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Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice (2020)
Journal Article
Galea, G., Delisser, P., Meakin, L., Price, J., & Windahl, S. (2020). Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice. BONE, 133, 115255. https://doi.org/10.1016/j.bone.2020.115255

The primary aim of osteoanabolic therapies is to strategically increase bone mass in skeletal regions likely to experience high strains. In the young healthy skeleton, this is primarily achieved by bone's adaptation to loading. This adaptation appear... Read More about Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice.

Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice (2020)
Journal Article
Galea, G., Delisser, P., Meakin, L., Price, J., & Windahl, S. (2020). Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice. BONE, 133, 115255. https://doi.org/10.1016/j.bone.2020.115255

The primary aim of osteoanabolic therapies is to strategically increase bone mass in skeletal regions likely to experience high strains. In the young healthy skeleton, this is primarily achieved by bone's adaptation to loading. This adaptation appear... Read More about Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice.

Network Analysis for Complex Neurodegenerative Diseases (2020)
Journal Article
Manzoni, C., Lewis, P. A., & Ferrari, R. (2020). Network Analysis for Complex Neurodegenerative Diseases. Current Genetic Medicine Reports, https://doi.org/10.1007/s40142-020-00181-z

Biomedicine is witnessing a paradigm shift in the way complex disorders are investigated. In particular, the need for big data interpretation has led to the development of pipelines that require the cooperation of different fields of expertise, inclu... Read More about Network Analysis for Complex Neurodegenerative Diseases.

Extracellular pyrophosphate: The body's “water softener” (2020)
Journal Article
Orriss, I. R. (2020). Extracellular pyrophosphate: The body's “water softener”. BONE, https://doi.org/10.1016/j.bone.2020.115243

Extracellular pyrophosphate (ePPi) was first identified as a key endogenous inhibitor of mineralisation in the 1960's by Fleisch and colleagues. The main source of ePPi seems to be extracellular ATP which is continually released from cells in a contr... Read More about Extracellular pyrophosphate: The body's “water softener”.

Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2 (2020)
Journal Article
Galea, G., Paradise, C., Meakin, L., Camilleri, E., Taipaleenmaki, H., Stein, G., Lanyon, L., Price, J., van Wijnen, A., & Dudakovic, A. (2020). Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2. https://doi.org/10.1016/j.gene.2020.100027

Mechanical loading-related strains trigger bone formation by osteoblasts while suppressing resorption by osteoclasts, uncoupling the processes of formation and resorption. Osteocytes may orchestrate this process in part by secreting sclerostin (SOST)... Read More about Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2.

Osteoarthritis-related nociceptive behaviour following mechanical joint loading correlates with cartilage damage (2020)
Journal Article
Ter Heegde, F., Luiz, A. P., Santana-Varela, S., Magnusdottir, R., Hopkinson, M., Chang, Y. M., Poulet, B., Fowkes, R. C., Wood, J. N., & Chenu, C. (2020). Osteoarthritis-related nociceptive behaviour following mechanical joint loading correlates with cartilage damage. Osteoarthritis and Cartilage, 28(3), 383-395. https://doi.org/10.1016/j.joca.2019.12.004

In osteoarthritis (OA), the pain-structure relationship remains complex and poorly understood. Here, we used the mechanical joint loading (MJL) model of OA to investigate both knee pathology and nociceptive behaviour.

Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity (2020)
Journal Article
Staines, K., Hopkinson, M., Dillon, S., Stephen, L., Fleming, R., Sophocleous, A., Buttle, D., Pitsillides, A., & Farquharson, C. (2020). Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity. Bioscience Reports, 40, https://doi.org/10.1042/BSR20190329

E11/Podoplanin (Pdpn) is implicated in early osteocytogenesis and the formation of osteocyte dendrites. This dendritic network is critical for bone modelling/remodelling, through the production of receptor activator of nuclear factor κ B (RANK)-ligan... Read More about Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity.

Minimalist analogue robot discovers animal-like walking gaits (2019)
Journal Article
Smith, B. J. H., & Usherwood, J. R. (2019). Minimalist analogue robot discovers animal-like walking gaits. https://doi.org/10.1088/1748-3190/ab654e

Robots based on simplified or abstracted biomechanical concepts can be a useful tool for investigating how and why animals move the way they do. In this paper we present an extremely simple quadruped robot, which is able to walk with no form of softw... Read More about Minimalist analogue robot discovers animal-like walking gaits.

Association between hyponatremia and neurological dysfunction in hospitalized foals (2019)
Journal Article
Dunkel, B., Dodson, F., Chang, Y. M., & Slovis, N. M. (2019). Association between hyponatremia and neurological dysfunction in hospitalized foals. Journal of Veterinary Emergency and Critical Care, 30(1), 66-73. https://doi.org/10.1111/vec.12906

Hyponatremia and rapid correction of hyponatremia can lead to neurological abnormalities. The objective of the study was to determine whether plasma sodium concentrations (Na+) and speed of correction of hyponatremia are significantly associated with... Read More about Association between hyponatremia and neurological dysfunction in hospitalized foals.

