphisms in the canine IL7R 3 ' UTR are associated with thymic output in Labrador retriever dogs and influence post-transcriptional regulation by microRNA 185. Developmental and Comparative Immunology, 81, 244-251. https://doi.org/10.1016/j.dci.2017.12.008

Interleukin-7 (IL-7) and its receptor (IL-7R) are essential for T cell development in the thymus, and changes in the IL-7/IL-7R pathway have been implicated in age-associated thymic involution which results in a reduction of naïve T cell output. The... Read More about Polymorphisms in the canine IL7R 3 ' UTR are associated with thymic output in Labrador retriever dogs and influence post-transcriptional regulation by microRNA 185.