Divergent evolution of terrestrial locomotor abilities in extant Crocodylia (2019)
Journal Article
Hutchinson, J. R., Felkler, D., Houston, K., Chang, Y. M., Brueggen, J., Kledzik, D., & Vliet, K. A. (2019). Divergent evolution of terrestrial locomotor abilities in extant Crocodylia. https://doi.org/10.1038/s41598-019-55768-6

Extant Crocodylia are exceptional because they employ almost the full range of quadrupedal footfall patterns (“gaits”) used by mammals; including asymmetrical gaits such as galloping and bounding. Perhaps this capacity evolved in stem Crocodylomorpha... Read More about Divergent evolution of terrestrial locomotor abilities in extant Crocodylia.

Antimicrobial susceptibility and genetic profile of Mycoplasma hyopneumoniae isolates from Brazil (2019)
Journal Article
Gonzaga, N. F., De Souza, L. F. L., Santos, M. R., Assao, V. S., Rycroft, A. N., Deeney, A. S., Fietto, J. L. R., Bressan, G. C., Moreira, M. A. S., & Silva-Júnior, A. (2019). Antimicrobial susceptibility and genetic profile of Mycoplasma hyopneumoniae isolates from Brazil. https://doi.org/10.1007/s42770-019-00185-0

Mycoplasma hyopneumoniae is the etiologic agent of porcine enzootic pneumonia, responsible for major production losses worldwide. The bacteria have a limited metabolism and need to obtain molecules from the growth environment, which causes multiple d... Read More about Antimicrobial susceptibility and genetic profile of Mycoplasma hyopneumoniae isolates from Brazil.

Aging and Mechanoadaptive Responsiveness of Bone (2019)
Journal Article
Javaheri, B., & Pitsillides, A. A. (2019). Aging and Mechanoadaptive Responsiveness of Bone. Current Osteoporosis Reports, 17(6), 560-569. https://doi.org/10.1007/s11914-019-00553-7

Osteoporosis is an age-related disorder characterized by bone loss and increased fracture susceptibility. Whether this is due to reduced loading in less active elderly individuals or inherent modifications in bone cells is uncertain. We suppose that... Read More about Aging and Mechanoadaptive Responsiveness of Bone.

Variation in limb loading magnitude and timing in tetrapods (2019)
Journal Article
Granatosky, M. C., McElroy, E. J., Lemelin, P., Reilly, S. M., Nyakatura, J. A., Andrada, E., Kilbourne, B. M., Allen, V. R., Butcher, M. T., Blob, R. W., & Ross, C. F. (2019). Variation in limb loading magnitude and timing in tetrapods. Journal of Experimental Biology, https://doi.org/10.1242/jeb.201525

Comparative analyses of locomotion in tetrapods reveal two patterns of stride cycle variability. Tachymetabolic tetrapods (birds and mammals) have lower inter-cycle variation in stride duration than bradymetabolic tetrapods (amphibians, lizards, turt... Read More about Variation in limb loading magnitude and timing in tetrapods.

The contribution of multicellular model organisms to Neuronal Ceroid Lipofuscinosis research (2019)
Journal Article
Russell, C., Huber, R., Hughes, S., Wenfei Liu, Morgan, A., & Tuxworth, R. (2019). The contribution of multicellular model organisms to Neuronal Ceroid Lipofuscinosis research. https://doi.org/10.1016/j.bbadis.2019.165614

The NCLs (neuronal ceroid lipofuscinosis) are forms of neurodegenerative disease that affect people of all ages and ethnicities but are most prevalent in children. Commonly known as Batten disease, this debilitating neurological disorder is comprised... Read More about The contribution of multicellular model organisms to Neuronal Ceroid Lipofuscinosis research.

Raman spectroscopy links differentiating osteoblast matrix signatures to pro-angiogenic potential (2019)
Journal Article
Sharma, A., Goring, A., Staines, K. A., Emery, R., Pitsillides, A. A., Oreffo, R. O. C., Mahajan, S., & Clarkin, C. E. (2019). Raman spectroscopy links differentiating osteoblast matrix signatures to pro-angiogenic potential. Matrix Biology, 5, https://doi.org/10.1016/j.mbplus.2019.100018

Mineralization of bone is achieved by the sequential maturation of the immature amorphous calcium phase to mature hydroxyapatite and is central to the process of bone development and repair. To study normal and dysregulated mineralization in vitro, s... Read More about Raman spectroscopy links differentiating osteoblast matrix signatures to pro-angiogenic potential.

A decade of optimizing drug development for rare neuromuscular disorders through TACT (2019)
Journal Article
Wagner, K. R., De Luca, A., Caizergues, D., Dowling, J., Goemans, N., Gordish-Dressman, H., Grounds, M. D., Kelly, M., Mayhew, A., McNally, E. M., Zoetis, T., Lee, J., Turner, C., Wells, D. J., Csimma, C., & Straub, V. (2019). A decade of optimizing drug development for rare neuromuscular disorders through TACT. Nature Reviews Drug Discovery, 19(1-2), https://doi.org/10.1038/d41573-019-00199-1